Atr (ATR serine/threonine kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Atr (ATR serine/threonine kinase) Heterocephalus glaber
Analyze
Symbol: Atr
Name: ATR serine/threonine kinase
RGD ID: 18918629
Description: ENCODES a protein that exhibits histone H2AXS139 kinase activity (ortholog); MutLalpha complex binding (ortholog); MutSalpha complex binding (ortholog); INVOLVED IN cellular response to gamma radiation (ortholog); cellular response to UV (ortholog); chromosome organization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); alpha thalassemia-X-linked intellectual disability syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN ATR-ATRIP complex (ortholog); chromosome (ortholog); extrinsic component of synaptic vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ataxia telangiectasia and Rad3 related; Serine/threonine-protein kinase ATR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473019,022,070 - 19,145,306 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473019,022,012 - 19,145,474 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Atr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473019,022,070 - 19,145,306 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473019,022,012 - 19,145,474 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ATR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383142,449,235 - 142,578,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3142,449,007 - 142,578,733 (-)EnsemblGRCh38hg38GRCh38
GRCh373142,168,077 - 142,297,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,650,767 - 143,780,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 343143,650,777 - 143,780,349NCBI
Celera3140,574,471 - 140,721,117 (-)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3139,541,210 - 139,670,336 (-)NCBIHuRef
CHM1_13142,131,099 - 142,260,691 (-)NCBICHM1_1
T2T-CHM13v2.03145,196,519 - 145,326,002 (-)NCBIT2T-CHM13v2.0
Atr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,739,655 - 95,834,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl995,739,650 - 95,833,834 (+)EnsemblGRCm39 Ensembl
GRCm38995,857,597 - 95,953,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,857,597 - 95,951,781 (+)EnsemblGRCm38mm10GRCm38
MGSCv37995,758,016 - 95,852,063 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera995,424,018 - 95,518,128 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.27NCBI
Atr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,306,299 - 105,403,742 (+)NCBIGRCr8
mRatBN7.2896,426,704 - 96,524,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08103,673,578 - 103,770,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,123,798 - 103,222,597 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,936,342 - 101,014,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,002,130 - 101,034,333 (+)NCBI
Celera895,873,052 - 95,969,777 (+)NCBICelera
Cytogenetic Map8q31NCBI
Atr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,337,432 - 3,440,257 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555083,337,036 - 3,440,313 (+)NCBIChiLan1.0ChiLan1.0
ATR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,360,351 - 140,490,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13140,365,083 - 140,494,866 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03139,482,606 - 139,612,274 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13147,074,993 - 147,204,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,075,185 - 147,196,261 (-)Ensemblpanpan1.1panPan2
ATR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12338,131,956 - 38,223,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2338,132,788 - 38,224,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2338,060,079 - 38,150,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02338,664,914 - 38,756,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,664,914 - 38,756,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12338,346,951 - 38,438,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02338,423,893 - 38,514,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,668,053 - 38,759,024 (-)NCBIUU_Cfam_GSD_1.0
Atr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560277,334,745 - 77,439,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365404,074,570 - 4,178,898 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365404,074,543 - 4,178,859 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,174,824 - 83,289,989 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11383,175,515 - 83,289,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,978,658 - 91,094,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,048,785 - 48,173,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,048,882 - 48,173,137 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604120,983,463 - 21,108,351 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000023872   ⟹   ENSHGLP00000023654
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473019,022,070 - 19,145,306 (-)Ensembl
RefSeq Acc Id: XM_004834379   ⟹   XP_004834436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473019,022,012 - 19,145,467 (-)NCBI
RefSeq Acc Id: XM_021252588   ⟹   XP_021108247
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473019,022,012 - 19,145,467 (-)NCBI
RefSeq Acc Id: XM_021252598   ⟹   XP_021108257
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473019,022,012 - 19,145,468 (-)NCBI
RefSeq Acc Id: XM_021252620   ⟹   XP_021108279
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473019,048,768 - 19,145,474 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004834436 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108247 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108257 (Get FASTA)   NCBI Sequence Viewer  
  XP_021108279 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB02316 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023654
  ENSHGLP00100045050
GenBank Protein JAN97741 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021108257   ⟸   XM_021252598
- Peptide Label: isoform X3
- UniProtKB: G5AZ55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108247   ⟸   XM_021252588
- Peptide Label: isoform X2
- UniProtKB: G5AZ55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834436   ⟸   XM_004834379
- Peptide Label: isoform X1
- UniProtKB: A0A0N8ESY4 (UniProtKB/TrEMBL),   G5AZ55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021108279   ⟸   XM_021252620
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000023654   ⟸   ENSHGLT00000023872


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016875 Ensembl, ENTREZGENE
  ENSHGLG00100010317 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000023872 ENTREZGENE
  ENSHGLT00100047995 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  FATC_dom UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
KEGG Report hgl:101701996 UniProtKB/TrEMBL
NCBI Gene Atr ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE ATR UniProtKB/TrEMBL
Pfam FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_REPEAT UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
SMART FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0N8ESY4 ENTREZGENE, UniProtKB/TrEMBL
  G5AZ55 ENTREZGENE, UniProtKB/TrEMBL