Manf (mesencephalic astrocyte-derived neurotrophic factor) - Rat Genome Database

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Gene: Manf (mesencephalic astrocyte-derived neurotrophic factor) Rattus norvegicus
Analyze
Symbol: Manf
Name: mesencephalic astrocyte-derived neurotrophic factor
RGD ID: 1307252
Description: Predicted to enable sulfatide binding activity. Predicted to be involved in ATF6-mediated unfolded protein response; neuron differentiation; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Located in extracellular space and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arginine-rich protein; arginine-rich, mutated in early stage tumors; Armet; LOC315989
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,427,053 - 116,430,259 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,427,048 - 116,429,910 (-)EnsemblGRCr8
mRatBN7.28107,500,856 - 107,551,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,548,352 - 107,551,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,172,000 - 113,175,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,371,174 - 111,374,380 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,213,953 - 109,217,159 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,623,175 - 115,626,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,623,178 - 115,626,380 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,982,000 - 114,985,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,111,358 - 112,113,311 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,861,528 - 106,863,481 (-)NCBICelera
RGSC_v3.18112,129,534 - 112,132,760 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketamine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quinolin-8-ol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. Piepoli A, etal., World J Gastroenterol. 2006 Oct 21;12(39):6343-8.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Shridhar R, etal., Cancer Res. 1996 Dec 15;56(24):5576-8.
7. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Shridhar V, etal., Oncogene. 1996 May 2;12(9):1931-9.
8. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. Shridhar V, etal., Oncogene. 1997 May 8;14(18):2213-6.
9. Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease. Voutilainen MH, etal., J Neurosci. 2009 Jul 29;29(30):9651-9.
10. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. Yu YQ, etal., J Cereb Blood Flow Metab. 2010 Jan;30(1):79-91. Epub 2009 Sep 23.
Additional References at PubMed
PMID:12477932   PMID:16854843   PMID:18718866   PMID:21047780   PMID:21630459   PMID:22637475   PMID:22658674   PMID:23173607   PMID:23255601   PMID:24587361   PMID:29497057   PMID:30211660  
PMID:32613670   PMID:32757264   PMID:38159526  


Genomics

Comparative Map Data
Manf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,427,053 - 116,430,259 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,427,048 - 116,429,910 (-)EnsemblGRCr8
mRatBN7.28107,500,856 - 107,551,595 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,548,352 - 107,551,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,172,000 - 113,175,206 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,371,174 - 111,374,380 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,213,953 - 109,217,159 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,623,175 - 115,626,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,623,178 - 115,626,380 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,982,000 - 114,985,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,111,358 - 112,113,311 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,861,528 - 106,863,481 (-)NCBICelera
RGSC_v3.18112,129,534 - 112,132,760 (-)NCBI
Cytogenetic Map8q32NCBI
MANF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38351,385,291 - 51,389,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl351,385,291 - 51,389,397 (+)Ensemblhg38GRCh38
GRCh37351,422,722 - 51,426,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,397,743 - 51,401,815 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34351,397,742 - 51,401,815NCBI
Celera351,397,046 - 51,401,182 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef351,479,919 - 51,484,055 (+)NCBIHuRef
CHM1_1351,374,600 - 51,378,736 (+)NCBICHM1_1
T2T-CHM13v2.0351,415,711 - 51,419,814 (+)NCBIT2T-CHM13v2.0
Manf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,765,952 - 106,769,137 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,715,511 - 106,769,178 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389106,888,753 - 106,891,938 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,838,312 - 106,891,979 (-)Ensemblmm10GRCm38
MGSCv379106,789,746 - 106,794,269 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369106,746,862 - 106,750,016 (-)NCBIMGSCv36mm8
Celera9106,511,559 - 106,516,080 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.98NCBI
Manf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,075,110 - 3,079,116 (+)Ensembl
ChiLan1.0NW_0049555323,075,195 - 3,077,505 (+)NCBIChiLan1.0ChiLan1.0
MANF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2251,370,135 - 51,374,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1351,374,946 - 51,379,034 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,315,948 - 51,320,022 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1352,550,244 - 52,554,343 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl352,548,933 - 52,554,343 (+)EnsemblpanPan2panpan1.1
MANF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,196,427 - 38,200,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,196,425 - 38,199,992 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2038,175,958 - 38,179,630 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02038,545,266 - 38,548,938 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,545,264 - 38,548,831 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,908,655 - 37,912,327 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,312,971 - 38,316,644 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,602,609 - 38,606,281 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Manf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,014,123 - 66,017,463 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,774,543 - 2,779,579 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,774,651 - 2,777,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MANF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,658,255 - 33,662,261 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11333,658,279 - 33,662,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,895,330 - 36,899,269 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MANF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12212,725,718 - 12,730,377 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2212,726,308 - 12,730,587 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041154,236,667 - 154,240,774 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Manf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247305,165,200 - 5,168,240 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247305,165,169 - 5,168,240 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Manf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,204,432 - 98,207,654 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Manf
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000019107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH129214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,548,385 - 107,548,535 (+)MAPPERmRatBN7.2
Rnor_6.08115,623,206 - 115,623,355NCBIRnor6.0
Rnor_5.08114,982,036 - 114,982,185UniSTSRnor5.0
RGSC_v3.48112,110,109 - 112,110,258UniSTSRGSC3.4
Celera8106,860,279 - 106,860,428UniSTS
Cytogenetic Map8q32UniSTS
D17914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,548,389 - 107,548,542 (+)MAPPERmRatBN7.2
Rnor_6.08115,623,210 - 115,623,362NCBIRnor6.0
Rnor_5.08114,982,040 - 114,982,192UniSTSRnor5.0
RGSC_v3.48112,110,113 - 112,110,265UniSTSRGSC3.4
Celera8106,860,283 - 106,860,435UniSTS
Cytogenetic Map8q32UniSTS
RH125717  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88116,427,084 - 116,427,229 (+)Marker Load Pipeline
mRatBN7.28107,548,388 - 107,548,534 (+)MAPPERmRatBN7.2
Rnor_6.08115,623,209 - 115,623,354NCBIRnor6.0
Rnor_5.08114,982,039 - 114,982,184UniSTSRnor5.0
RGSC_v3.48112,110,112 - 112,110,257UniSTSRGSC3.4
Celera8106,860,282 - 106,860,427UniSTS
Cytogenetic Map8q32UniSTS
AI144800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,552,421 - 107,552,528 (+)MAPPERmRatBN7.2
Rnor_6.08115,627,242 - 115,627,348NCBIRnor6.0
Rnor_5.08114,986,072 - 114,986,178UniSTSRnor5.0
RGSC_v3.48112,114,145 - 112,114,251UniSTSRGSC3.4
Celera8106,864,315 - 106,864,421UniSTS
RH 3.4 Map81138.0UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019107   ⟹   ENSRNOP00000019107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,427,048 - 116,429,910 (-)Ensembl
mRatBN7.2 Ensembl8107,548,352 - 107,551,438 (-)Ensembl
Rnor_6.0 Ensembl8115,623,178 - 115,626,380 (-)Ensembl
RefSeq Acc Id: NM_001401064   ⟹   NP_001387993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,427,053 - 116,430,259 (-)NCBI
mRatBN7.28107,548,357 - 107,551,563 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387993 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66980 (Get FASTA)   NCBI Sequence Viewer  
  EDL77266 (Get FASTA)   NCBI Sequence Viewer  
  EDL77267 (Get FASTA)   NCBI Sequence Viewer  
  EDL77268 (Get FASTA)   NCBI Sequence Viewer  
  P0C5H9 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000019107   ⟸   ENSRNOT00000019107
RefSeq Acc Id: NP_001387993   ⟸   NM_001401064
- Peptide Label: precursor
- UniProtKB: P0C5H9 (UniProtKB/Swiss-Prot),   A0A8L2Q9K9 (UniProtKB/TrEMBL),   B2RZ09 (UniProtKB/TrEMBL)
Protein Domains
ARMET C-terminal   ARMET N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C5H9-F1-model_v2 AlphaFold P0C5H9 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696262
Promoter ID:EPDNEW_R6787
Type:initiation region
Name:Manf_1
Description:mesencephalic astrocyte-derived neurotrophic factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08115,626,383 - 115,626,443EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307252 AgrOrtholog
BioCyc Gene G2FUF-29221 BioCyc
Ensembl Genes ENSRNOG00000014201 Ensembl
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot
  Saposin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7318164 IMAGE-MGC_LOAD
InterPro ARMET-like UniProtKB/Swiss-Prot
  ARMET_N UniProtKB/Swiss-Prot
  Armet_prot UniProtKB/Swiss-Prot
  SAP_dom_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:189069 IMAGE-MGC_LOAD
NCBI Gene 315989 ENTREZGENE
PANTHER MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR UniProtKB/Swiss-Prot
  PTHR12990 UniProtKB/Swiss-Prot
Pfam Armet UniProtKB/Swiss-Prot
  ARMET_N UniProtKB/Swiss-Prot
PhenoGen Manf PhenoGen
RatGTEx ENSRNOG00000014201 RatGTEx
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot
UniProt A0A8L2Q9K9 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ09 ENTREZGENE, UniProtKB/TrEMBL
  MANF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-20 Manf  mesencephalic astrocyte-derived neurotrophic factor  Armet  arginine-rich, mutated in early stage tumors  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Armet  arginine-rich, mutated in early stage tumors   Armet_predicted  arginine-rich, mutated in early stage tumors (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Armet_predicted  arginine-rich, mutated in early stage tumors (predicted)      Symbol and Name status set to approved 70820 APPROVED