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Gene: Mtap (methylthioadenosine phosphorylase) Rattus norvegicus

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Symbol:

Mtap

Name:

methylthioadenosine phosphorylase

RGD ID:

1310114

Description:

Enables S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase); PARTICIPATES IN methionine cycle/metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

5'-methylthioadenosine phosphorylase; Cc1-6; LOC298227; S-methyl-5'-thioadenosine phosphorylase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTAP (methylthioadenosine phosphorylase)	HGNC	Ensembl, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MTAP (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103241896 (S-methyl-5'-thioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mtap (methylthioadenosine phosphorylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ATP10A (ATPase phospholipid transporting 10A (putative))	HGNC	OMA
Homo sapiens (human):	OR5P3 (olfactory receptor family 5 subfamily P member 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MTAP (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mtap (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mtap (methylthioadenosine phosphorylase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31115	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	B0228.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MEU1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MEU1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mtap	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rgs1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mtap	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mtap	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,990,270 - 109,036,494 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	108,988,830 - 109,055,214 (+)	Ensembl				GRCr8
mRatBN7.2	5	103,874,460 - 103,920,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	103,873,020 - 103,939,406 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	106,308,258 - 106,354,482 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	108,037,874 - 108,084,086 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	108,118,643 - 108,164,834 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,711,077 - 107,777,530 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,711,077 - 107,777,530 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	111,679,661 - 111,746,208 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	108,788,725 - 108,861,905 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	102,587,860 - 102,654,739 (+)	NCBI		Celera
RGSC_v3.1	5	108,793,950 - 108,867,131 (+)	NCBI
Cytogenetic Map	5	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

biliary tract benign neoplasm (ISO)

common bile duct neoplasm (ISO)

Desbuquois dysplasia (ISO)

diaphyseal medullary stenosis with malignant fibrous histiocytoma (ISO)

melanoma (ISO)

Nevus (ISO)

pancreatic cancer (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

acrolein (ISO)

acrylamide (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

furfural (ISO)

gentamycin (EXP)

inulin (ISO)

isoniazide (ISO)

ivermectin (ISO)

L-methionine (ISO)

manganese(II) chloride (EXP)

methidathion (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

tamoxifen (ISO)

tanespimycin (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

topotecan (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

L-methionine salvage from methylthioadenosine (IBA,IEA)

methylation (ISO)

nicotinamide riboside catabolic process (ISO)

nucleoside metabolic process (IEA)

purine ribonucleoside salvage (IEA)

response to testosterone (IEP)

Cellular Component

cytoplasm (IEA)

cytosol (IBA,IEA,ISO)

nucleus (IEA)

Molecular Function

catalytic activity (IEA)

glycosyltransferase activity (IEA)

pentosyltransferase activity (IEA)

protein binding (ISO)

S-methyl-5-thioadenosine phosphorylase activity (IBA,IDA,IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

glycine N-methyltransferase deficiency pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (IMP,ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme.	Abbruzzese A, etal., J Neurochem. 1983 Feb;40(2):487-92.
2.	Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity.	Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
3.	Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung.	Garbers DL Biochim Biophys Acta. 1978 Mar 14;523(1):82-93.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy.	Hustinx SR, etal., Cancer Biol Ther. 2005 Jan;4(1):83-6. Epub 2005 Jan 15.
7.	Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.	Karikari CA, etal., Mol Cancer Ther. 2005 Dec;4(12):1860-6.
8.	S-adenosylmethionine in liver health, injury, and cancer.	Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	The stimulatory effect of testosterone propionate and 17 beta-estradiol on 5'-methylthioadenosine phosphorylase activity in rat target tissues.	Nicolette JA, etal., Biochim Biophys Acta. 1980 Jan 17;627(2):190-8.
11.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate.	Seidenfeld J, etal., Biochem Biophys Res Commun. 1980 Aug 29;95(4):1861-8.
18.	Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.	Subhi AL, etal., Clin Cancer Res. 2004 Nov 1;10(21):7290-6.

Additional References at PubMed

PMID:19001417	PMID:19056867	PMID:22952318	PMID:23376485	PMID:27748820

Genomics

Comparative Map Data

Mtap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,990,270 - 109,036,494 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	108,988,830 - 109,055,214 (+)	Ensembl				GRCr8
mRatBN7.2	5	103,874,460 - 103,920,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	103,873,020 - 103,939,406 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	106,308,258 - 106,354,482 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	108,037,874 - 108,084,086 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	108,118,643 - 108,164,834 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,711,077 - 107,777,530 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,711,077 - 107,777,530 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	111,679,661 - 111,746,208 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	108,788,725 - 108,861,905 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	102,587,860 - 102,654,739 (+)	NCBI		Celera
RGSC_v3.1	5	108,793,950 - 108,867,131 (+)	NCBI
Cytogenetic Map	5	q32	NCBI

MTAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	21,802,636 - 21,941,115 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	21,802,636 - 21,937,651 (+)	Ensembl			hg38	GRCh38
GRCh37	9	21,802,635 - 21,941,114 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	21,792,635 - 21,855,970 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	21,792,634 - 21,855,967	NCBI
Celera	9	21,740,998 - 21,804,334 (+)	NCBI		Celera
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	21,765,963 - 21,829,332 (+)	NCBI		HuRef
CHM1_1	9	21,802,515 - 21,865,858 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	21,816,863 - 21,955,417 (+)	NCBI		T2T-CHM13v2.0

Mtap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	89,055,607 - 89,099,327 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	89,055,359 - 89,099,318 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	89,137,370 - 89,181,090 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	89,137,122 - 89,181,081 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	88,783,274 - 88,826,994 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	88,608,657 - 88,652,314 (+)	NCBI		MGSCv36	mm8
Celera	4	87,620,095 - 87,663,899 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	42.15	NCBI

Mtap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	12,390,032 - 12,439,206 (-)	Ensembl
ChiLan1.0	NW_004955472	12,391,399 - 12,439,221 (-)	NCBI	ChiLan1.0	ChiLan1.0

MTAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	102,620,519 - 102,756,196 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	102,623,086 - 102,762,138 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	21,637,543 - 21,769,698 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	22,253,357 - 22,316,883 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	22,266,376 - 22,382,218 (+)	Ensembl			panPan2	panpan1.1

MTAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	41,148,389 - 41,200,635 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	41,148,404 - 41,264,504 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	39,820,541 - 39,872,745 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	42,090,758 - 42,142,952 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	42,090,124 - 42,142,944 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	40,760,953 - 40,813,082 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	40,648,752 - 40,701,001 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	41,262,101 - 41,314,256 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mtap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	155,762,052 - 155,800,008 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936652	3,431,171 - 3,472,071 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936652	3,431,588 - 3,468,770 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	200,882,956 - 200,934,445 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	200,882,954 - 200,934,389 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	224,075,795 - 224,126,822 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103241896
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	84,196,548 - 84,198,357 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	57,997,427 - 58,050,241 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	57,778,455 - 57,780,270 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mtap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	25,778,240 - 25,826,530 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	25,778,191 - 25,826,945 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mtap
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	65,067,397 - 65,120,581 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mtap
276 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	102
Count of miRNA genes:	89
Interacting mature miRNAs:	94
Transcripts:	ENSRNOT00000029486
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	84630798	129630798	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	84630798	129630798	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	104018576	124314782	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84630798	129630798	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	95062526	133270832	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	82032155	127032155	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	89369373	134369373	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	97492524	133270832	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	95062526	133270832	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
18	12	73	185	91	90	59	143	59	6	432	250	12	170	97	106	31	20	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001394049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029486 ⟹ ENSRNOP00000031214

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	108,988,830 - 109,055,214 (+)	Ensembl
mRatBN7.2 Ensembl	5	103,873,020 - 103,939,406 (+)	Ensembl
Rnor_6.0 Ensembl	5	107,711,077 - 107,777,530 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090739 ⟹ ENSRNOP00000073330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	108,990,270 - 109,036,494 (+)	Ensembl
mRatBN7.2 Ensembl	5	103,874,507 - 103,917,591 (+)	Ensembl
Rnor_6.0 Ensembl	5	107,712,579 - 107,758,686 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096850 ⟹ ENSRNOP00000082661

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	103,873,732 - 103,914,803 (+)	Ensembl

RefSeq Acc Id:

NM_001394049 ⟹ NP_001380978

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	108,990,270 - 109,036,494 (+)	NCBI
mRatBN7.2	5	103,874,460 - 103,920,684 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001380978	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031214.2
	ENSRNOP00000073330
	ENSRNOP00000073330.1

Ensembl Acc Id:

ENSRNOP00000073330 ⟸ ENSRNOT00000090739

Ensembl Acc Id:

ENSRNOP00000031214 ⟸ ENSRNOT00000029486

Ensembl Acc Id:

ENSRNOP00000082661 ⟸ ENSRNOT00000096850

RefSeq Acc Id:	NP_001380978 ⟸ NM_001394049
- UniProtKB:	A0A0G2K583 (UniProtKB/TrEMBL), A6JRF0 (UniProtKB/TrEMBL)

Protein Domains

Nucleoside phosphorylase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TP15-F1-model_v2	AlphaFold	Q7TP15	1-391	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693835

Promoter ID:

EPDNEW_R4356

Type:

initiation region

Name:

Mtap_1

Description:

methylthioadenosine phosphorylase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	107,712,599 - 107,712,659	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310114	AgrOrtholog
BioCyc Gene	G2FUF-40781	BioCyc
BioCyc Pathway	PWY-6756 [S-methyl-5'-thioadenosine degradation II]	BioCyc
BioCyc Pathway Image	PWY-6756	BioCyc
Ensembl Genes	ENSRNOG00000006615	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029486.5	UniProtKB/TrEMBL
	ENSRNOT00000090739	ENTREZGENE
	ENSRNOT00000090739.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1580	UniProtKB/TrEMBL
InterPro	MTAP	UniProtKB/TrEMBL
	Nucleoside_phosphorylase	UniProtKB/TrEMBL
	Nucleoside_phosphorylase_sf	UniProtKB/TrEMBL
	Purine_phosphorylase-2_CS	UniProtKB/TrEMBL
NCBI Gene	298227	ENTREZGENE
PANTHER	PTHR42679	UniProtKB/TrEMBL
	S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE	UniProtKB/TrEMBL
Pfam	PNP_UDP_1	UniProtKB/TrEMBL
PhenoGen	Mtap	PhenoGen
PROSITE	PNP_MTAP_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006615	RatGTEx
Superfamily-SCOP	SSF53167	UniProtKB/TrEMBL
UniProt	A0A0G2K583	ENTREZGENE, UniProtKB/TrEMBL
	A6JRF0	ENTREZGENE, UniProtKB/TrEMBL
	Q7TP15_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Mtap	methylthioadenosine phosphorylase	Mtap_predicted	methylthioadenosine phosphorylase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mtap_predicted	methylthioadenosine phosphorylase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways