Mapk8ip3 (mitogen-activated protein kinase 8 interacting protein 3) - Rat Genome Database

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Gene: Mapk8ip3 (mitogen-activated protein kinase 8 interacting protein 3) Rattus norvegicus
Analyze
Symbol: Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
RGD ID: 1563691
Description: Enables mitogen-activated protein kinase kinase binding activity. Involved in several processes, including anterograde axonal protein transport; axon regeneration; and positive regulation of JNK cascade. Located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JIP3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JSAP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Alc5 Alc9
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,422,936 - 14,463,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)EnsemblGRCr8
mRatBN7.21013,918,417 - 13,958,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,666,921 - 18,705,192 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,155,781 - 18,194,055 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,654,998 - 13,693,274 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,259,394 - 14,299,276 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,260,787 - 14,299,167 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,075,410 - 14,115,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,147,895 - 14,186,277 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,599,018 - 13,637,404 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
DDT  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
glafenine  (EXP)
glycidol  (EXP)
glyphosate  (EXP,ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axolemma  (IEA,ISO)
axon  (IDA,IEA,ISO)
axon cytoplasm  (IEA)
cell body  (IDA)
cytoplasm  (IBA,IEA,ISO)
cytoplasmic vesicle  (IEA)
dendrite  (IDA,IEA,ISO)
Golgi apparatus  (IEA)
Golgi membrane  (IEA,ISO)
growth cone  (IEA)
perinuclear region of cytoplasm  (IDA,IEA)
plasma membrane  (IEA,ISO)
smooth endoplasmic reticulum  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells. Bayarsaikhan M, etal., Biochem Biophys Res Commun. 2007 Feb 9;353(2):357-62. Epub 2006 Dec 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells. Sato S, etal., Gene. 2004 Mar 31;329:51-60.
9. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
10. JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation. Watt D, etal., J Biol Chem. 2015 Jun 19;290(25):15512-25. doi: 10.1074/jbc.M115.651885. Epub 2015 May 5.
11. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.
12. Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion. Xu B, etal., Can J Physiol Pharmacol. 2010 Nov;88(11):1084-92. doi: 10.1139/y10-088.
13. Blockade of the translocation and activation of mitogen-activated protein kinase kinase 4 (MKK4) signaling attenuates neuronal damage during later ischemia-reperfusion. Zhang QX, etal., J Neurochem. 2006 Jul;98(1):170-9.
14. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y and Dong C, Cell Mol Life Sci. 2007 Nov;64(21):2771-89.
Additional References at PubMed
PMID:10523642   PMID:10629060   PMID:11106729   PMID:12897243   PMID:15572149   PMID:15767678   PMID:16606357   PMID:18324732   PMID:25644797   PMID:28259553   PMID:29159770  


Genomics

Comparative Map Data
Mapk8ip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,422,936 - 14,463,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)EnsemblGRCr8
mRatBN7.21013,918,417 - 13,958,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,666,921 - 18,705,192 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,155,781 - 18,194,055 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,654,998 - 13,693,274 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,259,394 - 14,299,276 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,260,787 - 14,299,167 (-)Ensemblrn6Rnor6.0
Rnor_5.01014,075,410 - 14,115,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,147,895 - 14,186,277 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,599,018 - 13,637,404 (-)NCBICelera
Cytogenetic Map10q12NCBI
MAPK8IP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,706,195 - 1,770,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,706,166 - 1,770,351 (+)Ensemblhg38GRCh38
GRCh37161,756,196 - 1,820,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,696,222 - 1,760,319 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34161,696,221 - 1,760,318NCBI
Celera161,968,494 - 2,032,593 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,681,212 - 1,743,210 (+)NCBIHuRef
CHM1_1161,756,194 - 1,820,266 (+)NCBICHM1_1
T2T-CHM13v2.0161,722,043 - 1,786,181 (+)NCBIT2T-CHM13v2.0
Mapk8ip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,116,480 - 25,155,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,111,127 - 25,155,942 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,897,506 - 24,936,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,892,153 - 24,936,977 (-)Ensemblmm10GRCm38
MGSCv371725,034,451 - 25,073,922 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,625,154 - 24,664,568 (-)NCBIMGSCv36mm8
Celera1725,424,206 - 25,463,501 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Mapk8ip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,498,909 - 15,545,298 (-)Ensembl
ChiLan1.0NW_00495544215,498,909 - 15,545,298 (-)NCBIChiLan1.0ChiLan1.0
MAPK8IP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,972,062 - 2,036,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,753,961 - 5,818,396 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016327,995 - 392,691 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1161,777,038 - 1,822,716 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,759,171 - 1,821,246 (+)EnsemblpanPan2panpan1.1
MAPK8IP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,132,746 - 39,179,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,133,965 - 39,179,505 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,371,384 - 40,417,498 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,448,926 - 39,495,054 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,448,928 - 39,494,994 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,125,612 - 39,172,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,098,192 - 39,144,487 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,576,641 - 39,622,760 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mapk8ip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,446,068 - 104,486,444 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,222,996 - 2,263,390 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,223,020 - 2,263,388 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8IP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,196,875 - 40,241,291 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1340,196,873 - 40,241,453 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,660,821 - 41,705,647 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8IP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,616,672 - 1,679,350 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,616,668 - 1,677,721 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,406,891 - 29,469,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk8ip3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913481,207 - 529,070 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624913481,236 - 529,083 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mapk8ip3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,178,242 - 2,217,760 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mapk8ip3
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:80
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000042066
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH130942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,928,140 - 13,928,340 (+)MAPPERmRatBN7.2
Rnor_6.01014,269,118 - 14,269,317NCBIRnor6.0
Rnor_5.01014,085,134 - 14,085,333UniSTSRnor5.0
RGSC_v3.41014,156,226 - 14,156,425UniSTSRGSC3.4
Celera1013,607,349 - 13,607,548UniSTS
RH 3.4 Map10172.3UniSTS
Cytogenetic Map10q12UniSTS
BF388024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,919,345 - 13,919,563 (+)MAPPERmRatBN7.2
Rnor_6.01014,260,323 - 14,260,540NCBIRnor6.0
Rnor_5.01014,076,339 - 14,076,556UniSTSRnor5.0
RGSC_v3.41014,147,431 - 14,147,648UniSTSRGSC3.4
Celera1013,598,554 - 13,598,771UniSTS
RH 3.4 Map10192.4UniSTS
Cytogenetic Map10q12UniSTS
AI235144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,945,165 - 13,945,292 (+)MAPPERmRatBN7.2
Rnor_6.01014,286,143 - 14,286,269NCBIRnor6.0
Rnor_5.01014,102,159 - 14,102,285UniSTSRnor5.0
RGSC_v3.41014,173,251 - 14,173,377UniSTSRGSC3.4
Celera1013,624,374 - 13,624,500UniSTS
RH 3.4 Map10170.5UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB118217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB118218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ377222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042066   ⟹   ENSRNOP00000039682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)Ensembl
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)Ensembl
Rnor_6.0 Ensembl1014,260,787 - 14,299,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094258   ⟹   ENSRNOP00000082502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)Ensembl
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101875   ⟹   ENSRNOP00000089458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)Ensembl
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109512   ⟹   ENSRNOP00000096061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,422,936 - 14,462,812 (-)Ensembl
mRatBN7.2 Ensembl1013,918,400 - 13,958,273 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110227   ⟹   ENSRNOP00000096735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,918,400 - 13,958,193 (-)Ensembl
RefSeq Acc Id: NM_001100673   ⟹   NP_001094143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,462,812 (-)NCBI
mRatBN7.21013,918,417 - 13,958,296 (-)NCBI
Rnor_6.01014,260,787 - 14,299,167 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
RGSC_v3.41014,147,895 - 14,186,277 (-)RGD
Celera1013,599,018 - 13,637,404 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245953   ⟹   XP_006246015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,276 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245954   ⟹   XP_006246016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,276 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245955   ⟹   XP_006246017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,276 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245956   ⟹   XP_006246018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,276 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245957   ⟹   XP_006246019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,276 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245958   ⟹   XP_006246020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245959   ⟹   XP_006246021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245960   ⟹   XP_006246022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245961   ⟹   XP_006246023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245962   ⟹   XP_006246024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245963   ⟹   XP_006246025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Rnor_5.01014,075,410 - 14,115,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767567   ⟹   XP_008765789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,463,387 (-)NCBI
mRatBN7.21013,918,417 - 13,958,335 (-)NCBI
Rnor_6.01014,259,394 - 14,299,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767568   ⟹   XP_008765790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,442,082 (-)NCBI
mRatBN7.21013,918,417 - 13,937,659 (-)NCBI
Rnor_6.01014,259,394 - 14,278,634 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767569   ⟹   XP_008765791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,422,936 - 14,442,215 (-)NCBI
mRatBN7.21013,918,417 - 13,937,696 (-)NCBI
Rnor_6.01014,259,394 - 14,278,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268923   ⟹   XP_063124993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,428,748 - 14,463,387 (-)NCBI
RefSeq Acc Id: NP_001094143   ⟸   NM_001100673
- UniProtKB: E9PSK7 (UniProtKB/Swiss-Prot),   B0VXR4 (UniProtKB/Swiss-Prot),   A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246024   ⟸   XM_006245962
- Peptide Label: isoform X11
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246020   ⟸   XM_006245958
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246018   ⟸   XM_006245956
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246025   ⟸   XM_006245963
- Peptide Label: isoform X12
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246023   ⟸   XM_006245961
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246017   ⟸   XM_006245955
- Peptide Label: isoform X4
- UniProtKB: A0A8L2ULH9 (UniProtKB/TrEMBL),   A6HCY7 (UniProtKB/TrEMBL),   A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246022   ⟸   XM_006245960
- Peptide Label: isoform X9
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246016   ⟸   XM_006245954
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246021   ⟸   XM_006245959
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246019   ⟸   XM_006245957
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246015   ⟸   XM_006245953
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV07 (UniProtKB/TrEMBL),   A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765789   ⟸   XM_008767567
- Peptide Label: isoform X3
- UniProtKB: A0A8I6B3P0 (UniProtKB/TrEMBL),   A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765791   ⟸   XM_008767569
- Peptide Label: isoform X14
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765790   ⟸   XM_008767568
- Peptide Label: isoform X13
- UniProtKB: A0A8I6GI46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039682   ⟸   ENSRNOT00000042066
Ensembl Acc Id: ENSRNOP00000082502   ⟸   ENSRNOT00000094258
Ensembl Acc Id: ENSRNOP00000096061   ⟸   ENSRNOT00000109512
Ensembl Acc Id: ENSRNOP00000089458   ⟸   ENSRNOT00000101875
Ensembl Acc Id: ENSRNOP00000096735   ⟸   ENSRNOT00000110227
RefSeq Acc Id: XP_063124993   ⟸   XM_063268923
- Peptide Label: isoform X15
Protein Domains
RH1   RH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSK7-F1-model_v2 AlphaFold E9PSK7 1-1322 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563691 AgrOrtholog
BioCyc Gene G2FUF-25812 BioCyc
Ensembl Genes ENSRNOG00000033568 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042066 ENTREZGENE
  ENSRNOT00000094258 ENTREZGENE
  ENSRNOT00000109512 ENTREZGENE
Gene3D-CATH 1.20.58.1770 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot
  arf6 gtpase in complex with a specific effector, jip4 UniProtKB/Swiss-Prot
InterPro JIP3/JIP4 UniProtKB/Swiss-Prot
  JIP_LZII UniProtKB/Swiss-Prot
  RH1 UniProtKB/Swiss-Prot
  RH2 UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:302983 UniProtKB/Swiss-Prot
NCBI Gene 302983 ENTREZGENE
PANTHER C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 UniProtKB/Swiss-Prot
  PTHR13886 UniProtKB/Swiss-Prot
Pfam JIP_LZII UniProtKB/Swiss-Prot
  Jnk-SapK_ap_N UniProtKB/Swiss-Prot
  WD40_2 UniProtKB/Swiss-Prot
PhenoGen Mapk8ip3 PhenoGen
PROSITE RH1 UniProtKB/Swiss-Prot
  RH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033568 RatGTEx
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt A0A8I5ZV07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI46 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2ULH9 ENTREZGENE, UniProtKB/TrEMBL
  A6HCY7 ENTREZGENE, UniProtKB/TrEMBL
  B0VXR4 ENTREZGENE
  E9PSK7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B0VXR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mapk8ip3  mitogen-activated protein kinase 8 interacting protein 3  JSAP1  JNK/SAPK-associated protein 1  Symbol and Name updated 1299863 APPROVED
2006-02-09 JSAP1  JNK/SAPK-associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL