Atr (ATR checkpoint kinase) - Rat Genome Database

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Gene: Atr (ATR checkpoint kinase) Rattus norvegicus
Analyze
Symbol: Atr
Name: ATR checkpoint kinase (Ensembl:ATR serine/threonine kinase)
RGD ID: 1305796
Description: Predicted to enable MutLalpha complex binding activity; MutSalpha complex binding activity; and histone H2AXS139 kinase activity. Involved in response to arsenic-containing substance and response to xenobiotic stimulus. Predicted to be located in PML body; XY body; and male germ cell nucleus. Predicted to be part of ATR-ATRIP complex. Predicted to be active in several cellular components, including GABA-ergic synapse; nuclear envelope; and site of DNA damage. Predicted to be extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH amphetamine; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ataxia telangiectasia and Rad3 related; ataxia telangiectasia and rad3 related-like; ATR serine/threonine kinase; LOC300942; LOC685055; serine/threonine-protein kinase ATR; similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,306,299 - 105,403,742 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8105,306,305 - 105,403,718 (+)EnsemblGRCr8
mRatBN7.2896,426,704 - 96,524,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)EnsemblmRatBN7.2
Rnor_6.08103,673,578 - 103,770,886 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)Ensemblrn6Rnor6.0
Rnor_5.08103,123,798 - 103,222,597 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48100,936,342 - 101,014,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera895,873,052 - 95,969,777 (+)NCBICelera
RGSC_v3.18101,002,130 - 101,034,333 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aphidicolin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
DDE  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
flavanones  (ISO)
floxuridine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
isocyanates  (ISO)
lovastatin  (EXP)
lutein  (ISO)
metformin  (ISO)
methoxsalen  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
motexafin gadolinium  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nitenpyram  (ISO)
Nonidet P-40  (ISO)
O-methyleugenol  (ISO)
octamethylcyclotetrasiloxane  (ISO)
ouabain  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
Pf-06840003  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
quinoline yellow  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selinexor  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
yttrium chloride  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Andersson MK, etal., Oncogenesis. 2020 Jan 30;9(1):5. doi: 10.1038/s41389-020-0194-3.
2. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. Fang Y, etal., EMBO J. 2004 Aug 4;23(15):3164-74. doi: 10.1038/sj.emboj.7600315. Epub 2004 Jul 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970. Hall AB, etal., Oncotarget. 2014 Jul 30;5(14):5674-85. doi: 10.18632/oncotarget.2158.
6. Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease . Katsel P, etal., PLoS One. 2013 Jul 5;8(7):e68361. doi: 10.1371/journal.pone.0068361. Print 2013.
7. Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers. Lewis KA, etal., Genes Chromosomes Cancer. 2007 Dec;46(12):1061-8. doi: 10.1002/gcc.20486.
8. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18). Lu HF, etal., Neurochem Res. 2009 Aug;34(8):1491-7. Epub 2009 Mar 5.
9. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Murga M, etal., Nat Genet. 2009 Aug;41(8):891-8. doi: 10.1038/ng.420. Epub 2009 Jul 20.
10. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. O'Driscoll M, etal., Nat Genet. 2003 Apr;33(4):497-501. Epub 2003 Mar 17.
11. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. Okazaki T, etal., Clin Cancer Res. 2008 Apr 1;14(7):2042-8.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells. Wang M, etal., Cancer Biother Radiopharm. 2017 Aug;32(6):193-203. doi: 10.1089/cbr.2017.2212.
17. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. Watanabe R, etal., J Toxicol Pathol. 2017 Oct;30(4):333-337. doi: 10.1293/tox.2017-0020. Epub 2017 Jul 3.
Additional References at PubMed
PMID:9733515   PMID:9925639   PMID:10691732   PMID:12814551   PMID:12937170   PMID:14657349   PMID:15149599   PMID:15364958   PMID:15983387   PMID:16713580   PMID:18162465   PMID:18316482  
PMID:20639548   PMID:21829167   PMID:22549958   PMID:23039116   PMID:26586427   PMID:26586433   PMID:27723717   PMID:27723720  


Genomics

Comparative Map Data
Atr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,306,299 - 105,403,742 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8105,306,305 - 105,403,718 (+)EnsemblGRCr8
mRatBN7.2896,426,704 - 96,524,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)EnsemblmRatBN7.2
Rnor_6.08103,673,578 - 103,770,886 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)Ensemblrn6Rnor6.0
Rnor_5.08103,123,798 - 103,222,597 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48100,936,342 - 101,014,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera895,873,052 - 95,969,777 (+)NCBICelera
RGSC_v3.18101,002,130 - 101,034,333 (+)NCBI
Cytogenetic Map8q31NCBI
ATR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383142,449,235 - 142,578,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3142,449,007 - 142,578,781 (-)Ensemblhg38GRCh38
GRCh373142,168,077 - 142,297,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,650,767 - 143,780,358 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343143,650,777 - 143,780,349NCBI
Celera3140,574,471 - 140,721,117 (-)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3139,541,210 - 139,670,336 (-)NCBIHuRef
CHM1_13142,131,099 - 142,260,691 (-)NCBICHM1_1
T2T-CHM13v2.03145,196,519 - 145,326,002 (-)NCBIT2T-CHM13v2.0
Atr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,739,655 - 95,834,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl995,739,650 - 95,833,834 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38995,857,597 - 95,953,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,857,597 - 95,951,781 (+)Ensemblmm10GRCm38
MGSCv37995,758,016 - 95,852,063 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera995,424,018 - 95,518,128 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.27NCBI
Atr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,337,432 - 3,440,257 (+)Ensembl
ChiLan1.0NW_0049555083,337,036 - 3,440,313 (+)NCBIChiLan1.0ChiLan1.0
ATR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,360,351 - 140,490,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13140,365,083 - 140,494,866 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03139,482,606 - 139,612,274 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13147,074,993 - 147,204,399 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,075,185 - 147,196,261 (-)EnsemblpanPan2panpan1.1
ATR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12338,131,956 - 38,223,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2338,132,788 - 38,224,016 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2338,060,079 - 38,150,864 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02338,664,914 - 38,756,051 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,664,914 - 38,756,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12338,346,951 - 38,438,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02338,423,893 - 38,514,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,668,053 - 38,759,024 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560277,334,745 - 77,439,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365404,074,570 - 4,178,898 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365404,074,543 - 4,178,859 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,174,824 - 83,289,989 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11383,175,515 - 83,289,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,978,658 - 91,094,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,048,785 - 48,173,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,048,882 - 48,173,137 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604120,983,463 - 21,108,351 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473019,022,070 - 19,145,306 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473019,022,012 - 19,145,474 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Atr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1887,314,963 - 87,403,170 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atr
866 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:99
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000049967
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
AU047277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,429,963 - 96,430,158 (+)MAPPERmRatBN7.2
Rnor_6.08103,676,788 - 103,676,982NCBIRnor6.0
Rnor_5.08103,127,314 - 103,127,508UniSTSRnor5.0
RGSC_v3.48100,939,521 - 100,939,715UniSTSRGSC3.4
Celera895,876,262 - 95,876,454UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049967   ⟹   ENSRNOP00000043760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8105,306,305 - 105,403,718 (+)Ensembl
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)Ensembl
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097700   ⟹   ENSRNOP00000081218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl896,426,999 - 96,524,136 (+)Ensembl
RefSeq Acc Id: NM_001427167   ⟹   NP_001414096
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,306,322 - 105,403,728 (+)NCBI
RefSeq Acc Id: XM_006243600   ⟹   XP_006243662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,306,828 - 105,403,742 (+)NCBI
mRatBN7.2896,426,930 - 96,524,152 (+)NCBI
Rnor_6.08103,673,684 - 103,770,886 (+)NCBI
Rnor_5.08103,123,798 - 103,222,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082561   ⟹   XP_038938489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,307,077 - 105,403,742 (+)NCBI
mRatBN7.2896,428,889 - 96,524,152 (+)NCBI
RefSeq Acc Id: XM_063266146   ⟹   XP_063122216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,306,299 - 105,379,573 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414096 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243662 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938489 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122216 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043760
  ENSRNOP00000043760.5
RefSeq Acc Id: XP_006243662   ⟸   XM_006243600
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5M3 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043760   ⟸   ENSRNOT00000049967
RefSeq Acc Id: XP_038938489   ⟸   XM_039082561
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5M3 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081218   ⟸   ENSRNOT00000097700
RefSeq Acc Id: XP_063122216   ⟸   XM_063266146
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414096   ⟸   NM_001427167
- UniProtKB: D3Z822 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z822-F1-model_v2 AlphaFold D3Z822 1-2636 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696197
Promoter ID:EPDNEW_R6713
Type:initiation region
Name:Atr_1
Description:ATR serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08103,673,551 - 103,673,611EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305796 AgrOrtholog
BioCyc Gene G2FUF-29472 BioCyc
Ensembl Genes ENSRNOG00000010027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049967 ENTREZGENE
  ENSRNOT00000049967.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  ATR-like_M-HEAT UniProtKB/TrEMBL
  ATR-like_N-HEAT UniProtKB/TrEMBL
  DDR_Repair_Kinase UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_ATR UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
NCBI Gene Atr ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE ATR UniProtKB/TrEMBL
Pfam FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_ATR UniProtKB/TrEMBL
  M-HEAT_ATR UniProtKB/TrEMBL
  N-HEAT_ATR UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
PhenoGen Atr PhenoGen
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_REPEAT UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010027 RatGTEx
SMART FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I6G5M3 ENTREZGENE
  A6I268 ENTREZGENE, UniProtKB/TrEMBL
  D3Z822 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Atr  ATR checkpoint kinase  Atr  ATR serine/threonine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-06-25 Atr  ATR serine/threonine kinase  Atr  ataxia telangiectasia and Rad3 related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Atr  ataxia telangiectasia and Rad3 related  LOC100365674  ataxia telangiectasia and rad3 related-like  Data merged from RGD:2318611 1643240 APPROVED
2013-05-24 Atr  ataxia telangiectasia and Rad3 related  LOC367198  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1591987 1643240 APPROVED
2010-05-05 LOC100365674  ataxia telangiectasia and rad3 related-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-03-24 Atr  ataxia telangiectasia and Rad3 related   LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1583247 737654 APPROVED
2008-04-30 Atr  ataxia telangiectasia and Rad3 related   Atr_predicted  ataxia telangiectasia and Rad3 related (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  LOC684113  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1593937 1643240 APPROVED
2006-11-20 LOC367198  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684113  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Atr_predicted  ataxia telangiectasia and Rad3 related (predicted)      Symbol and Name status set to approved 70820 APPROVED