Rad51 (RAD51 recombinase) - Rat Genome Database

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Gene: Rad51 (RAD51 recombinase) Rattus norvegicus
Analyze
Symbol: Rad51
Name: RAD51 recombinase
RGD ID: 1563603
Description: Predicted to enable several functions, including ATP binding activity; DNA binding activity; and catalytic activity, acting on DNA. Involved in several processes, including cellular response to cisplatin; cellular response to gamma radiation; and response to X-ray. Predicted to be located in several cellular components, including chromosome, telomeric region; male germ cell nucleus; and nuclear lumen. Predicted to be part of chromatin and nuclear ubiquitin ligase complex. Predicted to be active in condensed nuclear chromosome; presynaptic intermediate filament cytoskeleton; and site of double-strand break. Used to study cardiomyopathy and hypertension. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH (-)-demecolcine; 1,4-dioxane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA repair protein RAD51 homolog 1; LOC499870; RAD51 homolog; RAD51 homolog (RecA homolog, E. coli); RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog (S. cerevisiae); RGD1563603; similar to DNA repair protein RAD51 homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,554,210 - 126,578,888 (+)NCBIGRCr8
mRatBN7.23106,099,753 - 106,125,038 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,100,381 - 106,125,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,773,488 - 109,798,183 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,369,034 - 118,393,719 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,029,412 - 116,054,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,918,240 - 110,942,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,918,243 - 110,942,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,468,402 - 117,493,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,625,265 - 105,650,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3105,013,953 - 105,038,371 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,4-dioxane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
busulfan  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
CX-5461  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
estragole  (EXP)
etoposide  (EXP)
fenthion  (ISO)
flumequine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
idarubicin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
Nonidet P-40  (ISO)
ochratoxin A  (EXP,ISO)
olaparib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phosphoramide mustard  (EXP)
phytoestrogen  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prodigiosin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
quizartinib  (ISO)
resveratrol  (EXP,ISO)
romidepsin  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Antoniou AC, etal., Am J Hum Genet. 2007 Dec;81(6):1186-200. Epub 2007 Oct 16.
2. Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Auranen A, etal., Int J Cancer. 2005 Nov 20;117(4):611-8.
3. HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression. Chipitsyna G, etal., Oncogene. 2004 Apr 8;23(15):2664-71.
4. Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1beta and SMC3. Eijpe M, etal., J Cell Biol. 2003 Mar 3;160(5):657-70.
5. A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women. Gal I, etal., Eur J Cancer. 2006 May;42(8):1129-34. Epub 2006 Apr 18.
6. 7,12-Dimethylbenzanthracene exposure induces the DNA repair response in neonatal rat ovaries. Ganesan S, etal., Toxicol Appl Pharmacol. 2013 Nov 1;272(3):690-6. doi: 10.1016/j.taap.2013.08.013. Epub 2013 Aug 19.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Sequestration of mammalian Rad51-recombination protein into micronuclei. Haaf T, etal., J Cell Biol. 1999 Jan 11;144(1):11-20.
9. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
10. Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis. Ishishita S, etal., Sci Rep. 2014 Aug 21;4:6148. doi: 10.1038/srep06148.
11. The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers. Jakubowska A, etal., Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):270-5.
12. Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats. Kuroda K, etal., Mutagenesis. 2014 Jan;29(1):27-36. doi: 10.1093/mutage/get054. Epub 2013 Nov 16.
13. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Loree J, etal., Int J Radiat Biol. 2006 Nov;82(11):805-15.
14. BRCA1 shields vascular smooth muscle cells from oxidative stress. Lovren F, etal., J Thorac Cardiovasc Surg. 2014 Jun;147(6):1946-55, 1955.e1. doi: 10.1016/j.jtcvs.2013.09.060. Epub 2013 Nov 13.
15. In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Marotta D, etal., Cancer Res. 2011 Feb 1;71(3):779-89. doi: 10.1158/0008-5472.CAN-10-3061. Epub 2011 Jan 25.
16. RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Martin RW, etal., Cancer Res. 2007 Oct 15;67(20):9658-65.
17. Rad51 immunocytology in rat and mouse spermatocytes and oocytes. Moens PB, etal., Chromosoma. 1997 Sep;106(4):207-15.
18. Genetic instability in the RAD51 and BRCA1 regions in breast cancer. Nowacka-Zawisza M, etal., Cell Mol Biol Lett. 2007;12(2):192-205. Epub 2006 Dec 18.
19. Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer. Nowacka-Zawisza M, etal., Pathol Int. 2008 May;58(5):275-81.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor. Tarasenko N, etal., PLoS One. 2012;7(2):e31393. doi: 10.1371/journal.pone.0031393. Epub 2012 Feb 23.
25. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Tryndyak VP, etal., Mol Carcinog. 2007 Mar;46(3):187-97.
26. Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. Vinson RK and Hales BF, Teratology. 2001 Dec;64(6):283-91.
27. [Expression of RAD51 and MAX in pancreatic cancer rats]. Yang L, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Feb;35(2):146-51. doi: 10.3969/j.issn.1672-7347.2010.02.010.
Additional References at PubMed
PMID:7988572   PMID:8816780   PMID:8929543   PMID:9396801   PMID:9469824   PMID:9660962   PMID:9774970   PMID:10809667   PMID:11309417   PMID:12091911   PMID:12442171   PMID:12477932  
PMID:12591952   PMID:12913077   PMID:14668445   PMID:15359272   PMID:15485900   PMID:16215984   PMID:16428451   PMID:16990250   PMID:17291760   PMID:17515903   PMID:17515904   PMID:18283110  
PMID:18417535   PMID:18694567   PMID:19622740   PMID:19628690   PMID:19995904   PMID:20413593   PMID:20551173   PMID:21076401   PMID:21743440   PMID:22164254   PMID:22530760   PMID:22778135  
PMID:23133398   PMID:23401855   PMID:23509288   PMID:23555294   PMID:23754376   PMID:24108124   PMID:24550317   PMID:24891606   PMID:25282148   PMID:25585578   PMID:26253028   PMID:26323318  
PMID:26490168   PMID:26681308   PMID:27760146   PMID:28864920  


Genomics

Comparative Map Data
Rad51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,554,210 - 126,578,888 (+)NCBIGRCr8
mRatBN7.23106,099,753 - 106,125,038 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,100,381 - 106,125,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,773,488 - 109,798,183 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,369,034 - 118,393,719 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,029,412 - 116,054,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,918,240 - 110,942,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,918,243 - 110,942,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,468,402 - 117,493,566 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,625,265 - 105,650,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3105,013,953 - 105,038,371 (+)NCBICelera
Cytogenetic Map3q35NCBI
RAD51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,694,733 - 40,732,340 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,694,774 - 40,732,340 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,987,372 - 41,024,538 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,774,651 - 38,811,648 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,774,660 - 38,811,646NCBI
Celera1517,755,220 - 17,792,245 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,834,870 - 17,872,189 (+)NCBIHuRef
CHM1_11541,107,382 - 41,144,356 (+)NCBICHM1_1
T2T-CHM13v2.01538,500,415 - 38,538,035 (+)NCBIT2T-CHM13v2.0
Rad51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,943,295 - 118,966,554 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,943,274 - 118,977,926 (+)EnsemblGRCm39 Ensembl
GRCm382119,112,814 - 119,136,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,112,793 - 119,147,445 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,938,553 - 118,961,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,804,258 - 118,827,511 (+)NCBIMGSCv36mm8
Celera2120,265,474 - 120,286,601 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.92NCBI
Rad51
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,566,686 - 7,590,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,566,715 - 7,590,628 (+)NCBIChiLan1.0ChiLan1.0
RAD51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,938,330 - 29,973,033 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,089,788 - 34,123,970 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,638,310 - 19,672,474 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,891,061 - 37,925,207 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,891,056 - 37,925,207 (+)Ensemblpanpan1.1panPan2
RAD51
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,842,540 - 7,877,128 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,842,540 - 7,877,606 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,896,289 - 7,931,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,968,785 - 8,004,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,968,784 - 8,004,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,892,599 - 7,927,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,999,640 - 8,034,564 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,128,251 - 8,163,404 (+)NCBIUU_Cfam_GSD_1.0
Rad51
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,263,812 - 86,288,764 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,114,530 - 4,136,248 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,119,020 - 4,136,811 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD51
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,586,665 - 130,640,136 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,592,414 - 130,640,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,751,297 - 145,798,501 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD51
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,281,085 - 42,319,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,279,608 - 42,318,169 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,661,431 - 98,701,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rad51
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,957,253 - 7,983,619 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,957,175 - 7,983,078 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rad51
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:92
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000056432
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

Markers in Region
RH131503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,124,726 - 106,124,946 (+)MAPPERmRatBN7.2
Rnor_6.03112,603,856 - 112,604,075NCBIRnor6.0
Rnor_6.03110,942,609 - 110,942,828NCBIRnor6.0
Rnor_5.03119,148,536 - 119,148,755UniSTSRnor5.0
Rnor_5.03117,493,247 - 117,493,466UniSTSRnor5.0
RGSC_v3.43105,650,084 - 105,650,303UniSTSRGSC3.4
Celera3105,038,063 - 105,038,282UniSTS
RH 3.4 Map3913.6UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 26 20 13 20 32 18 34
Low 1 16 27 17 6 17 4 7 42 17 7 11 4
Below cutoff 1 4 4 4 4 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056432   ⟹   ENSRNOP00000053270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,100,381 - 106,125,035 (+)Ensembl
Rnor_6.0 Ensembl3110,918,243 - 110,942,917 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104101   ⟹   ENSRNOP00000078187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,100,412 - 106,124,883 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109961   ⟹   ENSRNOP00000091500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,100,412 - 106,124,883 (+)Ensembl
RefSeq Acc Id: NM_001109204   ⟹   NP_001102674
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,554,210 - 126,578,885 (+)NCBI
mRatBN7.23106,100,351 - 106,125,035 (+)NCBI
Rnor_6.03110,918,243 - 110,942,917 (+)NCBI
Rnor_5.03117,468,402 - 117,493,566 (+)NCBI
RGSC_v3.43105,625,265 - 105,650,392 (+)RGD
Celera3105,013,953 - 105,038,371 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234784   ⟹   XP_006234846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,556,982 - 126,578,888 (+)NCBI
mRatBN7.23106,099,753 - 106,125,038 (+)NCBI
Rnor_6.03110,918,240 - 110,942,920 (+)NCBI
Rnor_5.03117,468,402 - 117,493,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063284362   ⟹   XP_063140432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,554,286 - 126,578,888 (+)NCBI
RefSeq Acc Id: XM_063284363   ⟹   XP_063140433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,554,286 - 126,573,016 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102674   ⟸   NM_001109204
- UniProtKB: B5DF04 (UniProtKB/TrEMBL),   A6HPE0 (UniProtKB/TrEMBL),   F7EX62 (UniProtKB/TrEMBL),   A0A8I6GJP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234846   ⟸   XM_006234784
- Peptide Label: isoform X1
- UniProtKB: B5DF04 (UniProtKB/TrEMBL),   A6HPE0 (UniProtKB/TrEMBL),   F7EX62 (UniProtKB/TrEMBL),   A0A8I6GJP5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053270   ⟸   ENSRNOT00000056432
RefSeq Acc Id: ENSRNOP00000091500   ⟸   ENSRNOT00000109961
RefSeq Acc Id: ENSRNOP00000078187   ⟸   ENSRNOT00000104101
RefSeq Acc Id: XP_063140432   ⟸   XM_063284362
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140433   ⟸   XM_063284363
- Peptide Label: isoform X3
Protein Domains
RecA family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF04-F1-model_v2 AlphaFold B5DF04 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692319
Promoter ID:EPDNEW_R2842
Type:initiation region
Name:Rad51_1
Description:RAD51 recombinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,918,277 - 110,918,337EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563603 AgrOrtholog
BioCyc Gene G2FUF-48219 BioCyc
Ensembl Genes ENSRNOG00000037302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056432 ENTREZGENE
  ENSRNOT00000056432.3 UniProtKB/TrEMBL
  ENSRNOT00000104101.1 UniProtKB/TrEMBL
  ENSRNOT00000109961.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  DNA_recomb/repair_Rad51 UniProtKB/TrEMBL
  DNA_recomb/repair_Rad51_C UniProtKB/TrEMBL
  DNA_recomb/repair_RecA-like UniProtKB/TrEMBL
  DNA_repair_Rad51/TF_NusA_a-hlx UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecA_ATP-bd UniProtKB/TrEMBL
  RecA_monomer-monomer_interface UniProtKB/TrEMBL
KEGG Report rno:499870 UniProtKB/TrEMBL
NCBI Gene 499870 ENTREZGENE
PANTHER DNA REPAIR PROTEIN RAD51 HOMOLOG 1 UniProtKB/TrEMBL
  RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER UniProtKB/TrEMBL
Pfam HHH_5 UniProtKB/TrEMBL
  Rad51 UniProtKB/TrEMBL
PhenoGen Rad51 PhenoGen
PIRSF Rad51 UniProtKB/TrEMBL
PROSITE RECA_2 UniProtKB/TrEMBL
  RECA_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037302 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF47794 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5YC80_RAT UniProtKB/TrEMBL
  A0A8I6GJP5 ENTREZGENE, UniProtKB/TrEMBL
  A6HPE0 ENTREZGENE, UniProtKB/TrEMBL
  B5DF04 ENTREZGENE
  F7EX62 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DF04 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-23 Rad51  RAD51 recombinase  Rad51  RAD51 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Rad51  RAD51 homolog (S. cerevisiae)  Rad51  RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rad51  RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)  Rad51  RAD51 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Rad51  RAD51 homolog (S. cerevisiae)  RGD1563603_predicted  similar to DNA repair protein RAD51 homolog 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563603_predicted  similar to DNA repair protein RAD51 homolog 1 (predicted)  LOC499870  similar to DNA repair protein RAD51 homolog 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499870  similar to DNA repair protein RAD51 homolog 1      Symbol and Name status set to provisional 70820 PROVISIONAL