Pxn (paxillin) - Rat Genome Database

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Gene: Pxn (paxillin) Heterocephalus glaber
Analyze
Symbol: Pxn
Name: paxillin
RGD ID: 18919045
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); BH4 domain binding (ortholog); integrin binding (ortholog); INVOLVED IN branching morphogenesis of an epithelial tube (ortholog); cell migration (ortholog); cellular response to reactive oxygen species (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; insulin-like growth factor signaling pathway; integrin mediated signaling pathway; ASSOCIATED WITH Experimental Melanoma (ortholog); lung non-small cell carcinoma (ortholog); Neoplasm Metastasis (ortholog); FOUND IN cell leading edge (ortholog); cell-cell junction (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,370,243 - 13,435,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,371,128 - 13,435,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Pxn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,370,243 - 13,435,714 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474713,371,128 - 13,435,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,210,447 - 120,265,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,210,439 - 120,265,771 (-)EnsemblGRCh38hg38GRCh38
GRCh3712120,648,250 - 120,703,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,132,640 - 119,187,892 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412119,110,976 - 119,166,229NCBI
Celera12120,281,352 - 120,336,672 (-)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12117,656,442 - 117,711,723 (-)NCBIHuRef
CHM1_112120,616,253 - 120,671,571 (-)NCBICHM1_1
T2T-CHM13v2.012120,197,626 - 120,252,894 (-)NCBIT2T-CHM13v2.0
Pxn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,630,035 - 115,694,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,644,735 - 115,694,046 (+)EnsemblGRCm39 Ensembl
GRCm385115,491,970 - 115,555,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,506,676 - 115,555,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv375115,956,711 - 116,005,995 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,767,751 - 115,815,656 (+)NCBIMGSCv36mm8
Celera5112,606,134 - 112,661,101 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.1NCBI
Pxn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,721,546 - 46,768,706 (-)NCBIGRCr8
mRatBN7.21241,060,791 - 41,107,952 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,060,791 - 41,107,931 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,228,092 - 42,275,199 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,841,747 - 42,888,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,902,292 - 41,949,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,797,953 - 46,845,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,797,954 - 46,845,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,595,399 - 48,642,177 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,322,193 - 42,370,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,185,581 - 42,233,895 (-)NCBI
Celera1242,684,240 - 42,731,375 (-)NCBICelera
Cytogenetic Map12q16NCBI
Pxn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,388,378 - 11,403,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545511,387,140 - 11,401,178 (+)NCBIChiLan1.0ChiLan1.0
PXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,272,300 - 128,327,525 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,268,677 - 128,323,899 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012117,785,614 - 117,840,816 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,160,295 - 121,200,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,160,295 - 121,176,667 (-)Ensemblpanpan1.1panPan2
PXN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,157,231 - 16,224,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,159,025 - 16,184,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2616,161,797 - 16,210,046 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02616,424,969 - 16,473,447 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,424,971 - 16,473,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,385,989 - 16,434,224 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,463,118 - 16,511,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,504,096 - 16,552,543 (-)NCBIUU_Cfam_GSD_1.0
Pxn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,161,497 - 146,210,393 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936668660,415 - 709,282 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,227,895 - 40,278,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11440,227,894 - 40,278,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,560,859 - 115,619,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,560,662 - 115,619,029 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037129,487,668 - 129,546,391 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000015444   ⟹   ENSHGLP00000015288
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474713,370,243 - 13,435,714 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000015445   ⟹   ENSHGLP00000015289
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474713,371,191 - 13,435,714 (+)Ensembl
RefSeq Acc Id: XM_004843676   ⟹   XP_004843733
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474713,371,166 - 13,435,619 (+)NCBI
RefSeq Acc Id: XM_004843678   ⟹   XP_004843735
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474713,371,166 - 13,435,619 (+)NCBI
RefSeq Acc Id: XM_021257354   ⟹   XP_021113013
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474713,371,166 - 13,435,619 (+)NCBI
RefSeq Acc Id: XM_021257355   ⟹   XP_021113014
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474713,371,128 - 13,435,619 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004843733 (Get FASTA)   NCBI Sequence Viewer  
  XP_004843735 (Get FASTA)   NCBI Sequence Viewer  
  XP_021113013 (Get FASTA)   NCBI Sequence Viewer  
  XP_021113014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015288
  ENSHGLP00000015289
  ENSHGLP00100019423
GenBank Protein JAO02043 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021113014   ⟸   XM_021257355
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021113013   ⟸   XM_021257354
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004843733   ⟸   XM_004843676
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JDJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843735   ⟸   XM_004843678
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000015288   ⟸   ENSHGLT00000015444
RefSeq Acc Id: ENSHGLP00000015289   ⟸   ENSHGLT00000015445


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010923 Ensembl, ENTREZGENE
  ENSHGLG00100014319 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000015444 ENTREZGENE
  ENSHGLT00000015445 ENTREZGENE
  ENSHGLT00100019625 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
InterPro Paxillin UniProtKB/TrEMBL
  Paxillin_Lim_dom2 UniProtKB/TrEMBL
  Paxillin_TGFB1I1_LIM_dom1 UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
NCBI Gene Pxn ENTREZGENE
PANTHER PAXILLIN-RELATED UniProtKB/TrEMBL
  PTHR24216:SF11 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
  Paxillin UniProtKB/TrEMBL
PRINTS PAXILLIN UniProtKB/TrEMBL
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A0P6JDJ4 ENTREZGENE, UniProtKB/TrEMBL