Ripor2 (RHO family interacting cell polarization regulator 2) - Rat Genome Database

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Gene: Ripor2 (RHO family interacting cell polarization regulator 2) Rattus norvegicus
Analyze
Symbol: Ripor2
Name: RHO family interacting cell polarization regulator 2
RGD ID: 1306939
Description: Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of T cell activation; positive regulation of cellular component organization; and regulation of leukocyte migration. Located in apical plasma membrane and stereocilium membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 21 and autosomal recessive nonsyndromic deafness 104. Orthologous to human RIPOR2 (RHO family interacting cell polarization regulator 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-162; Fam65b; family with sequence similarity 65, member B; hypothetical protein LOC306934; LOC306934; RGD1306939; rho family-interacting cell polarization regulator 2; similar to mKIAA0386 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,751,771 - 40,975,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,751,771 - 40,975,337 (-)EnsemblGRCr8
mRatBN7.21740,323,748 - 40,547,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,323,867 - 40,548,092 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,391,656 - 40,489,560 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,995,696 - 42,093,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,278,937 - 40,376,743 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,324,594 - 42,549,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,324,594 - 42,422,053 (-)Ensemblrn6Rnor6.0
Rnor_5.01744,192,188 - 44,415,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,394,370 - 47,492,203 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,960,748 - 40,058,550 (-)NCBICelera
RGSC_v3.11747,404,460 - 47,517,088 (-)NCBI
Cytogenetic Map17p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
lead diacetate  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrethrins  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin-based cell projection  (IEA)
apical plasma membrane  (IDA,IEA)
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
filopodium  (IEA,ISO,ISS)
stereocilium  (IDA,IEA,ISO)
stereocilium membrane  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing. Diaz-Horta O, etal., Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9864-8. doi: 10.1073/pnas.1401950111. Epub 2014 Jun 23.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17150207   PMID:23241886   PMID:24687993   PMID:25588844   PMID:27269051   PMID:27556504  


Genomics

Comparative Map Data
Ripor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,751,771 - 40,975,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,751,771 - 40,975,337 (-)EnsemblGRCr8
mRatBN7.21740,323,748 - 40,547,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,323,867 - 40,548,092 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,391,656 - 40,489,560 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,995,696 - 42,093,591 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,278,937 - 40,376,743 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,324,594 - 42,549,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,324,594 - 42,422,053 (-)Ensemblrn6Rnor6.0
Rnor_5.01744,192,188 - 44,415,275 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,394,370 - 47,492,203 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,960,748 - 40,058,550 (-)NCBICelera
RGSC_v3.11747,404,460 - 47,517,088 (-)NCBI
Cytogenetic Map17p11NCBI
RIPOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,804,284 - 25,042,168 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,803,362 - 25,042,170 (-)Ensemblhg38GRCh38
GRCh37624,804,512 - 25,042,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,947,566 - 24,985,562 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34624,947,575 - 24,985,562NCBI
Celera626,037,884 - 26,138,491 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,753,953 - 24,854,449 (-)NCBIHuRef
CHM1_1624,808,618 - 24,913,299 (-)NCBICHM1_1
T2T-CHM13v2.0624,675,432 - 24,907,349 (-)NCBIT2T-CHM13v2.0
Ripor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391324,685,513 - 24,917,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1324,685,508 - 24,917,799 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381324,501,524 - 24,733,806 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,501,525 - 24,733,816 (+)Ensemblmm10GRCm38
MGSCv371324,706,479 - 24,825,675 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361324,676,030 - 24,713,412 (+)NCBIMGSCv36mm8
Celera1324,845,270 - 24,964,462 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.5NCBI
Ripor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,048,324 - 2,256,589 (+)Ensembl
ChiLan1.0NW_0049554832,048,236 - 2,257,078 (+)NCBIChiLan1.0ChiLan1.0
RIPOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,455,658 - 39,581,492 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,455,205 - 35,581,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,642,239 - 24,768,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,973,412 - 25,099,034 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,973,412 - 25,204,745 (-)EnsemblpanPan2panpan1.1
RIPOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,823,053 - 23,041,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,824,106 - 23,041,743 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3522,790,986 - 23,009,662 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03522,945,432 - 23,164,390 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,945,030 - 23,164,199 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,750,468 - 22,968,713 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,799,010 - 23,016,747 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03524,234,583 - 24,454,231 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ripor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,388,691 - 2,556,595 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366711,051,742 - 1,093,021 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366711,064,937 - 1,232,985 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,609,358 - 19,838,093 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1719,609,358 - 19,842,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,762,727 - 20,990,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIPOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,197,067 - 47,441,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,308,984 - 47,451,779 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604424,739,532 - 24,983,846 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripor2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11443,700,304 - 43,789,743 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ripor2
1337 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:56
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000048298
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001014009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY325194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000048298   ⟹   ENSRNOP00000048390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,751,771 - 40,849,714 (-)Ensembl
mRatBN7.2 Ensembl1740,323,867 - 40,421,722 (-)Ensembl
Rnor_6.0 Ensembl1742,324,594 - 42,422,053 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097819   ⟹   ENSRNOP00000094332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,792,726 - 40,846,991 (-)Ensembl
mRatBN7.2 Ensembl1740,364,701 - 40,419,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101796   ⟹   ENSRNOP00000096913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,783,095 - 40,846,991 (-)Ensembl
mRatBN7.2 Ensembl1740,355,070 - 40,419,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102510   ⟹   ENSRNOP00000096012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,783,095 - 40,975,337 (-)Ensembl
mRatBN7.2 Ensembl1740,355,070 - 40,548,092 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107097   ⟹   ENSRNOP00000096131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1740,329,495 - 40,418,575 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110402   ⟹   ENSRNOP00000082516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,758,414 - 40,846,991 (-)Ensembl
mRatBN7.2 Ensembl1740,329,495 - 40,419,234 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117790   ⟹   ENSRNOP00000083444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,783,095 - 40,872,001 (-)Ensembl
mRatBN7.2 Ensembl1740,355,070 - 40,444,144 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117811   ⟹   ENSRNOP00000077001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,758,414 - 40,846,991 (-)Ensembl
mRatBN7.2 Ensembl1740,329,495 - 40,419,234 (-)Ensembl
RefSeq Acc Id: NM_001014009   ⟹   NP_001014031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,751,771 - 40,849,714 (-)NCBI
mRatBN7.21740,323,748 - 40,421,722 (-)NCBI
Rnor_6.01742,324,594 - 42,422,053 (-)NCBI
Rnor_5.01744,192,188 - 44,415,275 (-)NCBI
RGSC_v3.41747,394,370 - 47,492,203 (-)RGD
Celera1739,960,748 - 40,058,550 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253929   ⟹   XP_006253991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,871,818 (-)NCBI
mRatBN7.21740,329,494 - 40,443,820 (-)NCBI
Rnor_6.01742,330,223 - 42,444,317 (-)NCBI
Rnor_5.01744,192,188 - 44,415,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253930   ⟹   XP_006253992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,847,309 (-)NCBI
mRatBN7.21740,329,494 - 40,419,317 (-)NCBI
Rnor_6.01742,330,223 - 42,419,374 (-)NCBI
Rnor_5.01744,192,188 - 44,415,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600530   ⟹   XP_017456019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,975,611 (-)NCBI
mRatBN7.21740,329,494 - 40,547,480 (-)NCBI
Rnor_6.01742,330,223 - 42,549,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600531   ⟹   XP_017456020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,975,583 (-)NCBI
mRatBN7.21740,329,494 - 40,547,482 (-)NCBI
Rnor_6.01742,330,223 - 42,549,907 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600533   ⟹   XP_017456022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,975,611 (-)NCBI
mRatBN7.21740,329,494 - 40,547,476 (-)NCBI
Rnor_6.01742,330,223 - 42,549,905 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600534   ⟹   XP_017456023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,783,089 - 40,975,611 (-)NCBI
mRatBN7.21740,355,064 - 40,547,482 (-)NCBI
Rnor_6.01742,355,424 - 42,549,906 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600535   ⟹   XP_017456024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,783,089 - 40,975,611 (-)NCBI
mRatBN7.21740,355,064 - 40,547,475 (-)NCBI
Rnor_6.01742,355,424 - 42,549,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276411   ⟹   XP_063132481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,846,710 (-)NCBI
RefSeq Acc Id: XM_063276412   ⟹   XP_063132482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,871,966 (-)NCBI
RefSeq Acc Id: XM_063276413   ⟹   XP_063132483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,847,309 (-)NCBI
RefSeq Acc Id: XM_063276414   ⟹   XP_063132484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,757,519 - 40,847,051 (-)NCBI
RefSeq Acc Id: XM_063276415   ⟹   XP_063132485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,783,089 - 40,847,309 (-)NCBI
RefSeq Acc Id: XM_063276416   ⟹   XP_063132486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,783,089 - 40,871,818 (-)NCBI
RefSeq Acc Id: XM_063276417   ⟹   XP_063132487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,783,089 - 40,847,309 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014031 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253991 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253992 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456019 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456020 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456022 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456023 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132481 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132482 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132484 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132485 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132486 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP92595 (Get FASTA)   NCBI Sequence Viewer  
  EDL86507 (Get FASTA)   NCBI Sequence Viewer  
  EDL86508 (Get FASTA)   NCBI Sequence Viewer  
  EDL86509 (Get FASTA)   NCBI Sequence Viewer  
  EDL86510 (Get FASTA)   NCBI Sequence Viewer  
  EDL86511 (Get FASTA)   NCBI Sequence Viewer  
  EDL86512 (Get FASTA)   NCBI Sequence Viewer  
  EDL86513 (Get FASTA)   NCBI Sequence Viewer  
  EDL86514 (Get FASTA)   NCBI Sequence Viewer  
  EDL86515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048390
  ENSRNOP00000048390.1
  ENSRNOP00000077001
  ENSRNOP00000082516
  ENSRNOP00000083444
  ENSRNOP00000096012
  ENSRNOP00000096913
GenBank Protein Q7TP54 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014031   ⟸   NM_001014009
- UniProtKB: Q7TP54 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253991   ⟸   XM_006253929
- Peptide Label: isoform X3
- UniProtKB: A6KLG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253992   ⟸   XM_006253930
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y5T3 (UniProtKB/TrEMBL),   A6KLG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456020   ⟸   XM_017600531
- Peptide Label: isoform X2
- UniProtKB: A6KLG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456019   ⟸   XM_017600530
- Peptide Label: isoform X1
- UniProtKB: A6KLG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456022   ⟸   XM_017600533
- Peptide Label: isoform X6
- UniProtKB: A6KLG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456023   ⟸   XM_017600534
- Peptide Label: isoform X10
- UniProtKB: A6KLG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456024   ⟸   XM_017600535
- Peptide Label: isoform X12
- UniProtKB: A0A8I6AP27 (UniProtKB/TrEMBL),   A6KLG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048390   ⟸   ENSRNOT00000048298
Ensembl Acc Id: ENSRNOP00000082516   ⟸   ENSRNOT00000110402
Ensembl Acc Id: ENSRNOP00000077001   ⟸   ENSRNOT00000117811
Ensembl Acc Id: ENSRNOP00000083444   ⟸   ENSRNOT00000117790
Ensembl Acc Id: ENSRNOP00000096913   ⟸   ENSRNOT00000101796
Ensembl Acc Id: ENSRNOP00000096131   ⟸   ENSRNOT00000107097
Ensembl Acc Id: ENSRNOP00000094332   ⟸   ENSRNOT00000097819
Ensembl Acc Id: ENSRNOP00000096012   ⟸   ENSRNOT00000102510
RefSeq Acc Id: XP_063132482   ⟸   XM_063276412
- Peptide Label: isoform X7
- UniProtKB: A6KLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132483   ⟸   XM_063276413
- Peptide Label: isoform X8
- UniProtKB: A6KLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132484   ⟸   XM_063276414
- Peptide Label: isoform X9
- UniProtKB: A6KLG4 (UniProtKB/TrEMBL),   A0A8I5Y5T3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132481   ⟸   XM_063276411
- Peptide Label: isoform X5
- UniProtKB: A6KLG4 (UniProtKB/TrEMBL),   A0A8I6GLY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132486   ⟸   XM_063276416
- Peptide Label: isoform X13
- UniProtKB: A6KLG7 (UniProtKB/TrEMBL),   A0A8I5ZX07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132487   ⟸   XM_063276417
- Peptide Label: isoform X14
- UniProtKB: A6KLG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132485   ⟸   XM_063276415
- Peptide Label: isoform X11
- UniProtKB: A6KLG8 (UniProtKB/TrEMBL),   A0A8I6AQC8 (UniProtKB/TrEMBL)
Protein Domains
FAM65 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP54-F1-model_v2 AlphaFold Q7TP54 1-1310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306939 AgrOrtholog
BioCyc Gene G2FUF-9416 BioCyc
Ensembl Genes ENSRNOG00000018804 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048298 ENTREZGENE
  ENSRNOT00000048298.2 UniProtKB/Swiss-Prot
  ENSRNOT00000101796 ENTREZGENE
  ENSRNOT00000102510 ENTREZGENE
  ENSRNOT00000110402 ENTREZGENE
  ENSRNOT00000117790 ENTREZGENE
  ENSRNOT00000117811 ENTREZGENE
Gene3D-CATH 1.20.1260.10 UniProtKB/Swiss-Prot
  1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  FAM65_N UniProtKB/Swiss-Prot
  Ferritin-like UniProtKB/Swiss-Prot
  Ferritin-like_diiron UniProtKB/Swiss-Prot
  Ferritin-like_SF UniProtKB/Swiss-Prot
  Ferritin_CS UniProtKB/Swiss-Prot
  Ferritin_DPS_dom UniProtKB/Swiss-Prot
  RIPOR3 UniProtKB/Swiss-Prot
KEGG Report rno:306934 UniProtKB/Swiss-Prot
NCBI Gene 306934 ENTREZGENE
PANTHER PTHR15829 UniProtKB/Swiss-Prot
  PTHR15829:SF2 UniProtKB/Swiss-Prot
Pfam Ferritin UniProtKB/Swiss-Prot
  PL48 UniProtKB/Swiss-Prot
PhenoGen Ripor2 PhenoGen
PROSITE FERRITIN_2 UniProtKB/Swiss-Prot
  FERRITIN_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018804 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I5Y5T3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALX2_RAT UniProtKB/TrEMBL
  A0A8I6AP27 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLY0 ENTREZGENE
  A6KLG3 ENTREZGENE, UniProtKB/TrEMBL
  A6KLG4 ENTREZGENE, UniProtKB/TrEMBL
  A6KLG7 ENTREZGENE, UniProtKB/TrEMBL
  A6KLG8 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP54 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Ripor2  RHO family interacting cell polarization regulator 2  Fam65b  family with sequence similarity 65, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Fam65b  family with sequence similarity 65, member B  RGD1306939  similar to mKIAA0386 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306939  similar to mKIAA0386 protein  RGD1306939_predicted  similar to mKIAA0386 protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306939_predicted  similar to mKIAA0386 protein (predicted)  LOC306934_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306934_predicted  similar to mKIAA0386 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL