Nfatc2 (nuclear factor of activated T-cells 2) - Rat Genome Database

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Gene: Nfatc2 (nuclear factor of activated T-cells 2) Rattus norvegicus
Analyze
Symbol: Nfatc2
Name: nuclear factor of activated T-cells 2
RGD ID: 1307690
Description: Predicted to enable several functions, including 14-3-3 protein binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and phosphatase binding activity. Predicted to be involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of B cell proliferation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including lncRNA transcription; myotube cell development; and positive regulation of myoblast fusion. Predicted to be located in chromatin and cytosol. Predicted to be part of ribonucleoprotein complex and transcription factor AP-1 complex. Predicted to be active in cytoplasm and nucleus. Used to study pulmonary hypertension. Orthologous to human NFATC2 (nuclear factor of activated T cells 2); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311658; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,615,189 - 177,747,493 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3177,618,314 - 177,747,380 (-)EnsemblGRCr8
mRatBN7.23157,195,970 - 157,328,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3157,198,872 - 157,328,325 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,994,216 - 161,108,788 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,493,353 - 169,607,936 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03167,235,037 - 167,349,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)Ensemblrn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3155,769,159 - 155,882,096 (-)NCBICelera
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-Methoxyflavone  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erastin  (ISO)
ethanol  (ISO)
ferric oxide  (EXP)
ferrostatin-1  (ISO)
fisetin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
harmine  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ionomycin  (ISO)
KN-93  (ISO)
L-methionine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muscarine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
ribonucleoprotein complex  (IEA,ISO)
transcription regulator complex  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. Ho AM, etal., J Biol Chem. 1994 Nov 11;269(45):28181-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:7650004   PMID:8235597   PMID:8668213   PMID:8940147   PMID:8973343   PMID:10755616   PMID:11278367   PMID:12091710   PMID:12370307   PMID:12453415   PMID:12656674   PMID:12757709  
PMID:15319455   PMID:15790681   PMID:15857835   PMID:17875758   PMID:18319259   PMID:18676376   PMID:19561615   PMID:19752193   PMID:21295565   PMID:21709260   PMID:21871017   PMID:23123061  
PMID:23219532   PMID:23853098   PMID:24161931   PMID:24301466   PMID:25318679   PMID:26248042   PMID:27522126   PMID:28153703   PMID:28560440   PMID:33070779   PMID:33179105   PMID:34036377  
PMID:37951197  


Genomics

Comparative Map Data
Nfatc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,615,189 - 177,747,493 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3177,618,314 - 177,747,380 (-)EnsemblGRCr8
mRatBN7.23157,195,970 - 157,328,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3157,198,872 - 157,328,325 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,994,216 - 161,108,788 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,493,353 - 169,607,936 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03167,235,037 - 167,349,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)Ensemblrn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3155,769,159 - 155,882,096 (-)NCBICelera
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Cytogenetic Map3q42NCBI
NFATC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382051,386,963 - 51,562,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2051,386,957 - 51,562,831 (-)Ensemblhg38GRCh38
GRCh372050,003,500 - 50,179,378 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362049,441,172 - 49,592,665 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342049,441,311 - 49,592,665NCBI
Celera2046,712,014 - 46,883,320 (-)NCBICelera
Cytogenetic Map20q13.2NCBI
HuRef2046,752,104 - 46,926,810 (-)NCBIHuRef
CHM1_12049,909,009 - 50,084,547 (-)NCBICHM1_1
T2T-CHM13v2.02053,157,543 - 53,333,581 (-)NCBIT2T-CHM13v2.0
Nfatc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,318,330 - 168,443,900 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2168,318,330 - 168,443,577 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382168,476,410 - 168,601,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,476,410 - 168,601,657 (-)Ensemblmm10GRCm38
MGSCv372168,301,910 - 168,427,155 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362168,167,615 - 168,292,860 (-)NCBIMGSCv36mm8
Celera2174,418,074 - 174,542,304 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.91NCBI
Nfatc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,035,876 - 7,153,237 (+)Ensembl
ChiLan1.0NW_0049554457,035,876 - 7,153,199 (+)NCBIChiLan1.0ChiLan1.0
NFATC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22157,138,601 - 57,315,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12057,131,719 - 57,308,528 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02047,734,054 - 47,910,435 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12048,858,238 - 49,034,007 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,858,238 - 49,034,007 (-)EnsemblpanPan2panpan1.1
NFATC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,606,977 - 37,734,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,609,561 - 37,771,132 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2436,848,834 - 36,994,081 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02438,316,651 - 38,461,824 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2438,320,200 - 38,479,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12437,552,559 - 37,697,657 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02437,686,199 - 37,831,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02438,231,487 - 38,376,716 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101976824
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,030,736 - 188,129,333 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365143,467,178 - 3,578,882 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365143,453,475 - 3,579,292 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,743,568 - 52,906,821 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11752,743,570 - 52,907,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21759,183,329 - 59,348,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,412,935 - 12,585,275 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl212,430,744 - 12,540,131 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605060,814,273 - 60,985,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,366,406 - 4,484,432 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247904,366,440 - 4,484,279 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfatc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15149,394,076 - 149,523,168 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:97
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000065615
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
D3Rat141  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83177,741,661 - 177,741,895 (+)Marker Load Pipeline
mRatBN7.23157,322,804 - 157,323,038 (+)MAPPERmRatBN7.2
Rnor_6.03165,368,814 - 165,369,047NCBIRnor6.0
Rnor_5.03171,508,982 - 171,509,215UniSTSRnor5.0
RGSC_v3.43159,783,634 - 159,783,868RGDRGSC3.4
RGSC_v3.43159,783,635 - 159,783,868UniSTSRGSC3.4
Celera3155,890,790 - 155,891,023UniSTS
RGSC_v3.13159,689,670 - 159,689,904RGD
SHRSP x BN Map378.8999UniSTS
SHRSP x BN Map378.8999RGD
Cytogenetic Map3q42UniSTS
D3Rat142  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83177,728,139 - 177,728,348 (+)Marker Load Pipeline
mRatBN7.23157,309,278 - 157,309,487 (+)MAPPERmRatBN7.2
Rnor_6.03165,355,460 - 165,355,668NCBIRnor6.0
Rnor_5.03171,495,526 - 171,495,734UniSTSRnor5.0
RGSC_v3.43159,768,811 - 159,769,019UniSTSRGSC3.4
RGSC_v3.43159,768,810 - 159,769,019RGDRGSC3.4
Celera3155,877,270 - 155,877,494UniSTS
RGSC_v3.13159,674,847 - 159,675,055RGD
RH 3.4 Map31442.4UniSTS
RH 3.4 Map31442.4RGD
SHRSP x BN Map378.8999RGD
SHRSP x BN Map378.8999UniSTS
Cytogenetic Map3q42UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,960,823 - 151,962,481 (-)MAPPERmRatBN7.2
Rnor_6.0X156,532,524 - 156,534,181NCBIRnor6.0
Rnor_6.0X155,795,871 - 155,797,528NCBIRnor6.0
Rnor_5.01151,515,195 - 151,516,852UniSTSRnor5.0
Rnor_5.01152,273,584 - 152,275,241UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera1135,932,603 - 135,934,260UniSTS
Cytogenetic MapXq37UniSTS
Cytogenetic Map3q42UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23157,292,345 - 157,292,637 (+)MAPPERmRatBN7.2
Rnor_6.03165,338,534 - 165,338,825NCBIRnor6.0
Rnor_5.03171,478,298 - 171,478,589UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera3155,860,462 - 155,860,753UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000065615   ⟹   ENSRNOP00000059260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3177,618,314 - 177,733,091 (-)Ensembl
mRatBN7.2 Ensembl3157,199,459 - 157,314,117 (-)Ensembl
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102500   ⟹   ENSRNOP00000078664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3177,618,314 - 177,747,380 (-)Ensembl
mRatBN7.2 Ensembl3157,198,872 - 157,314,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103552   ⟹   ENSRNOP00000082665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3177,656,298 - 177,747,380 (-)Ensembl
mRatBN7.2 Ensembl3157,237,889 - 157,328,325 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105625   ⟹   ENSRNOP00000096538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,237,889 - 157,314,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110172   ⟹   ENSRNOP00000086352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3177,625,622 - 177,733,091 (-)Ensembl
mRatBN7.2 Ensembl3157,223,642 - 157,314,117 (-)Ensembl
RefSeq Acc Id: NM_001107805   ⟹   NP_001101275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,618,314 - 177,732,974 (-)NCBI
mRatBN7.23157,199,459 - 157,314,117 (-)NCBI
Rnor_6.03165,245,238 - 165,360,292 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
RGSC_v3.43159,656,032 - 159,773,643 (-)RGD
Celera3155,769,159 - 155,882,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235653   ⟹   XP_006235715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,656,114 - 177,733,101 (-)NCBI
mRatBN7.23157,237,235 - 157,314,245 (-)NCBI
Rnor_6.03165,283,039 - 165,360,286 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591799   ⟹   XP_017447288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,615,189 - 177,733,101 (-)NCBI
mRatBN7.23157,195,970 - 157,314,245 (-)NCBI
Rnor_6.03165,241,750 - 165,360,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591803   ⟹   XP_017447292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,656,114 - 177,747,493 (-)NCBI
mRatBN7.23157,237,235 - 157,328,640 (-)NCBI
Rnor_6.03165,283,039 - 165,374,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105142   ⟹   XP_038961070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,615,189 - 177,747,493 (-)NCBI
mRatBN7.23157,195,970 - 157,328,640 (-)NCBI
RefSeq Acc Id: XM_039105143   ⟹   XP_038961071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,615,189 - 177,747,493 (-)NCBI
mRatBN7.23157,195,970 - 157,328,640 (-)NCBI
RefSeq Acc Id: XM_039105144   ⟹   XP_038961072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83177,615,189 - 177,732,899 (-)NCBI
mRatBN7.23157,195,970 - 157,314,025 (-)NCBI
RefSeq Acc Id: NP_001101275   ⟸   NM_001107805
- UniProtKB: D4A0I8 (UniProtKB/TrEMBL),   A6JXQ0 (UniProtKB/TrEMBL),   A0A8I6A3G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235715   ⟸   XM_006235653
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AV80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447288   ⟸   XM_017591799
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLE7 (UniProtKB/TrEMBL),   A0A8I6A3G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447292   ⟸   XM_017591803
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000059260   ⟸   ENSRNOT00000065615
RefSeq Acc Id: XP_038961071   ⟸   XM_039105143
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961070   ⟸   XM_039105142
- Peptide Label: isoform X2
- UniProtKB: A6JXP9 (UniProtKB/TrEMBL),   A0A8I6A3G2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961072   ⟸   XM_039105144
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000078664   ⟸   ENSRNOT00000102500
Ensembl Acc Id: ENSRNOP00000096538   ⟸   ENSRNOT00000105625
Ensembl Acc Id: ENSRNOP00000082665   ⟸   ENSRNOT00000103552
Ensembl Acc Id: ENSRNOP00000086352   ⟸   ENSRNOT00000110172
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0I8-F1-model_v2 AlphaFold D4A0I8 1-931 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307690 AgrOrtholog
BioCyc Gene G2FUF-46697 BioCyc
Ensembl Genes ENSRNOG00000012175 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065615 ENTREZGENE
  ENSRNOT00000065615.3 UniProtKB/TrEMBL
  ENSRNOT00000102500 ENTREZGENE
  ENSRNOT00000102500.2 UniProtKB/TrEMBL
  ENSRNOT00000103552 ENTREZGENE
  ENSRNOT00000103552.2 UniProtKB/TrEMBL
  ENSRNOT00000110172.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:311658 UniProtKB/TrEMBL
NCBI Gene 311658 ENTREZGENE
PANTHER NFAT UniProtKB/TrEMBL
  NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2 UniProtKB/TrEMBL
Pfam RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Nfatc2 PhenoGen
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012175 RatGTEx
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A8I5ZLE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3G2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV80 ENTREZGENE
  A0A8I6G9R9 ENTREZGENE, UniProtKB/TrEMBL
  A6JXP9 ENTREZGENE, UniProtKB/TrEMBL
  A6JXQ0 ENTREZGENE, UniProtKB/TrEMBL
  D4A0I8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nfatc2  nuclear factor of activated T-cells 2  Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2   Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED