Fpgs (folylpolyglutamate synthase) - Rat Genome Database

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Gene: Fpgs (folylpolyglutamate synthase) Chinchilla lanigera
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Symbol: Fpgs
Name: folylpolyglutamate synthase
RGD ID: 8819100
Description: ENCODES a protein that exhibits tetrahydrofolylpolyglutamate synthase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cell population proliferation (ortholog); folic acid-containing compound metabolic process (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Colorectal Neoplasms (ortholog); congenital disorder of glycosylation Iu (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: folylpolyglutamate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419851,152 - 871,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955419853,891 - 871,729 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fpgs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419851,152 - 871,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955419853,891 - 871,729 (-)NCBIChiLan1.0ChiLan1.0
FPGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,802,858 - 127,814,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,794,597 - 127,814,327 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,565,137 - 130,576,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,604,975 - 129,616,377 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,644,728 - 127,655,892NCBI
Celera9101,215,991 - 101,227,396 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,181,664 - 100,193,374 (+)NCBIHuRef
CHM1_19130,716,672 - 130,728,086 (+)NCBICHM1_1
T2T-CHM13v2.09140,010,277 - 140,025,149 (+)NCBIT2T-CHM13v2.0
Fpgs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,572,621 - 32,594,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,572,621 - 32,594,157 (-)EnsemblGRCm39 Ensembl
GRCm38232,682,609 - 32,704,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,682,609 - 32,704,145 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,538,129 - 32,549,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,504,618 - 32,516,141 (-)NCBIMGSCv36mm8
Celera232,389,216 - 32,400,782 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Fpgs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,370,505 - 36,391,314 (-)NCBIGRCr8
mRatBN7.2315,972,800 - 15,993,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,972,800 - 15,993,563 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,041,419 - 19,052,326 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,626,427 - 27,637,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,877,501 - 25,888,585 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,717,667 - 11,729,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,717,667 - 11,723,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,058,730 - 17,068,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,713,719 - 10,724,786 (-)NCBICelera
Cytogenetic Map3p11NCBI
FPGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,541,063 - 11,552,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,543,055 - 11,555,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,921,986 - 98,933,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,593,631 - 127,604,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,593,592 - 127,604,200 (+)Ensemblpanpan1.1panPan2
FPGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,590,092 - 55,612,639 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,585,970 - 55,599,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,777,453 - 54,806,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,505,432 - 56,520,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,511,946 - 56,520,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,265,389 - 55,294,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,586,629 - 55,608,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,671,563 - 55,700,382 (-)NCBIUU_Cfam_GSD_1.0
Fpgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,684,498 - 195,698,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,453,032 - 15,468,985 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,453,010 - 15,466,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FPGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,287,765 - 268,309,398 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,281,298 - 268,309,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,206,606 - 302,231,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FPGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,316,664 - 10,329,497 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,317,137 - 10,335,271 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,892,216 - 5,904,652 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fpgs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,735,613 - 7,754,994 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,735,606 - 7,754,750 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000014332   ⟹   ENSCLAP00000014174
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955419851,152 - 871,522 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000014333   ⟹   ENSCLAP00000014175
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955419854,304 - 863,853 (-)Ensembl
RefSeq Acc Id: XM_005382406   ⟹   XP_005382463
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955419853,891 - 863,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513168   ⟹   XP_013368622
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955419853,891 - 871,633 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513169   ⟹   XP_013368623
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955419853,891 - 863,635 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513170   ⟹   XP_013368624
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955419853,891 - 871,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513171   ⟹   XP_013368625
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955419853,891 - 863,635 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005382463   ⟸   XM_005382406
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VEF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368624   ⟸   XM_013513170
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VEF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368622   ⟸   XM_013513168
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VEF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368623   ⟸   XM_013513169
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VEF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368625   ⟸   XM_013513171
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VEF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014174   ⟸   ENSCLAT00000014332
RefSeq Acc Id: ENSCLAP00000014175   ⟸   ENSCLAT00000014333


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014332.1 UniProtKB/TrEMBL
  ENSCLAT00000014333 ENTREZGENE
  ENSCLAT00000014333.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.10 UniProtKB/TrEMBL
  3.90.190.20 UniProtKB/TrEMBL
InterPro Folylpolyglutamate_synth UniProtKB/TrEMBL
  Folylpolyglutamate_synth_CS UniProtKB/TrEMBL
  Folylpolyglutamate_synth_euk UniProtKB/TrEMBL
  Mur-like_cat_sf UniProtKB/TrEMBL
  Mur_ligase_C_dom_sf UniProtKB/TrEMBL
NCBI Gene Fpgs ENTREZGENE
PANTHER PTHR11136 UniProtKB/TrEMBL
  PTHR11136:SF5 UniProtKB/TrEMBL
PIRSF FPGS UniProtKB/TrEMBL
PROSITE FOLYLPOLYGLU_SYNT_1 UniProtKB/TrEMBL
  FOLYLPOLYGLU_SYNT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53244 UniProtKB/TrEMBL
  SSF53623 UniProtKB/TrEMBL
UniProt A0A8C2VEF3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YPP9_CHILA UniProtKB/TrEMBL