Actr2 (actin related protein 2) - Rat Genome Database

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Gene: Actr2 (actin related protein 2) Rattus norvegicus
Analyze
Symbol: Actr2
Name: actin related protein 2
RGD ID: 1310826
Description: Enables cytoskeletal protein binding activity. Involved in several processes, including cellular response to trichostatin A; positive regulation of dendritic spine morphogenesis; and response to ethanol. Located in lamellipodium and podosome core. Is active in postsynapse. Orthologous to human ACTR2 (actin related protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-like protein 2; actin-related protein 2; ARP2 actin related protein 2 homolog; ARP2 actin-related protein 2 homolog; ARP2 actin-related protein 2 homolog (yeast); LOC289820; MGC95085
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,500,119 - 98,535,092 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1498,500,138 - 98,541,998 (-)EnsemblGRCr8
mRatBN7.21494,296,443 - 94,333,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,296,443 - 94,340,524 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1498,639,283 - 98,680,250 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01499,879,572 - 99,920,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01496,346,941 - 96,387,904 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014104,338,486 - 104,375,840 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)Ensemblrn6Rnor6.0
Rnor_5.014104,072,596 - 104,109,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414100,848,391 - 100,883,833 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1493,318,648 - 93,356,930 (-)NCBICelera
RGSC_v3.114100,867,618 - 100,903,044 (-)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
ethanol  (EXP)
eugenol  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rimonabant  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (EXP,ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cap  (IEA,ISO)
Arp2/3 protein complex  (IBA,IEA,ISO,ISS)
cell cortex  (IBA,IEA,ISO)
cell projection  (IEA)
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA)
lamellipodium  (IDA)
nucleolus  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
podosome core  (IDA)
postsynapse  (EXP,IDA)
site of double-strand break  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5.
2. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. Cai L, etal., J Biol Chem. 2005 Sep 9;280(36):31913-23. Epub 2005 Jul 18.
3. F-actin binding is essential for coronin 1B function in vivo. Cai L, etal., J Cell Sci. 2007 May 15;120(Pt 10):1779-90. Epub 2007 Apr 24.
4. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
5. Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells. de Graauw M, etal., J Pharmacol Exp Ther. 2007 Jul;322(1):89-100. Epub 2007 Apr 18.
6. N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361.
7. Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei. Esparza MA, etal., Eur J Neurosci. 2012 Oct;36(8):3103-17. doi: 10.1111/j.1460-9568.2012.08239.x. Epub 2012 Aug 12.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Regulation of spine density and morphology by IQGAP1 protein domains. Jausoro I, etal., PLoS One. 2013;8(2):e56574. doi: 10.1371/journal.pone.0056574. Epub 2013 Feb 18.
10. Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. Jilek JL, etal., Toxicol Sci. 2015 Oct;147(2):475-89. doi: 10.1093/toxsci/kfv145. Epub 2015 Jul 15.
11. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. LeClaire LL 3rd, etal., J Cell Biol. 2008 Aug 25;182(4):647-54. doi: 10.1083/jcb.200802145.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes. Miao J, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3297-305. doi: 10.1093/ndt/gfp338. Epub 2009 Jul 17.
14. Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
15. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, etal., J Biol Chem. 2004 May 14;279(20):21003-11. doi: 10.1074/jbc.M400103200. Epub 2004 Mar 12.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. Rombouts K, etal., J Hepatol. 2002 Dec;37(6):788-96.
20. Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomes. Siddiqui TA, etal., J Neuroinflammation. 2012 Nov 17;9:250. doi: 10.1186/1742-2094-9-250.
21. Stimuli associated with the presence or absence of amphetamine regulate cytoskeletal signaling and behavior. Singer BF, etal., Eur Neuropsychopharmacol. 2016 Oct 6. pii: S0924-977X(16)30835-5. doi: 10.1016/j.euroneuro.2016.09.639.
22. Relationship between learning and memory deficits and Arp2 expression in the hippocampus in rats with traumatic brain injury. Xia X, etal., World Neurosurg. 2012 Dec;78(6):689-96. doi: 10.1016/j.wneu.2011.07.042. Epub 2011 Nov 7.
23. Identification of the shared gene signatures between pulmonary fibrosis and pulmonary hypertension using bioinformatics analysis. Zhao H, etal., Front Immunol. 2023 Sep 4;14:1197752. doi: 10.3389/fimmu.2023.1197752. eCollection 2023.
Additional References at PubMed
PMID:11741539   PMID:12477932   PMID:15489334   PMID:16854843   PMID:17220302   PMID:17224451   PMID:18297063   PMID:19056867   PMID:19144319   PMID:19199708   PMID:19946888   PMID:20458337  
PMID:21423176   PMID:21494665   PMID:21874009   PMID:22684256   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23439682   PMID:23533145   PMID:24625528   PMID:24824085   PMID:29058690  
PMID:29925947  


Genomics

Comparative Map Data
Actr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,500,119 - 98,535,092 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1498,500,138 - 98,541,998 (-)EnsemblGRCr8
mRatBN7.21494,296,443 - 94,333,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,296,443 - 94,340,524 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1498,639,283 - 98,680,250 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01499,879,572 - 99,920,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01496,346,941 - 96,387,904 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014104,338,486 - 104,375,840 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)Ensemblrn6Rnor6.0
Rnor_5.014104,072,596 - 104,109,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414100,848,391 - 100,883,833 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1493,318,648 - 93,356,930 (-)NCBICelera
RGSC_v3.114100,867,618 - 100,903,044 (-)NCBI
Cytogenetic Map14q22NCBI
ACTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38265,227,831 - 65,271,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl265,227,745 - 65,271,253 (+)Ensemblhg38GRCh38
GRCh37265,454,965 - 65,498,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36265,308,406 - 65,351,891 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34265,366,552 - 65,410,036NCBI
Celera265,301,566 - 65,345,120 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef265,189,074 - 65,232,629 (+)NCBIHuRef
CHM1_1265,386,192 - 65,429,751 (+)NCBICHM1_1
T2T-CHM13v2.0265,237,506 - 65,280,921 (+)NCBIT2T-CHM13v2.0
Actr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,012,304 - 20,062,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,012,304 - 20,062,913 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381120,062,304 - 20,112,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,062,304 - 20,112,913 (-)Ensemblmm10GRCm38
MGSCv371119,962,307 - 20,012,954 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361119,962,307 - 20,012,915 (-)NCBIMGSCv36mm8
Celera1122,204,487 - 22,259,500 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.88NCBI
Actr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542419,293,949 - 19,333,170 (-)Ensembl
ChiLan1.0NW_00495542419,293,949 - 19,333,170 (-)NCBIChiLan1.0ChiLan1.0
ACTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21261,131,388 - 61,179,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A61,135,339 - 61,180,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A65,289,675 - 65,333,219 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A66,412,786 - 66,456,857 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A66,413,011 - 66,456,857 (+)EnsemblpanPan2panpan1.1
ACTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11064,696,068 - 64,733,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1064,696,111 - 64,730,553 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1064,582,083 - 64,619,025 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01065,705,072 - 65,742,073 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1065,705,085 - 65,742,062 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11065,383,665 - 65,420,656 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01065,691,644 - 65,728,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01065,986,809 - 66,023,812 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629218,549,870 - 18,591,068 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364919,979,427 - 10,022,043 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364919,980,228 - 10,021,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl376,691,280 - 76,729,252 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1376,691,275 - 76,729,269 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2380,487,347 - 80,525,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11441,740,432 - 41,780,045 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1441,739,968 - 41,779,964 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604570,111,314 - 70,152,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247628,281,433 - 8,339,830 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247628,282,415 - 8,339,818 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Actr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11188,333,762 - 88,377,909 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actr2
191 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006607
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582201Sffal2Serum free fatty acids level QTL 240.0002blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)1496755448100078267Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat

Markers in Region
RH144671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,303,260 - 94,303,437 (+)MAPPERmRatBN7.2
Rnor_6.014104,345,231 - 104,345,407NCBIRnor6.0
Rnor_5.014104,079,341 - 104,079,517UniSTSRnor5.0
RGSC_v3.414100,853,576 - 100,853,752UniSTSRGSC3.4
Celera1493,323,148 - 93,323,324UniSTS
RH 3.4 Map14745.89UniSTS
Cytogenetic Map14q22UniSTS
RH139107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,298,334 - 94,298,495 (+)MAPPERmRatBN7.2
Rnor_6.014104,340,379 - 104,340,539NCBIRnor6.0
Rnor_5.014104,074,489 - 104,074,649UniSTSRnor5.0
RGSC_v3.414100,847,987 - 100,848,147UniSTSRGSC3.4
Celera1493,318,244 - 93,318,404UniSTS
Cytogenetic Map14q22UniSTS
AA818437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,298,988 - 94,299,078 (+)MAPPERmRatBN7.2
Rnor_6.014104,341,033 - 104,341,122NCBIRnor6.0
Rnor_5.014104,075,143 - 104,075,232UniSTSRnor5.0
RGSC_v3.414100,848,641 - 100,848,730UniSTSRGSC3.4
Celera1493,318,898 - 93,318,987UniSTS
RH 3.4 Map14746.28UniSTS
Cytogenetic Map14q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001009268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC088442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006607   ⟹   ENSRNOP00000006607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,500,138 - 98,535,041 (-)Ensembl
mRatBN7.2 Ensembl1494,298,758 - 94,333,664 (-)Ensembl
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101111   ⟹   ENSRNOP00000081949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,321,952 - 94,340,524 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109487   ⟹   ENSRNOP00000083980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,500,138 - 98,524,644 (-)Ensembl
mRatBN7.2 Ensembl1494,296,443 - 94,333,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111423   ⟹   ENSRNOP00000081915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,296,919 - 94,333,719 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143311   ⟹   ENSRNOP00000104192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,500,138 - 98,541,998 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144082   ⟹   ENSRNOP00000102754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,506,679 - 98,535,092 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163421   ⟹   ENSRNOP00000107347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,500,138 - 98,534,980 (-)Ensembl
RefSeq Acc Id: NM_001009268   ⟹   NP_001009268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81498,500,119 - 98,535,092 (-)NCBI
mRatBN7.21494,298,739 - 94,333,715 (-)NCBI
Rnor_6.014104,340,783 - 104,375,648 (-)NCBI
Rnor_5.014104,072,596 - 104,109,950 (-)NCBI
RGSC_v3.414100,848,391 - 100,883,833 (-)RGD
Celera1493,318,648 - 93,356,930 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88442 (Get FASTA)   NCBI Sequence Viewer  
  EDL97930 (Get FASTA)   NCBI Sequence Viewer  
  EDL97931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006607
GenBank Protein Q5M7U6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009268   ⟸   NM_001009268
- UniProtKB: Q5M7U6 (UniProtKB/Swiss-Prot),   A6JQ13 (UniProtKB/TrEMBL),   A0A8I6GBC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006607   ⟸   ENSRNOT00000006607
Ensembl Acc Id: ENSRNOP00000083980   ⟸   ENSRNOT00000109487
Ensembl Acc Id: ENSRNOP00000081949   ⟸   ENSRNOT00000101111
Ensembl Acc Id: ENSRNOP00000081915   ⟸   ENSRNOT00000111423
Ensembl Acc Id: ENSRNOP00000104192   ⟸   ENSRNOT00000143311
Ensembl Acc Id: ENSRNOP00000107347   ⟸   ENSRNOT00000163421
Ensembl Acc Id: ENSRNOP00000102754   ⟸   ENSRNOT00000144082

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7U6-F1-model_v2 AlphaFold Q5M7U6 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699507
Promoter ID:EPDNEW_R10031
Type:initiation region
Name:Actr2_1
Description:ARP2 actin related protein 2 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014104,375,614 - 104,375,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310826 AgrOrtholog
BioCyc Gene G2FUF-14894 BioCyc
Ensembl Genes ENSRNOG00000004959 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006607 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126325 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:289820 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95085 IMAGE-MGC_LOAD
NCBI Gene 289820 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actr2 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004959 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I6GBC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q2R8_RAT UniProtKB/TrEMBL
  A0ABK0LA24_RAT UniProtKB/TrEMBL
  A0ABK0LDP6_RAT UniProtKB/TrEMBL
  A0ABK0LRN5_RAT UniProtKB/TrEMBL
  A6JQ13 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ14_RAT UniProtKB/TrEMBL
  ARP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actr2  actin related protein 2  Actr2  ARP2 actin related protein 2 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Actr2  ARP2 actin related protein 2 homolog  Actr2  ARP2 actin-related protein 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Actr2  ARP2 actin-related protein 2 homolog (yeast)  Actr2_predicted  ARP2 actin-related protein 2 homolog (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Actr2_predicted  ARP2 actin-related protein 2 homolog (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED