Aanat (aralkylamine N-acetyltransferase) - Rat Genome Database

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Gene: Aanat (aralkylamine N-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Aanat
Name: aralkylamine N-acetyltransferase
RGD ID: 2006
Description: Enables 14-3-3 protein binding activity and aralkylamine N-acetyltransferase activity. Involved in several processes, including response to copper ion; response to corticosterone; and response to prostaglandin E. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH (R)-noradrenaline; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA-NAT; arylakylamine N-acetyltransferase; arylalkylamine N - acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Nat4; seretonin N-acetyltransferase; serotonin acetylase; serotonin N-acetyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,323,647 - 102,330,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,326,135 - 102,330,635 (+)EnsemblGRCr8
mRatBN7.210101,827,072 - 101,831,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,883,977 - 106,888,805 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,347,070 - 106,351,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,748,363 - 101,752,675 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,568,091 - 105,572,407 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)Ensemblrn6Rnor6.0
Rnor_5.010105,231,006 - 105,235,322 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,709,371 - 106,713,683 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,399,613 - 100,403,925 (+)NCBICelera
RGSC_v3.110106,723,787 - 106,728,187 (+)NCBI
Cytogenetic Map10q32.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland. Bai L, etal., Brain Res. 2008 Apr 8;1203:89-96. Epub 2008 Feb 9.
2. Circadian expression of transcription factor Fra-2 in the rat pineal gland. Baler R and Klein DC, J Biol Chem 1995 Nov 10;270(45):27319-25.
3. The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. Baler R, etal., J Biol Chem 1997 Mar 14;272(11):6979-85.
4. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Borjigin J, etal., Nature 1995 Dec 21-28;378(6559):783-5.
5. Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland. Chansard M, etal., Brain Res Mol Brain Res. 2005 Oct 3;139(2):333-40.
6. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Coon SL, etal., Science 1995 Dec 8;270(5242):1681-3.
7. Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing. Fernandes PA, etal., J Pineal Res. 2006 Nov;41(4):344-50.
8. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Ganguly S, etal., Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8083-8. Epub 2001 Jun 26.
9. Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland. Garcia RA, etal., Life Sci. 2008 Jan 2;82(1-2):108-14. Epub 2007 Nov 1.
10. In vivo observation of a non-noradrenergic regulation of arylalkylamine N-acetyltransferase gene expression in the rat pineal complex. Garidou ML, etal., Neuroscience 2001;105(3):721-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Adrenergic inducibility of AP-1 binding in the rat pineal gland depends on prior photoperiod. Guillaumond F, etal., J Neurochem 2002 Oct;83(1):157-66.
14. Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. Han S, etal., J Biol Chem. 2005 Nov 18;280(46):38228-34. Epub 2005 Sep 15.
15. Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Hohjoh H, etal., Neurogenetics 2003 Apr;4(3):151-3. Epub 2002 Nov 29.
16. Expression and cellular localization of melatonin-synthesizing enzymes in the rat lens. Itoh MT, etal., J Pineal Res. 2007 Jan;42(1):92-6.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Arylalkylamine N-acetyltransferase: "the Timezyme". Klein DC J Biol Chem. 2007 Feb 16;282(7):4233-7. Epub 2006 Dec 12.
19. Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. Koch M, etal., J Neurochem. 2006 Jul;98(1):267-78.
20. Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes. Lee SY, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C1060-6. Epub 2005 Nov 9.
21. Daily profile in melanopsin transcripts depends on seasonal lighting conditions in the rat retina. Mathes A, etal., J Neuroendocrinol. 2007 Dec;19(12):952-7.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):135-43.
25. Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. Peschke E, etal., J Pineal Res. 2008 Jul 1.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
29. Accumulation of rat pineal serotonin N-acetyltransferase mRNA induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro. Rekasi Z and Czompoly T, J Mol Endocrinol 2002 Feb;28(1):19-31.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Prostaglandin E2 increases adenosine 3',5'-monophosphate concentration and binding-site occupancy, and stimulates serotonin-N-acetyltransferase activity in rat pineal glands in vitro. Ritta MN and Cardinali DP, Mol Cell Endocrinol. 1981 Aug;23(2):151-9.
33. Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Roseboom PH, etal., Endocrinology 1996 Jul;137(7):3033-45.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Biochemical characterization of recombinant serotonin N-acetyltransferase. Zhan-Poe X and Craft CM, J Pineal Res. 1999 Aug;27(1):49-58.
Additional References at PubMed
PMID:7545952   PMID:11313340   PMID:14617573   PMID:15046865   PMID:15193530   PMID:15228600   PMID:15798208   PMID:16099857   PMID:16687309   PMID:17363136   PMID:17364576   PMID:17403780  
PMID:20210853   PMID:21437622   PMID:22908386   PMID:23080076   PMID:23513468   PMID:24877634   PMID:25594545   PMID:27339900   PMID:28502584   PMID:30890428   PMID:31124080   PMID:37256589  
PMID:39149125  


Genomics

Comparative Map Data
Aanat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,323,647 - 102,330,639 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10102,326,135 - 102,330,635 (+)EnsemblGRCr8
mRatBN7.210101,827,072 - 101,831,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,883,977 - 106,888,805 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,347,070 - 106,351,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,748,363 - 101,752,675 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,568,091 - 105,572,407 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)Ensemblrn6Rnor6.0
Rnor_5.010105,231,006 - 105,235,322 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,709,371 - 106,713,683 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10100,399,613 - 100,403,925 (+)NCBICelera
RGSC_v3.110106,723,787 - 106,728,187 (+)NCBI
Cytogenetic Map10q32.2NCBI
AANAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,453,351 - 76,470,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,452,749 - 76,470,122 (+)Ensemblhg38GRCh38
GRCh371774,449,433 - 74,466,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,975,246 - 71,977,794 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341771,975,245 - 71,977,793NCBI
Celera1771,041,811 - 71,058,583 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,877,340 - 69,894,101 (+)NCBIHuRef
CHM1_11774,514,431 - 74,531,198 (+)NCBICHM1_1
T2T-CHM13v2.01777,349,434 - 77,366,693 (+)NCBIT2T-CHM13v2.0
Aanat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,482,547 - 116,489,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,477,258 - 116,488,506 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811116,591,721 - 116,597,680 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,586,432 - 116,597,680 (+)Ensemblmm10GRCm38
MGSCv3711116,455,001 - 116,458,994 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611116,409,777 - 116,413,634 (+)NCBIMGSCv36mm8
Celera11128,363,982 - 128,367,985 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.43NCBI
Aanat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,828,659 - 5,834,812 (-)Ensembl
ChiLan1.0NW_0049555065,828,666 - 5,834,812 (-)NCBIChiLan1.0ChiLan1.0
AANAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,495,416 - 92,513,399 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,321,123 - 97,338,596 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,401,103 - 70,418,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,951,915 - 75,967,411 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,951,915 - 75,967,411 (+)EnsemblpanPan2panpan1.1
AANAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,238,814 - 4,245,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,239,284 - 4,240,707 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha94,920,559 - 4,921,982 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.094,914,638 - 4,921,709 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,914,649 - 4,921,521 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,940,312 - 4,941,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,060,146 - 5,061,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,141,399 - 5,142,822 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aanat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,852,759 - 4,869,231 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,556,285 - 1,559,400 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,556,303 - 1,559,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100518330
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,042,897 - 5,044,505 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1125,042,897 - 5,047,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,887,637 - 4,897,028 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AANAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,206,233 - 45,215,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,206,377 - 45,207,591 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607715,946,938 - 15,949,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aanat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,331,505 - 6,333,599 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248016,329,090 - 6,333,290 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aanat
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1967,472,313 - 67,476,908 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aanat
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:70
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000015221
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
Aanat  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,831,462 - 101,831,692 (+)MAPPERmRatBN7.2
Rnor_6.010105,572,065 - 105,572,294NCBIRnor6.0
Rnor_5.010105,234,980 - 105,235,209UniSTSRnor5.0
RGSC_v3.410106,713,345 - 106,713,574UniSTSRGSC3.4
Celera10100,403,587 - 100,403,816UniSTS
Cytogenetic Map10q32.3UniSTS
D10Wox52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,827,515 - 101,827,789 (+)MAPPERmRatBN7.2
Rnor_6.010105,568,118 - 105,568,391NCBIRnor6.0
Rnor_5.010105,231,033 - 105,231,306UniSTSRnor5.0
RGSC_v3.410106,709,398 - 106,709,671UniSTSRGSC3.4
Celera10100,399,640 - 100,399,913UniSTS
Cytogenetic Map10q32.3UniSTS
D11Mit102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,826,812 - 101,826,964 (+)MAPPERmRatBN7.2
Rnor_6.010105,567,415 - 105,567,566NCBIRnor6.0
Rnor_5.010105,230,330 - 105,230,481UniSTSRnor5.0
RGSC_v3.410106,708,695 - 106,708,846UniSTSRGSC3.4
Celera10100,398,937 - 100,399,088UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 8 15 106 29 28 4 37 4 4 120 66 2 92 36 62 24 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000015221   ⟹   ENSRNOP00000015221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10102,326,135 - 102,330,635 (+)Ensembl
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)Ensembl
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)Ensembl
RefSeq Acc Id: NM_012818   ⟹   NP_036950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,326,323 - 102,330,635 (+)NCBI
mRatBN7.210101,827,489 - 101,831,801 (+)NCBI
Rnor_6.010105,568,091 - 105,572,403 (+)NCBI
Rnor_5.010105,231,006 - 105,235,322 (+)NCBI
RGSC_v3.410106,709,371 - 106,713,683 (+)RGD
Celera10100,399,613 - 100,403,925 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247792   ⟹   XP_006247854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,323,647 - 102,330,639 (+)NCBI
mRatBN7.210101,828,880 - 101,831,805 (+)NCBI
Rnor_6.010105,568,316 - 105,572,407 (+)NCBI
Rnor_5.010105,231,006 - 105,235,322 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036950   ⟸   NM_012818
- UniProtKB: Q4JL74 (UniProtKB/Swiss-Prot),   Q64553 (UniProtKB/Swiss-Prot),   Q64666 (UniProtKB/Swiss-Prot),   A6HKX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247854   ⟸   XM_006247792
- Peptide Label: isoform X1
- UniProtKB: Q4JL74 (UniProtKB/Swiss-Prot),   Q64553 (UniProtKB/Swiss-Prot),   Q64666 (UniProtKB/Swiss-Prot),   A6HKX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015221   ⟸   ENSRNOT00000015221
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64666-F1-model_v2 AlphaFold Q64666 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2006 AgrOrtholog
BioCyc Gene G2FUF-22594 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
BioCyc Pathway Image PWY-6030 BioCyc
Ensembl Genes ENSRNOG00000011182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015221 ENTREZGENE
  ENSRNOT00000015221.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.630.30 UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
  SNAT-like UniProtKB/Swiss-Prot
KEGG Report rno:25120 UniProtKB/Swiss-Prot
NCBI Gene 25120 ENTREZGENE
PANTHER SEROTONIN N-ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  SEROTONIN N-ACETYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Aanat PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011182 RatGTEx
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
TIGR TC222688
UniProt A6HKX7 ENTREZGENE, UniProtKB/TrEMBL
  Q4JL74 ENTREZGENE
  Q64553 ENTREZGENE
  Q64666 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4JL74 UniProtKB/Swiss-Prot
  Q64553 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Aanat  aralkylamine N-acetyltransferase  Aanat  arylalkylamine N-acetyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Aanat  arylalkylamine N-acetyltransferase    arylalkylamine N - acetyltransferase   Name updated 1299863 APPROVED
2002-06-10 Aanat  arylalkylamine N - acetyltransferase       Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Nat4  Seretonin N-acetyltransferase      Symbol withdrawn, duplicate entry of Aanat (RGD:2006) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs gene expression and activity are greatly stimulated by norepinephrine induced increase in cAMP and calcium levels 70285
gene_drugs circulating catecholamines have no effect on mRNA in ganglionectomized rats 70285
gene_expression expressed in the rat pineal gland 628397
gene_process penultimate enzyme in the melatonin biosynthetic pathway 67926
gene_process activity depends on the photoperiodic schedule 628397
gene_process mRNA level increases during the night and helps in the release of melatonin 628397
gene_process responsible for the N-acetylation of serotonin 70285
gene_process may act as the melatonin rhythm-generating enzyme 70285