Map2k3 (mitogen activated protein kinase kinase 3) - Rat Genome Database

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Gene: Map2k3 (mitogen activated protein kinase kinase 3) Rattus norvegicus
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Symbol: Map2k3
Name: mitogen activated protein kinase kinase 3
RGD ID: 1306620
Description: Predicted to enable MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to sorbitol; and response to ischemia. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; Fc epsilon receptor mediated signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen-activated protein kinase kinase 3-like; LOC100911550; LOC108348082; LOC303200; Mek3; Mkk3
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,107,639 - 46,128,986 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,106,548 - 46,129,004 (+)EnsemblGRCr8
mRatBN7.21045,608,145 - 45,629,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,310,306 - 50,331,733 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,800,693 - 49,822,120 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,304,279 - 45,325,706 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)Ensemblrn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acrolein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nimesulide  (EXP)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
2. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Demuth T, etal., Mol Cancer Ther. 2007 Apr;6(4):1212-22. Epub 2007 Apr 3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells. Guan Z, etal., J Biol Chem. 1999 Dec 17;274(51):36200-6.
6. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
7. Thioredoxin inhibits NMDA-induced neurotoxicity in the rat retina. Inomata Y, etal., J Neurochem. 2006 Jul;98(2):372-85.
8. Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. Jin Y, etal., Acta Pharmacol Sin. 2006 Oct;27(10):1309-16.
9. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
10. Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPbeta and -delta. Kelicen P and Tindberg N, J Biol Chem. 2004 Apr 16;279(16):15734-42. Epub 2003 Dec 11.
11. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
12. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
13. The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. Li LL, etal., J Neurosci. 2013 May 8;33(19):8185-201. doi: 10.1523/JNEUROSCI.4578-12.2013.
14. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
15. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Macneil AJ, etal., Cancer Res. 2013 Nov 14.
16. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Sorkin LS, etal., Neuroscience. 2009 Aug 18;162(2):462-71. doi: 10.1016/j.neuroscience.2009.05.008. Epub 2009 May 8.
25. Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Thirone AC, etal., Diabetes. 2006 Apr;55(4):942-51.
26. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. Uesugi M, etal., Brain Res. 2006 Feb 16;1073-1074:48-59. Epub 2006 Feb 2.
27. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Wang HY, etal., Cancer Lett. 2003 Mar 10;191(2):229-37.
28. Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK. Wang R, etal., Life Sci. 2007 Jun 6;80(26):2481-8. Epub 2007 Apr 21.
Additional References at PubMed
PMID:8900184   PMID:10097111   PMID:10202148   PMID:11279118   PMID:11980910   PMID:12477932   PMID:14709549   PMID:15767678   PMID:16407200   PMID:18948261   PMID:19946888   PMID:21981804  
PMID:22696064   PMID:27402810   PMID:28739872   PMID:29197828   PMID:31505169   PMID:38904879  


Genomics

Comparative Map Data
Map2k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,107,639 - 46,128,986 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1046,106,548 - 46,129,004 (+)EnsemblGRCr8
mRatBN7.21045,608,145 - 45,629,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1050,310,306 - 50,331,733 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,800,693 - 49,822,120 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,304,279 - 45,325,706 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,089,455 - 45,110,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)Ensemblrn6Rnor6.0
Rnor_5.01044,847,090 - 44,868,491 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41047,075,270 - 47,096,617NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1044,862,946 - 44,884,272 (+)NCBICelera
Cytogenetic Map10q22NCBI
MAP2K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381721,284,711 - 21,315,240 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1721,284,672 - 21,315,240 (+)Ensemblhg38GRCh38
GRCh371721,188,023 - 21,218,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361721,128,561 - 21,159,145 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341721,141,910 - 21,158,870NCBI
Cytogenetic Map17p11.2NCBI
HuRef1720,389,899 - 20,420,519 (+)NCBIHuRef
CHM1_11721,197,569 - 21,228,147 (+)NCBICHM1_1
T2T-CHM13v2.01721,233,580 - 21,264,159 (+)NCBIT2T-CHM13v2.0
Map2k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,822,880 - 60,843,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,822,859 - 60,843,637 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381160,932,054 - 60,952,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,932,033 - 60,952,811 (+)Ensemblmm10GRCm38
MGSCv371160,745,559 - 60,766,305 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361160,748,252 - 60,768,998 (+)NCBIMGSCv36mm8
Celera1165,171,267 - 65,191,964 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.95NCBI
Map2k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555771,237,287 - 1,248,541 (+)Ensembl
ChiLan1.0NW_0049555771,225,033 - 1,249,510 (+)NCBIChiLan1.0ChiLan1.0
MAP2K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,732,751 - 42,762,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,700,836 - 42,761,736 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha542,870,421 - 42,900,078 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0542,839,802 - 42,869,464 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,839,790 - 42,869,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,806,533 - 42,836,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,753,555 - 42,783,186 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,946,459 - 42,976,119 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map2k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560262,480,582 - 62,504,527 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741362,387 - 386,678 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936741362,682 - 386,633 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,396,369 - 61,417,321 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11261,396,337 - 61,417,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAP2K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11619,396,377 - 19,427,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1619,396,452 - 19,427,652 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660591,327,045 - 1,358,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,006,513 - 5,035,747 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248495,007,185 - 5,034,488 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k3
154 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:840
Count of miRNA genes:307
Interacting mature miRNAs:400
Transcripts:ENSRNOT00000008679, ENSRNOT00000073792
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
11528628Bss116Bone structure and strength QTL 1166.464e-07femur morphology trait (VT:0000559)femur length (CMO:0000442)104467931246132467Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128171  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81046,128,766 - 46,128,954 (+)Marker Load Pipeline
mRatBN7.21045,629,272 - 45,629,460 (+)MAPPERmRatBN7.2
Rnor_6.01045,110,583 - 45,110,770NCBIRnor6.0
Rnor_6.01047,203,561 - 47,203,748NCBIRnor6.0
Rnor_5.01046,977,037 - 46,977,224UniSTSRnor5.0
Rnor_5.01044,868,272 - 44,868,459UniSTSRnor5.0
RGSC_v3.41047,096,398 - 47,096,585UniSTSRGSC3.4
Celera1044,884,053 - 44,884,240UniSTS
Cytogenetic Map10q22UniSTS
MAP2K3_360  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,628,417 - 45,629,369 (+)MAPPERmRatBN7.2
Rnor_6.01047,202,706 - 47,203,657NCBIRnor6.0
Rnor_6.01045,109,728 - 45,110,679NCBIRnor6.0
Rnor_5.01044,867,417 - 44,868,368UniSTSRnor5.0
Rnor_5.01046,976,182 - 46,977,133UniSTSRnor5.0
RGSC_v3.41047,095,543 - 47,096,494UniSTSRGSC3.4
Celera1044,883,198 - 44,884,149UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 11 53 132 116 111 69 97 69 12 383 194 11 99 91 98 42 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008679   ⟹   ENSRNOP00000008679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,106,548 - 46,129,004 (+)Ensembl
mRatBN7.2 Ensembl1045,607,163 - 45,629,492 (+)Ensembl
Rnor_6.0 Ensembl1047,182,433 - 47,203,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073792   ⟹   ENSRNOP00000065373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,107,050 - 46,129,004 (+)Ensembl
mRatBN7.2 Ensembl1045,608,025 - 45,629,492 (+)Ensembl
Rnor_6.0 Ensembl1045,089,464 - 45,110,787 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138544   ⟹   ENSRNOP00000106059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1046,106,882 - 46,129,004 (+)Ensembl
RefSeq Acc Id: NM_001100674   ⟹   NP_001094144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,107,639 - 46,128,986 (+)NCBI
mRatBN7.21045,608,145 - 45,629,492 (+)NCBI
Rnor_6.01045,089,455 - 45,110,802 (+)NCBI
Rnor_5.01044,847,090 - 44,868,491 (+)NCBI
RGSC_v3.41047,075,270 - 47,096,617 (+)RGD
Celera1044,862,946 - 44,884,272 (+)RGD
Sequence:
RefSeq Acc Id: NP_001094144   ⟸   NM_001100674
- UniProtKB: B1H230 (UniProtKB/TrEMBL),   F7EXM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008679   ⟸   ENSRNOT00000008679
Ensembl Acc Id: ENSRNOP00000065373   ⟸   ENSRNOT00000073792
Ensembl Acc Id: ENSRNOP00000106059   ⟸   ENSRNOT00000138544
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H230-F1-model_v2 AlphaFold B1H230 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306620 AgrOrtholog
BioCyc Gene G2FUF-24830 BioCyc
Ensembl Genes ENSRNOG00000006612 Ensembl
  ENSRNOG00000049132 Ensembl
  ENSRNOG00000065992 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008679.9 UniProtKB/TrEMBL
  ENSRNOT00000073792 ENTREZGENE
  ENSRNOT00000073792.4 UniProtKB/TrEMBL
  ENSRNOT00000138544.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7374925 IMAGE-MGC_LOAD
  IMAGE:7458293 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:303200 UniProtKB/TrEMBL
MGC_CLONE MGC:112819 IMAGE-MGC_LOAD
  MGC:187561 IMAGE-MGC_LOAD
NCBI Gene 303200 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Map2k3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006612 RatGTEx
  ENSRNOG00000049132 RatGTEx
  ENSRNOG00000065992 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0ABK0LMA9_RAT UniProtKB/TrEMBL
  A6HF68_RAT UniProtKB/TrEMBL
  B1H230 ENTREZGENE, UniProtKB/TrEMBL
  F7EXM7 ENTREZGENE, UniProtKB/TrEMBL
  M0R7E7_RAT UniProtKB/TrEMBL
  Q498S1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Map2k3  mitogen activated protein kinase kinase 3  LOC108348082  dual specificity mitogen-activated protein kinase kinase 3-like  Data merged from RGD:11389050 737654 PROVISIONAL
2016-08-02 LOC108348082  dual specificity mitogen-activated protein kinase kinase 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2015-07-29 Map2k3  mitogen activated protein kinase kinase 3  LOC100911550  dual specificity mitogen-activated protein kinase kinase 3-like  Data merged from RGD:6492522 737654 PROVISIONAL
2012-07-05 LOC100911550  dual specificity mitogen-activated protein kinase kinase 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Map2k3  mitogen activated protein kinase kinase 3  Map2k3_predicted  mitogen activated protein kinase kinase 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Map2k3_predicted  mitogen activated protein kinase kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED