Acadvl (acyl-CoA dehydrogenase, very long chain) - Rat Genome Database

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Gene: Acadvl (acyl-CoA dehydrogenase, very long chain) Rattus norvegicus
Analyze
Symbol: Acadvl
Name: acyl-CoA dehydrogenase, very long chain
RGD ID: 2014
Description: Enables acyl-CoA dehydrogenase activity and heterocyclic compound binding activity. Involved in fatty acid beta-oxidation. Located in mitochondrial inner membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain); PARTICIPATES IN fatty acid beta degradation pathway; carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acyl-Coa dehydrogenase Very long chain; acyl-Coenzyme A dehydrogenase, very long chain; MGC93660; Very long chain Acyl-Coa dehydrogenase; very long-chain specific acyl-CoA dehydrogenase, mitochondrial; VLCAD; VLCAD very-long-chain acyl-CoA dehydrogenase; VLCAD, very-long-chain acyl-CoA dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,231,558 - 55,236,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,231,440 - 55,236,750 (-)EnsemblGRCr8
mRatBN7.21054,732,875 - 54,738,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,732,469 - 54,738,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,395,021 - 59,400,168 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,883,601 - 58,888,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,390,891 - 54,396,038 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,619,321 - 56,624,468 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,619,303 - 56,624,526 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,364,440 - 56,369,587 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,856,233 - 56,861,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,886,459 - 53,891,606 (-)NCBICelera
RGSC_v3.11056,869,857 - 56,875,003 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) adipate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
Clofop  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gemfibrozil  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
indometacin  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
lithocholic acid  (ISO)
meldonium  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
oleic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
Tanshinone I  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein. Aoyama T, etal., J Biol Chem 1994 Jul 22;269(29):19088-94.
2. Rozhledy v chirurgii : mesícník Ceskoslovenské chirurgické spolecnosti Bana J and Kralik J, Rozhl Chir 1978 Dec;57(12):813-20.
3. [A rare type of bone involvement in scleroderma (author's transl)] Bem Z and Birecka A, Pol Przegl Radiol Med Nukl 1978 Mar-Apr;42(2):115-7.
4. Potential roles of PINK1 for increased PGC-1alpha-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes. Choi J, etal., Mitochondrion. 2014 Sep;18:41-8. doi: 10.1016/j.mito.2014.09.005. Epub 2014 Sep 23.
5. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation. Chouchani ET, etal., Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.
6. Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. Fujikawa T, etal., J Nutr Sci. 2012 Sep 5;1:e10. doi: 10.1017/jns.2012.12. eCollection 2012.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Acyl-CoA dehydrogenases. A mechanistic overview. Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase. Izai K, etal., J Biol Chem. 1992 Jan 15;267(2):1027-33.
11. The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model. Jia X, etal., Life Sci. 2012 Jun 14;90(23-24):934-43. doi: 10.1016/j.lfs.2012.04.029. Epub 2012 Apr 30.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Selenium significantly inhibits adipocyte hypertrophy and abdominal fat accumulation in OLETF rats via induction of fatty acid beta-oxidation. Kim JE, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):360-70. doi: 10.1007/s12011-012-9519-1. Epub 2012 Oct 18.
14. Inhibition of very long chain acyl-CoA dehydrogenase during cardiac ischemia. Mason KE, etal., Arch Biochem Biophys. 2005 May 15;437(2):138-43. Epub 2005 Mar 19.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
22. Heat stress modulates hepatocyte membrane proteins during endotoxemia. Przkora R, etal., Burns. 2007 Aug;33(5):628-33. Epub 2007 Mar 19.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency: a role for glutaryl-coenzyme A. Sauer SW, etal., J Biol Chem. 2005 Jun 10;280(23):21830-6. Epub 2005 Apr 19.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7668252   PMID:12477932   PMID:14651853   PMID:15639194   PMID:16020546   PMID:18063578   PMID:18614015   PMID:21151927   PMID:21492153   PMID:26316108   PMID:26945066  


Genomics

Comparative Map Data
Acadvl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,231,558 - 55,236,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,231,440 - 55,236,750 (-)EnsemblGRCr8
mRatBN7.21054,732,875 - 54,738,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,732,469 - 54,738,075 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,395,021 - 59,400,168 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,883,601 - 58,888,748 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,390,891 - 54,396,038 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,619,321 - 56,624,468 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,619,303 - 56,624,526 (-)Ensemblrn6Rnor6.0
Rnor_5.01056,364,440 - 56,369,587 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,856,233 - 56,861,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,886,459 - 53,891,606 (-)NCBICelera
RGSC_v3.11056,869,857 - 56,875,003 (-)NCBI
Cytogenetic Map10q24NCBI
ACADVL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,217,125 - 7,225,266 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,217,125 - 7,225,269 (+)Ensemblhg38GRCh38
GRCh37177,120,444 - 7,128,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,063,877 - 7,069,309 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34177,063,956 - 7,069,306NCBI
Celera177,147,787 - 7,153,219 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,012,512 - 7,020,576 (+)NCBIHuRef
CHM1_1177,129,209 - 7,137,334 (+)NCBICHM1_1
T2T-CHM13v2.0177,118,036 - 7,126,177 (+)NCBIT2T-CHM13v2.0
Acadvl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,901,009 - 69,906,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,901,009 - 69,906,237 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381170,010,183 - 70,015,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,010,183 - 70,015,411 (-)Ensemblmm10GRCm38
MGSCv371169,823,694 - 69,828,909 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361169,826,387 - 69,831,602 (-)NCBIMGSCv36mm8
Celera1177,558,144 - 77,563,359 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
Acadvl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,684,250 - 9,689,356 (-)Ensembl
ChiLan1.0NW_0049554679,684,070 - 9,689,454 (-)NCBIChiLan1.0ChiLan1.0
ACADVL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,812,517 - 14,817,937 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,778,578 - 16,783,944 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,249,717 - 7,255,165 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,236,286 - 7,242,417 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,234,283 - 7,242,417 (+)EnsemblpanPan2panpan1.1
ACADVL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,189,191 - 32,194,255 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,186,502 - 32,327,990 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha532,327,393 - 32,332,562 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0532,294,698 - 32,299,874 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,292,139 - 32,335,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,260,008 - 32,265,180 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,219,055 - 32,224,215 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,395,976 - 32,401,145 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acadvl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,040,681 - 47,046,036 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595514,534 - 520,223 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936595514,883 - 520,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACADVL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,576,402 - 52,581,748 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,573,521 - 52,581,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,851,936 - 139,857,148 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACADVL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,593,288 - 6,598,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,593,287 - 6,598,979 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605914,811,795 - 14,817,522 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acadvl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,838,227 - 9,843,332 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247869,838,102 - 9,843,506 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acadvl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1949,616,754 - 49,621,945 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acadvl
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000024973
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024973   ⟹   ENSRNOP00000024973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,231,440 - 55,236,750 (-)Ensembl
mRatBN7.2 Ensembl1054,732,469 - 54,738,075 (-)Ensembl
Rnor_6.0 Ensembl1056,619,303 - 56,624,526 (-)Ensembl
RefSeq Acc Id: NM_012891   ⟹   NP_037023
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,231,558 - 55,236,705 (-)NCBI
mRatBN7.21054,732,875 - 54,738,022 (-)NCBI
Rnor_6.01056,619,321 - 56,624,468 (-)NCBI
Rnor_5.01056,364,440 - 56,369,587 (-)NCBI
RGSC_v3.41056,856,233 - 56,861,380 (-)RGD
Celera1053,886,459 - 53,891,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268458   ⟹   XP_063124528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,233,882 - 55,236,786 (-)NCBI
RefSeq Acc Id: NP_037023   ⟸   NM_012891
- Peptide Label: precursor
- UniProtKB: P45953 (UniProtKB/Swiss-Prot),   F7FEX1 (UniProtKB/TrEMBL),   Q5M9H2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024973   ⟸   ENSRNOT00000024973
RefSeq Acc Id: XP_063124528   ⟸   XM_063268458
- Peptide Label: isoform X1
Protein Domains
ACAD9/ACADV-like C-terminal   Acyl-CoA dehydrogenase/oxidase C-terminal   Acyl-CoA dehydrogenase/oxidase N-terminal   Acyl-CoA oxidase/dehydrogenase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45953-F1-model_v2 AlphaFold P45953 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697345
Promoter ID:EPDNEW_R7870
Type:initiation region
Name:Acadvl_1
Description:acyl-CoA dehydrogenase, very long chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,624,517 - 56,624,577EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2014 AgrOrtholog
BioCyc Gene G2FUF-24489 BioCyc
Ensembl Genes ENSRNOG00000018114 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024973 ENTREZGENE
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot
  2.40.110.10 UniProtKB/Swiss-Prot
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193535 IMAGE-MGC_LOAD
InterPro ACAD9/ACADV-like_C UniProtKB/Swiss-Prot
  Acyl-CoA_DH_CS UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot
  AcylCo_DH-like_C UniProtKB/Swiss-Prot
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot
KEGG Report rno:25363 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93660 IMAGE-MGC_LOAD
NCBI Gene 25363 ENTREZGENE
PANTHER ACYL-COA DEHYDROGENASE UniProtKB/Swiss-Prot
  VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam ACAD9-ACADV_C UniProtKB/Swiss-Prot
  Acyl-CoA_dh_1 UniProtKB/Swiss-Prot
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot
PharmGKB ACADVL RGD
PhenoGen Acadvl PhenoGen
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018114 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot
  SSF56645 UniProtKB/Swiss-Prot
TIGR TC217112
UniProt A6HG07_RAT UniProtKB/TrEMBL
  A6HG08_RAT UniProtKB/TrEMBL
  A6HG10_RAT UniProtKB/TrEMBL
  ACADV_RAT UniProtKB/Swiss-Prot
  F7FEX1 ENTREZGENE, UniProtKB/TrEMBL
  P45953 ENTREZGENE
  Q5M9H2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Acadvl  acyl-CoA dehydrogenase, very long chain  Acadvl  acyl-Coenzyme A dehydrogenase, very long chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Acadvl  acyl-Coenzyme A dehydrogenase, very long chain    Acyl-Coa dehydrogenase, Very long chain  Name updated 629478 APPROVED
2002-06-10 Acadvl  Acyl-Coa dehydrogenase, Very long chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 631729
gene_function catalyzes the beta-oxidation of long-chain fatty acids 631729
gene_process plays a role in long chain fatty acid metabolism 631729
gene_product member of the acyl-CoA dehydrogenase family 631729
gene_protein 655 amino acid sequence with 40 amino acid leader sequence and 615 amino acid residues in the mature protein 631729