Elavl1 (ELAV like RNA binding protein 1) - Rat Genome Database

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Gene: Elavl1 (ELAV like RNA binding protein 1) Rattus norvegicus
Analyze
Symbol: Elavl1
Name: ELAV like RNA binding protein 1
RGD ID: 1308649
Description: Enables mRNA 3'-UTR binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of autophagosome size; positive regulation of metabolic process; and response to glucose. Located in cytoplasm and nucleus. Biomarker of degenerative disc disease. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1); PARTICIPATES IN CRM1 export pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; ELAV-like protein 1; hu-antigen R; Hua; HuR; LOC363854; mRNA-stabilizing factor HuR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,441,699 - 7,482,625 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl127,441,699 - 7,482,631 (-)EnsemblGRCr8
mRatBN7.2122,640,936 - 2,684,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx123,291,952 - 3,332,869 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,915,541 - 3,956,458 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,678,578 - 2,719,442 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,461,502 - 2,502,432 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,614,839 - 4,655,379 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,459,046 - 1,500,042 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera124,459,379 - 4,500,318 (-)NCBICelera
RGSC_v3.1121,458,769 - 1,500,043 (+)NCBI
Cytogenetic Map12p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3',5'-cyclic UMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amsacrine  (ISO)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bisphenol B  (ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Goe 6976  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
muramyl dipeptide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
putrescine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
SB 431542  (ISO)
sepantronium  (ISO)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO,ISS)
cytoplasmic stress granule  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (IDA,IEA,ISO,ISS)
P-body  (IEA)
postsynapse  (IEA,ISO)
ribonucleoprotein complex  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Aguado A, etal., J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury. Gu L, etal., Antioxid Redox Signal. 2017 Nov 10;27(14):1013-1026. doi: 10.1089/ars.2016.6880. Epub 2017 Mar 28.
4. Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Liu L, etal., Mol Biol Cell. 2009 Dec;20(23):4885-98. doi: 10.1091/mbc.E09-07-0550. Epub 2009 Oct 7.
5. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Matsui K, etal., Hepatology. 2008 Feb;47(2):686-97.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
8. Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Nowotarski SL, etal., Amino Acids. 2016 May 19.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. RNA-binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration. Shao Z, etal., Cell Prolif. 2021 Feb;54(2):e12975. doi: 10.1111/cpr.12975. Epub 2020 Dec 28.
13. Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle. Tang K, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1497-504.
Additional References at PubMed
PMID:8626503   PMID:12477932   PMID:12832476   PMID:12876290   PMID:14517288   PMID:14523003   PMID:14731398   PMID:14976220   PMID:15883232   PMID:16126846   PMID:16168373   PMID:16690610  
PMID:16831604   PMID:17288565   PMID:17475777   PMID:17632515   PMID:17804813   PMID:17971298   PMID:19029303   PMID:19106619   PMID:19246637   PMID:19420108   PMID:19561594   PMID:19676129  
PMID:19946888   PMID:20001965   PMID:20102719   PMID:20599775   PMID:21164076   PMID:21266579   PMID:21613615   PMID:21700703   PMID:22215678   PMID:22492050   PMID:22658674   PMID:22681889  
PMID:23056314   PMID:23519412   PMID:24394384   PMID:24625528   PMID:25528059   PMID:25805336   PMID:26489465   PMID:26554012   PMID:26595526   PMID:26850084   PMID:26866372   PMID:27035432  
PMID:27089893   PMID:27401462   PMID:27430620   PMID:27475885   PMID:27521603   PMID:27609837   PMID:27616329   PMID:28031329   PMID:28763438   PMID:29107807   PMID:29180010   PMID:30092282  
PMID:31172341   PMID:31358969   PMID:32478392   PMID:32779957   PMID:33450132   PMID:33607255   PMID:33753727   PMID:34788763   PMID:35352799   PMID:36173508   PMID:37164303   PMID:37713069  
PMID:38342180  


Genomics

Comparative Map Data
Elavl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,441,699 - 7,482,625 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl127,441,699 - 7,482,631 (-)EnsemblGRCr8
mRatBN7.2122,640,936 - 2,684,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx123,291,952 - 3,332,869 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,915,541 - 3,956,458 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,678,578 - 2,719,442 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,461,502 - 2,502,432 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,614,839 - 4,655,379 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,459,046 - 1,500,042 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera124,459,379 - 4,500,318 (-)NCBICelera
RGSC_v3.1121,458,769 - 1,500,043 (+)NCBI
Cytogenetic Map12p12NCBI
ELAVL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,958,573 - 8,005,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,958,573 - 8,006,062 (-)Ensemblhg38GRCh38
GRCh37198,023,457 - 8,070,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,929,457 - 7,976,529 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34197,929,457 - 7,976,529NCBI
Celera197,894,704 - 7,941,773 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,693,669 - 7,740,685 (-)NCBIHuRef
CHM1_1198,022,943 - 8,069,993 (-)NCBICHM1_1
T2T-CHM13v2.0197,959,562 - 8,006,636 (-)NCBIT2T-CHM13v2.0
Elavl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,334,781 - 4,375,104 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,335,382 - 4,375,413 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3884,284,781 - 4,325,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,285,382 - 4,325,413 (-)Ensemblmm10GRCm38
MGSCv3784,284,782 - 4,325,100 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3684,288,343 - 4,324,906 (-)NCBIMGSCv36mm8
Celera84,485,398 - 4,525,701 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.0NCBI
Elavl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,283,421 - 1,315,283 (+)Ensembl
ChiLan1.0NW_0049555631,283,424 - 1,315,283 (+)NCBIChiLan1.0ChiLan1.0
ELAVL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,645,019 - 12,688,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,758,555 - 11,805,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,259,829 - 7,306,808 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,114,849 - 8,147,142 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,114,849 - 8,147,137 (-)EnsemblpanPan2panpan1.1
ELAVL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,648,878 - 52,677,578 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,454,132 - 52,491,784 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,179,951 - 53,217,640 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,180,820 - 53,217,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,383,218 - 52,420,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,827,713 - 52,865,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,059,378 - 53,097,043 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Elavl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,875,753 - 212,906,793 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,927,950 - 4,959,064 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,931,665 - 4,959,032 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAVL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,207,096 - 71,248,906 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1271,207,141 - 71,245,863 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,607,515 - 71,646,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELAVL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,419,489 - 7,448,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,414,757 - 7,448,445 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081353,624 - 400,190 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elavl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828914,141 - 948,831 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624828913,001 - 948,826 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Elavl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1162,420,527 - 2,464,406 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Elavl1
275 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:98
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000001415
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001415   ⟹   ENSRNOP00000001415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl127,441,699 - 7,482,631 (-)Ensembl
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)Ensembl
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)Ensembl
RefSeq Acc Id: NM_001108848   ⟹   NP_001102318
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,441,699 - 7,482,625 (-)NCBI
mRatBN7.2122,643,861 - 2,684,787 (-)NCBI
Rnor_6.0122,461,502 - 2,502,432 (+)NCBI
Rnor_5.0124,614,839 - 4,655,379 (+)NCBI
RGSC_v3.4121,459,046 - 1,500,042 (+)RGD
Celera124,459,379 - 4,500,318 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68972 (Get FASTA)   NCBI Sequence Viewer  
  B5DF91 (Get FASTA)   NCBI Sequence Viewer  
  BAG72208 (Get FASTA)   NCBI Sequence Viewer  
  EDL75000 (Get FASTA)   NCBI Sequence Viewer  
  EDL75001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001415
  ENSRNOP00000001415.5
RefSeq Acc Id: NP_001102318   ⟸   NM_001108848
- UniProtKB: B5DF91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001415   ⟸   ENSRNOT00000001415
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF91-F1-model_v2 AlphaFold B5DF91 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698380
Promoter ID:EPDNEW_R8904
Type:initiation region
Name:Elavl1_1
Description:ELAV like RNA binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,461,496 - 2,461,556EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308649 AgrOrtholog
BioCyc Gene G2FUF-20346 BioCyc
Ensembl Genes ENSRNOG00000001069 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001415 ENTREZGENE
  ENSRNOT00000001415.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro ELAD_HUD_SF UniProtKB/Swiss-Prot
  Hud_Sxl_RNA UniProtKB/Swiss-Prot
  HuR_RRM2 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:363854 UniProtKB/Swiss-Prot
NCBI Gene 363854 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Elavl1 PhenoGen
PRINTS HUDSXLRNA UniProtKB/Swiss-Prot
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001069 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt B5DF91 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Elavl1  ELAV like RNA binding protein 1  Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)   Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-23 Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)  Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)  Data merged from RGD:731215 737654 APPROVED
2005-01-12 Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds with high affinity and specificity to adenylate/uridylate-rich elements (AREs) located in the 3-untranslated region (3-UTR) of several mRNAs 625662
gene_product member of a family of RNA binding proteins 625662