RGD Reference Report - Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. - Rat Genome Database

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Involvement of Arp2/3 complex in the process of colorectal carcinogenesis.

Authors: Otsubo, T  Iwaya, K  Mukai, Y  Mizokami, Y  Serizawa, H  Matsuoka, T  Mukai, K 
Citation: Otsubo T, etal., Mod Pathol. 2004 Apr;17(4):461-7.
RGD ID: 11570560
Pubmed: PMID:14990971   (View Abstract at PubMed)
DOI: DOI:10.1038/modpathol.3800062   (Journal Full-text)

Increased motility is one of the characteristics of cancer cells, and actin polymerization and disassembly are essential for cellular motility. Since actin-related protein (Arp) 2/3 complex acts as a nucleus for actin polymerization, in this study, we immunohistochemically investigated the expression of Arp2 and Arp3 in 175 colorectal tumors in various stages of neoplastic progression. Arp2 and Arp3 showed identical expression patterns, and both were expressed in the stromal cells around neoplastic tubules or glands and in the tumor cells themselves. The frequency of expression of Arp2 and Arp3 (Arp2 and 3) by the stromal cells increased with the atypia of the colorectal neoplasms, from 5.5% (3/55) in adenoma with mild or moderate atypia, to 11.8% (2/17) in adenoma with severe atypia, 53.3% (16/30) in intramucosal carcinoma, and 91.8% (67/73) in invasive carcinoma (P<0.0001). The frequency of expression of Arp2 and 3 in the tumor cells was similar and was 1.8% (1/55) in adenoma with mild or moderate atypia, 23.5% (4/17) in adenoma with severe atypia, 23.5% (7/30) in intramucosal carcinoma, and 32.9% (24/73) in invasive carcinoma. Expression of Arp2 and 3 by the stromal cells was significantly correlated with nuclear accumulation of p53 in the tumor cells and stromal expression of CD10. These results suggest that formation of Arp2/3 complex by both neoplastic and stromal cells contributes to the increased motility of both cell types and thus provides suitable conditions for invasion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colorectal carcinoma severityIEP 11570560; 11570560protein:increased expression:colonic mucosa (human)RGD 
colorectal carcinoma severityISOACTR2 (Homo sapiens)11570560; 11570560protein:increased expression:colonic mucosa (human)RGD 
colorectal carcinoma severityISOACTR3 (Homo sapiens)11570560; 11570560protein:increased expression:colonic mucosa (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Actr2  (actin related protein 2)
Actr3  (actin related protein 3)

Genes (Mus musculus)
Actr2  (actin related protein 2)
Actr3  (ARP3 actin-related protein 3)

Genes (Homo sapiens)
ACTR2  (actin related protein 2)
ACTR3  (actin related protein 3)


Additional Information