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Gene: Ufl1 (Ufm1-specific ligase 1) Rattus norvegicus

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Symbol:

Ufl1

Name:

Ufm1-specific ligase 1

RGD ID:

1309308

Description:

Predicted to enable UFM1 ligase activity and protein kinase binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including endoplasmic reticulum; neuron projection; and site of double-strand break. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane and mitochondrial outer membrane. Orthologous to human UFL1 (UFM1 specific ligase 1); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; hypothetical protein LOC313115; LOC313115; Maxer; multiple alpha-helix protein located at ER; regulator of C53/LZAP and DDRGK1; RGD1309308; similar to RIKEN cDNA 1810074P20

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UFL1 (UFM1 specific ligase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ufl1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ufl1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UFL1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UFL1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ufl1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UFL1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UFL1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ufl1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ufl1 (UFM1 specific ligase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	UFL1 (UFM1 specific ligase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ufl1 (UFM1 specific ligase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ufl1 (UFM1-specific ligase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ufl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ufl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ufl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ufl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ufl1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	43,759,271 - 43,791,682 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	43,758,098 - 43,791,682 (-)	Ensembl				GRCr8
mRatBN7.2	5	38,962,721 - 38,995,134 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	38,962,171 - 38,995,199 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	41,059,728 - 41,092,114 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	42,658,744 - 42,691,132 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	42,592,082 - 42,624,470 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	39,616,479 - 39,650,894 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	39,615,956 - 39,650,895 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	44,244,327 - 44,277,549 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	40,307,712 - 40,340,062 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	37,888,662 - 37,920,107 (-)	NCBI		Celera
RGSC_v3.1	5	40,307,893 - 40,340,241 (-)	NCBI
Cytogenetic Map	5	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hereditary breast ovarian cancer syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

butanal (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (EXP)

nefazodone (EXP)

okadaic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sulindac (EXP)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP,ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage checkpoint signaling (IEA,ISO,ISS)

DNA damage response (IEA,ISO,ISS)

DNA repair (IEA)

erythrocyte differentiation (IEA,ISO,ISS)

hematopoietic stem cell differentiation (IEA,ISO,ISS)

negative regulation of apoptotic process (IMP)

negative regulation of IRE1-mediated unfolded protein response (IEA,ISO,ISS)

negative regulation of protein ubiquitination (IEA,ISO,ISS)

negative regulation of T cell activation (IEA,ISO,ISS)

negative regulation of T cell mediated immune response to tumor cell (IEA,ISO,ISS)

positive regulation of autophagy (IEA,ISO,ISS)

positive regulation of cell population proliferation (ISO)

positive regulation of glial cell proliferation (ISO)

positive regulation of proteolysis involved in protein catabolic process (IEA,ISO)

positive regulation of reticulophagy (IEA,ISO,ISS)

protein K69-linked ufmylation (IEA,ISO,ISS)

protein stabilization (IEA,ISO)

protein ufmylation (IEA,ISO,ISS)

regulation of canonical NF-kappaB signal transduction (ISS)

regulation of gene expression (ISO)

regulation of inflammatory response (ISS)

regulation of intracellular estrogen receptor signaling pathway (IEA,ISO,ISS)

regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

regulation of protein localization (ISO)

rescue of stalled cytosolic ribosome (IEA,ISO,ISS)

response to endoplasmic reticulum stress (IBA,IEA,ISO,ISS)

response to L-glutamate (ISO)

reticulophagy (IBA,IEA,ISO,ISS)

ribosome disassembly (IEA,ISO,ISS)

Cellular Component

chromosome (IEA)

cytoplasm (IEA,ISO,ISS)

cytosol (IEA)

endoplasmic reticulum (IEA,ISO,ISS)

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

mitochondrial outer membrane (IEA,ISO)

neuron projection (IEA,ISO)

nucleus (IEA,ISO,ISS)

protein-containing complex (IEA,ISO)

site of double-strand break (IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

protein kinase binding (IEA,ISO)

transferase activity (IEA)

UFM1 ligase activity (IEA,ISO,ISS)

UFM1 transferase activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.	Lemaire K, etal., PLoS One. 2011 Apr 6;6(4):e18517. doi: 10.1371/journal.pone.0018517.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16210410	PMID:20018847	PMID:20164180	PMID:20228063	PMID:20531390	PMID:23152784	PMID:25219498	PMID:30886146

Genomics

Comparative Map Data

Ufl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	43,759,271 - 43,791,682 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	43,758,098 - 43,791,682 (-)	Ensembl				GRCr8
mRatBN7.2	5	38,962,721 - 38,995,134 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	38,962,171 - 38,995,199 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	41,059,728 - 41,092,114 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	42,658,744 - 42,691,132 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	42,592,082 - 42,624,470 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	39,616,479 - 39,650,894 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	39,615,956 - 39,650,895 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	44,244,327 - 44,277,549 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	40,307,712 - 40,340,062 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	37,888,662 - 37,920,107 (-)	NCBI		Celera
RGSC_v3.1	5	40,307,893 - 40,340,241 (-)	NCBI
Cytogenetic Map	5	q21	NCBI

UFL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	96,521,806 - 96,555,276 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	96,521,595 - 96,555,276 (+)	Ensembl			hg38	GRCh38
GRCh37	6	96,969,682 - 97,003,152 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	97,076,438 - 97,109,873 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	97,076,437 - 97,109,873	NCBI
Celera	6	97,611,468 - 97,644,919 (+)	NCBI		Celera
Cytogenetic Map	6	q16.1	NCBI
HuRef	6	94,403,930 - 94,437,341 (+)	NCBI		HuRef
CHM1_1	6	97,231,702 - 97,265,153 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	97,693,702 - 97,727,174 (+)	NCBI		T2T-CHM13v2.0

Ufl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	25,247,149 - 25,281,821 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	25,248,600 - 25,281,821 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	25,247,149 - 25,281,821 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	25,248,600 - 25,281,821 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	25,175,733 - 25,208,968 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	25,340,780 - 25,372,395 (-)	NCBI		MGSCv36	mm8
Celera	4	24,983,514 - 25,016,784 (-)	NCBI		Celera
Cytogenetic Map	4	A3	NCBI
cM Map	4	10.59	NCBI

Ufl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	22,548,219 - 22,580,903 (+)	Ensembl
ChiLan1.0	NW_004955411	22,548,139 - 22,577,287 (+)	NCBI	ChiLan1.0	ChiLan1.0

UFL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	116,562,033 - 116,595,549 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	114,440,254 - 114,473,720 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	94,356,440 - 94,389,920 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	98,242,689 - 98,276,146 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	98,242,756 - 98,274,377 (+)	Ensembl			panPan2	panpan1.1

UFL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	54,988,200 - 55,023,414 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	54,988,264 - 55,021,626 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	54,804,603 - 54,837,183 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	55,807,531 - 55,840,491 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	55,807,537 - 55,840,242 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	55,142,814 - 55,175,742 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	55,004,468 - 55,036,715 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	55,251,683 - 55,284,623 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ufl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	89,564,693 - 89,598,140 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936699	1,129,344 - 1,163,530 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936699	1,131,385 - 1,163,310 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UFL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	63,638,596 - 63,700,476 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	63,638,589 - 63,698,931 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	72,007,561 - 72,067,762 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UFL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	77,357,239 - 77,387,385 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	77,357,141 - 77,387,367 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	49,653,195 - 49,682,283 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ufl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624810	8,805,964 - 8,832,358 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624810	8,804,330 - 8,832,460 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ufl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	152,369,587 - 152,402,671 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ufl1
292 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	178
Count of miRNA genes:	129
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000010421
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	8627230	52665523	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	17576633	62576633	Rat
1578774	Tcas8	Tongue tumor susceptibility QTL 8	3.47		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	15707451	60707451	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	31130421	48841739	Rat
1641922	Alcrsp8	Alcohol response QTL 8			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	5	17486080	62486080	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	8627230	53627230	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	14606078	59606078	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	17486080	62486080	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2303577	Gluco47	Glucose level QTL 47	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	16520019	61520019	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat

Markers in Region

AW551583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	38,963,844 - 38,963,929 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	39,618,349 - 39,618,433	NCBI	Rnor6.0
Rnor_5.0	5	44,246,197 - 44,246,281	UniSTS	Rnor5.0
RGSC_v3.4	5	40,308,836 - 40,308,920	UniSTS	RGSC3.4
Celera	5	37,889,786 - 37,889,870	UniSTS
Cytogenetic Map	5	q21	UniSTS

RH140378

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	38,962,056 - 38,962,265 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	39,616,561 - 39,616,769	NCBI	Rnor6.0
Rnor_5.0	5	44,244,409 - 44,244,617	UniSTS	Rnor5.0
RGSC_v3.4	5	40,307,048 - 40,307,256	UniSTS	RGSC3.4
Celera	5	37,887,998 - 37,888,206	UniSTS
RH 3.4 Map	5	189.3	UniSTS
Cytogenetic Map	5	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001126279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010421 ⟹ ENSRNOP00000010421

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	43,759,274 - 43,790,581 (-)	Ensembl
mRatBN7.2 Ensembl	5	38,962,724 - 38,995,134 (-)	Ensembl
Rnor_6.0 Ensembl	5	39,617,228 - 39,650,894 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000089522 ⟹ ENSRNOP00000072123

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	43,758,098 - 43,791,682 (-)	Ensembl
mRatBN7.2 Ensembl	5	38,962,171 - 38,995,199 (-)	Ensembl
Rnor_6.0 Ensembl	5	39,615,956 - 39,650,895 (-)	Ensembl

RefSeq Acc Id:

NM_001126279 ⟹ NP_001119751

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	43,759,271 - 43,791,682 (-)	NCBI
mRatBN7.2	5	38,962,721 - 38,995,134 (-)	NCBI
Rnor_6.0	5	39,617,225 - 39,650,894 (-)	NCBI
Rnor_5.0	5	44,244,327 - 44,277,549 (-)	NCBI
RGSC_v3.4	5	40,307,712 - 40,340,062 (-)	RGD
Celera	5	37,888,662 - 37,920,107 (-)	RGD

Sequence:

show sequence

GGCTGACGTGTCTGCCGTTTCCCGGTGTCGCGGAGAGCGGAGCAGTGATGGCGGACGCCTGGGA
GGAGATCCGGCGTCTGGCGGCTGACTTCCAGCGGGCGCAGTTTGCTGAGTCCACGCAAAGGCTG
TCAGAGCGGAACTGCATTGAGATTGTGAATAAATTGATCTCTCAGAAACAGCTGGAAGTAGTTC
ATACGCTTGATGGGAAGGAATATATCACTCCAGCCCAGATCAGTAAAGAAATGAGAGATGAGCT
ACATGTCCGAGGTGGTCGAGTAAACATTGTCGACTTACAACAGGTTATTAACGTGGACCTGACT
CATATTGAAAATAGAGTCGGCGACATTATTAAGTCGGAGAAGCATGTGCAGATGGTACTGGGAC
AGCTGGTCGATGAGAACTATCTGGATCGGTTATCAGAAGAGGTGAATGATAAATTGCAAGAAAG
TGGTCAAGTAACCGTCTCAGAGCTGTGTAAAACCTATGACCTTCCTGGGGATTTTCTGACACAG
GCATTAACTCAGCGACTTGGCCGGATTATCAATGGCCATCTTGACCTTGATAACAGAGGAGTGA
TTTTCACTGAGGCCTTTGTGGCTCGCCATAAAGCACGCATCCGTGGACTCTTCAGTGCTATTAC
CCGGCCTACAGCAGTGAACTCTTTGGTTTCAAAATATGGATTTCAGGAACAGCTCCTTTACTCT
GTGCTTGAGGAACTTGTTAGCACTGGCCGCCTACGAGGCACGGTGGTTGGCGGGCGACAGGACA
AAGCAGTGTTTGTCCCTGACATCTATTCCAGGACACAGAGTACTTGGGTGGATTCCTTCTTCAG
GCAGAACGGCTATCTAGAATTTGACGCTTTATCCAGACTTGGAATCCCAGATGCTGTGAACTAT
ATAAAGAAAAGGTATAAGAATACCCCACTCTTGTTTTTGAAGGCAACTTGTGTTGGCCAAGGGC
TCGTGGACCAGGTGGAAGCATCGGTAGAGGAGGCCATCAGCTCAGGAACATGGGTTGACGTTTC
GCCTCTGCTGCCCAGTTCTTTGTCAGTTGAAGATGCTGCTATGCTGCTTCAGCAGGTGATGAGA
CCATTTGGCAAGCATGCGTCAGCCACAGTCTTTAGTGACACTGTTGTGGTCAGCGAGAAATTCA
TCAATGACTGTACAAAACTGTTCAGCGAACGAATGCACCAAAAAGCTGAAAAGGAAATGAAAAA
TAATCCTGTGCATTTAATCACAGAAGAAGATCTGAAACAAATATCCATTTTAGAAAGTGTTAAT
ACAAATAAAAAGGATAAAAAAGATGAACGCAGGAAGAAAGCAACAGAGGGTTCTGGAAGTGTAA
GAGGCGGAGGAGGGGGCAATGCCAGAGAATACAAGATTAAGAAAGTCAAGAAGAAGGGAAGAAA
AGACGAGGACAGTGATGATGAGTCTCAGTCATCGCATGCTGGAAAGAAGAAGCCAGACATCACC
TTCATGTTCCAGGATGAAATTGAAGGTTGCTTAAGGAAACACATTCCAGATGCCCCTGAGGAGT
TTATTTCAGAACTTGCAGAACACTTAATAAAGCCTCTGAATAAAATGTATCTTGAGGTGGTACG
TTCAGTCTTCATGTCGTCAACATCTGCTTCTGGAACTGGCAGAAAACGCACGATCAAGGACTTA
CAAGAAGAGGTTTCAAATCTATACAATAATATCAGATTATTTGAAAAGGGGATGAAATATTTTG
CAGATGACACACAGACTGCTCTGACCAAGCACTTGCTGAAGACAGTGTGTACCGATATCACTAA
CCTCATGTTCAACTTCCTAGCCTCAGACTTGATGATGGCGGTGGAGGACCCTGCAACCATTACA
AGTGATATGAGAAAAAAAATTTTAAGCAAATTGACAGAAGAAACTAAAGTAGCTCTCACAAAAC
TCCACAACTCCCTGAATGAAAAAAGCATAGAAGACTTCCTTTCTTGTCTGGATTCTGCAACAGA
AGCTTGTGACATTATGGTGAAAAAGGGAGACAAAAAAAGGGAAAGGCAAATCCTTTTCCAGCAT
CGGCAGGCTCTGGCTGACCAGCTGAAGGTCACAGAAGACCCTGCTCTGATTTTACATCTCACAT
CAGTCCTGTTATTTCAGTTCTCAACCCACAGCATGCTCCATGCACCTGGAAGATGTGTCCCACA
GATCATCGCCTTTCTTCACAACAAAATCCCAGAGGATCAACATACTCTCTTGGTAAAATATCAA
GGATTGGTTGTGAAACAGTTAGTCAGTCAAAATAAGAAGAGTGGACAGGGAGAGGATCCGTCAA
GCGATGACTTAGACAAGGAACAACATGACGTCACCAATACTACTCGGAAGGAGCTTCAGGAACT
GTCTTTATCCATTAAGGACCTTGTTCTGAAGCCCAGGAAATCATCTGTGACAGAGGAGTAGTGC
CCCTAATTTACTTTTGTTACATAGTATTTTCTCCAGTAGATGAGTGATCACAGTCACTCAGTAC
ATCCTACTCCCCCATCAGCCCTCCCACGCAATCAAATAAAGTGGTGGTGTTGTAATAGATGAAC
ATTTTATGGGAAGCTTTACTGTTGAGTTCTCCATGAAACATTTTCTTTTCCCATAATCCTATGT
GTAACTTTTCATGTAATAAAAGTTCTTCAAAGAGTTCGAATCTAGAATATATGCTTTAATGTTC
TTCCAGATGTTAAAATGAAAAATAAAATAGAATACTTTTTATCTCTAGGAAAAAAAAAAAAAAA
AAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001119751	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66498	(Get FASTA)	NCBI Sequence Viewer
	B2GV24	(Get FASTA)	NCBI Sequence Viewer
	EDL98544	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010421
	ENSRNOP00000010421.5

RefSeq Acc Id:

NP_001119751 ⟸ NM_001126279

- UniProtKB:

B2GV24 (UniProtKB/Swiss-Prot), A0A0G2K266 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADAWEEIRRLAADFQRAQFAESTQRLSERNCIEIVNKLISQKQLEVVHTLDGKEYITPAQISK
EMRDELHVRGGRVNIVDLQQVINVDLTHIENRVGDIIKSEKHVQMVLGQLVDENYLDRLSEEVN
DKLQESGQVTVSELCKTYDLPGDFLTQALTQRLGRIINGHLDLDNRGVIFTEAFVARHKARIRG
LFSAITRPTAVNSLVSKYGFQEQLLYSVLEELVSTGRLRGTVVGGRQDKAVFVPDIYSRTQSTW
VDSFFRQNGYLEFDALSRLGIPDAVNYIKKRYKNTPLLFLKATCVGQGLVDQVEASVEEAISSG
TWVDVSPLLPSSLSVEDAAMLLQQVMRPFGKHASATVFSDTVVVSEKFINDCTKLFSERMHQKA
EKEMKNNPVHLITEEDLKQISILESVNTNKKDKKDERRKKATEGSGSVRGGGGGNAREYKIKKV
KKKGRKDEDSDDESQSSHAGKKKPDITFMFQDEIEGCLRKHIPDAPEEFISELAEHLIKPLNKM
YLEVVRSVFMSSTSASGTGRKRTIKDLQEEVSNLYNNIRLFEKGMKYFADDTQTALTKHLLKTV
CTDITNLMFNFLASDLMMAVEDPATITSDMRKKILSKLTEETKVALTKLHNSLNEKSIEDFLSC
LDSATEACDIMVKKGDKKRERQILFQHRQALADQLKVTEDPALILHLTSVLLFQFSTHSMLHAP
GRCVPQIIAFLHNKIPEDQHTLLVKYQGLVVKQLVSQNKKSGQGEDPSSDDLDKEQHDVTNTTR
KELQELSLSIKDLVLKPRKSSVTEE

hide sequence

Ensembl Acc Id:

ENSRNOP00000072123 ⟸ ENSRNOT00000089522

Ensembl Acc Id:

ENSRNOP00000010421 ⟸ ENSRNOT00000010421

Protein Domains

E3 UFM1-protein ligase 1-like E3 UFM1-protein ligase 1-like N-terminal E3 UFM1-protein ligase-like C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GV24-F1-model_v2	AlphaFold	B2GV24	1-793	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693605

Promoter ID:

EPDNEW_R4130

Type:

multiple initiation site

Name:

Ufl1_1

Description:

Ufm1-specific ligase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	39,650,868 - 39,650,928	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309308	AgrOrtholog
BioCyc Gene	G2FUF-41779	BioCyc
Ensembl Genes	ENSRNOG00000007831	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010421	ENTREZGENE
	ENSRNOT00000010421.6	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7114599	IMAGE-MGC_LOAD
InterPro	E3_UFM1_ligase_1	UniProtKB/Swiss-Prot
	Ufl1-like_C	UniProtKB/Swiss-Prot
	Ufl1_dom	UniProtKB/Swiss-Prot
	Ufl1_N	UniProtKB/Swiss-Prot
KEGG Report	rno:313115	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188046	IMAGE-MGC_LOAD
NCBI Gene	313115	ENTREZGENE
PANTHER	E3 UFM1-PROTEIN LIGASE 1	UniProtKB/Swiss-Prot
	PTHR31057	UniProtKB/Swiss-Prot
Pfam	E3_UFM1_ligase	UniProtKB/Swiss-Prot
	UFL1	UniProtKB/Swiss-Prot
	UFL1_C	UniProtKB/Swiss-Prot
PhenoGen	Ufl1	PhenoGen
RatGTEx	ENSRNOG00000007831	RatGTEx
UniProt	A0A0G2K266	ENTREZGENE, UniProtKB/TrEMBL
	B2GV24	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-09-02	Ufl1	Ufm1-specific ligase 1	Ufl1	E3 UFM1-protein ligase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-11-12	Ufl1	E3 UFM1-protein ligase 1	RGD1309308	similar to RIKEN cDNA 1810074P20	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309308	similar to RIKEN cDNA 1810074P20	RGD1309308_predicted	similar to RIKEN cDNA 1810074P20 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309308_predicted	similar to RIKEN cDNA 1810074P20 (predicted)	LOC313115_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313115_predicted	similar to RIKEN cDNA 1810074P20 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar