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Gene: Prps1l1 (phosphoribosyl pyrophosphate synthetase 1-like 1) Rattus norvegicus

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Symbol:

Prps1l1

Name:

phosphoribosyl pyrophosphate synthetase 1-like 1

RGD ID:

1306328

Description:

Predicted to enable ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Orthologous to human PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH ammonium chloride; bisphenol A; trichloroethene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC298954; Prps3; ribose-phosphate pyrophosphokinase 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	HGNC	Ensembl, HomoloGene, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	HGNC	OrthoDB, Panther
Homo sapiens (human):	PRPS2 (phosphoribosyl pyrophosphate synthetase 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder)
Homo sapiens (human):	PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PANTHER)
Mus musculus (house mouse):	Prps1l1 (phosphoribosyl pyrophosphate synthetase 1-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prps1a (phosphoribosyl pyrophosphate synthetase 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	prps1a (phosphoribosyl pyrophosphate synthetase 1A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R151.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R151.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6767	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6767	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	PRS4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRS4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prps1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	prps1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	57,412,331 - 57,414,021 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	57,411,794 - 57,415,712 (+)	Ensembl				GRCr8
mRatBN7.2	6	51,684,960 - 51,686,650 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	51,684,948 - 51,687,291 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	51,969,122 - 51,970,812 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	52,284,060 - 52,285,750 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	51,740,499 - 51,742,189 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	54,417,903 - 54,419,593 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	54,417,903 - 54,419,593 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	64,038,717 - 64,040,407 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	53,652,048 - 53,653,738 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	50,843,329 - 50,845,019 (+)	NCBI		Celera
RGSC_v3.1	6	53,655,288 - 53,656,268 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

paracetamol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

tamoxifen (ISO)

trichloroethene (EXP)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

5-phosphoribose 1-diphosphate biosynthetic process (IBA,IEA)

AMP biosynthetic process (IEA)

animal organ regeneration (IEA)

male gonad development (IEP)

nucleotide biosynthetic process (IEA)

purine nucleotide biosynthetic process (IBA)

ribonucleoside monophosphate biosynthetic process (IEA)

Cellular Component

cytoplasm (IBA)

ribose phosphate diphosphokinase complex (IBA)

Molecular Function

ADP binding (IEA)

AMP binding (IEA)

ATP binding (IEA)

GDP binding (IEA)

kinase activity (IEA)

magnesium ion binding (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

ribose phosphate diphosphokinase activity (IBA,IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Pediatric neurological syndromes and inborn errors of purine metabolism.	Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon.	Taira M, etal., J Biol Chem. 1990 Sep 25;265(27):16491-7.

Genomics

Comparative Map Data

Prps1l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	57,412,331 - 57,414,021 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	57,411,794 - 57,415,712 (+)	Ensembl				GRCr8
mRatBN7.2	6	51,684,960 - 51,686,650 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	51,684,948 - 51,687,291 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	51,969,122 - 51,970,812 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	52,284,060 - 52,285,750 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	51,740,499 - 51,742,189 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	54,417,903 - 54,419,593 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	54,417,903 - 54,419,593 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	64,038,717 - 64,040,407 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	53,652,048 - 53,653,738 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	50,843,329 - 50,845,019 (+)	NCBI		Celera
RGSC_v3.1	6	53,655,288 - 53,656,268 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

PRPS1L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	18,026,770 - 18,027,846 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	18,026,770 - 18,027,846 (-)	Ensembl			hg38	GRCh38
GRCh37	7	18,066,393 - 18,067,469 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	18,032,922 - 18,034,011 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	18,046,381 - 18,047,465 (-)	NCBI		Celera
Cytogenetic Map	7	p21.1	NCBI
HuRef	7	17,951,884 - 17,952,968 (-)	NCBI		HuRef
CHM1_1	7	18,067,488 - 18,068,577 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	18,156,457 - 18,157,533 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	18,119,717 - 18,120,801 (-)	NCBI

Prps1l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	35,034,760 - 35,036,435 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	35,034,760 - 35,036,435 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	34,984,761 - 34,986,436 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	34,984,761 - 34,986,436 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	35,669,433 - 35,671,108 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	35,569,833 - 35,571,508 (+)	NCBI		MGSCv36	mm8
Celera	12	36,410,649 - 36,412,324 (+)	NCBI		Celera
Cytogenetic Map	12	A3	NCBI
cM Map	12	15.64	NCBI

Prps1l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955410	20,987,289 - 20,988,852 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRPS1L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	22,859,141 - 22,860,249 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	71,183,865 - 71,184,973 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	18,680,579 - 18,681,655 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	18,006,809 - 18,007,885 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

Prps1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	76,657,634 - 76,658,744 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936546	4,332,773 - 4,333,738 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRPS1L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	87,163,252 - 87,164,208 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	87,161,863 - 87,164,314 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	96,258,718 - 96,259,873 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRPS1L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	40,120,251 - 40,121,975 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	40,120,963 - 40,121,919 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	64,405,873 - 64,407,128 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prps1l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	12,406,278 - 12,407,234 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624739	12,406,148 - 12,407,861 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Prps1l1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	48,274,636 - 48,276,315 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Prps1l1
5 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	458
Count of miRNA genes:	218
Interacting mature miRNAs:	249
Transcripts:	ENSRNOT00000052356
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	44510974	89510974	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
4889933	Bss88	Bone structure and strength QTL 88	3.8		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	6	53684921	98684921	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	40957564	85957564	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	45153786	90153786	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
5684992	Bmd83	Bone mineral density QTL 82	4.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	6	53684921	98684921	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	46047353	91047353	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
5684963	Bss99	Bone structure and strength QTL 99	3.1		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	6	53684921	98684921	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat

Markers in Region

UniSTS:488924

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	51,684,971 - 51,686,605 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	54,417,915 - 54,419,548	NCBI	Rnor6.0
Rnor_5.0	6	64,038,729 - 64,040,362	UniSTS	Rnor5.0
RGSC_v3.4	6	53,652,060 - 53,653,693	UniSTS	RGSC3.4
Celera	6	50,843,341 - 50,844,974	UniSTS
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
3	3	21	8	6	3	9	3	2	22	16	17	1	27	3	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000052356 ⟹ ENSRNOP00000066940

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	57,411,794 - 57,415,712 (+)	Ensembl
mRatBN7.2 Ensembl	6	51,684,948 - 51,687,291 (+)	Ensembl
Rnor_6.0 Ensembl	6	54,417,903 - 54,419,593 (+)	Ensembl

RefSeq Acc Id:

NM_001105678 ⟹ NP_001099148

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	57,412,331 - 57,414,021 (+)	NCBI
mRatBN7.2	6	51,684,960 - 51,686,650 (+)	NCBI
Rnor_6.0	6	54,417,903 - 54,419,593 (+)	NCBI
Rnor_5.0	6	64,038,717 - 64,040,407 (+)	NCBI
RGSC_v3.4	6	53,652,048 - 53,653,738 (+)	RGD
Celera	6	50,843,329 - 50,845,019 (+)	RGD

Sequence:

show sequence

GCACAACCGTTAGGGGAAGGGACAGTAACGGCTTTGTAACCACCCTCTGTGCACTGCCCGGAAA
CTGTTAGTCTGTGCTCCAGTTTACCTTCCAAGACGGAAGCTTTAAGTCTAGGATCTCTGGCCAG
GATGCCAAACATCAAAATCTTCAGCGGCAGCTCCCACCAGGACTTATCCCAGAAGATTACCGAG
CGCCTGGGCCTCGAGCTCGGCAAGGTGGTAACTAAGAAATTCAGCAACCAGGAGACCTGCGTGG
AAATTGGTGAGAGTGTGCGCGGAGAAGACGTCTACATAGTTCAGAGTGGTTGTGGTGAAATCAA
CGACAGTCTAATGGAACTTTTGATCATGATCAATGCCTGCAAGATCGCTTCCGCCAGCCGGGTG
ACTGCGGTCATCCCCTGCTTCCCTTACGCCAGGCAGGATAAAAAGGATAAGAGTCGGGCTCCCA
TGTCTGCGAAACTCATAGCAAATATGCTGTCTATAGCGGGTGCAGATCACATTATCACCATGGA
CCTACATGCTTCTCAGATTCAGGGGTTTTTTGACATCCCAGTAGATAATTTGTATGCAGAACCA
GCCGTCCTGAAGTGGATAAAGGAGAATATTTCTGACTGGAGAAACTGCACAATTGTTTCTCCTG
ATGCTGGCGGAGCCAAGAGGGTCACTTCCATCGCGGACCATTTGAATGTGGATTTTGCCTTGAT
TCACAAAGAACGGAAGAAAGCCAATGAAGTGGACCGCATGGTGCTTGTGGGTGACGTAAAGGAG
CGAGTGGCTATCCTTGTAGATGACATGGCTGACACTTGTGGTACAATCTGTTATGCGGCTGACA
AACTTCTGTCAGAGGGAGCTACCAGAGTTTATGCCATCTTGACTCACGGAATCTTTTCTGGCCC
AGCCATTGCTCGCATCAATGGCGCATGCTTTGAAGCAGTAGTGGTCACTAACACTATACCTCAA
GAAGACAAGATGAAACAGTGTAGCAAAATCCAGGTGATTGACATCTCCATGATTCTTGCTGAAG
CCATCCGGAGAACCCATAACGGAGAATCTGTTTCCTATCTGTTCAGTCATGTTCCCTTGTAACG
GAATGACATAAAATTTAAGGGCAGTAAGATAAAACAAAAATAAACCCTGTTCGCGTTTTTGCTT
CTGTATTTGATGAAATGTTCTGTCAGAGATCCAGTGGGGTCCACCATGGCCTCAGTAGATAGGA
GATTGTGGGTTTCCTCACATGGTCTTTTCATTCTGGCTTCTTTGATTTTGTGAGCTTTTGACTT
TTACAAAGTCCCATTGCCACAAGGTTTCTGATTTTGCAACACATTGCCTCATACTACCAGAGGA
CAAGTCAGTTACAAAGCCATTTGATCTAACACAGGCAATCATATTCCCCAAGTTCACCAGAGTC
TGTGGTAAACTTCAGCAAGTACCCTGGGCTTTCTTAACCTTCTCCTCTATTCTAAATTCACTGG
AAGGAAATGGCAGCTTCCAGGTTAAGCCACCACTGAGTTCAATAAGTCTACACAGCAAAGTACA
GCAAGTGTTCTTTGAGAAAGAAGACCTTGACTATCTATTTGCAGACTCATCTTAGATTCTTAAT
CCTACATCCTTCTTTAACTTTAGCTGTCCAGGCATCCTCTTCCTGGGCAAATATGCAATTGGGT
TCAAGTCTTCAATAGACCATAGTCTTG

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Protein Sequences


Protein RefSeqs	NP_001099148	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03299	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066940
	ENSRNOP00000066940.1
	ENSRNOP00000071101.2

RefSeq Acc Id:

NP_001099148 ⟸ NM_001105678

- UniProtKB:

M0RBK1 (UniProtKB/TrEMBL), A6HB94 (UniProtKB/TrEMBL), A0A8L2R3X1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPNIKIFSGSSHQDLSQKITERLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEIN
DSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPMSAKLIANMLSIAGADHIITMD
LHASQIQGFFDIPVDNLYAEPAVLKWIKENISDWRNCTIVSPDAGGAKRVTSIADHLNVDFALI
HKERKKANEVDRMVLVGDVKERVAILVDDMADTCGTICYAADKLLSEGATRVYAILTHGIFSGP
AIARINGACFEAVVVTNTIPQEDKMKQCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

hide sequence

Ensembl Acc Id:

ENSRNOP00000066940 ⟸ ENSRNOT00000052356

Protein Domains

Ribose-phosphate pyrophosphokinase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0RBK1-F1-model_v2	AlphaFold	M0RBK1	1-318	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694554

Promoter ID:

EPDNEW_R5079

Type:

single initiation site

Name:

Prps1l1_1

Description:

phosphoribosyl pyrophosphate synthetase 1-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	54,417,977 - 54,418,037	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306328	AgrOrtholog
BioCyc Gene	G2FUF-37815	BioCyc
BioCyc Pathway	PWY0-662 [PRPP biosynthesis]	BioCyc
BioCyc Pathway Image	PWY0-662	BioCyc
Ensembl Genes	ENSRNOG00000032513	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000060262	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000052356	ENTREZGENE
	ENSRNOT00000052356.5	UniProtKB/TrEMBL
	ENSRNOT00000078582.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.2020	UniProtKB/TrEMBL
InterPro	PRib_PP_synth_CS	UniProtKB/TrEMBL
	Pribosyltran_N	UniProtKB/TrEMBL
	PRibTrfase_dom	UniProtKB/TrEMBL
	PRTase-like	UniProtKB/TrEMBL
	Rib-P_diPkinase	UniProtKB/TrEMBL
	Rib-P_diPkinase_bac	UniProtKB/TrEMBL
KEGG Report	rno:298954	UniProtKB/TrEMBL
NCBI Gene	298954	ENTREZGENE
PANTHER	PTHR10210	UniProtKB/TrEMBL
	RIBOSE-PHOSPHATE DIPHOSPHOKINASE	UniProtKB/TrEMBL
	RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1	UniProtKB/TrEMBL
Pfam	Pribosyl_synth	UniProtKB/TrEMBL
	Pribosyltran_N	UniProtKB/TrEMBL
PhenoGen	Prps1l1	PhenoGen
PROSITE	PRPP_SYNTHASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000032513	RatGTEx
	ENSRNOG00000060262	RatGTEx
SMART	Pribosyltran_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53271	UniProtKB/TrEMBL
UniProt	A0A8L2R3X1	ENTREZGENE, UniProtKB/TrEMBL
	A6HB94	ENTREZGENE, UniProtKB/TrEMBL
	M0RBK1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Prps1l1	phosphoribosyl pyrophosphate synthetase 1-like 1	Prps1l1_predicted	phosphoribosyl pyrophosphate synthetase 1-like 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Prps1l1_predicted	phosphoribosyl pyrophosphate synthetase 1-like 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways