F12 (coagulation factor XII) - Rat Genome Database

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Gene: F12 (coagulation factor XII) Rattus norvegicus
Analyze
Symbol: F12
Name: coagulation factor XII
RGD ID: 1359175
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of plasminogen activation; protein maturation; and regulation of blood coagulation. Located in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor XII (Hageman factor); factor XII; HAF; hageman factor; LOC306761; similar to coagulation factor XII (Hageman factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,212,819 - 9,220,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,212,819 - 9,220,664 (+)EnsemblGRCr8
mRatBN7.2179,207,683 - 9,215,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,207,683 - 9,215,530 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,223,730 - 9,231,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,753,767 - 10,761,675 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,220,120 - 9,228,036 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,736,577 - 9,744,420 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,736,577 - 9,744,420 (+)Ensemblrn6Rnor6.0
Rnor_5.01711,845,561 - 11,853,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,251,611 - 15,259,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,286,222 - 9,294,037 (+)NCBICelera
RGSC_v3.11715,251,610 - 15,259,583 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
CGP 52608  (ISO)
chondroitin sulfate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
Ethyl icosapentate  (EXP)
flutamide  (EXP)
furan  (EXP)
hydralazine  (ISO)
isoflavones  (ISO)
kaolin  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
polyphosphates  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
raloxifene  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Coagulation factor XII (FXII) activity, activated FXII, distribution of FXII C46T gene polymorphism and coronary risk. Bach J, etal., J Thromb Haemost. 2008 Feb;6(2):291-6. Epub 2007 Nov 15.
2. A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor. Bork K, etal., Clin Immunol. 2011 Oct;141(1):31-5. doi: 10.1016/j.clim.2011.07.002. Epub 2011 Jul 30.
3. Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats. Chung DW, etal., Biochemistry 1986 May 6;25(9):2410-7.
4. Activation of the coagulation cascade in C1-inhibitor deficiencies. Cugno M, etal., Blood. 1997 May 1;89(9):3213-8.
5. Role of coagulation factor XII in unexplained recurrent abortions in the Greek population. Dendrinos S, etal., J Reprod Med. 2014 Jan-Feb;59(1-2):56-62.
6. Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor. Dewald G and Bork K, Biochem Biophys Res Commun. 2006 May 19;343(4):1286-9.
7. Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II. Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40.
8. Evidence of a U-shaped association between factor XII activity and overall survival. Endler G, etal., J Thromb Haemost. 2007 Jun;5(6):1143-8.
9. A common C-->T polymorphism at nt 46 in the promoter region of coagulation factor XII is associated with decreased factor XII activity. Endler G, etal., Thromb Res. 2001 Feb 15;101(4):255-60.
10. Paternal endothelial protein C receptor 219Gly variant as a mild and limited risk factor for deep vein thrombosis during pregnancy. Galanaud JP, etal., J Thromb Haemost. 2010 Apr;8(4):707-13. doi: 10.1111/j.1538-7836.2010.03770.x. Epub 2010 Feb 6.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Hepatocytes express blood coagulation factor XII (Hageman factor). Gordon EM, etal., J Lab Clin Med. 1990 Apr;115(4):463-9.
13. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. Kleinschnitz C, etal., J Exp Med. 2006 Mar 20;203(3):513-8. Epub 2006 Mar 13.
14. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
15. Molecular genetic analysis of Korean patients with coagulation factor XII deficiency. Kwon MJ, etal., Blood Coagul Fibrinolysis. 2010 Jun;21(4):308-12. doi: 10.1097/MBC.0b013e32833449df.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571----Ser substitution. Miyata T, etal., Proc Natl Acad Sci U S A. 1989 Nov;86(21):8319-22.
18. Molecular analysis of multiple genetic variants in Spanish FXII-deficient families. Mordillo C, etal., Haematologica. 2007 Nov;92(11):1569-72.
19. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
20. Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
21. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. Defective thrombus formation in mice lacking coagulation factor XII. Renne T, etal., J Exp Med. 2005 Jul 18;202(2):271-81. Epub 2005 Jul 11.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction. Roldan V, etal., Thromb Haemost. 2005 Dec;94(6):1294-9.
30. Homozygosity of the T allele of the 46 C->T polymorphism in the F12 gene is a risk factor for ischemic stroke in the Spanish population. Santamaria A, etal., Stroke. 2004 Aug;35(8):1795-9. Epub 2004 Jul 1.
31. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
32. Association after linkage analysis indicates that homozygosity for the 46C-->T polymorphism in the F12 gene is a genetic risk factor for venous thrombosis. Tirado I, etal., Thromb Haemost. 2004 May;91(5):899-904.
33. Preferential consumption of coagulation factors I, V, and VIII in rat endotoxemia. Yamaguchi K, etal., Shock. 2000 Nov;14(5):535-43.
Additional References at PubMed
PMID:89876   PMID:6793628   PMID:12477932   PMID:15351846   PMID:18725990   PMID:22216926   PMID:23376485   PMID:23533145   PMID:24733030  


Genomics

Comparative Map Data
F12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,212,819 - 9,220,664 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,212,819 - 9,220,664 (+)EnsemblGRCr8
mRatBN7.2179,207,683 - 9,215,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,207,683 - 9,215,530 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,223,730 - 9,231,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,753,767 - 10,761,675 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,220,120 - 9,228,036 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,736,577 - 9,744,420 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,736,577 - 9,744,420 (+)Ensemblrn6Rnor6.0
Rnor_5.01711,845,561 - 11,853,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,251,611 - 15,259,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,286,222 - 9,294,037 (+)NCBICelera
RGSC_v3.11715,251,610 - 15,259,583 (+)NCBI
Cytogenetic Map17p14NCBI
F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,402,141 - 177,409,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,402,133 - 177,416,583 (-)Ensemblhg38GRCh38
GRCh375176,829,142 - 176,836,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,761,745 - 176,769,183 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345176,761,746 - 176,769,183NCBI
Celera5171,664,877 - 171,672,315 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,749,566 - 171,757,004 (-)NCBIHuRef
CHM1_15176,262,187 - 176,269,625 (-)NCBICHM1_1
T2T-CHM13v2.05177,945,359 - 177,952,782 (-)NCBIT2T-CHM13v2.0
F12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,565,771 - 55,574,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,565,771 - 55,574,606 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381355,417,958 - 55,426,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,417,958 - 55,426,793 (-)Ensemblmm10GRCm38
MGSCv371355,519,327 - 55,528,163 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361355,427,610 - 55,436,409 (-)NCBIMGSCv36mm8
Celera1356,472,191 - 56,480,813 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
F12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,642,096 - 29,650,950 (-)Ensembl
ChiLan1.0NW_00495540829,644,279 - 29,665,161 (-)NCBIChiLan1.0ChiLan1.0
F12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,703,724 - 172,711,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,766,089 - 179,773,854 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,766,243 - 179,773,485 (-)EnsemblpanPan2panpan1.1
F12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,950,642 - 35,968,137 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,950,695 - 35,998,025 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,316,904 - 36,324,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
F12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,662,598 - 122,670,021 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365971,687,511 - 1,694,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,527,446 - 80,544,828 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1280,527,451 - 80,544,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,414,074 - 79,438,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,414,225 - 79,432,298 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607510,603,660 - 10,619,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,675,966 - 12,683,117 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473312,666,410 - 12,683,273 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
F12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11473,738,246 - 73,745,928 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in F12
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:53
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000066586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
BE102123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,215,294 - 9,215,468 (+)MAPPERmRatBN7.2
Rnor_6.0179,744,185 - 9,744,358NCBIRnor6.0
Rnor_5.01711,853,365 - 11,853,538UniSTSRnor5.0
RGSC_v3.41715,259,348 - 15,259,521UniSTSRGSC3.4
Celera179,293,802 - 9,293,975UniSTS
RH 3.4 Map1779.5UniSTS
Cytogenetic Map17p14UniSTS
F12  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8179,220,182 - 9,220,500 (+)Marker Load Pipeline
mRatBN7.2179,215,048 - 9,215,366 (+)MAPPERmRatBN7.2
Rnor_6.0179,743,939 - 9,744,256NCBIRnor6.0
Rnor_5.01711,853,119 - 11,853,436UniSTSRnor5.0
RGSC_v3.41715,259,102 - 15,259,419UniSTSRGSC3.4
Celera179,293,556 - 9,293,873UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 9 35 129 91 88 59 52 59 6 243 116 10 102 48 58 29 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000066586   ⟹   ENSRNOP00000061983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,212,819 - 9,220,664 (+)Ensembl
mRatBN7.2 Ensembl179,207,683 - 9,215,530 (+)Ensembl
Rnor_6.0 Ensembl179,736,577 - 9,744,420 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081920   ⟹   ENSRNOP00000074115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,212,819 - 9,220,664 (+)Ensembl
mRatBN7.2 Ensembl179,207,683 - 9,215,530 (+)Ensembl
Rnor_6.0 Ensembl179,736,786 - 9,744,341 (+)Ensembl
RefSeq Acc Id: NM_001014006   ⟹   NP_001014028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,212,819 - 9,220,664 (+)NCBI
mRatBN7.2179,207,683 - 9,215,530 (+)NCBI
Rnor_6.0179,736,577 - 9,744,420 (+)NCBI
Rnor_5.01711,845,561 - 11,853,600 (+)NCBI
RGSC_v3.41715,251,611 - 15,259,583 (+)RGD
Celera179,286,222 - 9,294,037 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88187 (Get FASTA)   NCBI Sequence Viewer  
  D3ZTE0 (Get FASTA)   NCBI Sequence Viewer  
  EDL93987 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061983
RefSeq Acc Id: NP_001014028   ⟸   NM_001014006
- Peptide Label: precursor
- UniProtKB: A0A0H2UI19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061983   ⟸   ENSRNOT00000066586
Ensembl Acc Id: ENSRNOP00000074115   ⟸   ENSRNOT00000081920
Protein Domains
EGF-like   Fibronectin type-I   Fibronectin type-II   Kringle   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTE0-F1-model_v2 AlphaFold D3ZTE0 1-595 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700316
Promoter ID:EPDNEW_R10829
Type:multiple initiation site
Name:F12_1
Description:coagulation factor XII
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,736,750 - 9,736,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359175 AgrOrtholog
BioCyc Gene G2FUF-10204 BioCyc
Ensembl Genes ENSRNOG00000015139 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000066586 ENTREZGENE
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot
  2.40.10.10 UniProtKB/Swiss-Prot
  2.40.20.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370526 IMAGE-MGC_LOAD
InterPro Coagulation_fac_XII/HGFA UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Fibronectin_type1 UniProtKB/Swiss-Prot
  FN_type2_dom UniProtKB/Swiss-Prot
  FN_type2_sf UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  Kringle_CS UniProtKB/Swiss-Prot
  Kringle_sf UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Serine_Proteases_S1 UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:306761 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108855 IMAGE-MGC_LOAD
NCBI Gene 306761 ENTREZGENE
PANTHER COAGULATION FACTOR XII UniProtKB/Swiss-Prot
  TRYPSIN-RELATED UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  fn1 UniProtKB/Swiss-Prot
  fn2 UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen F12 PhenoGen
PIRSF Factor_XII_HGFA UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
  FNTYPEII UniProtKB/Swiss-Prot
  KRINGLE UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  FN1_1 UniProtKB/Swiss-Prot
  FN1_2 UniProtKB/Swiss-Prot
  FN2_1 UniProtKB/Swiss-Prot
  FN2_2 UniProtKB/Swiss-Prot
  KRINGLE_1 UniProtKB/Swiss-Prot
  KRINGLE_2 UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015139 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FN1 UniProtKB/Swiss-Prot
  FN2 UniProtKB/Swiss-Prot
  SM00130 UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF50494 UniProtKB/Swiss-Prot
  SSF57440 UniProtKB/Swiss-Prot
UniProt A0A0H2UI19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UR23_RAT UniProtKB/TrEMBL
  D3ZTE0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5M879 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F12  coagulation factor XII  F12  coagulation factor XII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 F12  coagulation factor XII  F12  coagulation factor XII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 F12  coagulation factor XII  F12  coagulation factor XII (Hageman factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 F12  coagulation factor XII (Hageman factor)  LOC306761  similar to coagulation factor XII (Hageman factor); factor XII  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC306761  similar to coagulation factor XII (Hageman factor); factor XII      Symbol and Name status set to provisional 70820 PROVISIONAL