Dkk1 (dickkopf WNT signaling pathway inhibitor 1) - Rat Genome Database

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Gene: Dkk1 (dickkopf WNT signaling pathway inhibitor 1) Rattus norvegicus
Analyze
Symbol: Dkk1
Name: dickkopf WNT signaling pathway inhibitor 1
RGD ID: 1307313
Description: Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and regulation of neuron apoptotic process. Located in extracellular space. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dickkopf 1 homolog; dickkopf 1 homolog (Xenopus laevis); dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf-like protein 1; dickkopf-related protein 1; LOC293897; NEWGENE_1307313
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,794,969 - 237,798,650 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,794,969 - 237,798,650 (-)EnsemblGRCr8
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,756,597 - 236,760,287 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,686,298 - 243,689,990 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,516,916 - 236,520,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)Ensemblrn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,4-benzoquinone  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzamides  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
Bufotalin  (ISO)
buserelin  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chitosan  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyanidin cation  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethosuximide  (EXP,ISO)
finasteride  (ISO)
flavonoids  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
Harpagoside  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Icaritin  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
molibresib  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
neohesperidin  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
p-anisidine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
endoderm development  (ISO)
endoderm formation  (ISO)
face morphogenesis  (ISO)
forebrain development  (ISO)
hair follicle development  (ISO)
head morphogenesis  (ISO)
heart induction  (IEA,ISO)
learning or memory  (IEA,ISO)
limb development  (IEA,ISO)
mesoderm formation  (ISO)
motor learning  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of ossification  (IEA,IMP,ISO)
negative regulation of presynapse assembly  (IEA,ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of midbrain dopaminergic neuron differentiation  (IEA,ISO)
regulation of endodermal cell fate specification  (ISO)
regulation of neuron apoptotic process  (IGI)
regulation of receptor internalization  (ISO)
regulation of synapse organization  (IEA,ISO)
regulation of synaptic transmission, glutamatergic  (IEA,ISO)
regulation of Wnt signaling pathway  (ISO)
response to retinoic acid  (ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. Busceti CL, etal., Epilepsia. 2007 Apr;48(4):694-705.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Hie M, etal., Int J Mol Med. 2011 Sep;28(3):455-62. doi: 10.3892/ijmm.2011.697. Epub 2011 May 11.
5. Clusterin regulates ß-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Killick R, etal., Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.
6. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
7. Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury. Li X, etal., J Bone Miner Res. 2011 Nov;26(11):2610-21. doi: 10.1002/jbmr.472.
8. Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. Lin CL, etal., J Am Soc Nephrol. 2010 Jan;21(1):124-35. Epub 2009 Dec 17.
9. A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population. Liu H, etal., Eur J Oral Sci. 2012 Oct;120(5):378-85. doi: 10.1111/j.1600-0722.2012.00986.x. Epub 2012 Aug 18.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C Oncogene. 2006 Dec 4;25(57):7469-81.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Weng LH, etal., Arthritis Rheum. 2010 May;62(5):1393-402.
16. Dynamic expression of DKK1 protein in the process whereby Epimedium-derived flavonoids up-regulate osteogenic and down-regulate adipogenic differentiation of bone marrow stromal cells in ovariectomized rats. Xu YX, etal., Orthop Surg. 2011 May;3(2):119-26. doi: 10.1111/j.1757-7861.2011.00129.x.
Additional References at PubMed
PMID:11433302   PMID:11448771   PMID:11742004   PMID:12857724   PMID:15020244   PMID:15143170   PMID:15242796   PMID:16126904   PMID:16263759   PMID:16682203   PMID:16753024   PMID:16805831  
PMID:17027228   PMID:17055793   PMID:17064353   PMID:17127040   PMID:17128274   PMID:17360443   PMID:17699607   PMID:17804636   PMID:17804805   PMID:18044981   PMID:18166153   PMID:18174290  
PMID:18257070   PMID:18297060   PMID:18403408   PMID:18462699   PMID:18505732   PMID:18505822   PMID:18716201   PMID:19850024   PMID:19850029   PMID:20039315   PMID:20093360   PMID:20160075  
PMID:20383322   PMID:20559569   PMID:20723538   PMID:21347250   PMID:21540552   PMID:22133691   PMID:22399772   PMID:22615920   PMID:22902902   PMID:23152495   PMID:23164620   PMID:25318560  
PMID:26206087   PMID:26351298   PMID:27277008   PMID:27353797   PMID:28332284   PMID:28807065   PMID:29472591   PMID:29643768   PMID:33172955   PMID:35691117   PMID:37108841   PMID:37859694  
PMID:38597273  


Genomics

Comparative Map Data
Dkk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,794,969 - 237,798,650 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,794,969 - 237,798,650 (-)EnsemblGRCr8
mRatBN7.21228,381,521 - 228,385,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,756,597 - 236,760,287 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,686,298 - 243,689,990 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,516,916 - 236,520,591 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,952,896 - 248,956,579 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)Ensemblrn6Rnor6.0
Rnor_5.01256,133,073 - 256,136,756 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,392,743 - 234,396,426 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1225,519,220 - 225,522,904 (-)NCBICelera
Cytogenetic Map1q52NCBI
DKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381052,314,281 - 52,317,657 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1052,314,281 - 52,318,042 (+)Ensemblhg38GRCh38
GRCh371054,074,041 - 54,077,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361053,744,047 - 53,747,423 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341053,744,083 - 53,747,149NCBI
Celera1047,337,087 - 47,340,463 (+)NCBICelera
Cytogenetic Map10q21.1NCBI
HuRef1048,051,883 - 48,055,259 (+)NCBIHuRef
CHM1_11054,355,855 - 54,359,231 (+)NCBICHM1_1
T2T-CHM13v2.01053,160,859 - 53,164,235 (+)NCBIT2T-CHM13v2.0
Dkk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,523,276 - 30,526,896 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,523,263 - 30,527,065 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381930,545,876 - 30,549,496 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,545,863 - 30,549,665 (-)Ensemblmm10GRCm38
MGSCv371930,620,366 - 30,623,986 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361930,611,873 - 30,615,493 (-)NCBIMGSCv36mm8
Celera1931,330,434 - 31,334,040 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.16NCBI
Dkk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554257,353,964 - 7,357,599 (+)NCBIChiLan1.0ChiLan1.0
DKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2864,610,223 - 64,613,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11064,615,691 - 64,619,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01048,950,704 - 48,953,815 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11051,084,963 - 51,088,424 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1051,084,027 - 51,089,776 (+)EnsemblpanPan2panpan1.1
DKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,697,428 - 35,701,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,697,618 - 35,701,496 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2635,582,535 - 35,586,059 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02637,227,528 - 37,231,046 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,228,230 - 37,231,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,133,162 - 35,136,678 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,718,578 - 34,722,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,960,801 - 35,964,325 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dkk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,285,796 - 75,288,505 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787306,941 - 310,166 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936787307,290 - 309,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,487,226 - 97,490,288 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11497,487,854 - 97,490,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,115,155 - 106,117,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,836,803 - 78,840,158 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl978,835,162 - 78,840,146 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604839,790,339 - 39,794,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dkk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,313,142 - 11,315,982 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479111,313,139 - 11,316,998 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dkk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1230,663,645 - 30,667,426 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dkk1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:81
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000015771
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
BE117992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,387,043 - 228,387,210 (+)MAPPERmRatBN7.2
Rnor_6.01248,958,421 - 248,958,587NCBIRnor6.0
Rnor_6.01248,900,417 - 248,900,583NCBIRnor6.0
Rnor_5.01256,197,449 - 256,197,615UniSTSRnor5.0
Rnor_5.01256,138,598 - 256,138,764UniSTSRnor5.0
RGSC_v3.41234,398,268 - 234,398,434UniSTSRGSC3.4
Celera1225,524,746 - 225,524,912UniSTS
RH 3.4 Map11619.8UniSTS
Cytogenetic Map1q52UniSTS
UniSTS:498426  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81237,796,495 - 237,796,556 (+)Marker Load Pipeline
mRatBN7.21228,383,046 - 228,383,108 (+)MAPPERmRatBN7.2
Rnor_6.01248,896,420 - 248,896,481NCBIRnor6.0
Rnor_6.01248,954,424 - 248,954,485NCBIRnor6.0
Rnor_5.01256,193,452 - 256,193,513UniSTSRnor5.0
Rnor_5.01256,134,601 - 256,134,662UniSTSRnor5.0
RGSC_v3.41234,394,271 - 234,394,332UniSTSRGSC3.4
Celera1225,520,749 - 225,520,810UniSTS
Cytogenetic Map1q52UniSTS
UniSTS:498746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,383,396 - 228,384,384 (+)MAPPERmRatBN7.2
Rnor_6.01248,954,774 - 248,955,761NCBIRnor6.0
Rnor_6.01248,896,770 - 248,897,757NCBIRnor6.0
Rnor_5.01256,134,951 - 256,135,938UniSTSRnor5.0
Rnor_5.01256,193,802 - 256,194,789UniSTSRnor5.0
RGSC_v3.41234,394,621 - 234,395,608UniSTSRGSC3.4
Celera1225,521,099 - 225,522,086UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 1 22 72 12 15 10 1 10 118 34 11 67 67 38 5 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000015771   ⟹   ENSRNOP00000015771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1248,954,244 - 248,956,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074393   ⟹   ENSRNOP00000064286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1237,794,969 - 237,798,650 (-)Ensembl
mRatBN7.2 Ensembl1228,381,521 - 228,385,202 (-)Ensembl
Rnor_6.0 Ensembl1248,895,738 - 248,898,607 (-)Ensembl
RefSeq Acc Id: NM_001106350   ⟹   NP_001099820
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,794,969 - 237,798,650 (-)NCBI
mRatBN7.21228,381,521 - 228,385,202 (-)NCBI
Rnor_6.01248,952,896 - 248,956,579 (-)NCBI
Rnor_5.01256,133,073 - 256,136,756 (-)NCBI
RGSC_v3.41234,392,743 - 234,396,426 (-)RGD
Celera1225,519,220 - 225,522,904 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFI61655 (Get FASTA)   NCBI Sequence Viewer  
  EDM13121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064286
  ENSRNOP00000064286.1
RefSeq Acc Id: NP_001099820   ⟸   NM_001106350
- Peptide Label: precursor
- UniProtKB: D3Z9J1 (UniProtKB/TrEMBL),   A6I0Z0 (UniProtKB/TrEMBL),   M0R4J9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064286   ⟸   ENSRNOT00000074393
Ensembl Acc Id: ENSRNOP00000015771   ⟸   ENSRNOT00000015771
Protein Domains
Dickkopf N-terminal cysteine-rich   Dickkopf-related protein 1/2/4 C-terminal subdomain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9J1-F1-model_v2 AlphaFold D3Z9J1 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307313 AgrOrtholog
BioCyc Gene G2FUF-55938 BioCyc
Ensembl Genes ENSRNOG00000011692 Ensembl
  ENSRNOG00000048688 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074393 ENTREZGENE
  ENSRNOT00000074393.4 UniProtKB/TrEMBL
Gene3D-CATH Lipase, subunit A UniProtKB/TrEMBL
InterPro Dickkopf_N UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom1 UniProtKB/TrEMBL
  DIKK1/2/4_C-subdom2 UniProtKB/TrEMBL
  DKK-like UniProtKB/TrEMBL
  Dkk1_Cys2 UniProtKB/TrEMBL
  Dkk1_N UniProtKB/TrEMBL
KEGG Report rno:293897 UniProtKB/TrEMBL
NCBI Gene 293897 ENTREZGENE
PANTHER DICKKOPF-RELATED PROTEIN 1 UniProtKB/TrEMBL
  PTHR12113 UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom1 UniProtKB/TrEMBL
  DIKK1-2-4_C-subdom2 UniProtKB/TrEMBL
PhenoGen Dkk1 PhenoGen
RatGTEx ENSRNOG00000011692 RatGTEx
  ENSRNOG00000048688 RatGTEx
UniProt A6I0Z0 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9J1 ENTREZGENE
  M0R4J9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3Z9J1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dkk1  dickkopf WNT signaling pathway inhibitor 1  NEWGENE_1307313  dickkopf WNT signaling pathway inhibitor 1  Data merged from RGD:11410606 737654 PROVISIONAL
2016-08-02 NEWGENE_1307313  dickkopf WNT signaling pathway inhibitor 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-22 Dkk1  dickkopf WNT signaling pathway inhibitor 1  Dkk1  dickkopf 1 homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-06 Dkk1  dickkopf 1 homolog (Xenopus laevis)  Dkk1  dickkopf homolog 1 (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dkk1  dickkopf homolog 1 (Xenopus laevis)   Dkk1_predicted  dickkopf homolog 1 (Xenopus laevis) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dkk1_predicted  dickkopf homolog 1 (Xenopus laevis) (predicted)      Symbol and Name status set to approved 70820 APPROVED