Ncf2 (neutrophil cytosolic factor 2) - Rat Genome Database

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Gene: Ncf2 (neutrophil cytosolic factor 2) Rattus norvegicus
Analyze
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
RGD ID: 1309424
Description: Predicted to enable small GTPase binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Predicted to be located in acrosomal vesicle; cytosol; and membrane. Predicted to be part of NADPH oxidase complex. Used to study proteinuria; renal fibrosis; and status epilepticus. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 67 kDa neutrophil oxidase factor; LOC364018; NCF-2; neutrophil cytosol factor 2; neutrophil NADPH oxidase factor 2; p67phox
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ncf2em1Mcwi ; Ncf2em4Mcwi
Genetic Models: SS-Ncf2em1Mcwi ; SS-Ncf2em4Mcwi ; SS-Ncf2em1Mcwi-/- ; SS-Nox4em2Ncf2em1Mcwi ; SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi
Is Marker For: Strains:   SS.BN-(D13Rat151-D13Rat197)-Tg(Slc12a1-Ncf2-2A-Luc)26Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,505,492 - 67,536,015 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,505,375 - 67,536,149 (+)EnsemblGRCr8
mRatBN7.21364,955,622 - 64,986,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,557,295 - 67,587,614 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,844,234 - 68,874,605 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,095,157 - 66,125,664 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)Ensemblrn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1364,862,007 - 64,890,467 (+)NCBICelera
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arsenic acid  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (ISO)
brequinar  (ISO)
bromodichloromethane  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
ceric oxide  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
daunorubicin  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
dofetilide  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
ellagic acid  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (EXP)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kanamycin A  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (ISO)
Lasiocarpine  (ISO)
lead(II) chloride  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
medroxyprogesterone acetate  (EXP)
menadione  (ISO)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nebivolol  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
puerarin  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rottlerin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
superoxide  (EXP)
tamoxifen  (ISO)
telmisartan  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
membrane  (IEA,ISO)
NADPH oxidase complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Differential Effects of 17B -Estradiol and of Synthetic Progestins on Aldosterone-Salt Induced Kidney Disease. Arias-Loza PA, etal., Toxicol Pathol. 2009 Oct 19.
2. Reactive oxygen species are necessary for high flow (shear stress)-induced diameter enlargement of rat resistance arteries. Belin de Chantemele EJ, etal., Microcirculation. 2009 Jul;16(5):391-402. Epub 2009 Apr 7.
3. Flow-induced remodeling in resistance arteries from obese Zucker rats is associated with endothelial dysfunction. Bouvet C, etal., Hypertension. 2007 Jul;50(1):248-54. Epub 2007 May 21.
4. Alpha-phenyl-N-tert-butylnitrone attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats. Chang YS, etal., Exp Lung Res. 2009 Apr;35(3):234-49.
5. Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons. Coyoy A, etal., Free Radic Biol Med. 2008 Oct 15;45(8):1056-64. Epub 2008 Jul 2.
6. Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation. Erdos B, etal., Hypertens Res. 2009 Nov;32(11):983-8. Epub 2009 Aug 28.
7. Elevated expression of p47phox and p67phox proteins in neutrophils from burned rats. Fazal N, etal., Shock. 1997 Oct;8(4):256-60.
8. Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Feng D, etal., Cell Metab. 2012 Feb 8;15(2):201-8. doi: 10.1016/j.cmet.2012.01.003.
9. Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1). Francke U, etal., Am J Hum Genet. 1990 Sep;47(3):483-92.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine. Guo Z, etal., Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1728-36. Epub 2006 Nov 22.
13. Localization of NADPH oxidase subunits in neonatal sympathetic neurons. Hilburger EW, etal., Neurosci Lett. 2005 Mar 22;377(1):16-9. Epub 2004 Dec 24.
14. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Kitada M, etal., Diabetes. 2003 Oct;52(10):2603-14.
15. Exercise training raises expression of the cytosolic components of NADPH oxidase in rat neutrophils. Levada-Pires AC, etal., Eur J Appl Physiol. 2007 May;100(2):153-60. Epub 2007 Feb 20.
16. Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Mayhan WG, etal., Microcirculation. 2008 Apr-May;15(3):225-36.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity. Olsson LM, etal., Arthritis Res Ther. 2007;9(5):R98. doi: 10.1186/ar2299.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage. Patel M, etal., J Neurochem. 2005 Jan;92(1):123-31.
21. Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension. Pechanova O, etal., Pharmacol Rep. 2009 Jan-Feb;61(1):116-22.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. NADPH oxidase- and mitochondrion-derived superoxide at rostral ventrolateral medulla in endotoxin-induced cardiovascular depression. Sheh YL, etal., Free Radic Biol Med. 2007 May 15;42(10):1610-23. Epub 2007 Feb 28.
28. Activation of NADPH oxidase in Alzheimer's disease brains. Shimohama S, etal., Biochem Biophys Res Commun. 2000 Jun 24;273(1):5-9.
29. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Vaziri ND, etal., Brain Res. 2004 Jan 2;995(1):76-83.
30. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Wenzel P, etal., Atherosclerosis. 2008 May;198(1):65-76. Epub 2007 Dec 3.
31. Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.
32. Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42. Zhou J, etal., J Pineal Res. 2008 Sep;45(2):157-65. Epub 2008 Feb 19.
33. Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. Zhu LH, etal., Free Radic Biol Med. 2009 Oct 23.
Additional References at PubMed
PMID:8280052   PMID:8402898   PMID:9365277   PMID:9490028   PMID:15850784   PMID:16381931   PMID:17612411   PMID:22565378   PMID:22661470   PMID:24580748   PMID:25224032   PMID:25489057  
PMID:26062875   PMID:26514550   PMID:26989452  


Genomics

Comparative Map Data
Ncf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,505,492 - 67,536,015 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,505,375 - 67,536,149 (+)EnsemblGRCr8
mRatBN7.21364,955,622 - 64,986,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,557,295 - 67,587,614 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,844,234 - 68,874,605 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,095,157 - 66,125,664 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)Ensemblrn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1364,862,007 - 64,890,467 (+)NCBICelera
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Cytogenetic Map13q21NCBI
NCF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,555,562 - 183,601,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,554,461 - 183,593,499 (-)Ensemblhg38GRCh38
GRCh371183,524,697 - 183,560,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,791,320 - 181,826,339 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341180,256,354 - 180,291,668NCBI
Celera1156,635,747 - 156,671,088 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,760,563 - 154,795,907 (-)NCBIHuRef
CHM1_11184,947,718 - 184,983,070 (-)NCBICHM1_1
T2T-CHM13v2.01182,914,853 - 182,961,131 (-)NCBIT2T-CHM13v2.0
Ncf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,675,904 - 152,712,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,675,945 - 152,712,742 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,800,153 - 152,836,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,800,194 - 152,836,991 (+)Ensemblmm10GRCm38
MGSCv371154,655,020 - 154,684,120 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,570,108 - 154,599,208 (+)NCBIMGSCv36mm8
Celera1155,229,233 - 155,258,077 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.05NCBI
Ncf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,355,724 - 22,384,864 (-)Ensembl
ChiLan1.0NW_00495540622,355,717 - 22,384,746 (-)NCBIChiLan1.0ChiLan1.0
NCF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,126,780 - 66,162,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,809,948 - 65,845,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,085,923 - 159,121,259 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,243,636 - 163,280,547 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,243,636 - 163,278,420 (-)EnsemblpanPan2panpan1.1
NCF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,914,629 - 16,946,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,904,031 - 16,945,372 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha716,500,692 - 16,530,126 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0716,646,647 - 16,676,710 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,643,324 - 16,676,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,555,169 - 16,584,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,664,590 - 16,693,979 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,795,528 - 16,824,986 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ncf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,454,048 - 88,478,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,301,012 - 6,324,787 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,300,894 - 6,325,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,776,534 - 124,812,923 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19124,776,516 - 124,813,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29137,106,514 - 137,143,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12545,770,370 - 45,807,064 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2545,770,641 - 45,806,515 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605546,986,801 - 47,023,905 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,107,357 - 10,134,711 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462481410,107,351 - 10,134,737 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ncf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11032,270,049 - 32,298,799 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ncf2
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:100
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000066331
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat


Related Rat Strains
The following Strains have been annotated to Ncf2
SS.BN-(D13Rat151-D13Rat197)-Tg(Slc12a1-Ncf2-2A-Luc)26Mcwi    


Genetic Models
This gene Ncf2 is modified in the following models/strains:
SS-Ncf2em1Mcwi     SS-Ncf2em4Mcwi     SS-Ncf2em1Mcwi-/-     SS-Nox4em2Ncf2em1Mcwi     SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 92 59 6 355 192 11 131 80 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000066331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,505,396 - 67,536,149 (+)Ensembl
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)Ensembl
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,505,396 - 67,536,149 (+)Ensembl
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)Ensembl
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,243,447 - 70,257,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,245,909 - 70,257,576 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,226,647 - 70,240,863 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153688   ⟹   ENSRNOP00000101534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,505,375 - 67,536,149 (+)Ensembl
RefSeq Acc Id: NM_001395185   ⟹   NP_001382114
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,505,492 - 67,536,015 (+)NCBI
mRatBN7.21364,955,622 - 64,986,144 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382114 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A7E3N2 (Get FASTA)   NCBI Sequence Viewer  
  AFJ19026 (Get FASTA)   NCBI Sequence Viewer  
  AFJ19027 (Get FASTA)   NCBI Sequence Viewer  
  AFJ19028 (Get FASTA)   NCBI Sequence Viewer  
  EDM09556 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079682
GenBank Protein FAA00361 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001382114   ⟸   NM_001395185
- UniProtKB: R4I3Z7 (UniProtKB/TrEMBL),   A6ICU1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101534   ⟸   ENSRNOT00000153688
Protein Domains
PB1   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A7E3N2-F1-model_v2 AlphaFold A7E3N2 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309424 AgrOrtholog
BioCyc Gene G2FUF-17898 BioCyc
Ensembl Genes ENSRNOG00000028016 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000088724 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro NCF2_NOXA1 UniProtKB/Swiss-Prot
  P67-PHOX UniProtKB/Swiss-Prot
  p67phox_SH3_1 UniProtKB/Swiss-Prot
  PB1-like UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PB1_P67 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
NCBI Gene 364018 ENTREZGENE
PANTHER NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 UniProtKB/Swiss-Prot
  PTHR15175:SF3 UniProtKB/Swiss-Prot
Pfam PB1 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen Ncf2 PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
PROSITE PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028016 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A8I6A5E9_RAT UniProtKB/TrEMBL
  A0ABK0LJ25_RAT UniProtKB/TrEMBL
  A6ICU1 ENTREZGENE, UniProtKB/TrEMBL
  A7E3N2 ENTREZGENE, UniProtKB/Swiss-Prot
  R4I3Z7 ENTREZGENE, UniProtKB/TrEMBL
  R4I4V9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ncf2  neutrophil cytosolic factor 2   Ncf2_predicted  neutrophil cytosolic factor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ncf2_predicted  neutrophil cytosolic factor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED