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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564245
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myl2
Name: myosin light chain 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myl2decreases expressionISOMyl2 (Mus musculus)6480464CTDDexamethasone results in decreased expression of MYL2 mRNAPMID:22733784
Myl2increases expressionISOMyl2 (Mus musculus)6480464CTDDexamethasone results in increased expression of MYL2 mRNAPMID:19596060
Myl2multiple interactionsISOMyl2 (Mus musculus)6480464CTD[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA; Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]; Mifepristone inhibits the reaction [[Dexamethasone co-treated with Doxorubicin] results in increased expression of MYL2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [[Verapamil co-treated with Doxorubicin] results in decreased expression of MYL2 mRNA]]PMID:19596060
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