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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307313 Species: Rattus norvegicus RGD Object: Gene Symbol: Dkk1 Name: dickkopf 1 homolog (Xenopus laevis)

Acc ID: CHEBI:17026 Term: progesterone Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. CasRN: 57-83-0 Chemical ID: MESH:D011374

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1316435	6480464	CTD	Mifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 mRNA] Mifepristone inhibits the reaction [Progesterone results in increased expression of DKK1 protein]	PMID:16449346
multiple interactions	ISO	RGD:1316435	6480464	CTD	[Progesterone co-treated with Estradiol] results in increased expression of DKK1 mRNA	PMID:17404688
increases expression	ISO	RGD:1316435	6480464	CTD	Progesterone results in increased expression of DKK1 mRNA	PMID:17404688 PMID:16449346
increases expression	ISO	RGD:1316435	6480464	CTD	Progesterone results in increased expression of DKK1 protein	PMID:16449346
increases expression	ISO	RGD:1316435	6480464	CTD	Progesterone results in increased expression of DKK1 mRNA	PMID:16449346 PMID:17404688