Hexb (hexosaminidase subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hexb (hexosaminidase subunit beta) Rattus norvegicus
Analyze
Symbol: Hexb
Name: hexosaminidase subunit beta
RGD ID: 1307607
Description: Enables beta-N-acetylglucosaminidase activity; carbohydrate binding activity; and identical protein binding activity. Involved in N-acetylglucosamine metabolic process. Predicted to be located in extracellular space and secretory granule. Predicted to be part of beta-N-acetylhexosaminidase complex. Predicted to be active in lysosome and membrane. Human ortholog(s) of this gene implicated in Sandhoff disease and spinal muscular atrophy. Orthologous to human HEXB (hexosaminidase subunit beta); PARTICIPATES IN amino sugar metabolic pathway; ganglioside metabolic pathway; globoside metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-hexosaminidase subunit beta; beta-N-acetylhexosaminidase subunit beta; hexosaminidase B; hexosaminidase subunit B; LOC294673; N-acetyl-beta-glucosaminidase subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8230,218,608 - 30,238,771 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl230,218,608 - 30,238,771 (-)EnsemblGRCr8
mRatBN7.2228,483,997 - 28,504,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx235,537,922 - 35,558,126 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,632,260 - 33,652,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0228,445,997 - 28,466,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,983,925 - 28,003,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,984,117 - 28,003,186 (-)Ensemblrn6Rnor6.0
Rnor_5.0247,094,814 - 47,114,992 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4227,649,188 - 27,672,231 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera224,525,921 - 24,545,955 (-)NCBICelera
RGSC_v3.1227,569,557 - 27,592,600 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-Methylaziridine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (EXP)
alpha-curcumene  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ampicillin  (EXP)
Aristolactam I  (EXP)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astemizole  (EXP)
atracurium  (ISO)
atrazine  (EXP,ISO)
azithromycin  (EXP)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-2-ol  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bitertanol  (EXP)
Brodifacoum  (EXP)
buspirone  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cetirizine  (EXP)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
compound 48/80  (ISO)
cupressuflavone  (ISO)
cyclosporin A  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextromethorphan  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
digitonin  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flunarizine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
gamma-linolenic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hydroxyzine  (EXP)
indometacin  (ISO)
iodixanol  (ISO)
iohexol  (ISO)
ionomycin  (EXP,ISO)
iopromide  (ISO)
Ioversol  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
KN-93  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
metronidazole  (EXP)
Mibefradil  (EXP)
ML-7  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,O-dimethyltyramine  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (EXP)
nickel dichloride  (EXP)
oxatomide  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prothiofos  (EXP)
pyridaben  (EXP)
pyrimethamine  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
Salinomycin  (EXP)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
terbufos  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vecuronium bromide  (ISO)
Yessotoxin  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IEA,ISO)
azurophil granule  (IEA,ISO)
cortical granule  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA)
extracellular space  (IEA,ISO)
lysosome  (IBA,IEA,ISO)
membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Molecular basis of an adult form of beta-hexosaminidase B deficiency with motor neuron disease. Banerjee P, etal., Biochem Biophys Res Commun. 1991 Nov 27;181(1):108-15.
2. Pregnancy modulates the expression of beta-N-acetylhexosaminidase in rat serum and tissues. Emiliani C, etal., Int J Biochem. 1992 Oct;24(10):1599-605.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Purification and characterization of N-acetyl-beta-D-hexosaminidase in different anatomical regions of the adult rat epididymis. Hall JC, etal., Biochem Int. 1992 Dec;28(4):613-20.
6. beta-Hexosaminidase immunolocalization and alpha- and beta-subunit gene expression in the rat testis and epididymis. Hermo L, etal., Mol Reprod Dev. 1997 Mar;46(3):227-42.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Structure and distribution of an Alu-type deletion mutation in Sandhoff disease. Neote K, etal., J Clin Invest. 1990 Nov;86(5):1524-31.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
15. Evidence for the regulation of beta-N-acetylhexosaminidase expression during pregnancy in the rat. Tancini B, etal., Biochim Biophys Acta. 2000 Jul 3;1475(2):184-90.
Additional References at PubMed
PMID:6230359   PMID:7203014   PMID:7550345   PMID:8269854   PMID:8566348   PMID:8789434   PMID:8896570   PMID:9122231   PMID:9184660   PMID:9223328   PMID:9417048   PMID:9584189  
PMID:9645704   PMID:10021458   PMID:11854359   PMID:12477932   PMID:12617783   PMID:12657883   PMID:12756243   PMID:15155903   PMID:15198669   PMID:15489334   PMID:15748167   PMID:19710420  
PMID:19946888   PMID:23376485   PMID:23533145   PMID:25645918   PMID:26681805   PMID:29514215  


Genomics

Comparative Map Data
Hexb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8230,218,608 - 30,238,771 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl230,218,608 - 30,238,771 (-)EnsemblGRCr8
mRatBN7.2228,483,997 - 28,504,165 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx235,537,922 - 35,558,126 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0233,632,260 - 33,652,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0228,445,997 - 28,466,169 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0227,983,925 - 28,003,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl227,984,117 - 28,003,186 (-)Ensemblrn6Rnor6.0
Rnor_5.0247,094,814 - 47,114,992 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4227,649,188 - 27,672,231 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera224,525,921 - 24,545,955 (-)NCBICelera
RGSC_v3.1227,569,557 - 27,592,600 (-)NCBI
Cytogenetic Map2q12NCBI
HEXB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38574,640,023 - 74,721,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl574,640,023 - 74,722,647 (+)Ensemblhg38GRCh38
GRCh37573,935,848 - 74,017,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36574,016,767 - 74,052,869 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34574,016,766 - 74,052,869NCBI
Celera569,875,759 - 69,911,869 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef569,185,979 - 69,222,054 (+)NCBIHuRef
CHM1_1573,413,670 - 73,449,974 (+)NCBICHM1_1
T2T-CHM13v2.0575,120,988 - 75,202,190 (+)NCBIT2T-CHM13v2.0
Hexb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391397,312,839 - 97,334,865 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1397,312,839 - 97,334,865 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381397,176,331 - 97,198,357 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1397,176,331 - 97,198,357 (-)Ensemblmm10GRCm38
MGSCv371397,946,286 - 97,968,312 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361398,277,106 - 98,298,969 (-)NCBIMGSCv36mm8
Celera13100,809,364 - 100,830,755 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.66NCBI
Hexb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542525,942,278 - 25,961,312 (-)Ensembl
ChiLan1.0NW_00495542525,942,341 - 25,961,312 (-)NCBIChiLan1.0ChiLan1.0
HEXB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2440,590,788 - 40,626,533 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1538,744,423 - 38,780,168 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0540,589,448 - 40,625,176 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1541,199,681 - 41,232,693 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl541,199,681 - 41,232,693 (-)EnsemblpanPan2panpan1.1
HEXB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,221,809 - 57,248,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,222,186 - 57,248,417 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha254,199,623 - 54,228,736 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0257,746,022 - 57,775,171 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,745,874 - 57,775,170 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1254,810,104 - 54,839,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0255,573,246 - 55,602,349 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0256,470,393 - 56,499,556 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hexb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213188,915,295 - 188,940,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365491,917,327 - 1,943,691 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365491,918,482 - 1,943,665 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEXB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl283,744,627 - 83,784,759 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1283,745,263 - 83,784,762 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2285,331,866 - 85,371,568 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEXB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1469,037,532 - 69,065,925 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl469,037,583 - 69,065,814 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604917,815,486 - 17,843,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hexb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624924195,175 - 219,278 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624924195,406 - 219,232 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hexb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13199,427,021 - 199,447,139 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hexb
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:18
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000048554
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH127734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2228,487,833 - 28,488,039 (+)MAPPERmRatBN7.2
Rnor_6.0227,987,762 - 27,987,967NCBIRnor6.0
Rnor_5.0247,098,651 - 47,098,856UniSTSRnor5.0
RGSC_v3.4227,653,025 - 27,653,230UniSTSRGSC3.4
Celera224,529,758 - 24,529,963UniSTS
RH 3.4 Map231.5UniSTS
Cytogenetic Map2q12UniSTS
RH139614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2228,485,225 - 28,485,408 (+)MAPPERmRatBN7.2
Rnor_6.0227,985,154 - 27,985,336NCBIRnor6.0
Rnor_5.0247,096,043 - 47,096,225UniSTSRnor5.0
RGSC_v3.4227,650,417 - 27,650,599UniSTSRGSC3.4
Celera224,527,150 - 24,527,332UniSTS
RH 3.4 Map230.3UniSTS
Cytogenetic Map2q12UniSTS
RH140471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2228,485,225 - 28,485,331 (+)MAPPERmRatBN7.2
Rnor_6.0227,985,154 - 27,985,259NCBIRnor6.0
Rnor_5.0247,096,043 - 47,096,148UniSTSRnor5.0
RGSC_v3.4227,650,417 - 27,650,522UniSTSRGSC3.4
Celera224,527,150 - 24,527,255UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000048554   ⟹   ENSRNOP00000044480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl230,218,608 - 30,238,771 (-)Ensembl
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)Ensembl
Rnor_6.0 Ensembl227,984,117 - 28,003,186 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094603   ⟹   ENSRNOP00000085758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl230,218,608 - 30,238,771 (-)Ensembl
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094954   ⟹   ENSRNOP00000081466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl230,218,608 - 30,238,771 (-)Ensembl
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097138   ⟹   ENSRNOP00000081104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl230,218,608 - 30,238,771 (-)Ensembl
mRatBN7.2 Ensembl228,484,012 - 28,504,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152047   ⟹   ENSRNOP00000102325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl230,218,608 - 30,238,771 (-)Ensembl
RefSeq Acc Id: NM_001011946   ⟹   NP_001011946
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8230,218,608 - 30,238,771 (-)NCBI
mRatBN7.2228,483,997 - 28,504,165 (-)NCBI
Rnor_6.0227,983,925 - 28,003,260 (-)NCBI
Rnor_5.0247,094,814 - 47,114,992 (-)NCBI
RGSC_v3.4227,649,188 - 27,672,231 (-)RGD
Celera224,525,921 - 24,545,955 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001011946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79376 (Get FASTA)   NCBI Sequence Viewer  
  EDM10131 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081104
  ENSRNOP00000081104.1
GenBank Protein Q6AXR4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011946   ⟸   NM_001011946
- Peptide Label: precursor
- UniProtKB: Q6AXR4 (UniProtKB/Swiss-Prot),   A6I523 (UniProtKB/TrEMBL),   F1LR87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044480   ⟸   ENSRNOT00000048554
Ensembl Acc Id: ENSRNOP00000081466   ⟸   ENSRNOT00000094954
Ensembl Acc Id: ENSRNOP00000081104   ⟸   ENSRNOT00000097138
Ensembl Acc Id: ENSRNOP00000085758   ⟸   ENSRNOT00000094603
Ensembl Acc Id: ENSRNOP00000102325   ⟸   ENSRNOT00000152047
Protein Domains
Beta-hexosaminidase eukaryotic type N-terminal   Glycoside hydrolase family 20 catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXR4-F1-model_v2 AlphaFold Q6AXR4 1-537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691087
Promoter ID:EPDNEW_R1612
Type:initiation region
Name:Hexb_1
Description:hexosaminidase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0228,003,257 - 28,003,317EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307607 AgrOrtholog
BioCyc Gene G2FUF-54761 BioCyc
BioCyc Pathway PWY-6902 [chitin degradation II (Vibrio)] BioCyc
BioCyc Pathway Image PWY-6902 BioCyc
Ensembl Genes ENSRNOG00000025274 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000097138 ENTREZGENE
  ENSRNOT00000097138.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.379.10 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110247 IMAGE-MGC_LOAD
InterPro Beta_hexosaminidase_sua/sub UniProtKB/Swiss-Prot
  Glyco_hydro_20_cat UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Hex-like_dom2 UniProtKB/Swiss-Prot
  HEX_eukaryotic_N UniProtKB/Swiss-Prot
KEGG Report rno:294673 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94872 IMAGE-MGC_LOAD
NCBI Gene 294673 ENTREZGENE
PANTHER BETA-HEXOSAMINIDASE SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR22600 UniProtKB/Swiss-Prot
Pfam Glyco_hydro_20 UniProtKB/Swiss-Prot
  Glycohydro_20b2 UniProtKB/Swiss-Prot
PhenoGen Hexb PhenoGen
PIRSF B-hxosamndse_ab_euk_ UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE20 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025274 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
  SSF55545 UniProtKB/Swiss-Prot
UniProt A0A8I5ZT00_RAT UniProtKB/TrEMBL
  A0A8I6A2C4_RAT UniProtKB/TrEMBL
  A0ABK0LK99_RAT UniProtKB/TrEMBL
  A6I523 ENTREZGENE, UniProtKB/TrEMBL
  F1LR87 ENTREZGENE, UniProtKB/TrEMBL
  HEXB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Hexb  hexosaminidase subunit beta  Hexb  hexosaminidase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hexb  hexosaminidase B  Hexb_predicted  hexosaminidase B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hexb_predicted  hexosaminidase B (predicted)      Symbol and Name status set to approved 70820 APPROVED