Ccne2 (cyclin E2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ccne2 (cyclin E2) Rattus norvegicus
Analyze
Symbol: Ccne2
Name: cyclin E2
RGD ID: 1307783
Description: Enables protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within several processes, including DNA replication initiation; chromosome organization; and regulation of protein localization. Predicted to be part of cyclin E1-CDK2 complex and cyclin E2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; measles pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G1/S-specific cyclin-E2; LOC362485
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,082,169 - 29,094,879 (+)NCBIGRCr8
mRatBN7.2524,285,078 - 24,298,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,284,922 - 24,297,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx526,474,294 - 26,485,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,067,313 - 28,078,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0527,868,181 - 27,879,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0524,434,077 - 24,446,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,159,666 - 29,171,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,032,748 - 25,044,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,032,749 - 25,042,590 (+)NCBI
Celera523,504,417 - 23,515,951 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Ratcastration-resistant prostate carcinoma treatmentISOCCNE2 (Homo sapiens)13504681 RGD 
Ccne2Ratprostate adenocarcinoma  ISOCcne2 (Mus musculus)13504706 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Ratendometriosis  ISOCCNE2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
Ccne2Rathead and neck squamous cell carcinoma  ISOCCNE2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29464035
Ccne2Ratmalignant mesothelioma  ISOCCNE2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25756049
Ccne2Ratpolycystic ovary syndrome  ISOCCNE2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21411543

1 to 20 of 280 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Rat(+)-catechin multiple interactionsISOCCNE2 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CCNE2 mRNACTDPMID:24763279
Ccne2Rat(-)-demecolcine decreases expressionISOCCNE2 (Homo sapiens)6480464Demecolcine results in decreased expression of CCNE2 mRNACTDPMID:23649840
Ccne2Rat(1->4)-beta-D-glucan multiple interactionsISOCcne2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CCNE2 mRNACTDPMID:36331819
Ccne2Rat(S)-colchicine decreases expressionISOCCNE2 (Homo sapiens)6480464Colchicine results in decreased expression of CCNE2 mRNACTDPMID:24211769
Ccne2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionISOCCNE2 (Homo sapiens)6480464o and p'-DDT results in decreased expression of CCNE2 mRNACTDPMID:18204070
Ccne2Rat1,2-dimethylhydrazine decreases expressionISOCcne2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CCNE2 mRNACTDPMID:22206623
Ccne2Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases expressionEXP 6480464Citalopram results in decreased expression of CCNE2 mRNACTDPMID:28467792
Ccne2Rat1-chloro-2,4-dinitrobenzene affects expressionISOCcne2 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of CCNE2 mRNACTDPMID:22302311
Ccne2Rat1-fluoro-2,4-dinitrobenzene increases expressionISOCCNE2 (Homo sapiens)6480464Dinitrofluorobenzene results in increased expression of CCNE2 mRNACTDPMID:23999411
Ccne2Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of CCNE2 mRNACTDPMID:17351261
Ccne2Rat17beta-estradiol multiple interactionsISOCCNE2 (Homo sapiens)6480464Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] and sodium arsenite inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA]CTDPMID:15897899 and PMID:28880708
Ccne2Rat17beta-estradiol decreases expressionISOCcne2 (Mus musculus)6480464Estradiol results in decreased expression of CCNE2 mRNACTDPMID:39298647
Ccne2Rat17beta-estradiol decreases expressionISOCCNE2 (Homo sapiens)6480464Estradiol results in decreased expression of CCNE2 mRNACTDPMID:31646340
Ccne2Rat17beta-estradiol increases expressionISOCCNE2 (Homo sapiens)6480464Estradiol results in increased expression of CCNE2 mRNACTDPMID:15897899 more ...
Ccne2Rat17beta-estradiol affects expressionISOCCNE2 (Homo sapiens)6480464Estradiol affects the expression of CCNE2 mRNACTDPMID:21826169
Ccne2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCcne2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of CCNE2 mRNACTDPMID:16102516 and PMID:16120747
Ccne2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CCNE2 mRNACTDPMID:32109520 and PMID:33387578
Ccne2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCCNE2 (Homo sapiens)6480464[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CCNE2 mRNACTDPMID:26159488
Ccne2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCcne2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CCNE2 mRNACTDPMID:21570461
Ccne2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CCNE2 mRNACTDPMID:22298810

1 to 20 of 280 rows

Biological Process
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Ccne2Ratchromosome organization involved in meiotic cell cycle acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291MGI:88316 PMID:24586195RGDPMID:24586195
Ccne2Ratchromosome organization involved in meiotic cell cycle acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2RatDNA replication initiation acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291MGI:2675474 PMID:12941272RGDPMID:12941272
Ccne2RatDNA replication initiation acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2RatG1/S transition of mitotic cell cycle involved_inIBACGD:CAL0000185532 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Rathomologous chromosome pairing at meiosis acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291MGI:88316 PMID:24586195RGDPMID:24586195
Ccne2Rathomologous chromosome pairing at meiosis acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2Ratpositive regulation of G1/S transition of mitotic cell cycle involved_inIBAFB:FBgn0010382 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratregulation of cell cycle acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291 PMID:9840927RGDPMID:9840927
Ccne2Ratregulation of cell cycle acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2Ratregulation of protein localization acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291MGI:88316 PMID:24586195RGDPMID:24586195
Ccne2Ratregulation of protein localization acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2Rattelomere maintenance acts_upstream_of_or_withinISOCcne2 (Mus musculus)1624291MGI:88316 PMID:24586195RGDPMID:24586195
Ccne2Rattelomere maintenance acts_upstream_of_or_withinIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 15 of 15 rows

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Ratcyclin E1-CDK2 complex part_ofIBAMGI:88316 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratcyclin E2-CDK2 complex part_ofISOCCNE2 (Homo sapiens)1624291 PMID:15232106RGDPMID:15232106
Ccne2Ratcyclin E2-CDK2 complex part_ofIEAUniProtKB:O96020 and ensembl:ENSP000003091811600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2Ratcyclin E2-CDK2 complex part_ofIEAUniProtKB:Q9Z238 and ensembl:ENSMUSP000001306931600115GO_REF:0000107EnsemblGO_REF:0000107
Ccne2Ratcyclin E2-CDK2 complex part_ofISOCcne2 (Mus musculus)1624291 PMID:7739547RGDPMID:7739547
Ccne2Ratcyclin E2-CDK2 complex part_ofIBAMGI:1329034 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratcytoplasm is_active_inIBAFB:FBgn0000404 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratmicrotubule organizing center is_active_inIBAPANTHER:PTN007424001 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratnucleus is_active_inIBAFB:FBgn0000404 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ccne2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Ccne2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
1 to 11 of 11 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2RatG1/S transition pathway  ISOCCNE2 (Homo sapiens)8694143 RGD 
Ccne2RatG1/S transition pathway  ISOCCNE2 (Homo sapiens)8694150 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccne2Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Ccne2Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Ccne2Ratp53 signaling pathway   IEA 6907045 KEGGrno:04115
Ccne2Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Ccne2Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222

1 to 11 of 11 rows
#
Reference Title
Reference Citation
1. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
10. Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Wan L, etal., Cancer Prev Res (Phila). 2014 Dec;7(12):1228-39. doi: 10.1158/1940-6207.CAPR-14-0182. Epub 2014 Oct 14.
11. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Zhang L, etal., Mol Med Rep. 2016 Sep;14(3):2077-84. doi: 10.3892/mmr.2016.5469. Epub 2016 Jul 6.
1 to 11 of 11 rows
PMID:7739547   PMID:9840927   PMID:12941272   PMID:24586195  



Ccne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,082,169 - 29,094,879 (+)NCBIGRCr8
mRatBN7.2524,285,078 - 24,298,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,284,922 - 24,297,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx526,474,294 - 26,485,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,067,313 - 28,078,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0527,868,181 - 27,879,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0524,434,077 - 24,446,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,159,666 - 29,171,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,032,748 - 25,044,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,032,749 - 25,042,590 (+)NCBI
Celera523,504,417 - 23,515,951 (+)NCBICelera
Cytogenetic Map5q13NCBI
CCNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38894,880,224 - 94,896,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl894,879,770 - 94,896,678 (-)EnsemblGRCh38hg38GRCh38
GRCh37895,892,452 - 95,907,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,961,628 - 95,976,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 34895,961,630 - 95,976,658NCBI
Celera892,077,652 - 92,092,680 (-)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef891,100,427 - 91,115,467 (-)NCBIHuRef
CHM1_1895,932,798 - 95,947,824 (-)NCBICHM1_1
T2T-CHM13v2.0896,005,210 - 96,021,694 (-)NCBIT2T-CHM13v2.0
Ccne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,190,489 - 11,204,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,191,351 - 11,204,779 (+)EnsemblGRCm39 Ensembl
GRCm38411,190,433 - 11,204,779 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,191,351 - 11,204,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37411,118,501 - 11,131,926 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,118,501 - 11,131,829 (+)NCBIMGSCv36mm8
Celera411,001,670 - 11,015,258 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.07NCBI
Ccne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541711,027,749 - 11,040,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541711,027,749 - 11,039,945 (-)NCBIChiLan1.0ChiLan1.0
CCNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27112,208,849 - 112,225,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1887,745,867 - 87,765,107 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0891,499,647 - 91,518,488 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1893,702,104 - 93,717,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,702,104 - 93,717,151 (-)Ensemblpanpan1.1panPan2
CCNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,534,872 - 39,551,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,534,968 - 39,546,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,695,158 - 39,709,126 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02939,737,647 - 39,751,438 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2939,737,869 - 39,750,817 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,749,904 - 39,763,614 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02939,745,755 - 39,759,521 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02940,186,991 - 40,200,957 (-)NCBIUU_Cfam_GSD_1.0
Ccne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,939,436 - 39,953,135 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,839,113 - 7,851,335 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,839,730 - 7,852,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,804,377 - 41,821,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,802,090 - 41,821,870 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,119,630 - 45,139,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,846,670 - 89,863,432 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl889,848,077 - 89,862,037 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603950,971,304 - 50,986,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccne2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247632,243,305 - 2,257,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247632,242,584 - 2,258,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ccne2
38 total Variants

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:123
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000010696
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat

1 to 10 of 16 rows
UniSTS:496751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2524,296,107 - 24,296,238 (+)MAPPERmRatBN7.2
Rnor_6.0524,444,866 - 24,444,996NCBIRnor6.0
Rnor_5.0529,170,455 - 29,170,585UniSTSRnor5.0
RGSC_v3.4525,042,743 - 25,042,873UniSTSRGSC3.4
Celera523,514,411 - 23,514,541UniSTS
Cytogenetic Map5q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000010696   ⟹   ENSRNOP00000010696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,285,833 - 24,297,632 (+)Ensembl
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108289   ⟹   ENSRNOP00000084976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,284,922 - 24,297,312 (+)Ensembl
RefSeq Acc Id: NM_001108656   ⟹   NP_001102126
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,083,345 - 29,094,879 (+)NCBI
mRatBN7.2524,286,110 - 24,297,648 (+)NCBI
Rnor_6.0524,434,872 - 24,446,406 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
RGSC_v3.4525,032,748 - 25,044,509 (+)RGD
Celera523,504,417 - 23,515,951 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237873   ⟹   XP_006237935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,724 - 29,094,549 (+)NCBI
mRatBN7.2524,285,810 - 24,298,233 (+)NCBI
Rnor_6.0524,434,077 - 24,446,076 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237874   ⟹   XP_006237936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,083,314 - 29,094,549 (+)NCBI
mRatBN7.2524,286,075 - 24,298,233 (+)NCBI
Rnor_6.0524,434,863 - 24,446,076 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593468   ⟹   XP_017448957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,911 - 29,094,549 (+)NCBI
mRatBN7.2524,285,810 - 24,298,233 (+)NCBI
Rnor_6.0524,434,077 - 24,446,076 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110217   ⟹   XP_038966145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,236 - 29,094,549 (+)NCBI
mRatBN7.2524,285,078 - 24,298,258 (+)NCBI
RefSeq Acc Id: XM_063287900   ⟹   XP_063143970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,169 - 29,094,549 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001102126 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237935 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237936 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966145 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11673 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010696
  ENSRNOP00000010696.4
  ENSRNOP00000084976.1
1 to 10 of 10 rows
RefSeq Acc Id: NP_001102126   ⟸   NM_001108656
- UniProtKB: D3ZQ41 (UniProtKB/TrEMBL),   A6JFS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237935   ⟸   XM_006237873
- Peptide Label: isoform X1
- UniProtKB: D3ZQ41 (UniProtKB/TrEMBL),   A6JFS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237936   ⟸   XM_006237874
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A291 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448957   ⟸   XM_017593468
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A291 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010696   ⟸   ENSRNOT00000010696
Cyclin C-terminal   Cyclin-like

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ41-F1-model_v2 AlphaFold D3ZQ41 1-405 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693563
Promoter ID:EPDNEW_R4087
Type:multiple initiation site
Name:Ccne2_1
Description:cyclin E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0524,434,929 - 24,434,989EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-41960 BioCyc
Ensembl Genes ENSRNOG00000008055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010696 ENTREZGENE
  ENSRNOT00000010696.6 UniProtKB/TrEMBL
  ENSRNOT00000108289.1 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclin_related UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
KEGG Report rno:362485 UniProtKB/TrEMBL
NCBI Gene 362485 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PhenoGen Ccne2 PhenoGen
PROSITE CYCLINS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008055 RatGTEx
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP Cyclin_like UniProtKB/TrEMBL
UniProt A0A8I6A291 ENTREZGENE, UniProtKB/TrEMBL
  A6JFS7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQ41 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-01-25 Ccne2  cyclin E2  Ccne2_predicted  cyclin E2 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ccne2_predicted  cyclin E2 (predicted)      Symbol and Name status set to approved 70820 APPROVED