Psph (phosphoserine phosphatase) - Rat Genome Database

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Gene: Psph (phosphoserine phosphatase) Rattus norvegicus
Analyze
Symbol: Psph
Name: phosphoserine phosphatase
RGD ID: 1308764
Description: Predicted to enable L-phosphoserine phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in response to mechanical stimulus; response to nutrient levels; and response to testosterone. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304429; MGC109524; O-phosphoserine phosphohydrolase; PSP; PSPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,527,091 - 32,541,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1232,519,269 - 32,541,180 (+)EnsemblGRCr8
mRatBN7.21226,882,524 - 26,905,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,883,133 - 26,905,074 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1228,027,799 - 28,041,053 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,638,338 - 28,651,592 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,699,824 - 27,713,078 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,514,128 - 30,526,551 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,514,112 - 30,526,557 (+)Ensemblrn6Rnor6.0
Rnor_5.01232,455,767 - 32,468,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,969,748 - 27,984,318 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1228,596,700 - 28,610,791 (+)NCBICelera
RGSC_v3.11227,833,136 - 27,847,706 (-)NCBI
Cytogenetic Map12q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin 460  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel dichloride  (ISO)
Nutlin-3  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phorone  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The effects of hyperphenylalaninemia on fetal development: a new animal model of maternal phenylketonuria. Brass CA, etal., Pediatr Res. 1982 May;16(5):388-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The reactions of the phosphorylated pathway of L-serine biosynthesis: thermodynamic relationships in rat liver in vivo. Guynn RW, etal., Arch Biochem Biophys. 1986 Feb 15;245(1):204-11.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Regulation of enzymes of serine and one-carbon metabolism by testosterone in rat prostate, liver, and kidney. Sanborn TA, etal., Endocrinology. 1975 Oct;97(4):1000-7.
14. DNA microarray reveals novel genes induced by mechanical forces in fetal lung type II epithelial cells. Wang Y, etal., Pediatr Res. 2006 Aug;60(2):118-24.
15. Formation of D-serine from L-phosphoserine in brain synaptosomes. Wood PL, etal., J Neurochem. 1996 Oct;67(4):1485-90.
Additional References at PubMed
PMID:12477932   PMID:12777757   PMID:14673469   PMID:15291819   PMID:15489334   PMID:25416956   PMID:25502805   PMID:27996060   PMID:31515488  


Genomics

Comparative Map Data
Psph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,527,091 - 32,541,182 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1232,519,269 - 32,541,180 (+)EnsemblGRCr8
mRatBN7.21226,882,524 - 26,905,084 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,883,133 - 26,905,074 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1228,027,799 - 28,041,053 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,638,338 - 28,651,592 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,699,824 - 27,713,078 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,514,128 - 30,526,551 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,514,112 - 30,526,557 (+)Ensemblrn6Rnor6.0
Rnor_5.01232,455,767 - 32,468,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,969,748 - 27,984,318 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1228,596,700 - 28,610,791 (+)NCBICelera
RGSC_v3.11227,833,136 - 27,847,706 (-)NCBI
Cytogenetic Map12q13NCBI
PSPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38756,011,064 - 56,051,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl756,010,312 - 56,051,604 (-)Ensemblhg38GRCh38
GRCh37756,078,757 - 56,119,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36756,046,238 - 56,086,762 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34755,852,953 - 55,893,477NCBI
Celera767,132,178 - 67,172,669 (-)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,892,706 - 55,933,068 (-)NCBIHuRef
CHM1_1756,081,776 - 56,122,305 (-)NCBICHM1_1
T2T-CHM13v2.0756,170,861 - 56,211,278 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2756,082,991 - 56,123,515 (-)NCBI
Psph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,842,622 - 129,864,318 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,842,622 - 129,864,513 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl5129,834,223 - 129,851,289 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385129,765,558 - 129,787,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,765,558 - 129,787,449 (-)Ensemblmm10GRCm38
MGSCv375130,271,434 - 130,293,129 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365130,080,273 - 130,101,913 (-)NCBIMGSCv36mm8
Celera5126,809,895 - 126,831,826 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.26NCBI
Psph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,198,739 - 8,212,025 (-)Ensembl
ChiLan1.0NW_0049554568,198,739 - 8,212,111 (-)NCBIChiLan1.0ChiLan1.0
LOC100993185
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,590,596 - 60,615,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,915,322 - 108,940,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0756,351,434 - 56,376,714 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,772,872 - 56,799,703 (+)NCBIPanPan1.1PanPan1.1panPan2
PSPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16493,152 - 546,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6493,176 - 512,089 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha62,192,384 - 2,245,452 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.06296,475 - 349,789 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6295,715 - 349,758 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16240,702 - 293,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06234,329 - 287,631 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06405,548 - 458,858 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,114,035 - 126,136,253 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,900,283 - 7,922,541 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,900,319 - 7,922,529 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,877,923 - 16,907,952 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1316,877,904 - 16,903,062 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,136,056 - 17,161,335 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSPH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,728,490 - 2,761,805 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl212,753,284 - 2,757,008 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041179,930,973 - 179,974,113 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,213,574 - 8,226,224 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247408,212,051 - 8,233,358 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Psph
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11624,184,351 - 24,206,619 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psph
138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:104
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000001228
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH129042  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,904,855 - 26,905,052 (+)MAPPERmRatBN7.2
Rnor_6.01230,526,329 - 30,526,525NCBIRnor6.0
Rnor_5.01232,468,097 - 32,468,293UniSTSRnor5.0
RGSC_v3.41227,969,774 - 27,969,970UniSTSRGSC3.4
Celera1228,610,569 - 28,610,765UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map12q13UniSTS
AU049267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,891,740 - 26,891,898 (+)MAPPERmRatBN7.2
Rnor_6.01230,514,883 - 30,515,040NCBIRnor6.0
Rnor_5.01232,456,522 - 32,456,679UniSTSRnor5.0
RGSC_v3.41227,983,406 - 27,983,563UniSTSRGSC3.4
Celera1228,597,455 - 28,597,612UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map12q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001228   ⟹   ENSRNOP00000001228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,519,269 - 32,541,180 (+)Ensembl
mRatBN7.2 Ensembl1226,883,133 - 26,905,074 (+)Ensembl
Rnor_6.0 Ensembl1230,514,112 - 30,526,553 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1230,525,290 - 30,526,557 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098380   ⟹   ENSRNOP00000097878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,519,269 - 32,540,876 (+)Ensembl
mRatBN7.2 Ensembl1226,883,133 - 26,904,772 (+)Ensembl
RefSeq Acc Id: NM_001009679   ⟹   NP_001009679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,527,091 - 32,541,182 (+)NCBI
mRatBN7.21226,890,986 - 26,905,078 (+)NCBI
Rnor_6.01230,514,128 - 30,526,551 (+)NCBI
Rnor_5.01232,455,767 - 32,468,319 (+)NCBI
RGSC_v3.41227,969,748 - 27,984,318 (-)RGD
Celera1228,596,700 - 28,610,791 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009679 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88310 (Get FASTA)   NCBI Sequence Viewer  
  EDM13488 (Get FASTA)   NCBI Sequence Viewer  
  EDM13489 (Get FASTA)   NCBI Sequence Viewer  
  EDM13490 (Get FASTA)   NCBI Sequence Viewer  
  EDM13491 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001228
  ENSRNOP00000001228.4
GenBank Protein Q5M819 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009679   ⟸   NM_001009679
- UniProtKB: Q5M819 (UniProtKB/Swiss-Prot),   A6J0P9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001228   ⟸   ENSRNOT00000001228
Ensembl Acc Id: ENSRNOP00000097878   ⟸   ENSRNOT00000098380

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M819-F1-model_v2 AlphaFold Q5M819 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698587
Promoter ID:EPDNEW_R9112
Type:initiation region
Name:Psph_1
Description:phosphoserine phosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01230,514,147 - 30,514,207EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308764 AgrOrtholog
BioCyc Gene G2FUF-19497 BioCyc
BioCyc Pathway SERSYN-PWY [L-serine biosynthesis I] BioCyc
BioCyc Pathway Image SERSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000000925 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001228 ENTREZGENE
  ENSRNOT00000001228.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324292 IMAGE-MGC_LOAD
InterPro HAD-like_SerB UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  PSP UniProtKB/Swiss-Prot
KEGG Report rno:304429 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109524 IMAGE-MGC_LOAD
NCBI Gene 304429 ENTREZGENE
PANTHER PHOSPHOSERINE PHOSPHATASE UniProtKB/Swiss-Prot
  PHOSPHOSERINE PHOSPHATASE UniProtKB/Swiss-Prot
Pfam Hydrolase UniProtKB/Swiss-Prot
PhenoGen Psph PhenoGen
RatGTEx ENSRNOG00000000925 RatGTEx
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
UniProt A0A8I6B6F7_RAT UniProtKB/TrEMBL
  A6J0P9 ENTREZGENE, UniProtKB/TrEMBL
  A6J0Q2_RAT UniProtKB/TrEMBL
  Q5M819 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Psph  phosphoserine phosphatase  Psph_predicted  phosphoserine phosphatase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Psph_predicted  phosphoserine phosphatase (predicted)      Symbol and Name status set to approved 70820 APPROVED