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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfatc2
Name: nuclear factor of activated T-cells 2
Acc ID: CHEBI:5801
Term: hydroxychloroquine
Definition: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Chemical ID: MESH:D006886
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfatc2affects localizationISONFATC2 (Homo sapiens)6480464CTDHydroxychloroquine affects the localization of NFATC2 proteinPMID:28793932
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