Irf8 (interferon regulatory factor 8) - Rat Genome Database

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Gene: Irf8 (interferon regulatory factor 8) Rattus norvegicus
Analyze
Symbol: Irf8
Name: interferon regulatory factor 8
RGD ID: 1312024
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ICSBP; Icsbp1; interferon consensus sequence binding protein 1; LOC292060; transcription factor ICSBP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Leukc1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,699,284 - 65,721,066 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,699,284 - 65,721,062 (+)EnsemblGRCr8
mRatBN7.21948,790,581 - 48,812,363 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,790,588 - 48,811,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1955,588,302 - 55,604,928 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,269,197 - 56,285,845 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,487,122 - 58,503,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,314,859 - 54,336,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,314,865 - 54,336,640 (+)Ensemblrn6Rnor6.0
Rnor_5.01965,033,704 - 65,055,534 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,100,088 - 51,116,730 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,045,909 - 48,062,560 (+)NCBICelera
RGSC_v3.11951,104,968 - 51,121,611 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
folic acid  (ISO)
fonofos  (ISO)
Fulvic acid  (ISO)
gardiquimod  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
MK-2206  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease. Ahn Y, etal., Sci Rep. 2017 Jun 7;7(1):3018. doi: 10.1038/s41598-017-03251-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-gamma-mediated cytotoxic effects on oligodendroglial progenitor cells. Horiuchi M, etal., J Neuroinflammation. 2011 Jan 24;8(1):8.
4. [Silencing of ICSBP/IRF8 expression in U226 cells and bone marrow mononuclear cells from patients with multiple myeloma]. Jia G, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1127-30.
5. IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling. Jiang DS, etal., Nat Commun. 2014;5:3303. doi: 10.1038/ncomms4303.
6. Two Genetic Variations in the IRF8 region are associated with Behçet's disease in Han Chinese. Jiang Y, etal., Sci Rep. 2016 Jan 22;6:19651. doi: 10.1038/srep19651.
7. Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Jo SH, etal., Blood. 2010 Oct 14;116(15):2759-67. doi: 10.1182/blood-2009-07-234559. Epub 2010 Jun 28.
8. Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants. Leonard D, etal., Circ Cardiovasc Genet. 2013 Jun;6(3):255-63. doi: 10.1161/CIRCGENETICS.113.000044. Epub 2013 May 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA. Nakano N, etal., Immunogenetics. 2005 Mar;56(12):871-7. Epub 2005 Feb 2.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Ocular Behcet's disease is associated with aberrant methylation of interferon regulatory factor 8 (IRF8) in monocyte-derived dendritic cells. Qiu Y, etal., Oncotarget. 2017 Apr 19;8(31):51277-51287. doi: 10.18632/oncotarget.17235. eCollection 2017 Aug 1.
14. Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. Qiu Y, etal., Sci Rep. 2017 Apr 21;7(1):1007. doi: 10.1038/s41598-017-01249-7.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Genetic association study of systemic lupus erythematosus and disease subphenotypes in European populations. Ruiz-Larrañaga O, etal., Clin Rheumatol. 2016 May;35(5):1161-8. doi: 10.1007/s10067-016-3235-8. Epub 2016 Mar 28.
19. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
20. Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury. Xiang M, etal., J Neurochem. 2014 Jun;129(6):988-1001. doi: 10.1111/jnc.12682. Epub 2014 Mar 13.
21. Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin. Zhang SM, etal., Mol Cell Biol. 2014 Feb;34(3):400-14. doi: 10.1128/MCB.01070-13. Epub 2013 Nov 18.
Additional References at PubMed
PMID:1460054   PMID:9348310   PMID:12393690   PMID:18045875   PMID:22942423   PMID:25122610   PMID:25331958   PMID:28709638   PMID:30639279   PMID:36988364  


Genomics

Comparative Map Data
Irf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,699,284 - 65,721,066 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,699,284 - 65,721,062 (+)EnsemblGRCr8
mRatBN7.21948,790,581 - 48,812,363 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,790,588 - 48,811,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1955,588,302 - 55,604,928 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,269,197 - 56,285,845 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,487,122 - 58,503,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,314,859 - 54,336,643 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,314,865 - 54,336,640 (+)Ensemblrn6Rnor6.0
Rnor_5.01965,033,704 - 65,055,534 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,100,088 - 51,116,730 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1948,045,909 - 48,062,560 (+)NCBICelera
RGSC_v3.11951,104,968 - 51,121,611 (+)NCBI
Cytogenetic Map19q12NCBI
IRF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,899,162 - 85,922,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1685,899,116 - 85,922,606 (+)Ensemblhg38GRCh38
GRCh371685,932,768 - 85,956,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361684,490,275 - 84,513,713 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341684,490,274 - 84,513,710NCBI
Celera1670,235,758 - 70,259,207 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1671,673,680 - 71,697,160 (+)NCBIHuRef
CHM1_11687,344,316 - 87,367,790 (+)NCBICHM1_1
T2T-CHM13v2.01691,965,661 - 91,989,108 (+)NCBIT2T-CHM13v2.0
Irf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,463,097 - 121,483,433 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8121,463,097 - 121,483,433 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388120,736,358 - 120,756,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8120,736,358 - 120,756,694 (+)Ensemblmm10GRCm38
MGSCv378123,260,276 - 123,280,594 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368123,622,353 - 123,642,671 (+)NCBIMGSCv36mm8
Celera8124,952,030 - 124,972,392 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.05NCBI
Irf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541973,022 - 990,106 (+)Ensembl
ChiLan1.0NW_004955541973,004 - 988,493 (+)NCBIChiLan1.0ChiLan1.0
IRF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21895,651,335 - 95,675,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116101,568,444 - 101,593,081 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01666,568,370 - 66,591,949 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11685,905,334 - 85,929,073 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1685,905,334 - 85,929,073 (+)EnsemblpanPan2panpan1.1
IRF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,789,264 - 66,812,477 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,791,350 - 66,842,179 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha566,805,485 - 66,828,693 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0567,017,551 - 67,040,770 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl567,018,777 - 67,056,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1567,037,979 - 67,061,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0566,873,445 - 66,896,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0567,286,849 - 67,310,056 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934926,854,556 - 26,869,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366412,608,100 - 2,622,409 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366412,608,109 - 2,622,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl63,041,645 - 3,097,406 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.163,041,617 - 3,060,685 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.263,343,491 - 3,358,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
IRF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,301,878 - 71,325,622 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl571,302,233 - 71,325,613 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660474,408,156 - 4,432,299 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247462,272,389 - 2,290,455 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247462,272,385 - 2,290,400 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Irf8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11740,378,861 - 40,400,439 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:48
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000024069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024069   ⟹   ENSRNOP00000024069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1965,699,284 - 65,721,062 (+)Ensembl
mRatBN7.2 Ensembl1948,793,494 - 48,811,829 (+)Ensembl
Rnor_6.0 Ensembl1954,314,865 - 54,336,640 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093803   ⟹   ENSRNOP00000093890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,790,588 - 48,811,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113626   ⟹   ENSRNOP00000076839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1965,699,285 - 65,721,062 (+)Ensembl
mRatBN7.2 Ensembl1948,794,187 - 48,811,829 (+)Ensembl
RefSeq Acc Id: NM_001008722   ⟹   NP_001008722
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,699,284 - 65,721,066 (+)NCBI
mRatBN7.21948,790,581 - 48,812,363 (+)NCBI
Rnor_6.01954,318,463 - 54,335,105 (+)NCBI
Rnor_5.01965,033,704 - 65,055,534 (+)NCBI
RGSC_v3.41951,100,088 - 51,116,730 (+)RGD
Celera1948,045,909 - 48,062,560 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097646   ⟹   XP_038953574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,699,340 - 65,721,066 (+)NCBI
mRatBN7.21948,790,638 - 48,812,363 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001008722 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953574 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD77938 (Get FASTA)   NCBI Sequence Viewer  
  EDL92710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024069
  ENSRNOP00000024069.2
  ENSRNOP00000076839.2
RefSeq Acc Id: NP_001008722   ⟸   NM_001008722
- UniProtKB: Q5NUI4 (UniProtKB/TrEMBL),   A6IZN2 (UniProtKB/TrEMBL),   A0A8I6AJP7 (UniProtKB/TrEMBL),   F7EV00 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024069   ⟸   ENSRNOT00000024069
RefSeq Acc Id: XP_038953574   ⟸   XM_039097646
- Peptide Label: isoform X1
- UniProtKB: Q5NUI4 (UniProtKB/TrEMBL),   A6IZN2 (UniProtKB/TrEMBL),   A0A8I6AJP7 (UniProtKB/TrEMBL),   F7EV00 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076839   ⟸   ENSRNOT00000113626
Ensembl Acc Id: ENSRNOP00000093890   ⟸   ENSRNOT00000093803
Protein Domains
IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5NUI4-F1-model_v2 AlphaFold Q5NUI4 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701198
Promoter ID:EPDNEW_R11721
Type:single initiation site
Name:Irf8_1
Description:interferon regulatory factor 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01954,314,857 - 54,314,917EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312024 AgrOrtholog
BioCyc Gene G2FUF-5465 BioCyc
Ensembl Genes ENSRNOG00000017869 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024069 ENTREZGENE
  ENSRNOT00000024069.5 UniProtKB/TrEMBL
  ENSRNOT00000113626.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
InterPro Interferon_regulatory_factor UniProtKB/TrEMBL
  Interferon_regulatory_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:292060 UniProtKB/TrEMBL
NCBI Gene 292060 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  PTHR11949:SF7 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf8 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017869 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8I5Y754_RAT UniProtKB/TrEMBL
  A0A8I6AJP7 ENTREZGENE
  A6IZN2 ENTREZGENE, UniProtKB/TrEMBL
  F7EV00 ENTREZGENE, UniProtKB/TrEMBL
  Q5NUI4 ENTREZGENE
UniProt Secondary Q5NUI4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Irf8  interferon regulatory factor 8  Icsbp1  interferon consensus sequence binding protein 1  Symbol and Name updated 1299863 APPROVED
2005-12-06 Icsbp1  interferon consensus sequence binding protein 1  Icsbp1_predicted  interferon consensus sequence binding protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Icsbp1_predicted  interferon consensus sequence binding protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED