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Gene: Nck2 (NCK adaptor protein 2) Rattus norvegicus

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Symbol:

Nck2

Name:

NCK adaptor protein 2

RGD ID:

1305965

Description:

Predicted to enable several functions, including phosphotyrosine residue binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in postsynaptic density. Orthologous to human NCK2 (NCK adaptor protein 2); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cytoplasmic protein NCK2; LOC316369; non-catalytic region of tyrosine kinase adaptor protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NCK2 (NCK adaptor protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nck2 (non-catalytic region of tyrosine kinase adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nck2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NCK2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NCK2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nck2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NCK2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NCK2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nck2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nck2 (NCK adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	NCK2 (NCK adaptor protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nck2 (non-catalytic region of tyrosine kinase adaptor protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nck2b (NCK adaptor protein 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nck2b (NCK adaptor protein 2b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nck2a (NCK adaptor protein 2a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	nck2a (NCK adaptor protein 2a)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	nck-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	dock	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nck2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	nck2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	53,206,006 - 53,332,417 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	53,231,381 - 53,332,394 (+)	Ensembl				GRCr8
mRatBN7.2	9	45,713,979 - 45,840,330 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	45,714,883 - 45,840,307 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	54,216,238 - 54,348,337 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	59,339,036 - 59,471,142 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	57,619,256 - 57,751,368 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	50,246,767 - 50,373,307 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	50,247,692 - 50,373,284 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	49,914,483 - 50,040,945 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	42,650,261 - 42,776,967 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	43,431,256 - 43,557,014 (+)	NCBI		Celera
RGSC_v3.1	9	42,651,481 - 42,778,381 (+)	NCBI
Cytogenetic Map	9	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

Alzheimer's disease (ISO)

nephrotic syndrome (ISO)

proteinuria (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

atrazine (EXP)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

camptothecin (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

daunorubicin (ISO)

diquat (ISO)

doxorubicin (ISO)

etoposide (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

hydrazine (ISO)

hydrogen peroxide (ISO)

methapyrilene (ISO)

methimazole (EXP)

nitrates (ISO)

oxaliplatin (EXP)

p-toluidine (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenacetin (EXP)

phenylhydrazine (EXP)

pirinixic acid (ISO)

propiconazole (EXP)

rotenone (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloromethane (EXP)

theophylline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IEA,ISO)

cell migration (IBA,ISO)

dendritic spine development (IGI)

ephrin receptor signaling pathway (IBA,IEA,ISO)

immunological synapse formation (IGI)

lamellipodium assembly (IEA,ISO)

negative regulation of PERK-mediated unfolded protein response (IBA,IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of actin filament polymerization (IEA,ISO)

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (IBA,IEA,ISO)

positive regulation of T cell proliferation (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of translation in response to endoplasmic reticulum stress (IBA,IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

regulation of translation (IEA)

regulation of translation initiation in response to endoplasmic reticulum stress (IEA,ISO)

response to endoplasmic reticulum stress (IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA)

endoplasmic reticulum (IEA,ISO)

postsynaptic density (IDA)

synapse (IDA)

vesicle membrane (IEA,ISO)

Molecular Function

phosphotyrosine residue binding (IEA,ISO)

protein binding (ISO)

protein-containing complex binding (IEA,ISO)

receptor tyrosine kinase binding (IBA)

scaffold protein binding (IEA,ISO)

signaling adaptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

epidermal growth factor/neuregulin signaling pathway (IEA,ISO)

insulin signaling pathway (ISO)

insulin-like growth factor signaling pathway (ISO)

integrin mediated signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Reelin signaling pathway (ISO)

T cell receptor signaling pathway (IEA)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	ILK, PINCH and parvin: the tIPP of integrin signalling.	Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation.	Segura I, etal., Nat Neurosci. 2007 Mar;10(3):301-10. Epub 2007 Feb 18.

Additional References at PubMed

PMID:10026169	PMID:12091389	PMID:12110186	PMID:12147689	PMID:12637565	PMID:12808099	PMID:14676213	PMID:16511561	PMID:16835242	PMID:17591694	PMID:20624904	PMID:25468996

Genomics

Comparative Map Data

Nck2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	53,206,006 - 53,332,417 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	53,231,381 - 53,332,394 (+)	Ensembl				GRCr8
mRatBN7.2	9	45,713,979 - 45,840,330 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	45,714,883 - 45,840,307 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	54,216,238 - 54,348,337 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	59,339,036 - 59,471,142 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	57,619,256 - 57,751,368 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	50,246,767 - 50,373,307 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	50,247,692 - 50,373,284 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	49,914,483 - 50,040,945 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	42,650,261 - 42,776,967 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	43,431,256 - 43,557,014 (+)	NCBI		Celera
RGSC_v3.1	9	42,651,481 - 42,778,381 (+)	NCBI
Cytogenetic Map	9	q22	NCBI

NCK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	105,744,453 - 105,894,272 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	105,744,369 - 105,894,275 (+)	Ensembl			hg38	GRCh38
GRCh37	2	106,361,369 - 106,510,728 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	105,727,786 - 105,877,160 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	105,819,871 - 105,969,244	NCBI
Celera	2	100,633,297 - 100,711,182 (+)	NCBI		Celera
Cytogenetic Map	2	q12.2	NCBI
HuRef	2	100,201,822 - 100,279,928 (+)	NCBI		HuRef
CHM1_1	2	106,365,834 - 106,515,058 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	106,205,667 - 106,355,582 (+)	NCBI		T2T-CHM13v2.0

Nck2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	43,484,643 - 43,609,678 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	43,483,739 - 43,609,675 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	43,445,483 - 43,570,518 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	43,444,579 - 43,570,515 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	43,502,596 - 43,627,363 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	43,390,297 - 43,515,060 (+)	NCBI		MGSCv36	mm8
Celera	1	43,789,420 - 43,915,515 (+)	NCBI		Celera
Cytogenetic Map	1	C1.1	NCBI
cM Map	1	23.18	NCBI

Nck2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	10,487,481 - 10,593,046 (+)	Ensembl
ChiLan1.0	NW_004955470	10,487,962 - 10,593,046 (+)	NCBI	ChiLan1.0	ChiLan1.0

NCK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	21,826,888 - 21,977,466 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	21,829,652 - 21,980,231 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	95,939,197 - 96,089,163 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	106,827,621 - 106,976,362 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	106,898,547 - 106,976,363 (+)	Ensembl			panPan2	panpan1.1

NCK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	37,584,351 - 37,734,388 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	37,585,565 - 37,732,994 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	37,509,022 - 37,661,002 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	38,434,612 - 38,590,460 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	38,434,614 - 38,588,705 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	38,166,351 - 38,316,130 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	38,443,073 - 38,594,964 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	38,636,761 - 38,787,028 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	86,718,210 - 86,762,553 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936764	140,946 - 185,529 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936764	141,159 - 185,482 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NCK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	49,063,991 - 49,198,664 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	49,063,813 - 49,222,274 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	51,391,130 - 51,413,769 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NCK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	9,412,677 - 9,515,565 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	9,437,301 - 9,515,561 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	177,084,239 - 177,234,654 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nck2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	9,765,308 - 9,884,472 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nck2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	119,708,534 - 119,746,255 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nck2
1445 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	176
Count of miRNA genes:	114
Interacting mature miRNAs:	151
Transcripts:	ENSRNOT00000023029
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	31250432	68875676	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	31250432	65651574	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	31456061	57460683	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Markers in Region

RH137411

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	53,256,906 - 53,257,126 (+)	Marker Load Pipeline
mRatBN7.2	9	45,764,811 - 45,765,031 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	50,297,618 - 50,297,837	NCBI	Rnor6.0
Rnor_5.0	9	49,965,168 - 49,965,387	UniSTS	Rnor5.0
RGSC_v3.4	9	42,700,162 - 42,700,381	UniSTS	RGSC3.4
Celera	9	43,481,111 - 43,481,330	UniSTS
RH 3.4 Map	9	397.7	UniSTS
Cytogenetic Map	9	q22	UniSTS

BE107300

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	45,829,158 - 45,829,355 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	50,362,134 - 50,362,330	NCBI	Rnor6.0
Rnor_5.0	9	50,029,772 - 50,029,968	UniSTS	Rnor5.0
RGSC_v3.4	9	42,765,800 - 42,765,996	UniSTS	RGSC3.4
Celera	9	43,545,847 - 43,546,043	UniSTS
RH 3.4 Map	9	397.3	UniSTS
Cytogenetic Map	9	q22	UniSTS

AF043260

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	45,839,171 - 45,839,296 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	50,372,149 - 50,372,273	NCBI	Rnor6.0
Rnor_5.0	9	50,039,787 - 50,039,911	UniSTS	Rnor5.0
RGSC_v3.4	9	42,775,813 - 42,775,937	UniSTS	RGSC3.4
Celera	9	43,555,860 - 43,555,984	UniSTS
Cytogenetic Map	9	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267163	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY724492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023029 ⟹ ENSRNOP00000023029

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	53,231,381 - 53,332,394 (+)	Ensembl
mRatBN7.2 Ensembl	9	45,714,883 - 45,840,307 (+)	Ensembl
Rnor_6.0 Ensembl	9	50,247,692 - 50,373,284 (+)	Ensembl

RefSeq Acc Id:

NM_001108216 ⟹ NP_001101686

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	53,206,979 - 53,332,413 (+)	NCBI
mRatBN7.2	9	45,714,883 - 45,840,326 (+)	NCBI
Rnor_6.0	9	50,247,692 - 50,373,303 (+)	NCBI
Rnor_5.0	9	49,914,483 - 50,040,945 (+)	NCBI
RGSC_v3.4	9	42,650,261 - 42,776,967 (+)	RGD
Celera	9	43,431,256 - 43,557,014 (+)	RGD

Sequence:

show sequence

AGAGCGGCATCTGGGCGGGCGCAGCGCGGCCGCCGCCCCGGGACTAGCGCTGCTGCCCTCCGGC
CTCGGCGTGCACTGTGCAGCGAGATCCCAGAGGTTCCCTTCCTACAGTGTCATCCCGGCTGGCT
TGAGAGCTCGGACGGTCACTGCAGCTTTGTCACCTTCAAGGTGTCCTCAGACAGCAGAAAAACC
TCATCTTTTTGAAGAGTGCTACTATTTTTCCAGTCTCCTTGTAACTGCCTGCCAAAGAAGGGCT
CCATGAAAGATGACAGAAGAAGTCATTGTCATAGCCAAGTGGGACTACACTGCCCAGCAGGACC
AGGAGCTCGACATCAGGAAGAACGAGCGGCTGTGGCTGCTGGACGACTCCAAGACGTGGTGGCG
GGTGAGGAATGCGGCCAACAGGACAGGCTACGTGCCTTCCAACTACGTGGAGCGTAAGAACAGC
CTGAAGAAGGGGTCCCTGGTGAAGAATCTCAAGGACACGCTAGGCCTCGGGAAGACGCGGAGGA
AGCCAAGTGCTCGGGATGCGTCCCCAACGCCAAGCACTGATGCGGAATACCCAGCCAATGGCAG
CGGTGCTGACCGCATCTATGACCTCAACATCCCAGCCTTCGTCAAGTTCGCCTACGTAGCAGAA
CGAGAGGATGAGCTGTCCCTGGTGAAAGGCTCCCGGGTCACAGTTATGGAGAAATGCAGTGATG
GCTGGTGGCGTGGCAGCTTTAACGGGCAGATCGGCTGGTTCCCCTCCAACTACGTGTTGGAGGA
GGCGGACGAGGCTGCAGCTGAGGCCCCCAGCTTCCTGAGCCTGCGTCGGGGCACTGCGCTAAGC
AATGGGCAAGGTGCACGGGTGCTGCACGTGGTGCAGACGCTGTACCCCTTCAGCTCTGTCACTG
AGGAGGAGCTTAGTTTCGAGAAGGGGGAGACCATGGAGGTGATTGAGAAGCCGGAGAATGACCC
TGAATGGTGGAAATGCAAAAATGCCCGAGGCCAAGTGGGCCTGGTCCCCAAAAACTATGTGGTT
GTCCTCAGTGATGGGCCTGCACTGCACCCCACGCACACTCCACAGATCAGCTACACCGGGCCCT
CAGCCAGCGGGCGATTTGCCGGCCGTGAGTGGTACTATGGCAACGTGACACGGCACCAGGCCGA
GTGTGCGCTCAATGAGCGGGGCGTCGAGGGCGACTTCCTCATTAGAGACAGCGAATCCTCGCCC
AGTGACTTCTCCGTGTCTCTCAAAGCATCAGGGAGGAACAAGCACTTCAAAGTGCAGCTGGTGG
ACAGCGTCTACTGCATTGGGCAGCGGCGGTTCCACAGCATGGACGAGCTTGTGGAGCACTACAA
GAAGGCCCCCATCTTCACCAGCGAGCACGGGGAGAAGCTCTACCTCGTCCGAGCCCTGCAGTGA
AAGCAGCCATTGGCCCCCTCATGCCCTGCCCATTGTGGGCCTCGCTGCCACCTCCGCCTCCCAG
AGCCCAGCACTTCTGGCCACCTCCACCCATGTGGCCTGGATCACCTCTGTGGCCCAGTCTGTCC
TTCTTTTCAGCTTTGTTGGTCAACCATAGCTACCTAGGCCCTCATAGCCATGCCCATGGCCACC
ACCTTCTGGTGGTGAGGGTCAAAGGGAGCAAAGCTACGCACTATTTTCCTTTTCAGTTGGAAAC
GGTCTGTTTGAATCTTACACACACATACAGAGAGAGAGAGACAGAGACAGAGACAGAGACAGAG
ACAGAGACAGAGACAGAGACCGGGGCTTACTCAGAGGGCAGTGAGGCTCTATGTAGTGAATATG
TGACCTTGGCACACACTCCGAGAGCTGTGTCCATGGGTGTTTGGTGCCTCTCATCAGCTATGCT
GGTCCAGGCCAGCAGCCTGTGTCCTGGGCCTGCTTTTTTTTTTTGTTGTTGTTGTTTCTGTTTT
TGTGGCTCCAGGCTCTGCAGGAGTCCAAAAATGTGCGGATAGCAATACTGGAAACCCTGGGGAG
GTGGTGGTGAGGGAACTTCCCAGTGCCTTGGAGGCTGTGCTTGCAATAAAAGAGGGTTTTGGTG
AGAGTCAGTCTGCAAAAGAGGGAGGTGGCAACGCAGAAAGAAAGATACTCTGGTGATGTACCCC
AGGTGTGCCATCCACATAGTGCTTTTGCCCTTTGGCTTGTTTGAATTTCACAATTATGTATTTA
ATTCTCAAAGTAATATGTATCTTAGCTGTTTGTCGACACTAATAAGAGATGATTAAGGAAAACA
GCTGATCTCTTGGGAAGGGGAGCTACCAATACTTTATACACACACTATATATATATAATATGTG
TATATTATATATATATTATTTGCTTTACAGGGAAATTTTTCAGGGTTTACAAGAGAATATGTGA
TTAGTAGTAACAGAACGTTTATGAAGAAATTACATTTTCATTTTTCTTTACATCTGAACTTCTT
TACAGTTTGACTATAGAGTCTTGAGATGGCACATTCCTACAATTGAAGAAGGGGTCTTGGGATC
CCCTAAACTTGCATACCCAGTTTTTTGAATATTGTAATAAAAAAAAGTATTATG

hide sequence

RefSeq Acc Id:

XM_006244825 ⟹ XP_006244887

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	53,206,006 - 53,332,417 (+)	NCBI
mRatBN7.2	9	45,713,979 - 45,840,330 (+)	NCBI
Rnor_6.0	9	50,246,767 - 50,373,307 (+)	NCBI
Rnor_5.0	9	49,914,483 - 50,040,945 (+)	NCBI

Sequence:

show sequence

GTGAAGGAGCTTGGAGAAGGAACATCTGGATTCTGGTGTGTAAGATCCCAGAGGTTCCCTTCCT
ACAGTGTCATCCCGGCTGGCTTGAGAGCTCGGACGGTCACTGCAGCTTTGTCACCTTCAAGGTG
TCCTCAGACAGCAGAAAAACCTCATCTTTTTGAAGAGTGCTACTATTTTTCCAGTCTCCTTGTA
ACTGCCTGCCAAAGAAGGGCTCCATGAAAGATGACAGAAGAAGTCATTGTCATAGCCAAGTGGG
ACTACACTGCCCAGCAGGACCAGGAGCTCGACATCAGGAAGAACGAGCGGCTGTGGCTGCTGGA
CGACTCCAAGACGTGGTGGCGGGTGAGGAATGCGGCCAACAGGACAGGCTACGTGCCTTCCAAC
TACGTGGAGCGTAAGAACAGCCTGAAGAAGGGGTCCCTGGTGAAGAATCTCAAGGACACGCTAG
GCCTCGGGAAGACGCGGAGGAAGCCAAGTGCTCGGGATGCGTCCCCAACGCCAAGCACTGATGC
GGAATACCCAGCCAATGGCAGCGGTGCTGACCGCATCTATGACCTCAACATCCCAGCCTTCGTC
AAGTTCGCCTACGTAGCAGAACGAGAGGATGAGCTGTCCCTGGTGAAAGGCTCCCGGGTCACAG
TTATGGAGAAATGCAGTGATGGCTGGTGGCGTGGCAGCTTTAACGGGCAGATCGGCTGGTTCCC
CTCCAACTACGTGTTGGAGGAGGCGGACGAGGCTGCAGCTGAGGCCCCCAGCTTCCTGAGCCTG
CGTCGGGGCACTGCGCTAAGCAATGGGCAAGGTGCACGGGTGCTGCACGTGGTGCAGACGCTGT
ACCCCTTCAGCTCTGTCACTGAGGAGGAGCTTAGTTTCGAGAAGGGGGAGACCATGGAGGTGAT
TGAGAAGCCGGAGAATGACCCTGAATGGTGGAAATGCAAAAATGCCCGAGGCCAAGTGGGCCTG
GTCCCCAAAAACTATGTGGTTGTCCTCAGTGATGGGCCTGCACTGCACCCCACGCACACTCCAC
AGATCAGCTACACCGGGCCCTCAGCCAGCGGGCGATTTGCCGGCCGTGAGTGGTACTATGGCAA
CGTGACACGGCACCAGGCCGAGTGTGCGCTCAATGAGCGGGGCGTCGAGGGCGACTTCCTCATT
AGAGACAGCGAATCCTCGCCCAGTGACTTCTCCGTGTCTCTCAAAGCATCAGGGAGGAACAAGC
ACTTCAAAGTGCAGCTGGTGGACAGCGTCTACTGCATTGGGCAGCGGCGGTTCCACAGCATGGA
CGAGCTTGTGGAGCACTACAAGAAGGCCCCCATCTTCACCAGCGAGCACGGGGAGAAGCTCTAC
CTCGTCCGAGCCCTGCAGTGAAAGCAGCCATTGGCCCCCTCATGCCCTGCCCATTGTGGGCCTC
GCTGCCACCTCCGCCTCCCAGAGCCCAGCACTTCTGGCCACCTCCACCCATGTGGCCTGGATCA
CCTCTGTGGCCCAGTCTGTCCTTCTTTTCAGCTTTGTTGGTCAACCATAGCTACCTAGGCCCTC
ATAGCCATGCCCATGGCCACCACCTTCTGGTGGTGAGGGTCAAAGGGAGCAAAGCTACGCACTA
TTTTCCTTTTCAGTTGGAAACGGTCTGTTTGAATCTTACACACACATACAGAGAGAGAGAGACA
GAGACAGAGACAGAGACAGAGACAGAGACAGAGACAGAGACCGGGGCTTACTCAGAGGGCAGTG
AGGCTCTATGTAGTGAATATGTGACCTTGGCACACACTCCGAGAGCTGTGTCCATGGGTGTTTG
GTGCCTCTCATCAGCTATGCTGGTCCAGGCCAGCAGCCTGTGTCCTGGGCCTGCTTTTTTTTTT
TGTTGTTGTTGTTTCTGTTTTTGTGGCTCCAGGCTCTGCAGGAGTCCAAAAATGTGCGGATAGC
AATACTGGAAACCCTGGGGAGGTGGTGGTGAGGGAACTTCCCAGTGCCTTGGAGGCTGTGCTTG
CAATAAAAGAGGGTTTTGGTGAGAGTCAGTCTGCAAAAGAGGGAGGTGGCAACGCAGAAAGAAA
GATACTCTGGTGATGTACCCCAGGTGTGCCATCCACATAGTGCTTTTGCCCTTTGGCTTGTTTG
AATTTCACAATTATGTATTTAATTCTCAAAGTAATATGTATCTTAGCTGTTTGTCGACACTAAT
AAGAGATGATTAAGGAAAACAGCTGATCTCTTGGGAAGGGGAGCTACCAATACTTTATACACAC
ACTATATATATATAATATGTGTATATTATATATATATTATTTGCTTTACAGGGAAATTTTTCAG
GGTTTACAAGAGAATATGTGATTAGTAGTAACAGAACGTTTATGAAGAAATTACATTTTCATTT
TTCTTTACATCTGAACTTCTTTACAGTTTGACTATAGAGTCTTGAGATGGCACATTCCTACAAT
TGAAGAAGGGGTCTTGGGATCCCCTAAACTTGCATACCCAGTTTTTTGAATATTGTAATAAAAA
AAAGTATTATGACAA

hide sequence

RefSeq Acc Id:

XM_008767035 ⟹ XP_008765257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	53,231,424 - 53,332,417 (+)	NCBI
mRatBN7.2	9	45,739,464 - 45,840,330 (+)	NCBI
Rnor_6.0	9	50,270,393 - 50,373,307 (+)	NCBI

Sequence:

show sequence

AAATAGACAAAAGCAAAAAAGAGAAGAAAGAGGACAGCCAGGGTTGTTCAGTGGCGAGCTCTTT
GTGGCTGCCTTTGTGCACAGTCGTATCATAAGTCGAATTGAGTAATTGTGAGCCTGTGACCCAC
AGAGGCCAAAATACTGTGTTTATCGGGCTCCTTCTGGAAGAAGCCTGTTGACCCTGTGCGCAGG
AAGTACAGGGCTGAAGTGGGATGCTGCCGCATTGGAGCCTTGCCCGTCCCTTTCTTGGCACCAT
AGCTCTGTAGTCTTTTCTGGGGCAGGAGGAGGAGGCAGCCTTCAGCAGAGGGTTTCTGAAACAC
CTCGTGATTCCTGGCAGAAAACAAGTACTTCCTAACTAAATGTTAGCGACACCCCTCTCTTATA
TCCCATGTTTTGATATGTAGACTTGCTTGTTTCTTCATGGAAAACTTGAGGTAAATTTCAGAGC
GTTAAACCCAGTAGAAGTAGAGCGCACTCTGTGTGCGAGCACTGTAGGTGCAGCTCCAGTGACC
CCTGTAACTGCATGAAGAAAGTACAGGGGGGCAGACAGATTTTAGTGGTGTGTGGATTAGCCCA
TGTCATGCGGACATATAGTCAGTGTGACAAATCGCTACATTCTAACCTTTCGCGGAAGACTGCA
GTGTTCCTCTTGTTATGCCTCTTACTCTGTAGCACGTCACAGCTGGAATAGCCACATCCTGAGG
AAGCCACCATAATAGGCAGCCCCATCCTCTGATACCAGCTGGCTGTCCTCTAATAATCACCCTG
ATGCAGACTGGTACATTCCTCCTAAGTTCTGAGCACTTAACCCAACAAGATGCCCTGCCCCCCC
CCCCCACCCCAGTTCAGATGCCAGCTGCGGAAGAACCTCCTGTATTTCTGACTGATCAGTTATA
AGTTCCCATGGCTTCCCCTTCCTGTTCATGAATGCCATGTGTCAACTGCCAGAACTCAGGAATG
GCCCTGGGTCCACCTGCAGGGCCGCATTTTGCAGAAGTCAGTTACTGCTAGTTTATTAGGAAAC
AGGCAATCCGGGAATGGCAGGGGGCAAGGATGCACAGGGTGTGGCTGGGGGCATCGAGGGGCAG
CAGAGTTTTCACAACCTTTCCAGTTTCCTTCAGAAAATCATCTCAGGGGGCTCATTAACCAGGA
AGTCCTCAATCCAGGACTTAAGAGTTAAGTTACTGTCCACCTTCCCTTCTAGCAAGCCGTGGAG
GCAAGGCTGAAAGTCCCCTCTCTTTTTAGAGACCCCGTATTACTTCCCTTCATAGGCTCAGGCT
CAGTTGTGGCCGATTTTGGCTCAGGATCAACTATCACTCTGGAAATTCTGAGGTTTTCTGGGAG
CTGTATCAGAAGCCAGAACACTGCCCAGAGATACTTTTTTGTATTATTTCCATGACAGGGCAGC
ACTAACTCAAGGCCCACCCATCCCCACCCCTTCCCCAGCTGGCAAGACCTATTTAAAACACTTT
TCTGTGAGCCGCTGAGGCTTTCTTATTTTCCATTCTCCCTTGCCCTTGACTGAGTAATTGCGAA
TCTCACTGCACTGGTTAACTCCCCCACATCTTGGTTCTCAGGAAGCCAAGGCAGGAAAATATAG
TAACATTACTAGGGATCTTTAAATGTAGCATTGTGACTGTGCTCACAATAACTTGCTGAAGAAT
AACTGAGCTGTGGAAGATAAGTTTCCCCGTGGGTTTTCCGAGAATTAGGTTGTGTAGCTAAACA
CGCCGTCCTGCCCACTGTCCTTGTGAACACTGGGCAGATCAGACTGACATGGGAGCTTGTCTCG
TAACCTTGGCTCCCTGGATCTGAGAGGCTGCTTGGCCCCATCAGCCAGGTTTGGTGGGTAGGAC
GTGTGCTGCTCGTAAAGTTAACGTAGCAGAGGGTTTTAAGTCCTCAGGGTTGTGTTTAGCCTCT
CTTTGCCTTGAGTGATGCGGCTGCATGTGGTCCCCACCCCCTATGCTGGGAATAGAAGCTGGGG
CCTTGGGTACCCCTGGATGAGAAAGTTCGGTCACCGAGCTACACGCACTTGGCGTTTTAATGTT
TATTTCTGAGGTTTTTATCTGAAGTTGCATTCAGGATTCTGGAGCCTGAGCTCTGGCCCAGATC
TTGCCTTCTTTAGTCCGCCTGTATCGTGTAGATTGTTTCTCAGTGTCTCAGTTACTTTCTCTAG
GAGAGGATTTCTGTAGATGGATAGTTGGAATACGGACGCGGCTGGGTAGAACATTTGTTTAACT
TACGTGAGGCCCCGGGGTCCAGCTGCAGTGCCACAGAATAAACCCAGAAGGAAACAAGCAGAGC
AGCGCCTTGTGCAGAGCCTTCTTGAAGCATTTTCACAGGAATCGCGTCGGAATAGAAGAGACTA
GCGGAGAACCTCTGTGGAATTAAGTGGAACACGGCTGCCAAAGGGATGTCTGAGAGGTTTAAGT
GTTTCATATTCTGAACATGGCTTTGTACAGACCCTTTAAAGCTGAAGAGGATGGCTGAAATGGC
CTATCCCAGAGGTTCCCTTCCTACAGTGTCATCCCGGCTGGCTTGAGAGCTCGGACGGTCACTG
CAGCTTTGTCACCTTCAAGGTGTCCTCAGACAGCAGAAAAACCTCATCTTTTTGAAGAGTGCTA
CTATTTTTCCAGTCTCCTTGTAACTGCCTGCCAAAGAAGGGCTCCATGAAAGATGACAGAAGAA
GTCATTGTCATAGCCAAGTGGGACTACACTGCCCAGCAGGACCAGGAGCTCGACATCAGGAAGA
ACGAGCGGCTGTGGCTGCTGGACGACTCCAAGACGTGGTGGCGGGTGAGGAATGCGGCCAACAG
GACAGGCTACGTGCCTTCCAACTACGTGGAGCGTAAGAACAGCCTGAAGAAGGGGTCCCTGGTG
AAGAATCTCAAGGACACGCTAGGCCTCGGGAAGACGCGGAGGAAGCCAAGTGCTCGGGATGCGT
CCCCAACGCCAAGCACTGATGCGGAATACCCAGCCAATGGCAGCGGTGCTGACCGCATCTATGA
CCTCAACATCCCAGCCTTCGTCAAGTTCGCCTACGTAGCAGAACGAGAGGATGAGCTGTCCCTG
GTGAAAGGCTCCCGGGTCACAGTTATGGAGAAATGCAGTGATGGCTGGTGGCGTGGCAGCTTTA
ACGGGCAGATCGGCTGGTTCCCCTCCAACTACGTGTTGGAGGAGGCGGACGAGGCTGCAGCTGA
GGCCCCCAGCTTCCTGAGCCTGCGTCGGGGCACTGCGCTAAGCAATGGGCAAGGTGCACGGGTG
CTGCACGTGGTGCAGACGCTGTACCCCTTCAGCTCTGTCACTGAGGAGGAGCTTAGTTTCGAGA
AGGGGGAGACCATGGAGGTGATTGAGAAGCCGGAGAATGACCCTGAATGGTGGAAATGCAAAAA
TGCCCGAGGCCAAGTGGGCCTGGTCCCCAAAAACTATGTGGTTGTCCTCAGTGATGGGCCTGCA
CTGCACCCCACGCACACTCCACAGATCAGCTACACCGGGCCCTCAGCCAGCGGGCGATTTGCCG
GCCGTGAGTGGTACTATGGCAACGTGACACGGCACCAGGCCGAGTGTGCGCTCAATGAGCGGGG
CGTCGAGGGCGACTTCCTCATTAGAGACAGCGAATCCTCGCCCAGTGACTTCTCCGTGTCTCTC
AAAGCATCAGGGAGGAACAAGCACTTCAAAGTGCAGCTGGTGGACAGCGTCTACTGCATTGGGC
AGCGGCGGTTCCACAGCATGGACGAGCTTGTGGAGCACTACAAGAAGGCCCCCATCTTCACCAG
CGAGCACGGGGAGAAGCTCTACCTCGTCCGAGCCCTGCAGTGAAAGCAGCCATTGGCCCCCTCA
TGCCCTGCCCATTGTGGGCCTCGCTGCCACCTCCGCCTCCCAGAGCCCAGCACTTCTGGCCACC
TCCACCCATGTGGCCTGGATCACCTCTGTGGCCCAGTCTGTCCTTCTTTTCAGCTTTGTTGGTC
AACCATAGCTACCTAGGCCCTCATAGCCATGCCCATGGCCACCACCTTCTGGTGGTGAGGGTCA
AAGGGAGCAAAGCTACGCACTATTTTCCTTTTCAGTTGGAAACGGTCTGTTTGAATCTTACACA
CACATACAGAGAGAGAGAGACAGAGACAGAGACAGAGACAGAGACAGAGACAGAGACAGAGACC
GGGGCTTACTCAGAGGGCAGTGAGGCTCTATGTAGTGAATATGTGACCTTGGCACACACTCCGA
GAGCTGTGTCCATGGGTGTTTGGTGCCTCTCATCAGCTATGCTGGTCCAGGCCAGCAGCCTGTG
TCCTGGGCCTGCTTTTTTTTTTTGTTGTTGTTGTTTCTGTTTTTGTGGCTCCAGGCTCTGCAGG
AGTCCAAAAATGTGCGGATAGCAATACTGGAAACCCTGGGGAGGTGGTGGTGAGGGAACTTCCC
AGTGCCTTGGAGGCTGTGCTTGCAATAAAAGAGGGTTTTGGTGAGAGTCAGTCTGCAAAAGAGG
GAGGTGGCAACGCAGAAAGAAAGATACTCTGGTGATGTACCCCAGGTGTGCCATCCACATAGTG
CTTTTGCCCTTTGGCTTGTTTGAATTTCACAATTATGTATTTAATTCTCAAAGTAATATGTATC
TTAGCTGTTTGTCGACACTAATAAGAGATGATTAAGGAAAACAGCTGATCTCTTGGGAAGGGGA
GCTACCAATACTTTATACACACACTATATATATATAATATGTGTATATTATATATATATTATTT
GCTTTACAGGGAAATTTTTCAGGGTTTACAAGAGAATATGTGATTAGTAGTAACAGAACGTTTA
TGAAGAAATTACATTTTCATTTTTCTTTACATCTGAACTTCTTTACAGTTTGACTATAGAGTCT
TGAGATGGCACATTCCTACAATTGAAGAAGGGGTCTTGGGATCCCCTAAACTTGCATACCCAGT
TTTTTGAATATTGTAATAAAAAAAAGTATTATGACAA

hide sequence

RefSeq Acc Id:

XM_063267163 ⟹ XP_063123233

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	53,206,481 - 53,332,417 (+)	NCBI

RefSeq Acc Id:

XM_063267164 ⟹ XP_063123234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	53,206,028 - 53,332,417 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101686	(Get FASTA)	NCBI Sequence Viewer
	XP_006244887	(Get FASTA)	NCBI Sequence Viewer
	XP_008765257	(Get FASTA)	NCBI Sequence Viewer
	XP_063123233	(Get FASTA)	NCBI Sequence Viewer
	XP_063123234	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99145	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023029
	ENSRNOP00000023029.4

RefSeq Acc Id:

NP_001101686 ⟸ NM_001108216

- UniProtKB:

D4A3M8 (UniProtKB/TrEMBL), A6INR5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTEEVIVIAKWDYTAQQDQELDIRKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKK
GSLVKNLKDTLGLGKTRRKPSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERED
ELSLVKGSRVTVMEKCSDGWWRGSFNGQIGWFPSNYVLEEADEAAAEAPSFLSLRRGTALSNGQ
GARVLHVVQTLYPFSSVTEEELSFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLS
DGPALHPTHTPQISYTGPSASGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDF
SVSLKASGRNKHFKVQLVDSVYCIGQRRFHSMDELVEHYKKAPIFTSEHGEKLYLVRALQ

hide sequence

RefSeq Acc Id:	XP_006244887 ⟸ XM_006244825
- Peptide Label:	isoform X1
- UniProtKB:	D4A3M8 (UniProtKB/TrEMBL), A6INR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTEEVIVIAKWDYTAQQDQELDIRKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKK GSLVKNLKDTLGLGKTRRKPSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERED ELSLVKGSRVTVMEKCSDGWWRGSFNGQIGWFPSNYVLEEADEAAAEAPSFLSLRRGTALSNGQ GARVLHVVQTLYPFSSVTEEELSFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLS DGPALHPTHTPQISYTGPSASGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDF SVSLKASGRNKHFKVQLVDSVYCIGQRRFHSMDELVEHYKKAPIFTSEHGEKLYLVRALQ hide sequence

RefSeq Acc Id:	XP_008765257 ⟸ XM_008767035
- Peptide Label:	isoform X1
- UniProtKB:	D4A3M8 (UniProtKB/TrEMBL), A6INR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTEEVIVIAKWDYTAQQDQELDIRKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKK GSLVKNLKDTLGLGKTRRKPSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAERED ELSLVKGSRVTVMEKCSDGWWRGSFNGQIGWFPSNYVLEEADEAAAEAPSFLSLRRGTALSNGQ GARVLHVVQTLYPFSSVTEEELSFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLS DGPALHPTHTPQISYTGPSASGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDF SVSLKASGRNKHFKVQLVDSVYCIGQRRFHSMDELVEHYKKAPIFTSEHGEKLYLVRALQ hide sequence

Ensembl Acc Id:

ENSRNOP00000023029 ⟸ ENSRNOT00000023029

RefSeq Acc Id:	XP_063123234 ⟸ XM_063267164
- Peptide Label:	isoform X1
- UniProtKB:	A6INR5 (UniProtKB/TrEMBL), D4A3M8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123233 ⟸ XM_063267163
- Peptide Label:	isoform X1
- UniProtKB:	A6INR5 (UniProtKB/TrEMBL), D4A3M8 (UniProtKB/TrEMBL)

Protein Domains

SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3M8-F1-model_v2	AlphaFold	D4A3M8	1-380	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696640

Promoter ID:

EPDNEW_R7165

Type:

single initiation site

Name:

Nck2_1

Description:

NCK adaptor protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	50,247,712 - 50,247,772	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305965	AgrOrtholog
BioCyc Gene	G2FUF-27667	BioCyc
Ensembl Genes	ENSRNOG00000017155	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023029	ENTREZGENE
	ENSRNOT00000023029.9	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	Cytoplasmic_NCK	UniProtKB/TrEMBL
	Nck2_SH2	UniProtKB/TrEMBL
	Nck2_SH3_1	UniProtKB/TrEMBL
	Nck2_SH3_2	UniProtKB/TrEMBL
	Nck2_SH3_3	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyrosine-phos_adapter	UniProtKB/TrEMBL
KEGG Report	rno:316369	UniProtKB/TrEMBL
NCBI Gene	316369	ENTREZGENE
PANTHER	PTHR19969:SF12	UniProtKB/TrEMBL
	SH2-SH3 ADAPTOR PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
	SH3_9	UniProtKB/TrEMBL
PhenoGen	Nck2	PhenoGen
PIRSF	Cytoplasmic_NCK	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017155	RatGTEx
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A6INR5	ENTREZGENE, UniProtKB/TrEMBL
	D4A3M8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Nck2	NCK adaptor protein 2	Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	Nck2_predicted	non-catalytic region of tyrosine kinase adaptor protein 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Nck2_predicted	non-catalytic region of tyrosine kinase adaptor protein 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)