Fpgs (folylpolyglutamate synthase) - Rat Genome Database

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Gene: Fpgs (folylpolyglutamate synthase) Rattus norvegicus
Analyze
Symbol: Fpgs
Name: folylpolyglutamate synthase
RGD ID: 1587713
Description: Enables tetrahydrofolylpolyglutamate synthase activity. Involved in animal organ regeneration and liver development. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytosol and mitochondrial matrix. Orthologous to human FPGS (folylpolyglutamate synthase); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; INTERACTS WITH 17alpha-ethynylestradiol; 3,3',5-triiodo-L-thyronine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: folylpolyglutamate synthase, mitochondrial; LOC103691767; LOC687266; similar to Folylpolyglutamate synthase, mitochondrial precursor (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase); uncharacterized LOC103691767
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,370,505 - 36,391,314 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,370,300 - 36,391,068 (-)EnsemblGRCr8
mRatBN7.2315,972,800 - 15,993,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,972,800 - 15,993,563 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,041,419 - 19,052,326 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,626,427 - 27,637,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,877,501 - 25,888,585 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,717,667 - 11,729,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,717,667 - 11,723,327 (-)Ensemblrn6Rnor6.0
Rnor_5.0317,058,730 - 17,068,957 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera310,713,719 - 10,724,786 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymethotrexate  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
urethane  (ISO)
vorinostat  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IBA,IEA,ISO)
mitochondrial inner membrane  (IEA)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Barredo J and Moran RG, Mol Pharmacol. 1992 Oct;42(4):687-94.
2. Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. Bolanowska WE, etal., Arch Biochem Biophys 1990 Sep;281(2):198-203.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein. McGuire JJ, etal., Adv Exp Med Biol. 1983;163:199-214.
5. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. McGuire JJ, etal., J Biol Chem. 1980 Jun 25;255(12):5776-88.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Gamma-glutamyl hydrolase and drug resistance. Schneider E and Ryan TJ, Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10.
12. Folylpolyglutamate synthetase activity in regenerating rat liver. Tolomelli B, etal., Int J Vitam Nutr Res. 1987;57(2):169-72.
Additional References at PubMed
PMID:3619447   PMID:10739875   PMID:14651853   PMID:18614015   PMID:25164808  


Genomics

Comparative Map Data
Fpgs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,370,505 - 36,391,314 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,370,300 - 36,391,068 (-)EnsemblGRCr8
mRatBN7.2315,972,800 - 15,993,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,972,800 - 15,993,563 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx319,041,419 - 19,052,326 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,626,427 - 27,637,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,877,501 - 25,888,585 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,717,667 - 11,729,694 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,717,667 - 11,723,327 (-)Ensemblrn6Rnor6.0
Rnor_5.0317,058,730 - 17,068,957 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera310,713,719 - 10,724,786 (-)NCBICelera
Cytogenetic Map3p11NCBI
FPGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,802,858 - 127,814,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,794,597 - 127,814,494 (+)Ensemblhg38GRCh38
GRCh379130,565,137 - 130,576,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,604,975 - 129,616,377 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349127,644,728 - 127,655,892NCBI
Celera9101,215,991 - 101,227,396 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,181,664 - 100,193,374 (+)NCBIHuRef
CHM1_19130,716,672 - 130,728,086 (+)NCBICHM1_1
T2T-CHM13v2.09140,010,277 - 140,025,149 (+)NCBIT2T-CHM13v2.0
Fpgs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,572,621 - 32,594,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,572,621 - 32,594,157 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,682,609 - 32,704,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,682,609 - 32,704,145 (-)Ensemblmm10GRCm38
MGSCv37232,538,129 - 32,549,695 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,504,618 - 32,516,141 (-)NCBIMGSCv36mm8
Celera232,389,216 - 32,400,782 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Fpgs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419851,152 - 871,522 (-)Ensembl
ChiLan1.0NW_004955419853,891 - 871,729 (-)NCBIChiLan1.0ChiLan1.0
FPGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,541,063 - 11,552,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,543,055 - 11,555,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,921,986 - 98,933,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,593,631 - 127,604,658 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,593,592 - 127,604,200 (+)EnsemblpanPan2panpan1.1
FPGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,590,092 - 55,612,639 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,585,970 - 55,599,028 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,777,453 - 54,806,066 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,505,432 - 56,520,937 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,511,946 - 56,520,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,265,389 - 55,294,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,586,629 - 55,608,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,671,563 - 55,700,382 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fpgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,684,498 - 195,698,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,453,032 - 15,468,985 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,453,010 - 15,466,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FPGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,287,765 - 268,309,398 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,281,298 - 268,309,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,206,606 - 302,231,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FPGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,316,664 - 10,329,497 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,317,137 - 10,335,271 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660795,892,216 - 5,904,652 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fpgs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,735,613 - 7,754,994 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247607,735,606 - 7,754,750 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fpgs
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v152,944,766 - 2,956,174 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fpgs
223 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:69
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000070916
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH133417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,972,395 - 15,972,591 (+)MAPPERmRatBN7.2
Rnor_6.0311,717,263 - 11,717,458NCBIRnor6.0
Rnor_5.0317,058,326 - 17,058,521UniSTSRnor5.0
Celera310,713,315 - 10,713,510UniSTS
RH 3.4 Map372.7UniSTS
RH134698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,972,879 - 15,973,065 (+)MAPPERmRatBN7.2
Rnor_6.0311,717,747 - 11,717,932NCBIRnor6.0
Rnor_5.0317,058,810 - 17,058,995UniSTSRnor5.0
Celera310,713,799 - 10,713,984UniSTS
RH 3.4 Map370.8UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 90 59 6 354 190 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070916   ⟹   ENSRNOP00000064076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,370,505 - 36,381,431 (-)Ensembl
mRatBN7.2 Ensembl315,972,800 - 15,983,727 (-)Ensembl
Rnor_6.0 Ensembl311,717,667 - 11,723,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106975   ⟹   ENSRNOP00000088525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,370,505 - 36,391,068 (-)Ensembl
mRatBN7.2 Ensembl315,972,800 - 15,993,563 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139275   ⟹   ENSRNOP00000108804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,370,300 - 36,381,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154787   ⟹   ENSRNOP00000108396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,370,505 - 36,385,185 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166777   ⟹   ENSRNOP00000110735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,370,505 - 36,381,431 (-)Ensembl
RefSeq Acc Id: NM_001146125   ⟹   NP_001139597
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,505 - 36,381,431 (-)NCBI
mRatBN7.2315,972,800 - 15,983,727 (-)NCBI
Rnor_6.0311,717,667 - 11,729,694 (-)NCBI
Rnor_5.0317,058,730 - 17,068,957 (-)NCBI
Celera310,713,719 - 10,724,786 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105866   ⟹   XP_038961794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,381,498 (-)NCBI
mRatBN7.2315,973,167 - 15,984,826 (-)NCBI
RefSeq Acc Id: XM_063284562   ⟹   XP_063140632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,382,517 (-)NCBI
RefSeq Acc Id: XM_063284563   ⟹   XP_063140633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,391,314 (-)NCBI
RefSeq Acc Id: XM_063284564   ⟹   XP_063140634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,386,469 (-)NCBI
RefSeq Acc Id: XM_063284565   ⟹   XP_063140635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,381,490 (-)NCBI
RefSeq Acc Id: XM_063284566   ⟹   XP_063140636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,391,312 (-)NCBI
RefSeq Acc Id: XM_063284567   ⟹   XP_063140637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,386,459 (-)NCBI
RefSeq Acc Id: XM_063284568   ⟹   XP_063140638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,370,873 - 36,378,836 (-)NCBI
RefSeq Acc Id: NP_001139597   ⟸   NM_001146125
- Peptide Label: precursor
- UniProtKB: M0R401 (UniProtKB/TrEMBL),   A6JU77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064076   ⟸   ENSRNOT00000070916
RefSeq Acc Id: XP_038961794   ⟸   XM_039105866
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000088525   ⟸   ENSRNOT00000106975
RefSeq Acc Id: XP_063140633   ⟸   XM_063284563
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140636   ⟸   XM_063284566
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AA44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140634   ⟸   XM_063284564
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140637   ⟸   XM_063284567
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140632   ⟸   XM_063284562
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140635   ⟸   XM_063284565
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063140638   ⟸   XM_063284568
- Peptide Label: isoform X8
- UniProtKB: A6JU78 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108396   ⟸   ENSRNOT00000154787
Ensembl Acc Id: ENSRNOP00000110735   ⟸   ENSRNOT00000166777
Ensembl Acc Id: ENSRNOP00000108804   ⟸   ENSRNOT00000139275

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R401-F1-model_v2 AlphaFold M0R401 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587713 AgrOrtholog
BioCyc Gene G2FUF-50127 BioCyc
BioCyc Pathway PWY-2161 [folate polyglutamylation] BioCyc
BioCyc Pathway Image PWY-2161 BioCyc
Ensembl Genes ENSRNOG00000050780 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070916 ENTREZGENE
  ENSRNOT00000070916.4 UniProtKB/TrEMBL
  ENSRNOT00000106975 ENTREZGENE
  ENSRNOT00000106975.2 UniProtKB/TrEMBL
  ENSRNOT00000139275 ENTREZGENE
  ENSRNOT00000139275.1 UniProtKB/TrEMBL
  ENSRNOT00000154787 ENTREZGENE
  ENSRNOT00000154787.1 UniProtKB/TrEMBL
  ENSRNOT00000166777.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.10 UniProtKB/TrEMBL
  3.90.190.20 UniProtKB/TrEMBL
InterPro Folylpolyglutamate_synth UniProtKB/TrEMBL
  Folylpolyglutamate_synth_CS UniProtKB/TrEMBL
  Folylpolyglutamate_synth_euk UniProtKB/TrEMBL
  Mur-like_cat_sf UniProtKB/TrEMBL
  Mur_ligase_C_dom_sf UniProtKB/TrEMBL
KEGG Report rno:687266 UniProtKB/TrEMBL
NCBI Gene 687266 ENTREZGENE
PANTHER PTHR11136 UniProtKB/TrEMBL
  PTHR11136:SF5 UniProtKB/TrEMBL
PharmGKB FPGS RGD
PhenoGen Fpgs PhenoGen
PIRSF FPGS UniProtKB/TrEMBL
PROSITE FOLYLPOLYGLU_SYNT_1 UniProtKB/TrEMBL
  FOLYLPOLYGLU_SYNT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050780 RatGTEx
Superfamily-SCOP SSF53244 UniProtKB/TrEMBL
  SSF53623 UniProtKB/TrEMBL
UniProt A0A8I6AA44 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LIP9_RAT UniProtKB/TrEMBL
  A0ABK0LTV5_RAT UniProtKB/TrEMBL
  A0ABK0M0G5_RAT UniProtKB/TrEMBL
  A6JU77 ENTREZGENE, UniProtKB/TrEMBL
  A6JU78 ENTREZGENE, UniProtKB/TrEMBL
  M0R401 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fpgs  folylpolyglutamate synthase  LOC103691767  uncharacterized LOC103691767  Data merged from RGD:9467549 737654 PROVISIONAL
2014-08-25 LOC103691767  uncharacterized LOC103691767      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-15 Fpgs  folylpolyglutamate synthase  Fpgs_mapped  folylpolyglutamyl synthetase (mapped)  Data merged from RGD:2629 1643240 APPROVED
2009-03-13 Fpgs  folylpolyglutamate synthase  LOC687266  similar to Folylpolyglutamate synthase, mitochondrial precursor (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-19 LOC687266  similar to Folylpolyglutamate synthase, mitochondrial precursor (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Fpgs_mapped  folylpolyglutamyl synthetase (mapped)  Fpgs  folylpolyglutamyl synthetase  Symbol and Name updated 1556543 APPROVED
2002-11-06 Fpgs  folylpolyglutamyl synthetase    Folylpolyglutamate synthase  Name updated 625702 APPROVED
2002-06-10 Fpgs  Folylpolyglutamate synthase      Symbol and Name status set to approved 70586 APPROVED