Fkbp6 (FKBP prolyl isomerase family member 6) - Rat Genome Database

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Gene: Fkbp6 (FKBP prolyl isomerase family member 6) Rattus norvegicus
Analyze
Symbol: Fkbp6
Name: FKBP prolyl isomerase family member 6
RGD ID: 1308926
Description: Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)); INTERACTS WITH bisphenol A; 17alpha-ethynylestradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 36 kDa FK506 binding protein; FK506 binding protein 6; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; FKBP-36; immunophilin FKBP36; inactive peptidyl-prolyl cis-trans isomerase FKBP6; inactive PPIase FKBP6; peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP6; PPiase; rotamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   TT/Sgn
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,947,443 - 27,026,913 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,947,384 - 27,026,913 (+)EnsemblGRCr8
mRatBN7.21221,318,251 - 21,390,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,461,416 - 22,532,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,073,748 - 23,144,453 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,140,220 - 22,210,927 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,365,941 - 24,438,088 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,363,264 - 26,435,311 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,474,002 - 22,544,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,082,103 - 23,152,967 (+)NCBICelera
RGSC_v3.11222,464,474 - 22,476,654 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO,ISS)
fibrillar center  (IEA,ISO)
nucleus  (IEA)
synaptonemal complex  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes. Atagi Y, etal., J Vet Med Sci. 1993 Apr;55(2):301-6.
2. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Crackower MA, etal., Science. 2003 May 23;300(5623):1291-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A novel human gene FKBP6 is deleted in Williams syndrome. Meng X, etal., Genomics. 1998 Sep 1;52(2):130-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7493967   PMID:18408354   PMID:22902560   PMID:26567527  


Genomics

Comparative Map Data
Fkbp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,947,443 - 27,026,913 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1226,947,384 - 27,026,913 (+)EnsemblGRCr8
mRatBN7.21221,318,251 - 21,390,350 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1222,461,416 - 22,532,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,073,748 - 23,144,453 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,140,220 - 22,210,927 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,365,941 - 24,438,088 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)Ensemblrn6Rnor6.0
Rnor_5.01226,363,264 - 26,435,311 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41222,474,002 - 22,544,784 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,082,103 - 23,152,967 (+)NCBICelera
RGSC_v3.11222,464,474 - 22,476,654 (+)NCBI
Cytogenetic Map12q12NCBI
FKBP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,328,161 - 73,358,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,328,161 - 73,358,637 (+)Ensemblhg38GRCh38
GRCh37772,742,164 - 72,772,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,380,236 - 72,410,577 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34771,884,933 - 72,217,283NCBI
Celera768,220,437 - 68,250,915 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef768,623,892 - 68,654,372 (+)NCBIHuRef
CHM1_1772,888,174 - 72,918,659 (+)NCBICHM1_1
T2T-CHM13v2.0774,528,332 - 74,558,802 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,075,227 - 72,105,718 (+)NCBI
Fkbp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,320,558 - 135,380,662 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,320,558 - 135,378,898 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385135,291,704 - 135,351,809 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,291,704 - 135,350,044 (-)Ensemblmm10GRCm38
MGSCv375135,767,574 - 135,825,861 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365135,576,331 - 135,634,618 (-)NCBIMGSCv36mm8
Celera5132,303,410 - 132,361,697 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.11NCBI
Fkbp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,291,260 - 14,318,310 (-)Ensembl
ChiLan1.0NW_00495545614,291,445 - 14,318,310 (-)NCBIChiLan1.0ChiLan1.0
FKBP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,543,547 - 91,573,368 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,808,180 - 139,838,025 (-)NCBINHGRI_mPanPan1
PanPan1.1780,481,443 - 80,511,813 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,481,443 - 80,511,813 (+)EnsemblpanPan2panpan1.1
FKBP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,836,043 - 6,868,268 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,836,086 - 6,868,818 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha68,533,363 - 8,565,559 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.066,656,533 - 6,688,674 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,656,576 - 6,688,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,626,768 - 6,658,955 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,589,432 - 6,621,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,752,768 - 6,784,970 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fkbp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,367,109 - 131,398,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,638,016 - 2,646,589 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,638,189 - 2,646,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,669,664 - 10,682,618 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1310,659,456 - 10,716,210 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,365,246 - 10,407,830 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,688,493 - 9,718,633 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660706,744,849 - 6,774,903 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,369,164 - 14,400,480 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474014,369,214 - 14,400,560 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fkbp6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11618,661,315 - 18,732,104 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fkbp6
1349 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000001971
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
11530002Bss119Bone structure and strength QTL 11916.394e-17lumbar vertebra area (VT:0010570)lumbar vertebra area (CMO:0001688)122651003826983303Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
Fkbp6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81226,965,768 - 26,966,248 (+)Marker Load Pipeline
mRatBN7.21221,329,204 - 21,329,685 (+)MAPPERmRatBN7.2
Rnor_6.01224,376,848 - 24,377,328NCBIRnor6.0
Rnor_5.01226,374,151 - 26,374,631UniSTSRnor5.0
RGSC_v3.41222,483,639 - 22,484,119UniSTSRGSC3.4
Celera1223,091,638 - 23,092,118UniSTS
Cytogenetic Map12q12UniSTS
D5S503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,381,405 - 21,382,889 (+)MAPPERmRatBN7.2
Rnor_6.01224,429,050 - 24,430,532NCBIRnor6.0
Rnor_5.01226,426,353 - 26,427,835UniSTSRnor5.0
RGSC_v3.41222,535,841 - 22,537,323UniSTSRGSC3.4
Celera1223,143,832 - 23,145,506UniSTS
Cytogenetic Map12q12UniSTS


Related Rat Strains
The following Strains have been annotated to Fkbp6
TT/Sgn    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 6 53 54 18 13 10 11 10 4 102 68 2 50 19 62 3 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000001971   ⟹   ENSRNOP00000001971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,954,884 - 27,026,912 (+)Ensembl
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094090   ⟹   ENSRNOP00000086905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,954,884 - 27,026,912 (+)Ensembl
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098264   ⟹   ENSRNOP00000083089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1226,947,384 - 27,026,913 (+)Ensembl
mRatBN7.2 Ensembl1221,319,682 - 21,390,350 (+)Ensembl
RefSeq Acc Id: NM_001105922   ⟹   NP_001099392
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,956,131 - 27,026,913 (+)NCBI
mRatBN7.21221,319,568 - 21,390,350 (+)NCBI
Rnor_6.01224,367,211 - 24,437,993 (+)NCBI
Rnor_5.01226,363,264 - 26,435,311 (+)NCBI
RGSC_v3.41222,474,002 - 22,544,784 (+)RGD
Celera1223,082,103 - 23,152,967 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249131   ⟹   XP_006249193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,956,208 - 27,026,913 (+)NCBI
mRatBN7.21221,319,645 - 21,390,313 (+)NCBI
Rnor_6.01224,367,308 - 24,438,088 (+)NCBI
Rnor_5.01226,363,264 - 26,435,311 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769130   ⟹   XP_008767352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,954,816 - 26,974,896 (+)NCBI
mRatBN7.21221,318,251 - 21,340,953 (+)NCBI
Rnor_6.01224,365,941 - 24,380,793 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598299   ⟹   XP_017453788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,954,817 - 27,026,913 (+)NCBI
mRatBN7.21221,318,252 - 21,390,345 (+)NCBI
Rnor_6.01224,365,941 - 24,438,087 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271155   ⟹   XP_063127225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,947,443 - 27,026,913 (+)NCBI
RefSeq Acc Id: XM_063271157   ⟹   XP_063127227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,956,236 - 26,974,896 (+)NCBI
RefSeq Acc Id: NP_001099392   ⟸   NM_001105922
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249193   ⟸   XM_006249131
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZW77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767352   ⟸   XM_008769130
- Peptide Label: isoform X2
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453788   ⟸   XM_017598299
- Peptide Label: isoform X2
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001971   ⟸   ENSRNOT00000001971
Ensembl Acc Id: ENSRNOP00000086905   ⟸   ENSRNOT00000094090
Ensembl Acc Id: ENSRNOP00000083089   ⟸   ENSRNOT00000098264
RefSeq Acc Id: XP_063127225   ⟸   XM_063271155
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127227   ⟸   XM_063271157
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZW77 (UniProtKB/TrEMBL)
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQF4-F1-model_v2 AlphaFold D3ZQF4 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698555
Promoter ID:EPDNEW_R9080
Type:multiple initiation site
Name:Fkbp6_1
Description:FK506 binding protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,367,204 - 24,367,264EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308926 AgrOrtholog
BioCyc Gene G2FUF-19615 BioCyc
Ensembl Genes ENSRNOG00000001451 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001971 ENTREZGENE
  ENSRNOT00000001971.5 UniProtKB/Swiss-Prot
  ENSRNOT00000098264 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  3.10.50.40 UniProtKB/Swiss-Prot
InterPro FKBP6/shu UniProtKB/Swiss-Prot
  PPIase_dom_sf UniProtKB/Swiss-Prot
  PPIase_FKBP_dom UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:288597 UniProtKB/Swiss-Prot
NCBI Gene 288597 ENTREZGENE
PANTHER INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 UniProtKB/Swiss-Prot
  PTHR46674 UniProtKB/Swiss-Prot
Pfam FKBP_C UniProtKB/Swiss-Prot
PhenoGen Fkbp6 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001451 RatGTEx
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot
  SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZW77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6Z3_RAT UniProtKB/TrEMBL
  D3ZQF4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Fkbp6  FKBP prolyl isomerase family member 6  Fkbp6  FKBP prolyl isomerase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-11-09 Fkbp6  FKBP prolyl isomerase 6  Fkbp6  FK506 binding protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Fkbp6  FK506 binding protein 6  Fkbp6  FK506 binding protein 6, 36kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Fkbp6  FK506 binding protein 6, 36kDa  Fkbp6  FK506 binding protein 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fkbp6  FK506 binding protein 6   Fkbp6_predicted  FK506 binding protein 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fkbp6_predicted  FK506 binding protein 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED