Pxn (paxillin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pxn (paxillin) Rattus norvegicus
Analyze
Symbol: Pxn
Name: paxillin
RGD ID: 1305759
Description: Enables integrin binding activity and protein kinase binding activity. Involved in response to peptide. Located in focal adhesion. Orthologous to human PXN (paxillin); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; integrin mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inverted formin-2-like; LOC108352464; LOC360820; myocardial ischemic preconditioning associated protein 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,721,546 - 46,768,706 (-)NCBIGRCr8
mRatBN7.21241,060,791 - 41,107,952 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,060,791 - 41,107,931 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,228,092 - 42,275,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,841,747 - 42,888,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,902,292 - 41,949,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,797,953 - 46,845,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,797,954 - 46,845,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,595,399 - 48,642,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,322,193 - 42,370,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,185,581 - 42,233,895 (-)NCBI
Celera1242,684,240 - 42,731,375 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxycoumarin  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
Anetholtrithion  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
BQ 123  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (ISO)
glucose  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
isoflavones  (ISO)
ivermectin  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP,ISO)
oxotremorine M  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
T-2 toxin  (ISO)
terbinafine  (ISO)
toxaphene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cholecystokinin rapidly stimulates CrkII function in vivo in rat pancreatic acini. Formation of CrkII-protein complexes. Andreolotti AG, etal., Eur J Biochem 2003 Dec;270(23):4706-13.
2. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. Cerna J, etal., J Mol Biol. 2006 Oct 6;362(5):954-65. Epub 2006 Aug 1.
3. Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. Chun SJ, etal., J Cell Biol. 2003 Oct 27;163(2):397-408.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. Kim S, etal., J Biol Chem. 2003 Feb 21;278(8):6291-300. Epub 2002 Dec 6.
7. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko J, etal., J Neurosci. 2003 Mar 1;23(5):1667-77.
8. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Rafiq K, etal., J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9054445   PMID:9348226   PMID:9710592   PMID:10809671   PMID:10925297   PMID:11146548   PMID:11304546   PMID:11784865   PMID:11807098   PMID:12477932   PMID:12686598   PMID:14636584  
PMID:14699151   PMID:15308668   PMID:15322113   PMID:15467718   PMID:15489334   PMID:15728191   PMID:15889232   PMID:15911746   PMID:16399995   PMID:16641100   PMID:16717130   PMID:17136425  
PMID:17412802   PMID:17449030   PMID:17513457   PMID:17591694   PMID:17603879   PMID:18042622   PMID:18697830   PMID:18794329   PMID:19004813   PMID:19007553   PMID:19151925   PMID:19779731  
PMID:19885391   PMID:20086044   PMID:21423176   PMID:22110278   PMID:23574715   PMID:23658024   PMID:24036928   PMID:24457422   PMID:24841562   PMID:24863063   PMID:25217619   PMID:25705373  
PMID:25753039   PMID:26616057   PMID:27061092   PMID:28759036  


Genomics

Comparative Map Data
Pxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,721,546 - 46,768,706 (-)NCBIGRCr8
mRatBN7.21241,060,791 - 41,107,952 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,060,791 - 41,107,931 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,228,092 - 42,275,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,841,747 - 42,888,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,902,292 - 41,949,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,797,953 - 46,845,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,797,954 - 46,845,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,595,399 - 48,642,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,322,193 - 42,370,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,185,581 - 42,233,895 (-)NCBI
Celera1242,684,240 - 42,731,375 (-)NCBICelera
Cytogenetic Map12q16NCBI
PXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,210,447 - 120,265,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,210,439 - 120,265,771 (-)EnsemblGRCh38hg38GRCh38
GRCh3712120,648,250 - 120,703,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,132,640 - 119,187,892 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412119,110,976 - 119,166,229NCBI
Celera12120,281,352 - 120,336,672 (-)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12117,656,442 - 117,711,723 (-)NCBIHuRef
CHM1_112120,616,253 - 120,671,571 (-)NCBICHM1_1
T2T-CHM13v2.012120,197,626 - 120,252,894 (-)NCBIT2T-CHM13v2.0
Pxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,630,035 - 115,694,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,644,735 - 115,694,046 (+)EnsemblGRCm39 Ensembl
GRCm385115,491,970 - 115,555,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,506,676 - 115,555,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,956,711 - 116,005,995 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,767,751 - 115,815,656 (+)NCBIMGSCv36mm8
Celera5112,606,134 - 112,661,101 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
Pxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,388,378 - 11,403,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,387,140 - 11,401,178 (+)NCBIChiLan1.0ChiLan1.0
PXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,272,300 - 128,327,525 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,268,677 - 128,323,899 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,785,614 - 117,840,816 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,160,295 - 121,200,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,160,295 - 121,176,667 (-)Ensemblpanpan1.1panPan2
PXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,157,231 - 16,224,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,159,025 - 16,184,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,161,797 - 16,210,046 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,424,969 - 16,473,447 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,424,971 - 16,473,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,385,989 - 16,434,224 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,463,118 - 16,511,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,504,096 - 16,552,543 (-)NCBIUU_Cfam_GSD_1.0
Pxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,161,497 - 146,210,393 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936668660,415 - 709,282 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,227,895 - 40,278,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,227,894 - 40,278,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,560,859 - 115,619,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,560,662 - 115,619,029 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,487,668 - 129,546,391 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,370,243 - 13,435,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,371,128 - 13,435,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pxn
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1026
Count of miRNA genes:301
Interacting mature miRNAs:372
Transcripts:ENSRNOT00000047466, ENSRNOT00000064115
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
D11S1348  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,069,480 - 41,070,277 (+)MAPPERmRatBN7.2
Rnor_6.01246,806,642 - 46,807,437NCBIRnor6.0
Rnor_5.01248,604,088 - 48,604,883UniSTSRnor5.0
RGSC_v3.41242,330,877 - 42,331,672UniSTSRGSC3.4
Celera1242,692,924 - 42,693,719UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001408855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY641810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047466   ⟹   ENSRNOP00000043928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,072,710 (-)Ensembl
Rnor_6.0 Ensembl1246,797,959 - 46,845,079 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064115   ⟹   ENSRNOP00000061647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,107,931 (-)Ensembl
Rnor_6.0 Ensembl1246,797,954 - 46,845,080 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081134   ⟹   ENSRNOP00000070477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,072,935 (-)Ensembl
Rnor_6.0 Ensembl1246,799,762 - 46,809,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105395   ⟹   ENSRNOP00000089712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,107,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112063   ⟹   ENSRNOP00000081906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,074,002 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113962   ⟹   ENSRNOP00000095501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,060,791 - 41,073,406 (-)Ensembl
RefSeq Acc Id: NM_001401037   ⟹   NP_001387966
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,768,679 (-)NCBI
mRatBN7.21241,060,791 - 41,107,934 (-)NCBI
RefSeq Acc Id: NM_001401038   ⟹   NP_001387967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,768,679 (-)NCBI
mRatBN7.21241,060,791 - 41,107,934 (-)NCBI
RefSeq Acc Id: NM_001408855   ⟹   NP_001395784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,768,697 (-)NCBI
mRatBN7.21241,060,791 - 41,107,952 (-)NCBI
RefSeq Acc Id: XM_039089602   ⟹   XP_038945530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,737,030 (-)NCBI
mRatBN7.21241,060,791 - 41,074,564 (-)NCBI
RefSeq Acc Id: XM_039089603   ⟹   XP_038945531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,737,030 (-)NCBI
mRatBN7.21241,060,791 - 41,074,563 (-)NCBI
RefSeq Acc Id: XM_039089606   ⟹   XP_038945534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,737,022 (-)NCBI
mRatBN7.21241,060,791 - 41,074,558 (-)NCBI
RefSeq Acc Id: XM_039089607   ⟹   XP_038945535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,751,123 (-)NCBI
mRatBN7.21241,060,791 - 41,087,900 (-)NCBI
RefSeq Acc Id: XM_039089608   ⟹   XP_038945536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,734,386 (-)NCBI
mRatBN7.21241,060,791 - 41,074,523 (-)NCBI
RefSeq Acc Id: XM_039089610   ⟹   XP_038945538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,736,285 (-)NCBI
mRatBN7.21241,060,791 - 41,074,512 (-)NCBI
RefSeq Acc Id: XM_063271540   ⟹   XP_063127610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,768,706 (-)NCBI
RefSeq Acc Id: XM_063271542   ⟹   XP_063127612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,736,279 (-)NCBI
RefSeq Acc Id: XM_063271543   ⟹   XP_063127613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,721,546 - 46,768,703 (-)NCBI
Ensembl Acc Id: ENSRNOP00000043928   ⟸   ENSRNOT00000047466
Ensembl Acc Id: ENSRNOP00000070477   ⟸   ENSRNOT00000081134
Ensembl Acc Id: ENSRNOP00000061647   ⟸   ENSRNOT00000064115
RefSeq Acc Id: XP_038945535   ⟸   XM_039089607
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038945530   ⟸   XM_039089602
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945531   ⟸   XM_039089603
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945534   ⟸   XM_039089606
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038945536   ⟸   XM_039089608
- Peptide Label: isoform X6
- UniProtKB: A6J1T6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945538   ⟸   XM_039089610
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AJT3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095501   ⟸   ENSRNOT00000113962
Ensembl Acc Id: ENSRNOP00000081906   ⟸   ENSRNOT00000112063
Ensembl Acc Id: ENSRNOP00000089712   ⟸   ENSRNOT00000105395
RefSeq Acc Id: NP_001395784   ⟸   NM_001408855
- Peptide Label: isoform 3
- UniProtKB: A0A8I6AAE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387967   ⟸   NM_001401038
- Peptide Label: isoform 2
- UniProtKB: Q1EG89 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387966   ⟸   NM_001401037
- Peptide Label: isoform 1
- UniProtKB: F7FID5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127610   ⟸   XM_063271540
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127613   ⟸   XM_063271543
- Peptide Label: isoform X9
- UniProtKB: Q66H76 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063127612   ⟸   XM_063271542
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZUE4 (UniProtKB/TrEMBL)
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H76-F1-model_v2 AlphaFold Q66H76 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698687
Promoter ID:EPDNEW_R9212
Type:initiation region
Name:Pxn_1
Description:paxillin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01246,845,074 - 46,845,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305759 AgrOrtholog
BioCyc Gene G2FUF-19003 BioCyc
Ensembl Genes ENSRNOG00000001149 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047466.4 UniProtKB/TrEMBL
  ENSRNOT00000064115.4 UniProtKB/TrEMBL
  ENSRNOT00000081134.2 UniProtKB/TrEMBL
  ENSRNOT00000105395.1 UniProtKB/TrEMBL
  ENSRNOT00000112063.1 UniProtKB/TrEMBL
  ENSRNOT00000113962.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128801 IMAGE-MGC_LOAD
InterPro Cell_Adhesion-Viral_Mod UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paxillin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paxillin_Lim_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paxillin_TGFB1I1_LIM_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tgfb1i1/Leupaxin/TGFB1I1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94176 IMAGE-MGC_LOAD
NCBI Gene 360820 ENTREZGENE
PANTHER PAXILLIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24216:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paxillin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pxn PhenoGen
PIRSF Leupaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PAXILLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001149 RatGTEx
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JY12_RAT UniProtKB/TrEMBL
  A0A8I5ZUE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QL86_RAT UniProtKB/TrEMBL
  A6J1T6 ENTREZGENE, UniProtKB/TrEMBL
  F7FID5 ENTREZGENE, UniProtKB/TrEMBL
  PAXI_RAT UniProtKB/Swiss-Prot
  Q1EG89 ENTREZGENE, UniProtKB/TrEMBL
  Q66H76 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pxn  paxillin  LOC108352464  inverted formin-2-like  Data merged from RGD:11447483 737654 PROVISIONAL
2016-08-02 LOC108352464  inverted formin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Pxn  paxillin  Pxn_predicted  paxillin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pxn_predicted  paxillin (predicted)      Symbol and Name status set to approved 70820 APPROVED