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Gene: Rxfp2 (relaxin family peptide receptor 2) Rattus norvegicus

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Symbol:

Rxfp2

Name:

relaxin family peptide receptor 2

RGD ID:

1309449

Description:

Enables peptide hormone binding activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of apoptotic process; and oocyte maturation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Gpcr; INSL3 receptor; leucine-rich repeat-containing G protein-coupled receptor 8; Lgr8; LOC363866; relaxin receptor 2; relaxin/insulin-like family peptide receptor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RXFP2 (relaxin family peptide receptor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rxfp2 (relaxin/insulin-like family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rxfp2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RXFP2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RXFP2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rxfp2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RXFP2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RXFP2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rxfp2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rxfp2 (relaxin family peptide receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RXFP2 (relaxin family peptide receptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rxfp2 (relaxin/insulin-like family peptide receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rxfp2b (relaxin family peptide receptor 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rxfp2a (relaxin family peptide receptor 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lgr3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lgr3	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Lgr4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Lgr4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rxfp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rxfp2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	9,961,175 - 10,023,098 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	9,961,175 - 10,023,098 (-)	Ensembl				GRCr8
mRatBN7.2	12	4,924,747 - 4,986,672 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	4,925,722 - 4,986,596 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	5,607,447 - 5,667,839 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	6,230,858 - 6,291,250 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	5,258,465 - 5,318,859 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	6,016,884 - 6,078,411 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	6,016,884 - 6,078,411 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	8,118,997 - 8,182,240 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	5,326,997 - 5,388,674 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	6,704,247 - 6,765,055 (-)	NCBI		Celera
RGSC_v3.1	12	5,326,996 - 5,388,674 (-)	NCBI
Cytogenetic Map	12	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cryptorchidism (ISO)

disorder of sexual development (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

5-aza-2'-deoxycytidine (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

dibutyl phthalate (ISO)

genistein (ISO)

Muraglitazar (EXP)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

Tesaglitazar (EXP)

troglitazone (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IDA)

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA)

male gonad development (ISO)

negative regulation of apoptotic process (IDA)

negative regulation of cell population proliferation (IDA)

oocyte maturation (IDA)

signal transduction (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

peptide hormone binding (IPI)

protein-hormone receptor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats.	Boockfor FR, etal., Reproduction. 2001 Dec;122(6):899-906.
2.	Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney.	Fu P, etal., Ann N Y Acad Sci. 2005 May;1041:516-9.
3.	Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation.	Fu P, etal., J Endocrinol. 2006 May;189(2):397-408.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Mutations of the GREAT gene cause cryptorchidism.	Gorlov IP, etal., Hum Mol Genet. 2002 Sep 15;11(19):2309-18.
6.	Paracrine regulation of mammalian oocyte maturation and male germ cell survival.	Kawamura K, etal., Proc Natl Acad Sci U S A. 2004 May 11;101(19):7323-8. Epub 2004 May 3.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Characterization of the rat INSL3 receptor.	Scott DJ, etal., Ann N Y Acad Sci. 2005 May;1041:13-6.

Additional References at PubMed

PMID:15956705	PMID:15956753	PMID:17524297	PMID:17623071	PMID:18706979	PMID:19328193	PMID:19493424	PMID:21251292	PMID:24465164	PMID:24642882	PMID:29029788

Genomics

Comparative Map Data

Rxfp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	9,961,175 - 10,023,098 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	9,961,175 - 10,023,098 (-)	Ensembl				GRCr8
mRatBN7.2	12	4,924,747 - 4,986,672 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	4,925,722 - 4,986,596 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	5,607,447 - 5,667,839 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	6,230,858 - 6,291,250 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	5,258,465 - 5,318,859 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	6,016,884 - 6,078,411 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	6,016,884 - 6,078,411 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	8,118,997 - 8,182,240 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	5,326,997 - 5,388,674 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	6,704,247 - 6,765,055 (-)	NCBI		Celera
RGSC_v3.1	12	5,326,996 - 5,388,674 (-)	NCBI
Cytogenetic Map	12	p12	NCBI

RXFP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	31,739,526 - 31,803,389 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	31,739,526 - 31,803,389 (+)	Ensembl			hg38	GRCh38
GRCh37	13	32,313,663 - 32,377,526 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	31,211,679 - 31,275,009 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	31,211,678 - 31,275,009	NCBI
Celera	13	13,380,672 - 13,444,008 (+)	NCBI		Celera
Cytogenetic Map	13	q13.1	NCBI
HuRef	13	13,124,780 - 13,188,196 (+)	NCBI		HuRef
CHM1_1	13	32,281,218 - 32,344,573 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	30,962,734 - 31,026,637 (+)	NCBI		T2T-CHM13v2.0

Rxfp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	149,941,487 - 150,006,015 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	149,942,140 - 150,005,649 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	150,018,675 - 150,082,550 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	150,018,675 - 150,082,184 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	150,821,250 - 150,884,761 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	150,287,054 - 150,349,715 (+)	NCBI		MGSCv36	mm8
Celera	5	148,024,761 - 148,088,307 (+)	NCBI		Celera
Cytogenetic Map	5	G3	NCBI
cM Map	5	89.23	NCBI

Rxfp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	14,050,694 - 14,114,902 (-)	Ensembl
ChiLan1.0	NW_004955431	14,050,537 - 14,105,852 (-)	NCBI	ChiLan1.0	ChiLan1.0

RXFP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	31,305,175 - 31,368,996 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	22,411,782 - 22,475,594 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	12,998,696 - 13,062,548 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	31,434,308 - 31,497,203 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	31,434,379 - 31,496,736 (+)	Ensembl			panPan2	panpan1.1

RXFP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	8,307,850 - 8,368,438 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	8,307,850 - 8,368,834 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	8,345,591 - 8,406,138 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	8,412,178 - 8,472,771 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	8,411,795 - 8,472,893 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	8,311,212 - 8,371,791 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	8,310,016 - 8,370,508 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	8,361,957 - 8,422,571 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rxfp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	169,463,645 - 169,526,355 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	26,425,951 - 26,487,240 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	26,425,829 - 26,487,700 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RXFP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	8,282,517 - 8,321,020 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	8,266,898 - 8,321,021 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	8,190,120 - 8,220,113 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RXFP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	10,486,993 - 10,561,164 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	10,489,596 - 10,556,665 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666057	33,799,487 - 33,869,833 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rxfp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624776	6,138,843 - 6,186,665 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624776	6,137,967 - 6,186,656 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rxfp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	3,768,171 - 3,830,493 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rxfp2
697 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	35
Interacting mature miRNAs:	40
Transcripts:	ENSRNOT00000001197
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
724526	Uae3	Urinary albumin excretion QTL 3	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	12	1	15486827	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1357337	Gluco3	Glucose level QTL 3		0.0004	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	12	1	16966671	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
61334	Gluco17	Glucose level QTL 17	6.3		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	12	1	16966671	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	1	11869600	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat

Markers in Region

BF403538

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	4,958,972 - 4,959,187 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	6,050,376 - 6,050,590	NCBI	Rnor6.0
Rnor_5.0	12	8,153,464 - 8,153,678	UniSTS	Rnor5.0
RGSC_v3.4	12	5,360,625 - 5,360,839	UniSTS	RGSC3.4
Celera	12	6,737,459 - 6,737,673	UniSTS
RH 3.4 Map	12	0.0	UniSTS
Cytogenetic Map	12	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	6	63	120	39	44	19	39	19	6	223	125	9	97	66	92	25	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY906861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001197 ⟹ ENSRNOP00000001197

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	9,961,175 - 10,023,098 (-)	Ensembl
mRatBN7.2 Ensembl	12	4,925,722 - 4,986,596 (-)	Ensembl
Rnor_6.0 Ensembl	12	6,016,884 - 6,078,411 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100776 ⟹ ENSRNOP00000080832

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	4,925,722 - 4,970,675 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109042 ⟹ ENSRNOP00000095282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	9,961,175 - 10,023,098 (-)	Ensembl
mRatBN7.2 Ensembl	12	4,925,722 - 4,986,596 (-)	Ensembl

RefSeq Acc Id:

NM_001012475 ⟹ NP_001012493

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	9,961,175 - 10,023,098 (-)	NCBI
mRatBN7.2	12	4,924,747 - 4,986,672 (-)	NCBI
Rnor_6.0	12	6,016,884 - 6,078,411 (-)	NCBI
Rnor_5.0	12	8,118,997 - 8,182,240 (-)	NCBI
RGSC_v3.4	12	5,326,997 - 5,388,674 (-)	RGD
Celera	12	6,704,247 - 6,765,055 (-)	RGD

Sequence:

show sequence

ATGTGGCTTCTACTTCATGTCGTCCTTCTGATGGAGGTCAAAGATTTCACACTGGCTGGCAGCA
ATATGGTGGCTCCTCTGTGCCCAAAAGGGTATTTCCCCTGTGGGAATCTCACCAAGTGCTTACC
CCGAGCCTTTCACTGCGACGGCGTGGATGATTGCGGGAATGGTGCGGATGAGGACAACTGTGGT
GACACTAGTGGATGGACGACCATATTTGGCACAGTCCATGGAAATGTCAATAAAGTGACATTAA
CAGAGGAGTGCTTTCTCAGCCGGTACCCACAGCACTGTTACTGCAGAGAAAATGAACTAGAATG
CGTAAACGCCGACTTAAAAGCTGTGCCAAAGGTTTCCAGCAACGTAACATTACTATCTCTTAAG
AAAAACAAAATTCACAGACTTCCAGTCAAGGTTTTCAGCAAATACGCAGAACTCAGAAAGATAT
TCCTCCAGCACAACTGCATCACACACATCTCCAGGAGAGCGTTCCTTGGATTACATAACCTACA
GATACTGTATCTCAGCCATAACTGCATTACCTCTCTCAGGCCTGGGATATTCAAAGACTTGCAT
CAGCTCGCTTGGCTAATTTTAGATGACAACCCAATCACCAGAATCTCACAGAGGTCCTTTACTG
GATTAAACTCCTTGTTTTTCTTGTCCATGGTGAGTAACCGGCTGGAGGCCCTTCCTGAAAGGCT
GTGCGCCCAGATGCCTCAACTCAACTGGGTGGATCTGGCAAACAATGGGATAAAGTTCATAACG
AACTCCACCTTCCTGACGTGCGACTCGCTCACGGTTCTGTTTCTGCCTAGAAATCAAATTGGTT
TTGTTCCAGAGAAGACATTTTCTTCATTAAAAAATTTAGGAGAACTGGACCTGTCTAGCAATGT
GATAGCAAAACTACCAGCCCACCTTTTCAGCGACCTTCACCTTCTCCAAAAGCTGAACCTGTCG
TCCAACCCTCTTCTGTATGTCCACAAGAACCAGTTTGGAAGTCTCAAACAACTTCAGTCTCTAG
ACCTGGAAAGGATAGAGATTCCAAACATAAACACCGGAATGTTCCGGCCCATGAAGAACCTTTC
TCACATATATTTGAAAACCTTTCGGTACTGCTCCTATGTTCCCCATGTCCGAATCTGTATGCCC
TCGACTGATGGTATATCTTCATCTGAGGACCTCTTGGCTAACAGTATCCTCAGAGTGTCTGTCT
GGGTTATAGCTTTCATTACCTGCGCTGGGAATTTCCTCGTCATAGCCGTGAGATCTCTCATTAA
GGCTGAGAATACGACTCACGCTATGTCCATCAAAATCCTTTGTTGTGCCGACTGCCTGATGGGG
GTGTACCTGTTCTCCGTGGGCGTCTTTGACATCAAGTACCGAGGGCAGTATCAGAAGTATGCGC
TGCTGTGGATGGAGAGTGTACCCTGCCGCCTGCTGGGCTTCCTGGCCACGCTGTCCACAGAGGT
CTCGGTGCTGCTGCTGACATTCCTGACCCTGGAGAAGTTCCTGGTCATCGTATTCCCTTTCAGC
AACCTGCGCCTGGGCAAGCGTCAGACGGCCGTGGTCCTCGCCAGCATCTGGGTGGCGGGATTTC
TCATAGCGGCCGTTCCCTTCACCAGCGAGGATTATTTTGGCAACTTTTATGGGAAAAACGGAGT
CTGCTTCCCACTTCATTACGACCAAGCAGAAGATTTTGGAAGTAGAGGGTACTCCCTTGGGATT
TTCCTAGGCGTGAACTTGCTGGCTTTCCTCGTCATCACGTTCTCCTATGTCACCATGTTCTGCT
CCATTCAGAAAACAGCCCTCCAGACTGCAGAAGTGAGGAGCCACATCGGGAAGGAGGTGGCTGT
CGCCAACCGGTTCTTTTTCATCGTGTTCTCTGACGCCATCTGCTGGATTCCTGTGTTTGTCGTT
AAAATCCTGTCTCTCCTTCAAGTAGAGATACCAGGCACAATCACTTCCTGGATCGTGGTTTTTT
TCCTTCCGGTAAACAGCGCCTTAAACCCCATCCTCTACACTCTCACCACCTCCCTTTTTAAGGA
CAAGTTGAAACAGTTGCTGCACAAACATCGGAGGAAATCCATTTTCAAAGTTAAGAAGAAAAGT
CTATCTGCTTCCATTGTGTGGACAGATGACTCTTCACTTAAACTTGGAGTGTTGAACAAAATAG
CCCTTGGGGACAGTATAATGAAGCCGGTCTCCCCGTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001012493	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAW84088	(Get FASTA)	NCBI Sequence Viewer
	EDL89513	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001197
	ENSRNOP00000001197.2
	ENSRNOP00000095282.1

RefSeq Acc Id:	NP_001012493 ⟸ NM_001012475
- Peptide Label:	precursor
- UniProtKB:	Q5ECL0 (UniProtKB/TrEMBL), A6K155 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWLLLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCG DTSGWTTIFGTVHGNVNKVTLTEECFLSRYPQHCYCRENELECVNADLKAVPKVSSNVTLLSLK KNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLH QLAWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANNGIKFIT NSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLLQKLNLS SNPLLYVHKNQFGSLKQLQSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMP STDGISSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMG VYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFS NLRLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGI FLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVV KILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSLFKDKLKQLLHKHRRKSIFKVKKKS LSASIVWTDDSSLKLGVLNKIALGDSIMKPVSP hide sequence

Ensembl Acc Id:

ENSRNOP00000001197 ⟸ ENSRNOT00000001197

Ensembl Acc Id:

ENSRNOP00000080832 ⟸ ENSRNOT00000100776

Ensembl Acc Id:

ENSRNOP00000095282 ⟸ ENSRNOT00000109042

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5ECL0-F1-model_v2	AlphaFold	Q5ECL0	1-737	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309449	AgrOrtholog
BioCyc Gene	G2FUF-20238	BioCyc
Ensembl Genes	ENSRNOG00000000897	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001197	ENTREZGENE
	ENSRNOT00000001197.5	UniProtKB/TrEMBL
	ENSRNOT00000109042.2	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	Relaxin_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:363866	UniProtKB/TrEMBL
NCBI Gene	363866	ENTREZGENE
PANTHER	GLYCOPROTEIN HORMONE RECEPTOR	UniProtKB/TrEMBL
	RELAXIN RECEPTOR 2	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Rxfp2	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	RELAXINR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	LRR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000897	RatGTEx
SMART	LDLa	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
	L domain-like	UniProtKB/TrEMBL
	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
UniProt	A0A8I6AND4_RAT	UniProtKB/TrEMBL
	A6K155	ENTREZGENE, UniProtKB/TrEMBL
	Q5ECL0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-01	Rxfp2	relaxin family peptide receptor 2	Rxfp2	relaxin/insulin-like family peptide receptor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Rxfp2	relaxin/insulin-like family peptide receptor 2	Lgr8	leucine-rich repeat-containing G protein-coupled receptor 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Lgr8	leucine-rich repeat-containing G protein-coupled receptor 8	Lgr8_predicted	leucine-rich repeat-containing G protein-coupled receptor 8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lgr8_predicted	leucine-rich repeat-containing G protein-coupled receptor 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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