FPGS (folylpolyglutamate synthase) - Rat Genome Database

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Gene: FPGS (folylpolyglutamate synthase) Canis lupus familiaris
Analyze
Symbol: FPGS
Name: folylpolyglutamate synthase
RGD ID: 12207598
Description: ENCODES a protein that exhibits tetrahydrofolylpolyglutamate synthase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cell population proliferation (ortholog); glycine metabolic process (ortholog); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; hereditary folate malabsorption pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Colorectal Neoplasms (ortholog); congenital disorder of glycosylation Iu (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrial inner membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: folylpolyglutamate synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,590,092 - 55,612,639 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,585,970 - 55,599,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,777,453 - 54,806,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,505,432 - 56,520,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,511,946 - 56,520,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,265,389 - 55,294,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,586,629 - 55,608,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,671,563 - 55,700,382 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FPGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,590,092 - 55,612,639 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,585,970 - 55,599,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,777,453 - 54,806,066 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,505,432 - 56,520,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,511,946 - 56,520,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,265,389 - 55,294,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,586,629 - 55,608,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,671,563 - 55,700,382 (-)NCBIUU_Cfam_GSD_1.0
FPGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,802,858 - 127,814,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,794,597 - 127,814,327 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,565,137 - 130,576,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,604,975 - 129,616,377 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,644,728 - 127,655,892NCBI
Celera9101,215,991 - 101,227,396 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,181,664 - 100,193,374 (+)NCBIHuRef
CHM1_19130,716,672 - 130,728,086 (+)NCBICHM1_1
T2T-CHM13v2.09140,010,277 - 140,025,149 (+)NCBIT2T-CHM13v2.0
Fpgs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,572,621 - 32,594,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,572,621 - 32,594,157 (-)EnsemblGRCm39 Ensembl
GRCm38232,682,609 - 32,704,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,682,609 - 32,704,145 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,538,129 - 32,549,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,504,618 - 32,516,141 (-)NCBIMGSCv36mm8
Celera232,389,216 - 32,400,782 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Fpgs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,370,505 - 36,391,314 (-)NCBIGRCr8
mRatBN7.2315,972,800 - 15,993,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,972,800 - 15,993,563 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,041,419 - 19,052,326 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,626,427 - 27,637,332 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,877,501 - 25,888,585 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,717,667 - 11,729,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,717,667 - 11,723,327 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,058,730 - 17,068,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,713,719 - 10,724,786 (-)NCBICelera
Cytogenetic Map3p11NCBI
Fpgs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419851,152 - 871,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955419853,891 - 871,729 (-)NCBIChiLan1.0ChiLan1.0
FPGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,541,063 - 11,552,677 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,543,055 - 11,555,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,921,986 - 98,933,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,593,631 - 127,604,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,593,592 - 127,604,200 (+)Ensemblpanpan1.1panPan2
Fpgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,684,498 - 195,698,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,453,032 - 15,468,985 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,453,010 - 15,466,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FPGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,287,765 - 268,309,398 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,281,298 - 268,309,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,206,606 - 302,231,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FPGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,316,664 - 10,329,497 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,317,137 - 10,335,271 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,892,216 - 5,904,652 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fpgs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,735,613 - 7,754,994 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,735,606 - 7,754,750 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FPGS
312 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 17 6 1 6 3 8 5 2
Low 5 5 5 5 6 6 9 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000032010   ⟹   ENSCAFP00000029808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl955,587,991 - 55,599,028 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069678   ⟹   ENSCAFP00000052748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl955,587,991 - 55,599,028 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085993   ⟹   ENSCAFP00000058484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl955,585,970 - 55,599,028 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009506   ⟹   ENSCAFP00845007429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl956,511,946 - 56,520,955 (-)Ensembl
RefSeq Acc Id: XM_003639312   ⟹   XP_003639360
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1955,590,092 - 55,599,061 (-)NCBI
Dog10K_Boxer_Tasha954,777,453 - 54,792,944 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005625331   ⟹   XP_005625388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1955,590,092 - 55,612,639 (-)NCBI
Dog10K_Boxer_Tasha954,777,453 - 54,806,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038487335   ⟹   XP_038343263
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1955,265,389 - 55,294,226 (-)NCBI
RefSeq Acc Id: XM_038487336   ⟹   XP_038343264
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1955,265,389 - 55,280,889 (-)NCBI
RefSeq Acc Id: XM_038549264   ⟹   XP_038405192
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0955,671,563 - 55,700,382 (-)NCBI
RefSeq Acc Id: XM_038549265   ⟹   XP_038405193
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0955,671,563 - 55,687,043 (-)NCBI
RefSeq Acc Id: XM_038613207   ⟹   XP_038469135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0955,586,629 - 55,608,958 (-)NCBI
RefSeq Acc Id: XM_038613208   ⟹   XP_038469136
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0955,586,630 - 55,595,628 (-)NCBI
RefSeq Acc Id: XM_038678499   ⟹   XP_038534427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0956,505,432 - 56,520,937 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005625388   ⟸   XM_005625331
- Peptide Label: isoform X8
- UniProtKB: A0A8C0SW68 (UniProtKB/TrEMBL),   A0A8P0P2D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003639360   ⟸   XM_003639312
- Peptide Label: isoform X9
- UniProtKB: A0A8C0N3I7 (UniProtKB/TrEMBL),   A0A8P0P7N2 (UniProtKB/TrEMBL),   A0A8C0SW68 (UniProtKB/TrEMBL),   A0A8P0P2D4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000052748   ⟸   ENSCAFT00000069678
RefSeq Acc Id: ENSCAFP00000058484   ⟸   ENSCAFT00000085993
RefSeq Acc Id: ENSCAFP00000029808   ⟸   ENSCAFT00000032010
RefSeq Acc Id: XP_038343263   ⟸   XM_038487335
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038343264   ⟸   XM_038487336
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038469135   ⟸   XM_038613207
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038469136   ⟸   XM_038613208
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038534427   ⟸   XM_038678499
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SW68 (UniProtKB/TrEMBL),   A0A8P0P2D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405192   ⟸   XM_038549264
- Peptide Label: isoform X6
- UniProtKB: A0A8C0SW68 (UniProtKB/TrEMBL),   A0A8P0P2D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405193   ⟸   XM_038549265
- Peptide Label: isoform X7
- UniProtKB: A0A8C0N3I7 (UniProtKB/TrEMBL),   A0A8C0SW68 (UniProtKB/TrEMBL),   A0A8P0P2D4 (UniProtKB/TrEMBL),   A0A8P0P7N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845007429   ⟸   ENSCAFT00845009506

Promoters
RGD ID:13684831
Promoter ID:EPDNEW_C2899
Type:initiation region
Name:FPGS_1
Description:folylpolyglutamate synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1955,598,981 - 55,599,041EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020111 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011373 UniProtKB/TrEMBL
  ENSCAFG00040016624 UniProtKB/TrEMBL
  ENSCAFG00845005346 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000069678.2 UniProtKB/TrEMBL
  ENSCAFT00000085993.2 UniProtKB/TrEMBL
  ENSCAFT00030021351.1 UniProtKB/TrEMBL
  ENSCAFT00030021465.1 UniProtKB/TrEMBL
  ENSCAFT00040030940.1 UniProtKB/TrEMBL
  ENSCAFT00040031036.1 UniProtKB/TrEMBL
  ENSCAFT00040031143.1 UniProtKB/TrEMBL
  ENSCAFT00845009506 ENTREZGENE
  ENSCAFT00845009506.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.10 UniProtKB/TrEMBL
  3.90.190.20 UniProtKB/TrEMBL
InterPro Folylpolyglutamate_synth UniProtKB/TrEMBL
  Folylpolyglutamate_synth_CS UniProtKB/TrEMBL
  Folylpolyglutamate_synth_euk UniProtKB/TrEMBL
  Mur-like_cat_sf UniProtKB/TrEMBL
  Mur_ligase_C_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:100855785 UniProtKB/TrEMBL
NCBI Gene FPGS ENTREZGENE
PANTHER PTHR11136 UniProtKB/TrEMBL
  PTHR11136:SF5 UniProtKB/TrEMBL
PIRSF FPGS UniProtKB/TrEMBL
PROSITE FOLYLPOLYGLU_SYNT_1 UniProtKB/TrEMBL
  FOLYLPOLYGLU_SYNT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53244 UniProtKB/TrEMBL
  SSF53623 UniProtKB/TrEMBL
UniProt A0A8C0N3I7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SUM6_CANLF UniProtKB/TrEMBL
  A0A8C0SW68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MXH3_CANLF UniProtKB/TrEMBL
  A0A8P0P2D4 ENTREZGENE
  A0A8P0P7N2 ENTREZGENE
UniProt Secondary A0A8P0P2D4 UniProtKB/TrEMBL
  A0A8P0P7N2 UniProtKB/TrEMBL
VGNC ID VGNC:40973 ENTREZGENE