Actr2 (actin related protein 2) - Rat Genome Database

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Gene: Actr2 (actin related protein 2) Rattus norvegicus
Analyze
Symbol: Actr2
Name: actin related protein 2
RGD ID: 1310826
Description: Enables cytoskeletal protein binding activity. Involved in several processes, including cellular response to trichostatin A; positive regulation of dendritic spine morphogenesis; and response to ethanol. Located in lamellipodium and podosome core. Is active in postsynapse. Orthologous to human ACTR2 (actin related protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-like protein 2; actin-related protein 2; ARP2 actin related protein 2 homolog; ARP2 actin-related protein 2 homolog; ARP2 actin-related protein 2 homolog (yeast); LOC289820; MGC95085
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,500,119 - 98,535,092 (-)NCBIGRCr8
mRatBN7.21494,296,443 - 94,333,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,296,443 - 94,340,524 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1498,639,283 - 98,680,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01499,879,572 - 99,920,537 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01496,346,941 - 96,387,904 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014104,338,486 - 104,375,840 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014104,072,596 - 104,109,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414100,848,391 - 100,883,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114100,867,618 - 100,903,044 (-)NCBI
Celera1493,318,648 - 93,356,930 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Qualifier
Evidence
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Reference
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Original Reference(s)
Actr2RatBrain Injuries  IEP 11530046mRNA and protein:decreased expression:hippocampus (rat)RGD 
Actr2Ratcolorectal carcinoma severityISOACTR2 (Homo sapiens)11570560protein:increased expression:colonic mucosa (human)RGD 
Actr2Ratlung disease  ISOACTR2 (Homo sapiens)401851918mRNA:decreased expression:lung (human)RGD 
Actr2RatPuromycin Aminonucleoside Nephrosis  IEP 11530057mRNA and protein:increased expression:cortex of kidney (rat)RGD 

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Original Reference(s)
Actr2Rat1,2-dimethylhydrazine multiple interactionsISOActr2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ACTR2 mRNACTDPMID:22206623
Actr2Rat1,2-dimethylhydrazine decreases expressionISOActr2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ACTR2 mRNACTDPMID:22206623
Actr2Rat1,8-cineole multiple interactionsISOActr2 (Mus musculus)6480464Eucalyptol inhibits the reaction [Glucose results in decreased expression of ACTR2 protein]CTDPMID:31483951
Actr2Rat17alpha-ethynylestradiol increases expressionISOActr2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ACTR2 mRNACTDPMID:17942748
Actr2Rat17alpha-ethynylestradiol affects expressionISOActr2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ACTR2 mRNACTDPMID:17555576
Actr2Rat17alpha-ethynylestradiol multiple interactionsISOActr2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTR2 mRNACTDPMID:17942748
Actr2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOActr2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACTR2 mRNACTDPMID:17942748
Actr2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ACTR2 mRNACTDPMID:33387578
Actr2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ACTR2 mRNACTDPMID:34747641
Actr2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ACTR2 mRNACTDPMID:32109520
Actr2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOActr2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ACTR2 mRNACTDPMID:24680724
Actr2Rat2,6-dimethoxyphenol multiple interactionsISOACTR2 (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of and affects the localization of ACTR2 proteinCTDPMID:38598786
Actr2Rat2-methylcholine affects expressionISOACTR2 (Homo sapiens)6480464beta-methylcholine affects the expression of ACTR2 mRNACTDPMID:21179406
Actr2Rat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expressionEXP 6480464Puromycin Aminonucleoside results in increased expression of ACTR2 mRNA and Puromycin Aminonucleoside results in increased expression of ACTR2 proteinCTDPMID:19617259
Actr2Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ACTR2 mRNACTDPMID:30071829
Actr2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOACTR2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ACTR2 mRNACTDPMID:28628672
Actr2Rat4,4'-sulfonyldiphenol increases expressionISOActr2 (Mus musculus)6480464bisphenol S results in increased expression of ACTR2 mRNACTDPMID:39298647
Actr2Rat4,4'-sulfonyldiphenol increases expressionISOACTR2 (Homo sapiens)6480464bisphenol S results in increased expression of ACTR2 proteinCTDPMID:34186270
Actr2Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of ACTR2 mRNACTDPMID:30047161
Actr2Ratactinomycin D multiple interactionsISOACTR2 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of ACTR2 proteinCTDPMID:38460933

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Biological Process
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Original Reference(s)
Actr2Ratactin cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratactin cytoskeleton organization acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291 PMID:21874009RGDPMID:21874009
Actr2RatArp2/3 complex-mediated actin nucleation involved_inISSUniProtKB:P611601600115GO_REF:0000024UniProtGO_REF:0000024
Actr2RatArp2/3 complex-mediated actin nucleation involved_inIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2RatArp2/3 complex-mediated actin nucleation involved_inIBAPANTHER:PTN000233596 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Actr2RatArp2/3 complex-mediated actin nucleation involved_inIEAUniRule:UR0010297591600115GO_REF:0000104UniProtGO_REF:0000104
Actr2RatArp2/3 complex-mediated actin nucleation involved_inISOACTR2 (Homo sapiens)1624291 PMID:11741539 more ...RGDPMID:11741539 more ...
Actr2Ratassociative learning  IEP 11567211 RGD 
Actr2Ratasymmetric cell division acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291MGI:1921367 PMID:21494665RGDPMID:21494665
Actr2Ratasymmetric cell division acts_upstream_of_or_withinIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcellular response to trichostatin A  IEP 632492 RGD 
Actr2Ratcellular response to type II interferon acts_upstream_of_or_withinIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcellular response to type II interferon acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291MGI:1921367 PMID:19144319RGDPMID:19144319
Actr2Ratcilium assembly acts_upstream_of_or_withinISOACTR2 (Homo sapiens)1624291 PMID:22684256RGDPMID:22684256
Actr2Ratcilium assembly acts_upstream_of_or_withinIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcytosolic transport acts_upstream_of_or_withinIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcytosolic transport acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291 PMID:21874009RGDPMID:21874009
Actr2Ratestablishment or maintenance of cell polarity acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291MGI:1921367 PMID:21494665RGDPMID:21494665
Actr2Ratestablishment or maintenance of cell polarity acts_upstream_of_or_withinIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratmeiotic cell cycle acts_upstream_of_or_withinISOActr2 (Mus musculus)1624291MGI:1921367 PMID:21494665RGDPMID:21494665
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Cellular Component
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Original Reference(s)
Actr2Ratactin cap located_inIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratactin cap located_inISOActr2 (Mus musculus)1624291 PMID:21494665 and PMID:21874009RGDPMID:21494665 and PMID:21874009
Actr2RatArp2/3 protein complex part_ofISSUniProtKB:P611601600115GO_REF:0000024UniProtGO_REF:0000024
Actr2RatArp2/3 protein complex part_ofIBAPANTHER:PTN000233596 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Actr2RatArp2/3 protein complex part_ofIEAUniRule:UR0010297591600115GO_REF:0000104UniProtGO_REF:0000104
Actr2RatArp2/3 protein complex part_ofIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2RatArp2/3 protein complex part_ofISOACTR2 (Homo sapiens)1624291 PMID:11741539 and PMID:17220302RGDPMID:11741539 and PMID:17220302
Actr2Ratcell cortex is_active_inIBAMGI:1913963 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Actr2Ratcell cortex located_inIEAUniProtKB:P61161 and ensembl:ENSMUSP000000001371600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcell cortex located_inISOActr2 (Mus musculus)1624291 PMID:21494665RGDPMID:21494665
Actr2Ratcell cortex located_inISOACTR2 (Sus scrofa)1624291 PMID:24824085RGDPMID:24824085
Actr2Ratcell projection located_inIEAUniProtKB-SubCell:SL-02801600115GO_REF:0000044UniProtGO_REF:0000044
Actr2Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Actr2Ratcytoplasm located_inIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Actr2Ratcytoplasm located_inISOACTR2 (Homo sapiens)1624291 PMID:17220302 and PMID:22684256RGDPMID:17220302 and PMID:22684256
Actr2Ratcytoplasm located_inISSUniProtKB:P611601600115GO_REF:0000024UniProtGO_REF:0000024
Actr2Ratcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Actr2Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Actr2Ratcytosol located_inIEAGO:00164821600115GO_REF:0000108GOCGO_REF:0000108
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Molecular Function
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Original Reference(s)
Actr2Ratactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Actr2Ratactin filament binding contributes_toISOACTR2 (Homo sapiens)1624291 PMID:11741539RGDPMID:11741539
Actr2Ratactin filament binding contributes_toIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
Actr2Ratactin filament binding contributes_toIBAPANTHER:PTN000233596 and UniProtKB:P611601600115GO_REF:0000033GO_CentralGO_REF:0000033
Actr2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Actr2RatATP binding enablesIEAUniRule:UR0010297591600115GO_REF:0000104UniProtGO_REF:0000104
Actr2Ratcytoskeletal protein binding  IDA 11530065Arpc1RGD 
Actr2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Actr2Ratprotein binding  IPICrk (Rattus norvegicus)8693596 RGD 
Actr2Ratprotein binding enablesISOActr2 (Mus musculus)1624291PR:Q9JLI7 PMID:31146259RGDPMID:31146259
Actr2Ratprotein binding enablesISOACTR2 (Homo sapiens)1624291UniProtKB:O75366 more ...RGDPMID:29058690 and PMID:32128961
Actr2Ratstructural constituent of cytoskeleton enablesISOACTR2 (Homo sapiens)1624291 PMID:11741539RGDPMID:11741539
Actr2Ratstructural constituent of cytoskeleton enablesIEAUniProtKB:P61160 and ensembl:ENSP000002606411600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Actr2Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   IMP 10054052 RGD 
Actr2RatRab family mediated signaling pathway  IMP 10054052 RGD 

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Actr2Ratplatelet-derived growth factor signaling pathway  ISOACTR2 (Homo sapiens)6484113 PIDPID:200149

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#
Reference Title
Reference Citation
1. Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5.
2. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. Cai L, etal., J Biol Chem. 2005 Sep 9;280(36):31913-23. Epub 2005 Jul 18.
3. F-actin binding is essential for coronin 1B function in vivo. Cai L, etal., J Cell Sci. 2007 May 15;120(Pt 10):1779-90. Epub 2007 Apr 24.
4. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
5. Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells. de Graauw M, etal., J Pharmacol Exp Ther. 2007 Jul;322(1):89-100. Epub 2007 Apr 18.
6. N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361.
7. Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei. Esparza MA, etal., Eur J Neurosci. 2012 Oct;36(8):3103-17. doi: 10.1111/j.1460-9568.2012.08239.x. Epub 2012 Aug 12.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Regulation of spine density and morphology by IQGAP1 protein domains. Jausoro I, etal., PLoS One. 2013;8(2):e56574. doi: 10.1371/journal.pone.0056574. Epub 2013 Feb 18.
10. Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. Jilek JL, etal., Toxicol Sci. 2015 Oct;147(2):475-89. doi: 10.1093/toxsci/kfv145. Epub 2015 Jul 15.
11. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. LeClaire LL 3rd, etal., J Cell Biol. 2008 Aug 25;182(4):647-54. doi: 10.1083/jcb.200802145.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes. Miao J, etal., Nephrol Dial Transplant. 2009 Nov;24(11):3297-305. doi: 10.1093/ndt/gfp338. Epub 2009 Jul 17.
14. Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
15. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. Peng J, etal., J Biol Chem. 2004 May 14;279(20):21003-11. doi: 10.1074/jbc.M400103200. Epub 2004 Mar 12.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. Rombouts K, etal., J Hepatol. 2002 Dec;37(6):788-96.
20. Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomes. Siddiqui TA, etal., J Neuroinflammation. 2012 Nov 17;9:250. doi: 10.1186/1742-2094-9-250.
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PMID:11741539   PMID:12477932   PMID:15489334   PMID:16854843   PMID:17220302   PMID:17224451   PMID:18297063   PMID:19056867   PMID:19144319   PMID:19199708   PMID:19946888   PMID:20458337  
PMID:21423176   PMID:21494665   PMID:21874009   PMID:22684256   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23439682   PMID:23533145   PMID:24625528   PMID:24824085   PMID:29058690  
PMID:29925947  



Actr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,500,119 - 98,535,092 (-)NCBIGRCr8
mRatBN7.21494,296,443 - 94,333,735 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,296,443 - 94,340,524 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1498,639,283 - 98,680,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01499,879,572 - 99,920,537 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01496,346,941 - 96,387,904 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014104,338,486 - 104,375,840 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014104,072,596 - 104,109,950 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414100,848,391 - 100,883,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114100,867,618 - 100,903,044 (-)NCBI
Celera1493,318,648 - 93,356,930 (-)NCBICelera
Cytogenetic Map14q22NCBI
ACTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38265,227,831 - 65,271,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl265,227,788 - 65,271,253 (+)EnsemblGRCh38hg38GRCh38
GRCh37265,454,965 - 65,498,387 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36265,308,406 - 65,351,891 (+)NCBINCBI36Build 36hg18NCBI36
Build 34265,366,552 - 65,410,036NCBI
Celera265,301,566 - 65,345,120 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef265,189,074 - 65,232,629 (+)NCBIHuRef
CHM1_1265,386,192 - 65,429,751 (+)NCBICHM1_1
T2T-CHM13v2.0265,237,506 - 65,280,921 (+)NCBIT2T-CHM13v2.0
Actr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,012,304 - 20,062,951 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,012,304 - 20,062,913 (-)EnsemblGRCm39 Ensembl
GRCm381120,062,304 - 20,112,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,062,304 - 20,112,913 (-)EnsemblGRCm38mm10GRCm38
MGSCv371119,962,307 - 20,012,954 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361119,962,307 - 20,012,915 (-)NCBIMGSCv36mm8
Celera1122,204,487 - 22,259,500 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.88NCBI
Actr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542419,293,949 - 19,333,170 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542419,293,949 - 19,333,170 (-)NCBIChiLan1.0ChiLan1.0
ACTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21261,131,388 - 61,179,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A61,135,339 - 61,180,922 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A65,289,675 - 65,333,219 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A66,412,786 - 66,456,857 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A66,413,011 - 66,456,857 (+)Ensemblpanpan1.1panPan2
ACTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11064,696,068 - 64,733,027 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1064,696,111 - 64,730,553 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1064,582,083 - 64,619,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01065,705,072 - 65,742,073 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1065,705,085 - 65,742,062 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11065,383,665 - 65,420,656 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01065,691,644 - 65,728,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01065,986,809 - 66,023,812 (+)NCBIUU_Cfam_GSD_1.0
Actr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629218,549,870 - 18,591,068 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364919,979,427 - 10,022,043 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364919,980,228 - 10,021,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl376,691,280 - 76,729,252 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1376,691,275 - 76,729,269 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2380,487,347 - 80,525,297 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11441,740,432 - 41,780,045 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1441,739,968 - 41,779,964 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604570,111,314 - 70,152,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247628,281,433 - 8,339,830 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247628,282,415 - 8,339,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Actr2
209 total Variants

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006607
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582201Sffal2Serum free fatty acids level QTL 240.0002blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)149255388695876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat

1 to 10 of 15 rows
RH144671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,303,260 - 94,303,437 (+)MAPPERmRatBN7.2
Rnor_6.014104,345,231 - 104,345,407NCBIRnor6.0
Rnor_5.014104,079,341 - 104,079,517UniSTSRnor5.0
RGSC_v3.414100,853,576 - 100,853,752UniSTSRGSC3.4
Celera1493,323,148 - 93,323,324UniSTS
RH 3.4 Map14745.89UniSTS
Cytogenetic Map14q22UniSTS
RH139107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,298,334 - 94,298,495 (+)MAPPERmRatBN7.2
Rnor_6.014104,340,379 - 104,340,539NCBIRnor6.0
Rnor_5.014104,074,489 - 104,074,649UniSTSRnor5.0
RGSC_v3.414100,847,987 - 100,848,147UniSTSRGSC3.4
Celera1493,318,244 - 93,318,404UniSTS
Cytogenetic Map14q22UniSTS
AA818437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,298,988 - 94,299,078 (+)MAPPERmRatBN7.2
Rnor_6.014104,341,033 - 104,341,122NCBIRnor6.0
Rnor_5.014104,075,143 - 104,075,232UniSTSRnor5.0
RGSC_v3.414100,848,641 - 100,848,730UniSTSRGSC3.4
Celera1493,318,898 - 93,318,987UniSTS
RH 3.4 Map14746.28UniSTS
Cytogenetic Map14q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 25 of 25 rows
RefSeq Transcripts NM_001009268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC088442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 25 of 25 rows

Ensembl Acc Id: ENSRNOT00000006607   ⟹   ENSRNOP00000006607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,298,758 - 94,333,664 (-)Ensembl
Rnor_6.0 Ensembl14104,340,434 - 104,375,649 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101111   ⟹   ENSRNOP00000081949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,321,952 - 94,340,524 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109487   ⟹   ENSRNOP00000083980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,296,443 - 94,333,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111423   ⟹   ENSRNOP00000081915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1494,296,919 - 94,333,719 (-)Ensembl
RefSeq Acc Id: NM_001009268   ⟹   NP_001009268
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81498,500,119 - 98,535,092 (-)NCBI
mRatBN7.21494,298,739 - 94,333,715 (-)NCBI
Rnor_6.014104,340,783 - 104,375,648 (-)NCBI
Rnor_5.014104,072,596 - 104,109,950 (-)NCBI
RGSC_v3.414100,848,391 - 100,883,833 (-)RGD
Celera1493,318,648 - 93,356,930 (-)RGD
Sequence:
Protein RefSeqs NP_001009268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88442 (Get FASTA)   NCBI Sequence Viewer  
  EDL97930 (Get FASTA)   NCBI Sequence Viewer  
  EDL97931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006607
GenBank Protein Q5M7U6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009268   ⟸   NM_001009268
- UniProtKB: Q5M7U6 (UniProtKB/Swiss-Prot),   A6JQ13 (UniProtKB/TrEMBL),   A0A8I6GBC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006607   ⟸   ENSRNOT00000006607
Ensembl Acc Id: ENSRNOP00000083980   ⟸   ENSRNOT00000109487
Ensembl Acc Id: ENSRNOP00000081949   ⟸   ENSRNOT00000101111
Ensembl Acc Id: ENSRNOP00000081915   ⟸   ENSRNOT00000111423

Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7U6-F1-model_v2 AlphaFold Q5M7U6 1-394 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699507
Promoter ID:EPDNEW_R10031
Type:initiation region
Name:Actr2_1
Description:ARP2 actin related protein 2 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014104,375,614 - 104,375,674EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-14894 BioCyc
Ensembl Genes ENSRNOG00000004959 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006607 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126325 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:289820 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95085 IMAGE-MGC_LOAD
NCBI Gene 289820 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actr2 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004959 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8I5ZU02_RAT UniProtKB/TrEMBL
  A0A8I5ZW15_RAT UniProtKB/TrEMBL
  A0A8I6GBC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q2R8_RAT UniProtKB/TrEMBL
  A6JQ13 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ14_RAT UniProtKB/TrEMBL
  ARP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actr2  actin related protein 2  Actr2  ARP2 actin related protein 2 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Actr2  ARP2 actin related protein 2 homolog  Actr2  ARP2 actin-related protein 2 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Actr2  ARP2 actin-related protein 2 homolog (yeast)  Actr2_predicted  ARP2 actin-related protein 2 homolog (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Actr2_predicted  ARP2 actin-related protein 2 homolog (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED