Xrn2 (5'-3' exoribonuclease 2) - Rat Genome Database

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Gene: Xrn2 (5'-3' exoribonuclease 2) Rattus norvegicus
Analyze
Symbol: Xrn2
Name: 5'-3' exoribonuclease 2
RGD ID: 1310218
Description: Predicted to enable several functions, including RNA exonuclease activity, producing 5'-phosphomonoesters; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Involved in hippocampus development; neuron differentiation; and retina development in camera-type eye. Predicted to be located in nucleolus. Predicted to be active in nucleus. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362229
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,888,558 - 154,962,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3154,890,061 - 154,962,486 (+)EnsemblGRCr8
mRatBN7.23134,436,916 - 134,509,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3138,350,638 - 138,422,835 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,934,742 - 147,006,929 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03144,637,900 - 144,710,092 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03141,224,858 - 141,298,272 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3141,225,290 - 141,298,265 (+)Ensemblrn6Rnor6.0
Rnor_5.03147,641,256 - 147,716,287 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43135,651,059 - 135,724,442 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3133,299,770 - 133,372,470 (+)NCBICelera
RGSC_v3.13135,541,370 - 135,629,673 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. Bell A, etal., Cancer. 2011 Jul 1;117(13):2898-909. doi: 10.1002/cncr.25818. Epub 2011 Jan 11.
2. Pre-mRNA 3'-end processing complex assembly and function. Chan S, etal., Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):321-35. doi: 10.1002/wrna.54. Epub 2010 Oct 18.
3. Gene expression signatures of primary and metastatic uterine leiomyosarcoma. Davidson B, etal., Hum Pathol. 2014 Apr;45(4):691-700. doi: 10.1016/j.humpath.2013.11.003. Epub 2013 Nov 13.
4. Developmental and functional expression of miRNA-stability related genes in the nervous system. de Sousa E, etal., PLoS One. 2013 May 20;8(5):e56908. doi: 10.1371/journal.pone.0056908. Print 2013.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A possible new mechanism for the control of miRNA expression in neurons. Kinjo ER, etal., Exp Neurol. 2013 Oct;248:546-58. doi: 10.1016/j.expneurol.2013.07.022. Epub 2013 Aug 7.
8. Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. Kinjo ER, etal., Sci Rep. 2016 Feb 12;6:20969. doi: 10.1038/srep20969.
9. Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. Lu Y, etal., Oncogene. 2010 Feb 18;29(7):1041-9. doi: 10.1038/onc.2009.396. Epub 2009 Nov 16.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA. Sloan KE, etal., RNA. 2014 Apr;20(4):540-50. doi: 10.1261/rna.043471.113. Epub 2014 Feb 18.
Additional References at PubMed
PMID:7885830   PMID:10409438   PMID:12429849   PMID:15565158   PMID:19946888   PMID:21700224   PMID:22658674   PMID:22681889   PMID:23482395  


Genomics

Comparative Map Data
Xrn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,888,558 - 154,962,519 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3154,890,061 - 154,962,486 (+)EnsemblGRCr8
mRatBN7.23134,436,916 - 134,509,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3138,350,638 - 138,422,835 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,934,742 - 147,006,929 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03144,637,900 - 144,710,092 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03141,224,858 - 141,298,272 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3141,225,290 - 141,298,265 (+)Ensemblrn6Rnor6.0
Rnor_5.03147,641,256 - 147,716,287 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43135,651,059 - 135,724,442 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3133,299,770 - 133,372,470 (+)NCBICelera
RGSC_v3.13135,541,370 - 135,629,673 (+)NCBI
Cytogenetic Map3q41NCBI
XRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382021,303,331 - 21,389,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2021,303,304 - 21,389,826 (+)Ensemblhg38GRCh38
GRCh372021,283,969 - 21,370,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,231,942 - 21,318,463 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342021,231,941 - 21,318,463NCBI
Celera2021,360,521 - 21,444,351 (+)NCBICelera
Cytogenetic Map20p11.22NCBI
HuRef2021,248,976 - 21,332,731 (+)NCBIHuRef
CHM1_12021,284,715 - 21,370,457 (+)NCBICHM1_1
T2T-CHM13v2.02021,362,698 - 21,446,483 (+)NCBIT2T-CHM13v2.0
Xrn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,854,672 - 146,919,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,854,916 - 146,919,920 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382147,012,755 - 147,078,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,012,996 - 147,078,000 (+)Ensemblmm10GRCm38
MGSCv372146,838,796 - 146,903,736 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362146,704,563 - 146,766,521 (+)NCBIMGSCv36mm8
Celera2148,268,335 - 148,333,354 (+)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
Xrn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,107,034 - 29,175,538 (+)Ensembl
ChiLan1.0NW_00495541529,107,060 - 29,175,374 (+)NCBIChiLan1.0ChiLan1.0
XRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,192,379 - 22,278,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12022,188,948 - 22,275,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02021,260,871 - 21,347,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12021,222,138 - 21,308,561 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2021,222,138 - 21,308,561 (+)EnsemblpanPan2panpan1.1
XRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,042,521 - 2,128,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,042,888 - 2,128,867 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha242,070,749 - 2,157,181 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0242,449,943 - 2,536,442 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,449,949 - 2,536,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,046,962 - 2,133,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,150,331 - 2,236,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,427,267 - 2,513,473 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xrn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640150,649,492 - 150,724,750 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366204,069,934 - 4,145,745 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366204,069,956 - 4,145,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,107,667 - 29,193,479 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11729,107,641 - 29,193,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21733,060,057 - 33,145,974 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1250,287,718 - 50,373,869 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl250,288,073 - 50,373,883 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660785,086,667 - 5,173,118 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xrn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474121,691,199 - 21,767,790 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474121,691,099 - 21,768,267 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Xrn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15126,636,476 - 126,674,419 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Xrn2
240 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:69
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000016351
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016351   ⟹   ENSRNOP00000016350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3154,890,061 - 154,962,486 (+)Ensembl
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)Ensembl
Rnor_6.0 Ensembl3141,225,290 - 141,298,265 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102292   ⟹   ENSRNOP00000082832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3154,890,061 - 154,962,486 (+)Ensembl
mRatBN7.2 Ensembl3134,437,145 - 134,509,306 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106395   ⟹   ENSRNOP00000086056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3154,890,348 - 154,962,486 (+)Ensembl
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)Ensembl
RefSeq Acc Id: NM_001108596   ⟹   NP_001102066
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83154,890,361 - 154,962,494 (+)NCBI
mRatBN7.23134,437,145 - 134,509,281 (+)NCBI
RefSeq Acc Id: XM_039105475   ⟹   XP_038961403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83154,888,558 - 154,962,519 (+)NCBI
mRatBN7.23134,436,916 - 134,509,308 (+)NCBI
Ensembl Acc Id: ENSRNOP00000016350   ⟸   ENSRNOT00000016351
RefSeq Acc Id: XP_038961403   ⟸   XM_039105475
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A511 (UniProtKB/TrEMBL),   A6K7A0 (UniProtKB/TrEMBL),   A0A8I5ZUU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001102066   ⟸   NM_001108596
- UniProtKB: D4A914 (UniProtKB/TrEMBL),   A6K799 (UniProtKB/TrEMBL),   A0A8I5ZUU8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086056   ⟸   ENSRNOT00000106395
Ensembl Acc Id: ENSRNOP00000082832   ⟸   ENSRNOT00000102292
Protein Domains
Xrn1 helical   Xrn1 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A914-F1-model_v2 AlphaFold D4A914 1-951 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692510
Promoter ID:EPDNEW_R3018
Type:initiation region
Name:Xrn2_1
Description:5'-3' exoribonuclease 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03141,225,328 - 141,225,388EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310218 AgrOrtholog
BioCyc Gene G2FUF-47557 BioCyc
Ensembl Genes ENSRNOG00000011785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016351 ENTREZGENE
  ENSRNOT00000016351.9 UniProtKB/TrEMBL
  ENSRNOT00000102292.2 UniProtKB/TrEMBL
  ENSRNOT00000106395 ENTREZGENE
  ENSRNOT00000106395.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.1050 UniProtKB/TrEMBL
  3.40.50.12390 UniProtKB/TrEMBL
InterPro 5_3_exoribonuclease UniProtKB/TrEMBL
  5_3_exoribonuclease_2/3 UniProtKB/TrEMBL
  Put_53exo UniProtKB/TrEMBL
  Xrn1_helical UniProtKB/TrEMBL
NCBI Gene 362229 ENTREZGENE
PANTHER 5'-3' EXORIBONUCLEASE 2 UniProtKB/TrEMBL
  PTHR12341 UniProtKB/TrEMBL
Pfam XRN_M UniProtKB/TrEMBL
  XRN_N UniProtKB/TrEMBL
PhenoGen Xrn2 PhenoGen
PIRSF Exonuclease_Xrn2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011785 RatGTEx
UniProt A0A8I5ZUU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A511 ENTREZGENE, UniProtKB/TrEMBL
  A6K799 ENTREZGENE, UniProtKB/TrEMBL
  A6K7A0 ENTREZGENE, UniProtKB/TrEMBL
  D4A914 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Xrn2  5'-3' exoribonuclease 2   Xrn2_predicted  5'-3' exoribonuclease 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Xrn2_predicted  5'-3' exoribonuclease 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED