Spi1 (Spi-1 proto-oncogene) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Spi1 (Spi-1 proto-oncogene) Rattus norvegicus
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene
RGD ID: 1359607
Description: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in cellular response to ethanol; osteoclast differentiation; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of chromatin and transcription regulator complex. Predicted to be active in nucleus. Used to study alcohol use disorder. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hematopoietic transcription factor PU.1; LOC103691845; Pu.1; SFFV proviral integration 1; Sfpi1; spleen focus forming virus (SFFV) proviral integration oncogene; spleen focus forming virus (SFFV) proviral integration oncogene spi1; spleen focus forming virus proviral integration oncogene spi1; transcription factor PU.1; uncharacterized LOC103691845
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
cellular response to ethanol  (IEP)
defense response to tumor cell  (IEA,ISO)
endothelial to hematopoietic transition  (ISO)
erythrocyte differentiation  (ISO)
follicular B cell differentiation  (ISO)
germinal center B cell differentiation  (ISO)
granulocyte differentiation  (ISO)
immature B cell differentiation  (ISO)
interleukin-6-mediated signaling pathway  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lymphocyte differentiation  (ISO)
lymphoid progenitor cell differentiation  (ISO)
macrophage differentiation  (ISO)
myeloid dendritic cell differentiation  (ISO)
myeloid leukocyte differentiation  (IEA,ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of neutrophil degranulation  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
oncogene-induced cell senescence  (ISO)
osteoclast differentiation  (IEP)
pericyte cell differentiation  (ISO)
positive regulation of antifungal innate immune response  (ISO)
positive regulation of B cell differentiation  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of microglial cell mediated cytotoxicity  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of myeloid dendritic cell chemotaxis  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
pro-T cell differentiation  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of erythrocyte differentiation  (IEA,ISO)
regulation of myeloid progenitor cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to ethanol  (IEP)
somatic stem cell population maintenance  (ISO)
TRAIL-activated apoptotic signaling pathway  (IEA,ISO)
transcription initiation-coupled chromatin remodeling  (IEA,ISO,ISS)
transforming growth factor beta receptor signaling pathway  (ISO)
vasculature development  (ISO)

Cellular Component
chromatin  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. Dakic A, etal., J Exp Med 2005 May 2;201(9):1487-502.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. PU.1 and USF are required for macrophage-specific mannose receptor promoter activity. Egan BS, etal., J Biol Chem. 1999 Mar 26;274(13):9098-107.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. Harendza S, etal., J Biol Chem 2000 Jun 30;275(26):19552-9.
6. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
7. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. Joshi PC, etal., J Immunol. 2005 Nov 15;175(10):6837-45.
8. Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Mehta AJ, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1519-28. doi: 10.1111/j.1530-0277.2011.01488.x. Epub 2011 Mar 29.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA. Nakano N, etal., Immunogenetics. 2005 Mar;56(12):871-7. Epub 2005 Feb 2.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. PU.1 expression in microglia. Walton MR, etal., J Neuroimmunol. 2000 May 1;104(2):109-15.
18. PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation. Xu XW, etal., World J Gastroenterol. 2013 Nov 21;19(43):7766-71. doi: 10.3748/wjg.v19.i43.7766.
Additional References at PubMed
PMID:1409581   PMID:7592651   PMID:9133423   PMID:10648399   PMID:11980719   PMID:12833137   PMID:14962908   PMID:15100295   PMID:15187136   PMID:15304324   PMID:15304486   PMID:15361867  
PMID:16002702   PMID:16163358   PMID:16735694   PMID:18063754   PMID:18384814   PMID:19379700   PMID:19796622   PMID:20139074   PMID:20972335   PMID:22206666   PMID:23775123   PMID:23980096  
PMID:24429361   PMID:25840997   PMID:29482641   PMID:33970748   PMID:36299239  


Genomics

Comparative Map Data
Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,354,860 - 47,378,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,354,860 - 47,409,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
T2T-CHM13v2.01147,511,687 - 47,538,667 (-)NCBIT2T-CHM13v2.0
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)EnsemblGRCm39 Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBIMGSCv36mm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,555,991 - 49,581,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,575,785 - 49,601,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,908,267 - 42,924,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBIUU_Cfam_GSD_1.0
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,852,740 - 1,870,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,881 - 15,245,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spi1
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:54
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000016306
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

Markers in Region
RH135185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,081,666 - 77,081,876 (+)MAPPERmRatBN7.2
Rnor_6.0379,926,980 - 79,927,189NCBIRnor6.0
Rnor_5.0386,635,733 - 86,635,942UniSTSRnor5.0
RGSC_v3.4375,464,322 - 75,464,531UniSTSRGSC3.4
Celera376,290,041 - 76,290,250UniSTS
Cytogenetic Map3q24UniSTS
PMC186377P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,092,176 - 77,092,256 (+)MAPPERmRatBN7.2
Rnor_6.0379,937,489 - 79,937,568NCBIRnor6.0
Rnor_5.0386,646,242 - 86,646,321UniSTSRnor5.0
RGSC_v3.4375,475,505 - 75,475,584UniSTSRGSC3.4
Celera376,300,463 - 76,300,542UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 11 6 16 6 3 10
Low 1 41 46 35 3 35 8 11 74 35 36 1 8
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016306   ⟹   ENSRNOP00000016306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,075,595 - 77,092,393 (+)Ensembl
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114733   ⟹   ENSRNOP00000077751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)Ensembl
RefSeq Acc Id: NM_001005892   ⟹   NP_001005892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,529,509 - 97,548,204 (+)NCBI
mRatBN7.2377,073,696 - 77,092,394 (+)NCBI
Rnor_6.0379,919,011 - 79,937,706 (+)NCBI
Rnor_5.0386,627,684 - 86,646,468 (+)NCBI
RGSC_v3.4375,456,353 - 75,475,722 (+)RGD
Celera376,282,068 - 76,300,680 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234532   ⟹   XP_006234594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,529,567 - 97,548,204 (+)NCBI
mRatBN7.2377,072,615 - 77,093,730 (+)NCBI
Rnor_6.0379,918,127 - 79,937,708 (+)NCBI
Rnor_5.0386,627,684 - 86,646,468 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001005892   ⟸   NM_001005892
- UniProtKB: Q5BK69 (UniProtKB/Swiss-Prot),   Q6BDS1 (UniProtKB/Swiss-Prot),   A6HNA6 (UniProtKB/TrEMBL),   A0A8L2UIY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234594   ⟸   XM_006234532
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJK5 (UniProtKB/TrEMBL),   A0A8L2UIY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016306   ⟸   ENSRNOT00000016306
RefSeq Acc Id: ENSRNOP00000077751   ⟸   ENSRNOT00000114733
Protein Domains
ETS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6BDS1-F1-model_v2 AlphaFold Q6BDS1 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692206
Promoter ID:EPDNEW_R2731
Type:multiple initiation site
Name:Spi1_1
Description:Spi-1 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,918,976 - 79,919,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359607 AgrOrtholog
BioCyc Gene G2FUF-48751 BioCyc
Ensembl Genes ENSRNOG00000012172 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016306 ENTREZGENE
  ENSRNOT00000016306.7 UniProtKB/TrEMBL
  ENSRNOT00000114733.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366435 IMAGE-MGC_LOAD
InterPro Ets_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108838 IMAGE-MGC_LOAD
NCBI Gene 366126 ENTREZGENE
PANTHER PTHR11849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR PU.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ets UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spi1 PhenoGen
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012172 RatGTEx
SMART ETS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZJK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UIY0 ENTREZGENE, UniProtKB/TrEMBL
  A6HNA6 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK69 ENTREZGENE
  Q6BDS1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5BK69 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spi1  Spi-1 proto-oncogene  LOC103691845  uncharacterized LOC103691845  Data merged from RGD:9236003 737654 PROVISIONAL
2014-08-25 LOC103691845  uncharacterized LOC103691845      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-10 Spi1  Spi-1 proto-oncogene  Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Spi1  spleen focus forming virus (SFFV) proviral integration oncogene spi1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-24 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene spi1  Spi1  spleen focus forming virus proviral integration oncogene spi1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-23 Spi1  spleen focus forming virus proviral integration oncogene spi1  Sfpi1  SFFV proviral integration 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sfpi1  SFFV proviral integration 1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Sfpi1  SFFV proviral integration 1      Symbol and Name status set to provisional 70820 PROVISIONAL