Nfkb2 (nuclear factor kappa B subunit 2) - Rat Genome Database

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Gene: Nfkb2 (nuclear factor kappa B subunit 2) Rattus norvegicus
Analyze
Symbol: Nfkb2
Name: nuclear factor kappa B subunit 2
RGD ID: 1307189
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cytokine and response to lipopolysaccharide. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Bcl3/NF-kappaB2 complex. Predicted to be active in cytoplasm and nucleus. Used to study Parkinsonism. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2); PARTICIPATES IN adenosine signaling pathway; interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC309452; MGC93816; nuclear factor NF-kappa-B p100 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; RGD1307189; similar to nuclear factor kappa B subunit p100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,106,010 - 255,114,649 (+)NCBIGRCr8
mRatBN7.21245,164,586 - 245,173,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,288,361 - 253,294,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,983,048 - 259,989,300 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,634,805 - 252,641,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,050,634 - 266,059,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,481,574 - 273,490,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,521,559 - 251,527,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,784,632 - 251,790,888 (+)NCBI
Celera1240,949,824 - 240,956,078 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
anthracene  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
famotidine  (ISO)
fenamidone  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
MeIQx  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Bcl3/NF-kappaB2 complex  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
2. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
3. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
4. The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats. Cao JP, etal., Brain Res Bull. 2008 Jul 30;76(5):505-11. Epub 2008 Apr 9.
5. The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. Droebner K, etal., Viral Immunol. 2010 Jun;23(3):295-308. doi: 10.1089/vim.2009.0101.
6. Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression. Frier BC, etal., Cell Stress Chaperones. 2008 Jul 17.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
10. The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB. Lee JK, etal., Life Sci. 2003 Jun 20;73(5):595-609.
11. Age-dependent modulation of NF-kappaB expression in rat adrenal gland. Medicherla R, etal., Mech Ageing Dev. 2002 May;123(9):1211-27.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
Additional References at PubMed
PMID:8360178   PMID:9407099   PMID:10402669   PMID:10586052   PMID:12477932   PMID:12835724   PMID:15677444   PMID:18703048   PMID:23564451   PMID:23583643   PMID:26824492  


Genomics

Comparative Map Data
Nfkb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,106,010 - 255,114,649 (+)NCBIGRCr8
mRatBN7.21245,164,586 - 245,173,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,288,361 - 253,294,615 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,983,048 - 259,989,300 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,634,805 - 252,641,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,050,634 - 266,059,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,481,574 - 273,490,218 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,521,559 - 251,527,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,784,632 - 251,790,888 (+)NCBI
Celera1240,949,824 - 240,956,078 (+)NCBICelera
Cytogenetic Map1q54NCBI
NFKB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,394,110 - 102,402,529 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,394,110 - 102,402,524 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,153,867 - 104,162,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,144,219 - 104,152,271 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410104,145,452 - 104,152,257NCBI
Celera1097,895,118 - 97,903,169 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,787,077 - 97,795,460 (+)NCBIHuRef
CHM1_110104,437,286 - 104,445,707 (+)NCBICHM1_1
T2T-CHM13v2.010103,279,058 - 103,287,478 (+)NCBIT2T-CHM13v2.0
Nfkb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,285,478 - 46,300,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,292,759 - 46,300,824 (+)EnsemblGRCm39 Ensembl
GRCm381946,300,994 - 46,312,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,304,320 - 46,312,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,379,227 - 46,386,580 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,358,929 - 46,365,401 (+)NCBIMGSCv36mm8
Celera1947,067,972 - 47,075,305 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.8NCBI
Nfkb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,994,874 - 8,000,444 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,994,730 - 8,001,776 (-)NCBIChiLan1.0ChiLan1.0
NFKB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,278,824 - 114,290,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,284,119 - 114,295,805 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,997,604 - 99,006,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,463,503 - 102,471,907 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,463,503 - 102,471,907 (+)Ensemblpanpan1.1panPan2
NFKB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,902,212 - 14,910,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,902,706 - 14,910,395 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,075,041 - 15,082,885 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,376,710 - 15,384,554 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,376,790 - 15,384,554 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,921,754 - 14,929,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,960,852 - 14,968,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,093,467 - 15,101,311 (+)NCBIUU_Cfam_GSD_1.0
Nfkb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,861,791 - 31,868,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,465,162 - 3,471,205 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,465,016 - 3,471,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,406,004 - 113,414,169 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,406,412 - 113,414,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,260,742 - 123,270,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFKB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,426,193 - 95,434,560 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,427,785 - 95,434,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,531,952 - 56,540,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,803,917 - 1,810,187 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,804,050 - 1,810,309 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkb2
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:68
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000026235
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026235   ⟹   ENSRNOP00000026235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)Ensembl
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103016   ⟹   ENSRNOP00000080319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)Ensembl
RefSeq Acc Id: NM_001008349   ⟹   NP_001008350
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,108,374 - 255,114,628 (+)NCBI
mRatBN7.21245,166,950 - 245,173,204 (+)NCBI
Rnor_6.01266,053,002 - 266,059,256 (+)NCBI
Rnor_5.01273,481,574 - 273,490,218 (+)NCBI
RGSC_v3.41251,521,559 - 251,527,815 (+)RGD
Celera1240,949,824 - 240,956,078 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231503   ⟹   XP_006231565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,106,010 - 255,114,649 (+)NCBI
mRatBN7.21245,164,586 - 245,173,225 (+)NCBI
Rnor_6.01266,050,634 - 266,059,277 (+)NCBI
Rnor_5.01273,481,574 - 273,490,218 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008350 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231565 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85800 (Get FASTA)   NCBI Sequence Viewer  
  EDL94341 (Get FASTA)   NCBI Sequence Viewer  
  EDL94342 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026235.2
  ENSRNOP00000080319.1
RefSeq Acc Id: NP_001008350   ⟸   NM_001008349
- UniProtKB: Q5U2Z4 (UniProtKB/TrEMBL),   A6JHL8 (UniProtKB/TrEMBL),   A0A8I6G6F3 (UniProtKB/TrEMBL),   A6JHL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231565   ⟸   XM_006231503
- Peptide Label: isoform X1
- UniProtKB: Q5U2Z4 (UniProtKB/TrEMBL),   A6JHL8 (UniProtKB/TrEMBL),   A0A8I6G6F3 (UniProtKB/TrEMBL),   A6JHL7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026235   ⟸   ENSRNOT00000026235
Ensembl Acc Id: ENSRNOP00000080319   ⟸   ENSRNOT00000103016
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2Z4-F1-model_v2 AlphaFold Q5U2Z4 1-898 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690960
Promoter ID:EPDNEW_R1485
Type:initiation region
Name:Nfkb2_1
Description:nuclear factor kappa B subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01266,053,002 - 266,053,062EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307189 AgrOrtholog
BioCyc Gene G2FUF-55518 BioCyc
Ensembl Genes ENSRNOG00000019311 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026235.4 UniProtKB/TrEMBL
  ENSRNOT00000103016.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110486 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NF_Rel_dor UniProtKB/TrEMBL
  NFkB_p100 UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:309452 UniProtKB/TrEMBL
MGC_CLONE MGC:93816 IMAGE-MGC_LOAD
NCBI Gene 309452 ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF21 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Nfkb2 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
  NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019311 RatGTEx
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  IPT UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  DEATH_like UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A8I6G6F3 ENTREZGENE, UniProtKB/TrEMBL
  A6JHL7 ENTREZGENE, UniProtKB/TrEMBL
  A6JHL8 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2Z4 ENTREZGENE
UniProt Secondary Q5U2Z4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nfkb2  nuclear factor kappa B subunit 2  Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2  Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100  RGD1307189  similar to nuclear factor kappa B subunit p100  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307189  similar to nuclear factor kappa B subunit p100  RGD1307189_predicted  similar to nuclear factor kappa B subunit p100 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307189_predicted  similar to nuclear factor kappa B subunit p100 (predicted)  LOC309452_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC309452_predicted  similar to nuclear factor kappa B subunit p100 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL