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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307607
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hexb
Name: hexosaminidase subunit beta
Acc ID: CHEBI:63954
Term: ionomycin
Definition: A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
Chemical ID: MESH:D015759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hexbincreases secretionEXP 6480464CTDIonomycin results in increased secretion of HEXB proteinPMID:14499669
Hexbmultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Ionomycin results in increased secretion of HEXB protein]; KN 93 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein]; ML 7 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Ionomycin results in increased secretion of HEXB protein]PMID:14499669
Hexbincreases secretionISOHEXB (Homo sapiens)6480464CTDIonomycin results in increased secretion of HEXB proteinPMID:19758318
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