Gene: AANAT (aralkylamine N-acetyltransferase) Homo sapiens
Symbol: AANAT
Name: aralkylamine N-acetyltransferase
Description: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA-NAT; arylalkylamine n - acetyltransferase; arylalkylamine N-acetyltransferase; DSPS; serotonin acetylase; serotonin N-acetyltransferase; SNAT
Orthologs:
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Genome Assembly GRCh381776,453,351 - 76,470,117+NCBI
Human Alternate Assembly CHM1_11774,514,431 - 74,531,198+NCBI
Human Genome Assembly HuRef1769,877,340 - 69,894,101+NCBI
Human Genome Assembly GRCh371774,449,433 - 74,466,199+NCBI
Human Genome Assembly Build 361771,975,246 - 71,977,794+NCBI
Human Cytogenetic Map17q25.1 NCBI
Human Genome Assembly1771,975,245 - 71,977,793 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AANAT
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 736736
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2014-06-04
Status: ACTIVE