Gene: AANAT (aralkylamine N-acetyltransferase) Homo sapiens
Symbol: AANAT
Name: aralkylamine N-acetyltransferase
Description: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA-NAT; arylalkylamine n - acetyltransferase; arylalkylamine N-acetyltransferase; DSPS; serotonin acetylase; serotonin N-acetyltransferase; SNAT
Orthologs:
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,452,853 - 76,470,790 (+)NCBIGRCh38hg38GRCh38
GRCh371774,449,433 - 74,466,199 (+)NCBIGRCh37hg19GRCh37
Build 361771,975,246 - 71,977,794 (+)NCBINCBI36hg18NCBI36
Build 341771,975,245 - 71,977,793NCBI
Celera1771,041,811 - 71,058,583 (+)NCBI
Cytogenetic Map17q25.1NCBImapview
HuRef1769,877,340 - 69,894,101 (+)NCBI
CHM1_11774,514,431 - 74,531,198 (+)NCBI
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AANAT
Entrez Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 736736
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2016-04-19
Status: ACTIVE