Myl2 (myosin light chain 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Myl2 (myosin light chain 2) Rattus norvegicus
Analyze
Symbol: Myl2
Name: myosin light chain 2
RGD ID: 1564245
Description: Predicted to enable actin monomer binding activity and calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction; cell growth involved in cardiac muscle cell development; and regulation of the force of heart contraction. Located in myofibril. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 10; and infantile-onset myofibrillar myopathy 12 with cardiomyopathy. Orthologous to human MYL2 (myosin light chain 2); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH (R)-adrenaline; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac myosin light chain-2; Mlc-2; MLC-2s/v; MLC-2v; Mlc2; myosin light chain 2, slow skeletal/ventricular muscle isoform; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,114,964 - 40,126,236 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,114,958 - 40,129,149 (-)EnsemblGRCr8
mRatBN7.21234,454,223 - 34,468,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,454,218 - 34,468,983 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,626,649 - 35,633,589 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,237,862 - 36,244,802 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,290,342 - 35,297,282 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,951,863 - 39,959,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,951,987 - 39,958,239 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,831,137 - 41,835,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,653,745 - 35,664,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,122,106 - 36,128,911 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amifostine  (ISO)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
Cyclocurcumin  (EXP)
dexamethasone  (ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flavonoids  (EXP)
graphite  (EXP)
hydrogen peroxide  (ISO)
icariin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
quercitrin  (ISO)
resveratrol  (EXP,ISO)
serotonin  (EXP)
sodium arsenite  (ISO)
sodium nitrate  (ISO)
sunitinib  (ISO)
triclosan  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
UTP  (EXP)
verapamil  (ISO)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
A band  (IEA)
actin cytoskeleton  (IEA,ISO)
cardiac myofibril  (IEA,ISO)
contractile muscle fiber  (IDA)
cytoplasm  (IBA)
cytoskeleton  (IEA,ISO)
myofibril  (IBA,IDA,ISO)
myosin complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations. Andersen PS, etal., J Med Genet. 2001 Dec;38(12):E43.
2. Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy. Flavigny J, etal., J Mol Med. 1998 Mar;76(3-4):208-14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. Nakagawa O, etal., J Clin Invest. 1995 Sep;96(3):1280-7.
5. Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development. Olsson MC, etal., Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2712-8. Epub 2004 Aug 26.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation. Rossmanith GH, etal., J Physiol. 1997 Nov 15;505 ( Pt 1):217-27.
13. Effects of calmodulin and okadaic acid on myofibrillar Ca2+ sensitivity in cardiac myocytes. Suematsu N, etal., Basic Res Cardiol. 2002 Mar;97(2):137-44.
14. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Wu LL, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R408-16.
Additional References at PubMed
PMID:1379240   PMID:2808370   PMID:3005270   PMID:3380697   PMID:8673105   PMID:8777429   PMID:9180271   PMID:9422794   PMID:10409661   PMID:11102452   PMID:11356630   PMID:12477932  
PMID:15308581   PMID:15489334   PMID:15824735   PMID:16908724   PMID:17043135   PMID:18703533   PMID:22199233   PMID:25771144   PMID:25982880   PMID:26316108   PMID:27748856   PMID:30161304  
PMID:35352799   PMID:38474189  


Genomics

Comparative Map Data
Myl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,114,964 - 40,126,236 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,114,958 - 40,129,149 (-)EnsemblGRCr8
mRatBN7.21234,454,223 - 34,468,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,454,218 - 34,468,983 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,626,649 - 35,633,589 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,237,862 - 36,244,802 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,290,342 - 35,297,282 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,951,863 - 39,959,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,951,987 - 39,958,239 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,831,137 - 41,835,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,653,745 - 35,664,700 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,122,106 - 36,128,911 (-)NCBICelera
Cytogenetic Map12q16NCBI
MYL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,910,845 - 110,921,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12110,909,996 - 111,052,434 (-)Ensemblhg38GRCh38
GRCh3712111,348,649 - 111,359,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,833,032 - 109,842,764 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412109,811,347 - 109,821,085NCBI
Celera12110,975,312 - 110,985,091 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12108,365,094 - 108,374,877 (-)NCBIHuRef
CHM1_112111,316,331 - 111,326,109 (-)NCBICHM1_1
T2T-CHM13v2.012110,890,028 - 110,900,632 (-)NCBIT2T-CHM13v2.0
Myl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,230,787 - 122,251,536 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,239,014 - 122,251,535 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385122,092,724 - 122,113,473 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,100,951 - 122,113,472 (+)Ensemblmm10GRCm38
MGSCv375122,550,989 - 122,556,863 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,361,596 - 122,367,471 (+)NCBIMGSCv36mm8
Celera5119,192,003 - 119,197,855 (+)NCBICelera
Cytogenetic Map5FNCBI
Myl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,705,912 - 7,713,870 (-)Ensembl
ChiLan1.0NW_0049554827,708,436 - 7,713,877 (-)NCBIChiLan1.0ChiLan1.0
MYL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210118,973,570 - 118,983,467 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112118,969,974 - 118,979,871 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,479,941 - 108,489,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112111,873,270 - 111,883,047 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,873,270 - 111,883,047 (-)EnsemblpanPan2panpan1.1
MYL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,624,147 - 8,632,166 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,464,176 - 8,632,232 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha268,787,327 - 8,795,347 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0268,883,864 - 8,891,901 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,722,700 - 8,891,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,840,577 - 8,848,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,902,481 - 8,910,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,855,848 - 8,863,872 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,725,869 - 155,733,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,745,864 - 3,753,681 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,746,227 - 3,753,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,205,273 - 32,213,722 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11432,205,953 - 32,213,848 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,177,329 - 34,185,167 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,154,803 - 106,164,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,155,017 - 106,164,675 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037138,926,204 - 138,936,011 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,109,061 - 21,113,993 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474721,108,998 - 21,113,993 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Myl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11631,727,874 - 31,734,588 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myl2
74 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:55
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000050368
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
BE110694  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81240,121,763 - 40,121,921 (+)Marker Load Pipeline
mRatBN7.21234,461,022 - 34,461,180 (+)MAPPERmRatBN7.2
Rnor_6.01239,958,916 - 39,959,073NCBIRnor6.0
Rnor_5.01241,835,657 - 41,835,814UniSTSRnor5.0
RGSC_v3.41235,664,539 - 35,664,696UniSTSRGSC3.4
Celera1236,128,762 - 36,128,919UniSTS
RH 3.4 Map12610.1UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 12 62 104 54 52 22 84 22 6 258 179 10 75 42 63 30 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000050368   ⟹   ENSRNOP00000039707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,114,958 - 40,122,015 (-)Ensembl
mRatBN7.2 Ensembl1234,454,218 - 34,461,190 (-)Ensembl
Rnor_6.0 Ensembl1239,951,987 - 39,958,239 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095667   ⟹   ENSRNOP00000076784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,114,958 - 40,121,106 (-)Ensembl
mRatBN7.2 Ensembl1234,454,218 - 34,460,366 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099110   ⟹   ENSRNOP00000091606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,115,082 - 40,122,015 (-)Ensembl
mRatBN7.2 Ensembl1234,454,342 - 34,460,764 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109106   ⟹   ENSRNOP00000077578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,114,958 - 40,129,149 (-)Ensembl
mRatBN7.2 Ensembl1234,454,218 - 34,468,983 (-)Ensembl
RefSeq Acc Id: NM_001035252   ⟹   NP_001030329
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,114,964 - 40,121,913 (-)NCBI
mRatBN7.21234,454,224 - 34,461,172 (-)NCBI
Rnor_6.01239,951,863 - 39,959,065 (-)NCBI
Rnor_5.01241,831,137 - 41,835,806 (-)NCBI
RGSC_v3.41235,653,745 - 35,664,700 (-)RGD
Celera1236,122,106 - 36,128,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089640   ⟹   XP_038945568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,114,964 - 40,126,236 (-)NCBI
mRatBN7.21234,454,223 - 34,468,554 (-)NCBI
RefSeq Acc Id: NP_001030329   ⟸   NM_001035252
- UniProtKB: A0JMZ7 (UniProtKB/Swiss-Prot),   P08733 (UniProtKB/Swiss-Prot),   A0A8I5Y0S1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039707   ⟸   ENSRNOT00000050368
RefSeq Acc Id: XP_038945568   ⟸   XM_039089640
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y0S1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076784   ⟸   ENSRNOT00000095667
Ensembl Acc Id: ENSRNOP00000091606   ⟸   ENSRNOT00000099110
Ensembl Acc Id: ENSRNOP00000077578   ⟸   ENSRNOT00000109106
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08733-F1-model_v2 AlphaFold P08733 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564245 AgrOrtholog
BioCyc Gene G2FUF-19228 BioCyc
Ensembl Genes ENSRNOG00000030848 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050368 ENTREZGENE
  ENSRNOT00000050368.6 UniProtKB/Swiss-Prot
  ENSRNOT00000095667 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190683 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Myosin_RLC UniProtKB/Swiss-Prot
KEGG Report rno:363925 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156486 IMAGE-MGC_LOAD
NCBI Gene 363925 ENTREZGENE
PANTHER MYOSIN REGULATORY LIGHT CHAIN 2 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Myl2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030848 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0S1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y6I0_RAT UniProtKB/TrEMBL
  A0A8I6AET1_RAT UniProtKB/TrEMBL
  A0JMZ7 ENTREZGENE
  A6I9M5_RAT UniProtKB/TrEMBL
  A6I9M6_RAT UniProtKB/TrEMBL
  A6I9M9_RAT UniProtKB/TrEMBL
  D3Z9K3_RAT UniProtKB/TrEMBL
  MLRV_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JMZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Myl2  myosin light chain 2  Myl2  myosin, light chain 2, regulatory, cardiac, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Myl2  myosin, light chain 2, regulatory, cardiac, slow  Myl2  myosin, light polypeptide 2, regulatory, cardiac, slow  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-23 Myl2  myosin, light polypeptide 2, regulatory, cardiac, slow  Mlc2  myosin regulatory light chain 2, ventricular/cardiac muscle isoform  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 PROVISIONAL
2006-02-09 Mlc2  myosin regulatory light chain 2, ventricular/cardiac muscle isoform      Symbol and Name status set to provisional 70820 PROVISIONAL