Hexb (hexosaminidase subunit beta)

Gene: Hexb (hexosaminidase subunit beta) Ictidomys tridecemlineatus

Analyze

Symbol:

Hexb

Name:

hexosaminidase subunit beta

RGD ID:

12466065

Description:

ENCODES a protein that exhibits beta-N-acetylglucosaminidase activity (ortholog); carbohydrate binding (ortholog); hexosaminidase activity (ortholog); INVOLVED IN ganglioside catabolic process (ortholog); glycosaminoglycan metabolic process (ortholog); glycosphingolipid metabolic process (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); COVID-19 (ortholog); genetic disease (ortholog); FOUND IN beta-N-acetylhexosaminidase complex (ortholog); lysosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

beta-hexosaminidase subunit beta

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	188,915,295 - 188,940,491 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	1,917,327 - 1,943,691 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	1,918,482 - 1,943,665 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

COVID-19 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

Sandhoff disease (ISO)

Sandhoff Disease, Adult Type (ISO)

Sandhoff Disease, Infantile Type (ISO)

Sandhoff Disease, Juvenile Type (ISO)

spinal muscular atrophy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte cell migration (IEA)

carbohydrate metabolic process (IEA)

chondroitin sulfate catabolic process (IEA)

dermatan sulfate catabolic process (IEA)

ganglioside catabolic process (IEA,ISO)

glycosaminoglycan metabolic process (IEA,ISO)

glycosphingolipid metabolic process (IEA,ISO)

hyaluronan catabolic process (IEA)

intracellular calcium ion homeostasis (IEA,ISO)

lipid storage (IEA,ISO)

locomotory behavior (IEA,ISO)

lysosome organization (IEA,ISO)

maintenance of location in cell (IEA,ISO)

male courtship behavior (IEA,ISO)

myelination (IEA,ISO)

N-acetylglucosamine metabolic process (ISO)

neuromuscular process (IEA,ISO)

neuromuscular process controlling balance (IEA,ISO)

neuron cellular homeostasis (IEA,ISO)

oligosaccharide catabolic process (IEA,ISO)

oogenesis (IEA,ISO)

penetration of zona pellucida (IEA,ISO)

phospholipid biosynthetic process (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

protein metabolic process (ISO)

regulation of cell shape (IEA)

sensory perception of sound (IEA,ISO)

sexual reproduction (IEA,ISO)

single fertilization (IEA,ISO)

skeletal system development (IEA,ISO)

Cellular Component

acrosomal vesicle (IEA)

azurophil granule (IEA)

beta-N-acetylhexosaminidase complex (IEA,ISO)

cortical granule (IEA)

extracellular space (IEA)

lysosome (IEA,ISO)

membrane (IEA)

Molecular Function

acetylglucosaminyltransferase activity (IEA)

beta-N-acetylglucosaminidase activity (ISO)

beta-N-acetylhexosaminidase activity (IEA)

carbohydrate binding (ISO)

hexosaminidase activity (IEA,ISO)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA)

identical protein binding (IEA,ISO)

N-acetyl-beta-D-galactosaminidase activity (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hexb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	188,915,295 - 188,940,491 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	1,917,327 - 1,943,691 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	1,918,482 - 1,943,665 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HEXB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	74,640,023 - 74,721,288 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	74,640,023 - 74,722,647 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	73,935,848 - 74,017,113 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	74,016,767 - 74,052,869 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	74,016,766 - 74,052,869	NCBI
Celera	5	69,875,759 - 69,911,869 (+)	NCBI		Celera
Cytogenetic Map	5	q13.3	NCBI
HuRef	5	69,185,979 - 69,222,054 (+)	NCBI		HuRef
CHM1_1	5	73,413,670 - 73,449,974 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	75,120,988 - 75,202,190 (+)	NCBI		T2T-CHM13v2.0

Hexb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	97,312,839 - 97,334,865 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	97,312,839 - 97,334,865 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	97,176,331 - 97,198,357 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	97,176,331 - 97,198,357 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	97,946,286 - 97,968,312 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	98,277,106 - 98,298,969 (-)	NCBI		MGSCv36	mm8
Celera	13	100,809,364 - 100,830,755 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	50.66	NCBI

Hexb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	30,218,608 - 30,238,771 (-)	NCBI		GRCr8
mRatBN7.2	2	28,483,997 - 28,504,165 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	28,484,012 - 28,504,223 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	35,537,922 - 35,558,126 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	33,632,260 - 33,652,462 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	28,445,997 - 28,466,169 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	27,983,925 - 28,003,260 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	27,984,117 - 28,003,186 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	47,094,814 - 47,114,992 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	27,649,188 - 27,672,231 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	27,569,557 - 27,592,600 (-)	NCBI
Celera	2	24,525,921 - 24,545,955 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Hexb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	25,942,278 - 25,961,312 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	25,942,341 - 25,961,312 (-)	NCBI	ChiLan1.0	ChiLan1.0

HEXB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	40,590,788 - 40,626,533 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	38,744,423 - 38,780,168 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	40,589,448 - 40,625,176 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	41,199,681 - 41,232,693 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	41,199,681 - 41,232,693 (-)	Ensembl	panpan1.1		panPan2

HEXB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	57,221,809 - 57,248,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	57,222,186 - 57,248,417 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	54,199,623 - 54,228,736 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	57,746,022 - 57,775,171 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	57,745,874 - 57,775,170 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	54,810,104 - 54,839,238 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	55,573,246 - 55,602,349 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	56,470,393 - 56,499,556 (+)	NCBI		UU_Cfam_GSD_1.0

HEXB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	83,744,627 - 83,784,759 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	83,745,263 - 83,784,762 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	85,331,866 - 85,371,568 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HEXB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	69,037,532 - 69,065,925 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	69,037,583 - 69,065,814 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	17,815,486 - 17,843,814 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hexb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624924	195,175 - 219,278 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624924	195,406 - 219,232 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000007908 ⟹ ENSSTOP00000007076

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936549	1,917,327 - 1,943,691 (-)	Ensembl

RefSeq Acc Id:

XM_005328951 ⟹ XP_005329008

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	188,915,295 - 188,940,491 (+)	NCBI
SpeTri2.0	NW_004936549	1,918,482 - 1,943,665 (-)	NCBI

Sequence:

show sequence

TCTTCCCACAAGGCCTGGGCGGGAAGTCAGACCTCTGGACTCCGGCTTAGCAGAGGCTGCGGAC
TGCAGCCCAGCGGCCATGGAGCAGCGCCAGCTATCGCCGCGCGGTTCTGGAAGGCCGGGGCTTC
CGGGGCTTCTTCGGCTGCTGCTGCTGCTGCTGCTGCTGGCGCACACCCCGCGCGCCTTGGTCCA
GCCCGGACCCGCGCTGTGGCCCCTGCCGCTGTCGGTGCAGGATTTCAAGCGCCAGCTGCACCTA
GCCCCCAAGGAATTTTCCATCGGTCACGGCCCCAATTCCACGGCGGGTCCCTCCTGCTCCCTGC
TGCAAGAGGCCTTTCGGCGATACCATGACTATATTTTTGGTCCCTACAAGCAGCAGCGTCGACC
TACTAAATTTAAAACTGGAGCACAATTAAATCAACTTCTTGTCTCAGTTGTCCTTGAGTCAGAG
TGTAATGCTTTCCCCAGTGTGACTTCAGATGAGTCCTATTCTTTACTTGTGCAAGAACCAGTGG
CTGTCCTCAAGGCCAACAGAGTTTGGGGAGTATTGAGAGGTTTAGAGACCTTTAGCCAGCTAGT
TTATGAAGATTCTTTTGGGGCTTTCACCATCAATGAATCCAGCATTGTTGATTCTCCAAGATTT
CCTTATCGAGGTATTTTAATTGATACATCCAGACACTACTTGTCCGTTAAGACTATTCTTAAAA
CTCTGGATGCCATGGCTTTTAATAAGTTTAATGTTCTTCACTGGCACATAGTGGATGACCAGTC
TTTCCCTTATCAGAGCACCACTTTTCCTGAGTTAAGCAATAAAGGAAGCTATTCTTCGTCTCAT
GTTTATACACCAAATGATGTTCATATGGTGATTGAATATGCCCGATTACGAGGGATTCGAATCA
TACCAGAATTTGATAGCCCCGGCCATACAGAGTCTTGGGGAAAAGGTCAGAAAAACCTCCTGAC
TGCATGTTACAGCCCAGAGCAACGTATACAAGGTGTTGGGCCTATTAACCCCACTCTAAATACA
ACTTATGCATTCTTGACTTCAATTTTCACAGAAGTCAGTAAAGTGTTTCCAGATCAGTTCATTC
ATTTGGGAGGAGATGAAGTGAATTTCGAATGTTGGGCATCAAATCCCAAAATCCAAAATTTCAT
GAAGAAAAAAGGCTTTGGTGAAGATTATACAAAACTACAATCTTTCTATATGCTAAAGCTTATG
AATATTATTGCGTCCCTAAACAAAGTACCCATCGTCTGGCAAGAAGTTTTTGATAATAAAGCAC
AGCTTATTCCAGGTACAGTAATTCAAGTGTGGAAAGATTTAAATTATTTTGAGGAATTAAGGCT
CATCACAGCAGCTGGCTTCCCTGTAATCCTTTCTGCTCCTTGGTACTTGGATTGGATTAGTTAT
GGGCAAGATTGGAGAAAATACTATACAGTGGAACCTCTTAATTTCTCAGGTACTGAAAAACAGA
AAAAACTTATCCTTGGTGGAGAAGCATGTCTTTGGGGAGAATATGTGGATGCAACTAACCTTAC
TCCAAGATTATGGCCTCGGGCAAGTGCTGTTGGTGAAAGACTCTGGAGTCGTGGAGATATCAGG
GACCTTGGTGATGCTTATGCTAGACTAACAAGGCACCGCTGCAGAATGGTCAAACGTGGAATAG
AAGCAGAACCGCTGTTTACTGGATATTGTAACCATGAGAACAAGCTGTAACCATGTAAACATGA
GAGAAAAAGACCACAACAATCTGTACTACAATCAACTTGATTTTGAAATCATGTAAATTTTTTG
AAATAAATTATTTTTATGAATCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005329008	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007076.3

RefSeq Acc Id:

XP_005329008 ⟸ XM_005328951

- UniProtKB:

I3MAN0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEQRQLSPRGSGRPGLPGLLRLLLLLLLLAHTPRALVQPGPALWPLPLSVQDFKRQLHLAPKEF
SIGHGPNSTAGPSCSLLQEAFRRYHDYIFGPYKQQRRPTKFKTGAQLNQLLVSVVLESECNAFP
SVTSDESYSLLVQEPVAVLKANRVWGVLRGLETFSQLVYEDSFGAFTINESSIVDSPRFPYRGI
LIDTSRHYLSVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYSSSHVYTPN
DVHMVIEYARLRGIRIIPEFDSPGHTESWGKGQKNLLTACYSPEQRIQGVGPINPTLNTTYAFL
TSIFTEVSKVFPDQFIHLGGDEVNFECWASNPKIQNFMKKKGFGEDYTKLQSFYMLKLMNIIAS
LNKVPIVWQEVFDNKAQLIPGTVIQVWKDLNYFEELRLITAAGFPVILSAPWYLDWISYGQDWR
KYYTVEPLNFSGTEKQKKLILGGEACLWGEYVDATNLTPRLWPRASAVGERLWSRGDIRDLGDA
YARLTRHRCRMVKRGIEAEPLFTGYCNHENKL

hide sequence

RefSeq Acc Id:

ENSSTOP00000007076 ⟸ ENSSTOT00000007908

Protein Domains

Beta-hexosaminidase eukaryotic type N-terminal Glycoside hydrolase family 20 catalytic

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007903	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007908.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.379.10	UniProtKB/TrEMBL
	Glycosidases	UniProtKB/TrEMBL
InterPro	Beta_hexosaminidase_sua/sub	UniProtKB/TrEMBL
	Glyco_hydro_20_cat	UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/TrEMBL
	Hex-like_dom2	UniProtKB/TrEMBL
	HEX_eukaryotic_N	UniProtKB/TrEMBL
NCBI Gene	Hexb	ENTREZGENE
PANTHER	BETA-HEXOSAMINIDASE SUBUNIT BETA	UniProtKB/TrEMBL
	PTHR22600	UniProtKB/TrEMBL
Pfam	Glyco_hydro_20	UniProtKB/TrEMBL
	Glycohydro_20b2	UniProtKB/TrEMBL
PIRSF	B-hxosamndse_ab_euk	UniProtKB/TrEMBL
PRINTS	GLHYDRLASE20	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51445	UniProtKB/TrEMBL
	SSF55545	UniProtKB/TrEMBL
UniProt	I3MAN0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - CTD

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