Plaat1 (phospholipase A and acyltransferase 1) - Rat Genome Database

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Gene: Plaat1 (phospholipase A and acyltransferase 1) Rattus norvegicus
Analyze
Symbol: Plaat1
Name: phospholipase A and acyltransferase 1
RGD ID: 1309485
Description: Enables phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process; lens fiber cell differentiation; and organelle disassembly. Predicted to act upstream of or within ether lipid metabolic process and peroxisome organization. Predicted to be located in several cellular components, including lysosome; nuclear envelope lumen; and peroxisome. Predicted to be active in cytoplasm. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A-C1; HRAS-like suppressor; HRAS-like suppressor 1; Hrasls; HRSL1; LOC288025; LRAT-like protein-2; phospholipase A; phospholipid-metabolizing enzyme A-C1; RLP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,022,297 - 85,041,999 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,022,297 - 85,031,826 (-)EnsemblGRCr8
mRatBN7.21171,517,492 - 71,537,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,517,493 - 71,527,020 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1180,362,872 - 80,382,740 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,997,835 - 73,017,709 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,052,204 - 72,070,855 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,125,951 - 75,145,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,125,952 - 75,144,903 (-)Ensemblrn6Rnor6.0
Rnor_5.01178,170,404 - 78,189,434 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,420,971 - 73,439,334 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,479,740 - 70,498,243 (-)NCBICelera
RGSC_v3.11173,480,346 - 73,496,872 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISS)
endoplasmic reticulum  (ISS)
lysosome  (ISS)
membrane  (IEA)
mitochondrion  (ISS)
nuclear envelope lumen  (ISO)
nucleus  (IEA,ISO)
peroxisome  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. Shinohara N, etal., J Lipid Res. 2011 Nov;52(11):1927-35. doi: 10.1194/jlr.M015081. Epub 2011 Aug 31.
Additional References at PubMed
PMID:10542256   PMID:22134920   PMID:22825852   PMID:27623847  


Genomics

Comparative Map Data
Plaat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,022,297 - 85,041,999 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,022,297 - 85,031,826 (-)EnsemblGRCr8
mRatBN7.21171,517,492 - 71,537,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,517,493 - 71,527,020 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1180,362,872 - 80,382,740 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,997,835 - 73,017,709 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,052,204 - 72,070,855 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,125,951 - 75,145,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,125,952 - 75,144,903 (-)Ensemblrn6Rnor6.0
Rnor_5.01178,170,404 - 78,189,434 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,420,971 - 73,439,334 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,479,740 - 70,498,243 (-)NCBICelera
RGSC_v3.11173,480,346 - 73,496,872 (-)NCBI
Cytogenetic Map11q22NCBI
PLAAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383193,240,606 - 193,281,426 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3193,240,620 - 193,277,738 (+)Ensemblhg38GRCh38
GRCh373192,959,011 - 192,988,644 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,441,612 - 194,471,338 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343194,441,619 - 194,471,345NCBI
Celera3191,374,190 - 191,403,914 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3190,346,050 - 190,375,772 (+)NCBIHuRef
CHM1_13192,921,789 - 192,951,509 (+)NCBICHM1_1
T2T-CHM13v2.03195,935,989 - 195,976,800 (+)NCBIT2T-CHM13v2.0
Plaat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,027,883 - 29,049,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,028,447 - 29,049,283 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381629,209,133 - 29,230,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1629,209,695 - 29,230,531 (+)Ensemblmm10GRCm38
MGSCv371629,209,781 - 29,230,616 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361629,129,442 - 29,150,277 (+)NCBIMGSCv36mm8
Celera1629,721,795 - 29,742,626 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1620.01NCBI
Plaat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542015,305,901 - 15,314,900 (-)Ensembl
ChiLan1.0NW_00495542015,305,901 - 15,326,444 (-)NCBIChiLan1.0ChiLan1.0
PLAAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22191,162,262 - 191,202,942 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13191,166,983 - 191,207,644 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03190,536,749 - 190,577,714 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13200,855,093 - 200,885,563 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3200,855,093 - 200,885,563 (+)EnsemblpanPan2panpan1.1
PLAAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13424,751,404 - 24,770,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3424,760,155 - 24,770,690 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3428,841,475 - 28,860,797 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03424,699,872 - 24,719,186 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3424,708,647 - 24,729,271 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13424,731,681 - 24,751,003 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03424,701,639 - 24,721,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03424,942,491 - 24,961,816 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plaat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602122,827,008 - 122,860,390 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367111,403,760 - 1,414,544 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367111,389,664 - 1,422,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,290,518 - 130,307,202 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113130,282,114 - 130,303,359 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213139,805,374 - 139,825,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLAAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11587,317,822 - 87,353,220 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604160,983,946 - 61,019,382 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plaat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473064,282,091 - 64,302,617 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473064,282,404 - 64,302,581 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plaat1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1414,129,180 - 14,147,323 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plaat1
109 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:198
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000002329
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH129433  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2932,811,722 - 32,811,915 (-)MAPPERmRatBN7.2
mRatBN7.21171,517,540 - 71,517,733 (+)MAPPERmRatBN7.2
Rnor_6.01175,126,000 - 75,126,192NCBIRnor6.0
Rnor_5.01178,170,453 - 78,170,645UniSTSRnor5.0
RGSC_v3.41173,421,019 - 73,421,211UniSTSRGSC3.4
Celera1170,479,788 - 70,479,980UniSTS
Celera930,633,972 - 30,634,164UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 67 143 83 82 51 27 51 6 267 127 11 115 68 92 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000002329   ⟹   ENSRNOP00000002329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,022,297 - 85,031,826 (-)Ensembl
mRatBN7.2 Ensembl1171,517,493 - 71,527,020 (-)Ensembl
Rnor_6.0 Ensembl1175,125,952 - 75,144,903 (-)Ensembl
RefSeq Acc Id: NM_001105871   ⟹   NP_001099341
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,022,297 - 85,040,966 (-)NCBI
mRatBN7.21171,517,493 - 71,536,160 (-)NCBI
Rnor_6.01175,125,952 - 75,144,903 (-)NCBI
Rnor_5.01178,170,404 - 78,189,434 (-)NCBI
RGSC_v3.41173,420,971 - 73,439,334 (-)RGD
Celera1170,479,740 - 70,498,243 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248510   ⟹   XP_006248572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,024,473 - 85,041,999 (-)NCBI
mRatBN7.21171,517,492 - 71,537,142 (-)NCBI
Rnor_6.01175,125,951 - 75,145,868 (-)NCBI
Rnor_5.01178,170,404 - 78,189,434 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001099341   ⟸   NM_001105871
- UniProtKB: D2KX21 (UniProtKB/TrEMBL),   A6JRW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248572   ⟸   XM_006248510
- Peptide Label: isoform X1
- UniProtKB: D2KX21 (UniProtKB/TrEMBL),   A6JRW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002329   ⟸   ENSRNOT00000002329
Protein Domains
LRAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D2KX21-F1-model_v2 AlphaFold D2KX21 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698232
Promoter ID:EPDNEW_R8757
Type:initiation region
Name:Hrasls_1
Description:HRAS-like suppressor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01175,144,924 - 75,144,984EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309485 AgrOrtholog
BioCyc Gene G2FUF-20964 BioCyc
Ensembl Genes ENSRNOG00000001711 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002329 ENTREZGENE
  ENSRNOT00000002329.4 UniProtKB/Swiss-Prot
Gene3D-CATH endopeptidase domain like (from Nostoc punctiforme) UniProtKB/Swiss-Prot
InterPro H-rev107_PLA/AT UniProtKB/Swiss-Prot
  LRAT_dom UniProtKB/Swiss-Prot
KEGG Report rno:288025 UniProtKB/Swiss-Prot
NCBI Gene 288025 ENTREZGENE
PANTHER HRAS-LIKE SUPPRESSOR - RELATED UniProtKB/Swiss-Prot
  PHOSPHOLIPASE A AND ACYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam LRAT UniProtKB/Swiss-Prot
PhenoGen Plaat1 PhenoGen
PROSITE LRAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001711 RatGTEx
UniProt A6JRW7 ENTREZGENE, UniProtKB/TrEMBL
  D2KX21 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Plaat1  phospholipase A and acyltransferase 1  Hrasls  HRAS-like suppressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hrasls  HRAS-like suppressor   Hrasls_predicted  HRAS-like suppressor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hrasls_predicted  HRAS-like suppressor (predicted)      Symbol and Name status set to approved 70820 APPROVED