NCK2 (NCK adaptor protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NCK2 (NCK adaptor protein 2) Chlorocebus sabaeus
Analyze
Symbol: NCK2
Name: NCK adaptor protein 2
RGD ID: 18422023
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); protein-containing complex binding (inferred); receptor tyrosine kinase binding (inferred); INVOLVED IN actin filament organization (ortholog); cell migration (ortholog); dendritic spine development (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Albuminuria (ortholog); Alzheimer's disease (ortholog); nephrotic syndrome (ortholog); FOUND IN postsynaptic density (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytoplasmic protein NCK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,412,677 - 9,515,565 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl149,437,301 - 9,515,561 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041177,084,239 - 177,234,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,412,677 - 9,515,565 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl149,437,301 - 9,515,561 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041177,084,239 - 177,234,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382105,744,453 - 105,894,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2105,744,912 - 105,894,274 (+)EnsemblGRCh38hg38GRCh38
GRCh372106,361,369 - 106,510,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362105,727,786 - 105,877,160 (+)NCBINCBI36Build 36hg18NCBI36
Build 342105,819,871 - 105,969,244NCBI
Celera2100,633,297 - 100,711,182 (+)NCBICelera
Cytogenetic Map2q12.2NCBI
HuRef2100,201,822 - 100,279,928 (+)NCBIHuRef
CHM1_12106,365,834 - 106,515,058 (+)NCBICHM1_1
T2T-CHM13v2.02106,205,667 - 106,355,582 (+)NCBIT2T-CHM13v2.0
Nck2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,484,643 - 43,609,678 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,483,739 - 43,609,675 (+)EnsemblGRCm39 Ensembl
GRCm38143,445,483 - 43,570,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,444,579 - 43,570,515 (+)EnsemblGRCm38mm10GRCm38
MGSCv37143,502,596 - 43,627,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36143,390,297 - 43,515,060 (+)NCBIMGSCv36mm8
Celera143,789,420 - 43,915,515 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.18NCBI
Nck2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,206,006 - 53,332,417 (+)NCBIGRCr8
mRatBN7.2945,713,979 - 45,840,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,714,883 - 45,840,307 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,216,238 - 54,348,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,339,036 - 59,471,142 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,619,256 - 57,751,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,246,767 - 50,373,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,247,692 - 50,373,284 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0949,914,483 - 50,040,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,650,261 - 42,776,967 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,651,481 - 42,778,381 (+)NCBI
Celera943,431,256 - 43,557,014 (+)NCBICelera
Cytogenetic Map9q22NCBI
Nck2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547010,487,481 - 10,593,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547010,487,962 - 10,593,046 (+)NCBIChiLan1.0ChiLan1.0
NCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21221,826,888 - 21,977,466 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A21,829,652 - 21,980,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A95,939,197 - 96,089,163 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A106,827,621 - 106,976,362 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A106,898,547 - 106,976,363 (+)Ensemblpanpan1.1panPan2
NCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11037,584,351 - 37,734,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1037,585,565 - 37,732,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1037,509,022 - 37,661,002 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01038,434,612 - 38,590,460 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1038,434,614 - 38,588,705 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11038,166,351 - 38,316,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01038,443,073 - 38,594,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01038,636,761 - 38,787,028 (-)NCBIUU_Cfam_GSD_1.0
Nck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629286,718,210 - 86,762,553 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936764140,946 - 185,529 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936764141,159 - 185,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl349,063,991 - 49,198,664 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1349,063,813 - 49,222,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2351,391,130 - 51,413,769 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nck2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247499,765,308 - 9,884,472 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 14 58
Low 6 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000015162   ⟹   ENSCSAP00000013109
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl149,437,301 - 9,515,561 (+)Ensembl
RefSeq Acc Id: XM_008008289   ⟹   XP_008006480
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1149,437,301 - 9,515,565 (+)NCBI
Vero_WHO_p1.0NW_023666041177,084,239 - 177,234,654 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038004278   ⟹   XP_037860206
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041177,084,239 - 177,234,654 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008006480 (Get FASTA)   NCBI Sequence Viewer  
  XP_037860206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013109
  ENSCSAP00000013109.1
RefSeq Acc Id: XP_008006480   ⟸   XM_008008289
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RWX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013109   ⟸   ENSCSAT00000015162
RefSeq Acc Id: XP_037860206   ⟸   XM_038004278
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015162.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro NCK UniProtKB/TrEMBL
  Nck2_SH2 UniProtKB/TrEMBL
  Nck2_SH3_1 UniProtKB/TrEMBL
  Nck2_SH3_2 UniProtKB/TrEMBL
  Nck2_SH3_3 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report csab:103241188 UniProtKB/TrEMBL
NCBI Gene NCK2 ENTREZGENE
PANTHER PTHR19969:SF12 UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PIRSF Cytoplasmic_NCK UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9RWX0 ENTREZGENE, UniProtKB/TrEMBL