Gene: NFKB2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100))  Homo sapiens
Symbol: NFKB2
Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Description: This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, May 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA-binding factor KBF2; H2TF1; H2TF1; lymphocyte translocation chromosome 10 protein; LYT-10; LYT10; NF-kB2; nuclear factor NF-kappa-B p100 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 2; oncogene Lyt-10; OTTHUMP00000020371; OTTHUMP00000059136; p105; p52
Orthologs: Mus musculus : Nfkb2 (nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100)  MGI
Rattus norvegicus : Nfkb2 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_110104,516,420 - 104,524,840+NCBI
Human Genome Assembly HuRef1097,787,077 - 97,795,460+NCBI
Human Genome Assembly GRCh3710104,153,867 - 104,162,286+NCBI
Human Genome Assembly Build 3610104,144,219 - 104,152,271+NCBI
Human Cytogenetic Map10q24 NCBI
Human Genome Assembly10104,145,452 - 104,152,257 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on NFKB2
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1316230
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2013-03-06
Status: ACTIVE



Contact Us |  About Us |  Jobs at RGD