Xrn2 (5'-3' exoribonuclease 2) - Rat Genome Database

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Gene: Xrn2 (5'-3' exoribonuclease 2) Heterocephalus glaber
Analyze
Symbol: Xrn2
Name: 5'-3' exoribonuclease 2
RGD ID: 18930847
Description: ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); 5'-3' exonuclease activity (ortholog); identical protein binding (ortholog); INVOLVED IN hippocampus development (ortholog); neuron differentiation (ortholog); retina development in camera-type eye (ortholog); PARTICIPATES IN 3'-end pre-mRNA processing pathway; ribosome biogenesis pathway; RNA polymerase II transcription termination pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); familial hyperinsulinemic hypoglycemia 1 (ortholog); leiomyosarcoma (ortholog); FOUND IN aggresome (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474121,691,199 - 21,767,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474121,691,099 - 21,768,267 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
aggresome  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Xrn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474121,691,199 - 21,767,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474121,691,099 - 21,768,267 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
XRN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382021,303,331 - 21,389,825 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2021,303,331 - 21,389,825 (+)EnsemblGRCh38hg38GRCh38
GRCh372021,283,969 - 21,370,463 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362021,231,942 - 21,318,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 342021,231,941 - 21,318,463NCBI
Celera2021,360,521 - 21,444,351 (+)NCBICelera
Cytogenetic Map20p11.22NCBI
HuRef2021,248,976 - 21,332,731 (+)NCBIHuRef
CHM1_12021,284,715 - 21,370,457 (+)NCBICHM1_1
T2T-CHM13v2.02021,362,698 - 21,446,483 (+)NCBIT2T-CHM13v2.0
Xrn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392146,854,672 - 146,919,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2146,854,916 - 146,919,920 (+)EnsemblGRCm39 Ensembl
GRCm382147,012,755 - 147,078,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2147,012,996 - 147,078,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv372146,838,796 - 146,903,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362146,704,563 - 146,766,521 (+)NCBIMGSCv36mm8
Celera2148,268,335 - 148,333,354 (+)NCBICelera
Cytogenetic Map2G2NCBI
cM Map272.63NCBI
Xrn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83154,888,558 - 154,962,519 (+)NCBIGRCr8
mRatBN7.23134,436,916 - 134,509,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3134,437,109 - 134,509,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3138,350,638 - 138,422,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03146,934,742 - 147,006,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03144,637,900 - 144,710,092 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03141,224,858 - 141,298,272 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3141,225,290 - 141,298,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03147,641,256 - 147,716,287 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43135,651,059 - 135,724,442 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13135,541,370 - 135,629,673 (+)NCBI
Celera3133,299,770 - 133,372,470 (+)NCBICelera
Cytogenetic Map3q41NCBI
Xrn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,107,034 - 29,175,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541529,107,060 - 29,175,374 (+)NCBIChiLan1.0ChiLan1.0
XRN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22122,192,379 - 22,278,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12022,188,948 - 22,275,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02021,260,871 - 21,347,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12021,222,138 - 21,308,561 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2021,222,138 - 21,308,561 (+)Ensemblpanpan1.1panPan2
XRN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,042,521 - 2,128,942 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,042,888 - 2,128,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha242,070,749 - 2,157,181 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,449,943 - 2,536,442 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,449,949 - 2,536,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,046,962 - 2,133,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,150,331 - 2,236,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,427,267 - 2,513,473 (-)NCBIUU_Cfam_GSD_1.0
Xrn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640150,649,492 - 150,724,750 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366204,069,934 - 4,145,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366204,069,956 - 4,145,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,107,667 - 29,193,479 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11729,107,641 - 29,193,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21733,060,057 - 33,145,974 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1250,287,718 - 50,373,869 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl250,288,073 - 50,373,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660785,086,667 - 5,173,118 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000020934   ⟹   ENSHGLP00000020731
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474121,691,199 - 21,767,790 (+)Ensembl
RefSeq Acc Id: XM_004840901   ⟹   XP_004840958
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474121,691,099 - 21,768,267 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004840958 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000020731
GenBank Protein JAO00138 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004840958   ⟸   XM_004840901
- UniProtKB: G5CBC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000020731   ⟸   ENSHGLT00000020934


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014831 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020934 ENTREZGENE
Gene3D-CATH 1.25.40.1050 UniProtKB/TrEMBL
  3.40.50.12390 UniProtKB/TrEMBL
InterPro 5_3_exoribonuclease UniProtKB/TrEMBL
  Put_53exo UniProtKB/TrEMBL
  Xrn1_helical UniProtKB/TrEMBL
  Xrn2/3/4 UniProtKB/TrEMBL
KEGG Report hgl:101697198 UniProtKB/TrEMBL
NCBI Gene Xrn2 ENTREZGENE
PANTHER 5'-3' EXORIBONUCLEASE 2 UniProtKB/TrEMBL
  PTHR12341 UniProtKB/TrEMBL
Pfam XRN_M UniProtKB/TrEMBL
  XRN_N UniProtKB/TrEMBL
PIRSF Exonuclease_Xrn2 UniProtKB/TrEMBL
UniProt G5CBC2 ENTREZGENE, UniProtKB/TrEMBL