UFL1 (UFM1 specific ligase 1) - Rat Genome Database

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Gene: UFL1 (UFM1 specific ligase 1) Canis lupus familiaris
Analyze
Symbol: UFL1
Name: UFM1 specific ligase 1
RGD ID: 12235750
Description: ENCODES a protein that exhibits protein kinase binding (inferred); transferase activity (inferred); UFM1 ligase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of T cell activation (ortholog); negative regulation of T cell mediated immune response to tumor cell (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); mitochondrial outer membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 UFM1-protein ligase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11254,988,200 - 55,023,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1254,988,264 - 55,021,626 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1254,804,603 - 54,837,183 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01255,807,531 - 55,840,491 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1255,807,537 - 55,840,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11255,142,814 - 55,175,742 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01255,004,468 - 55,036,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01255,251,683 - 55,284,623 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11254,988,200 - 55,023,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1254,988,264 - 55,021,626 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1254,804,603 - 54,837,183 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01255,807,531 - 55,840,491 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1255,807,537 - 55,840,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11255,142,814 - 55,175,742 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01255,004,468 - 55,036,715 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01255,251,683 - 55,284,623 (+)NCBIUU_Cfam_GSD_1.0
UFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38696,521,806 - 96,555,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl696,521,595 - 96,555,276 (+)EnsemblGRCh38hg38GRCh38
GRCh37696,969,682 - 97,003,152 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36697,076,438 - 97,109,873 (+)NCBINCBI36Build 36hg18NCBI36
Build 34697,076,437 - 97,109,873NCBI
Celera697,611,468 - 97,644,919 (+)NCBICelera
Cytogenetic Map6q16.1NCBI
HuRef694,403,930 - 94,437,341 (+)NCBIHuRef
CHM1_1697,231,702 - 97,265,153 (+)NCBICHM1_1
T2T-CHM13v2.0697,693,702 - 97,727,174 (+)NCBIT2T-CHM13v2.0
Ufl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39425,247,149 - 25,281,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl425,248,600 - 25,281,821 (-)EnsemblGRCm39 Ensembl
GRCm38425,247,149 - 25,281,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl425,248,600 - 25,281,821 (-)EnsemblGRCm38mm10GRCm38
MGSCv37425,175,733 - 25,208,968 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36425,340,780 - 25,372,395 (-)NCBIMGSCv36mm8
Celera424,983,514 - 25,016,784 (-)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.59NCBI
Ufl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8543,759,271 - 43,791,682 (-)NCBIGRCr8
mRatBN7.2538,962,721 - 38,995,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl538,962,171 - 38,995,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx541,059,728 - 41,092,114 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0542,658,744 - 42,691,132 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0542,592,082 - 42,624,470 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0539,616,479 - 39,650,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl539,615,956 - 39,650,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0544,244,327 - 44,277,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4540,307,712 - 40,340,062 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1540,307,893 - 40,340,241 (-)NCBI
Celera537,888,662 - 37,920,107 (-)NCBICelera
Cytogenetic Map5q21NCBI
Ufl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541122,548,219 - 22,580,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541122,548,139 - 22,577,287 (+)NCBIChiLan1.0ChiLan1.0
UFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25116,562,033 - 116,595,549 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16114,440,254 - 114,473,720 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0694,356,440 - 94,389,920 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1698,242,689 - 98,276,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl698,242,756 - 98,274,377 (+)Ensemblpanpan1.1panPan2
Ufl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494689,564,693 - 89,598,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366991,129,344 - 1,163,530 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366991,131,385 - 1,163,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,638,596 - 63,700,476 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,638,589 - 63,698,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2172,007,561 - 72,067,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11377,357,239 - 77,387,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1377,357,141 - 77,387,367 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604049,653,195 - 49,682,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ufl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248108,805,964 - 8,832,358 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248108,804,330 - 8,832,460 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UFL1
377 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 16 2 6 7 10 5
Low 3 5 6 6 4 6 6 5 8 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038492455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038492456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038554757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038618635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038674503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038684197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000005519   ⟹   ENSCAFP00000005113
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1254,988,264 - 55,021,626 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015033   ⟹   ENSCAFP00845011660
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1255,807,537 - 55,840,242 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015095   ⟹   ENSCAFP00845011717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1255,808,184 - 55,840,242 (+)Ensembl
RefSeq Acc Id: XM_038492455   ⟹   XP_038348383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11255,142,814 - 55,175,742 (+)NCBI
RefSeq Acc Id: XM_038492456   ⟹   XP_038348384
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11255,144,467 - 55,175,742 (+)NCBI
RefSeq Acc Id: XM_038554756   ⟹   XP_038410684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01255,251,683 - 55,284,623 (+)NCBI
RefSeq Acc Id: XM_038554757   ⟹   XP_038410685
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01255,253,339 - 55,284,623 (+)NCBI
RefSeq Acc Id: XM_038618634   ⟹   XP_038474562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01255,004,468 - 55,036,715 (+)NCBI
RefSeq Acc Id: XM_038618635   ⟹   XP_038474563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01255,006,122 - 55,036,715 (+)NCBI
RefSeq Acc Id: XM_038674494   ⟹   XP_038530422
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1254,804,603 - 54,837,183 (+)NCBI
RefSeq Acc Id: XM_038674503   ⟹   XP_038530431
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1254,806,264 - 54,837,183 (+)NCBI
RefSeq Acc Id: XM_038684196   ⟹   XP_038540124
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01255,807,531 - 55,840,491 (+)NCBI
RefSeq Acc Id: XM_038684197   ⟹   XP_038540125
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01255,809,190 - 55,840,491 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000005113   ⟸   ENSCAFT00000005519
RefSeq Acc Id: XP_038348383   ⟸   XM_038492455
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038348384   ⟸   XM_038492456
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038474562   ⟸   XM_038618634
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038474563   ⟸   XM_038618635
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038540124   ⟸   XM_038684196
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KWA3 (UniProtKB/TrEMBL),   A0A8C0MJI2 (UniProtKB/TrEMBL),   A0A8I3MY93 (UniProtKB/TrEMBL),   A0A8C0Q7A1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038540125   ⟸   XM_038684197
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KTW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530422   ⟸   XM_038674494
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KWA3 (UniProtKB/TrEMBL),   A0A8C0MJI2 (UniProtKB/TrEMBL),   A0A8I3MY93 (UniProtKB/TrEMBL),   A0A8C0Q7A1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038530431   ⟸   XM_038674503
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KTW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410684   ⟸   XM_038554756
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KWA3 (UniProtKB/TrEMBL),   A0A8C0MJI2 (UniProtKB/TrEMBL),   A0A8C0Q7A1 (UniProtKB/TrEMBL),   A0A8I3MY93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410685   ⟸   XM_038554757
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KTW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011717   ⟸   ENSCAFT00845015095
RefSeq Acc Id: ENSCAFP00845011660   ⟸   ENSCAFT00845015033

Promoters
RGD ID:13685511
Promoter ID:EPDNEW_C3579
Type:initiation region
Name:UFL1_1
Description:UFM1 specific ligase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11254,988,257 - 54,988,317EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003430 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004910 UniProtKB/TrEMBL
  ENSCAFG00040004507 UniProtKB/TrEMBL
  ENSCAFG00845008549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005519.5 UniProtKB/TrEMBL
  ENSCAFT00030009019.1 UniProtKB/TrEMBL
  ENSCAFT00040008557.1 UniProtKB/TrEMBL
  ENSCAFT00845015033 ENTREZGENE
  ENSCAFT00845015033.1 UniProtKB/TrEMBL
  ENSCAFT00845015095.1 UniProtKB/TrEMBL
InterPro Ufl1 UniProtKB/TrEMBL
NCBI Gene UFL1 ENTREZGENE
PANTHER E3 UFM1-PROTEIN LIGASE 1 UniProtKB/TrEMBL
  PTHR31057 UniProtKB/TrEMBL
Pfam E3_UFM1_ligase UniProtKB/TrEMBL
UniProt A0A8C0KTW7 ENTREZGENE
  A0A8C0KWA3 ENTREZGENE
  A0A8C0MJI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q7A1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MY93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RW63_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48115 ENTREZGENE