Lrp8 (LDL receptor related protein 8) - Rat Genome Database

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Gene: Lrp8 (LDL receptor related protein 8) Rattus norvegicus
Analyze
Symbol: Lrp8
Name: LDL receptor related protein 8
RGD ID: 1305729
Description: Enables high-density lipoprotein particle binding activity and kinesin binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to growth factor stimulus; and cerebral cortex development. Located in axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8); PARTICIPATES IN altered Reelin signaling pathway; Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362558; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85127,792,236 - 127,864,207 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)EnsemblGRCr8
mRatBN7.25122,563,468 - 122,635,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)EnsemblmRatBN7.2
Rnor_6.05127,404,348 - 127,476,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,404,450 - 127,476,641 (+)Ensemblrn6Rnor6.0
Rnor_5.05131,252,497 - 131,324,785 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45128,905,612 - 128,975,702 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5121,304,991 - 121,373,312 (+)NCBICelera
RGSC_v3.15128,910,685 - 128,980,029 (+)NCBI
Cytogenetic Map5q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
Diisodecyl phthalate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hexaconazole  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
Tanshinone I  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Beffert U, etal., Neuron. 2005 Aug 18;47(4):567-79.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia. Helbecque N, etal., Neurobiol Aging. 2009 Feb;30(2):266-71. Epub 2007 Jul 5.
4. Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer's disease patients. Hosoda A, etal., Biosci Biotechnol Biochem. 2010;74(3):677-9. Epub 2010 Mar 7.
5. The reelin signaling pathway: some recent developments. Jossin Y, etal., Cereb Cortex 2003 Jun;13(6):627-33.
6. Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. Kim DH, etal., J Biol Chem. 1996 Apr 5;271(14):8373-80.
7. Partial purification of the apolipoprotein E receptor of rat liver membrane. Kinoshita M, etal., J Biochem. 1985 Jun;97(6):1803-6.
8. Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Kosacka J, etal., Neuroscience. 2009 Aug 18;162(2):282-91. Epub 2009 May 3.
9. Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. Lieb W, etal., J Mol Med. 2008 Oct;86(10):1163-70. Epub 2008 Jul 1.
10. Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease. Ma SL, etal., Neurosci Lett. 2002 Nov 8;332(3):216-8.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene. Myant NB Proc Biol Sci. 2010 Feb 7;277(1680):345-51. Epub 2009 Oct 21.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Maternal Thyroid Hormone before the Onset of Fetal Thyroid Function Regulates Reelin and Downstream Signaling Cascade Affecting Neocortical Neuronal Migration. Pathak A, etal., Cereb Cortex. 2010 Apr 5.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Uptake of lipoproteins for axonal growth of sympathetic neurons. Posse De Chaves EI, etal., J Biol Chem. 2000 Jun 30;275(26):19883-90.
17. Reelin promotes peripheral synapse elimination and maturation. Quattrocchi CC, etal., Science 2003 Aug 1;301(5633):649-53.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. Romay-Penabad Z, etal., Blood. 2011 Jan 27;117(4):1408-14. Epub 2010 Nov 30.
23. An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction. Shen GQ, etal., Am J Hum Genet. 2007 Oct;81(4):780-91. Epub 2007 Aug 31.
24. The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain. Stockinger W, etal., J Biol Chem. 1998 Nov 27;273(48):32213-21.
25. Impact of the Reelin signaling cascade (Ligands-Receptors-Adaptor Complex) on cognition in schizophrenia. Verbrugghe P, etal., Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):392-404. doi: 10.1002/ajmg.b.32042. Epub 2012 Mar 14.
26. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. Verhey KJ, etal., J Cell Biol. 2001 Mar 5;152(5):959-70.
Additional References at PubMed
PMID:10571240   PMID:11369809   PMID:12526740   PMID:15950758   PMID:16227578   PMID:17314095   PMID:17330141   PMID:18089558   PMID:18778775   PMID:19946888   PMID:20711475   PMID:21852430  
PMID:22761431   PMID:23382219   PMID:25233900   PMID:25340851   PMID:27653801   PMID:29336888  


Genomics

Comparative Map Data
Lrp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85127,792,236 - 127,864,207 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)EnsemblGRCr8
mRatBN7.25122,563,468 - 122,635,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)EnsemblmRatBN7.2
Rnor_6.05127,404,348 - 127,476,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5127,404,450 - 127,476,641 (+)Ensemblrn6Rnor6.0
Rnor_5.05131,252,497 - 131,324,785 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45128,905,612 - 128,975,702 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5121,304,991 - 121,373,312 (+)NCBICelera
RGSC_v3.15128,910,685 - 128,980,029 (+)NCBI
Cytogenetic Map5q34NCBI
LRP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38153,242,364 - 53,328,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl153,242,364 - 53,328,469 (-)Ensemblhg38GRCh38
GRCh37153,708,036 - 53,793,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36153,483,800 - 53,566,409 (-)NCBIBuild 36Build 36hg18NCBI36
Celera151,999,058 - 52,081,130 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef151,823,713 - 51,909,108 (-)NCBIHuRef
CHM1_1153,825,039 - 53,910,558 (-)NCBICHM1_1
T2T-CHM13v2.0153,123,827 - 53,210,280 (-)NCBIT2T-CHM13v2.0
Lrp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394107,659,337 - 107,734,037 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4107,659,066 - 107,734,037 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384107,802,200 - 107,876,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4107,801,869 - 107,876,840 (+)Ensemblmm10GRCm38
MGSCv374107,474,864 - 107,549,445 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364107,300,193 - 107,370,305 (+)NCBIMGSCv36mm8
Celera4106,150,293 - 106,225,723 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.18NCBI
Lrp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554645,837,009 - 5,911,672 (+)Ensembl
ChiLan1.0NW_0049554645,837,002 - 5,912,178 (+)NCBIChiLan1.0ChiLan1.0
LRP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21173,510,322 - 173,592,041 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,651,090 - 172,732,799 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0152,515,534 - 52,600,390 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1154,118,057 - 54,199,448 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl154,114,909 - 54,199,452 (-)EnsemblpanPan2panpan1.1
LRP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1555,604,878 - 55,684,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl555,604,878 - 55,699,736 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha555,671,125 - 55,750,885 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0555,794,174 - 55,873,703 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl555,793,975 - 55,873,703 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1555,787,220 - 55,866,738 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0555,677,366 - 55,756,833 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,066,954 - 56,146,662 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505867,595,806 - 67,675,403 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365227,740,887 - 7,816,297 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365227,740,887 - 7,820,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6158,905,410 - 158,983,382 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16158,905,464 - 158,984,743 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26146,568,027 - 146,649,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12079,596,138 - 79,681,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2079,596,370 - 79,677,278 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603337,601,413 - 37,686,958 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249341,146,000 - 1,215,922 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249341,145,982 - 1,220,177 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrp8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1146,959,141 - 46,982,414 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrp8
369 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:41
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000017575, ENSRNOT00000017584
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH134765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25122,635,144 - 122,635,352 (+)MAPPERmRatBN7.2
Rnor_6.05127,476,347 - 127,476,554NCBIRnor6.0
Rnor_5.05131,324,496 - 131,324,703UniSTSRnor5.0
RGSC_v3.45128,978,108 - 128,978,315UniSTSRGSC3.4
Celera5121,376,617 - 121,376,824UniSTS
RH 3.4 Map5819.8UniSTS
Cytogenetic Map5q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 90 89 58 91 58 6 352 191 11 143 79 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_342877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017575   ⟹   ENSRNOP00000017575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,860,678 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Rnor_6.0 Ensembl5127,404,450 - 127,476,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096386   ⟹   ENSRNOP00000081536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103471   ⟹   ENSRNOP00000088514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)Ensembl
mRatBN7.2 Ensembl5122,563,475 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112075   ⟹   ENSRNOP00000088471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,860,678 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112745   ⟹   ENSRNOP00000087919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114227   ⟹   ENSRNOP00000094896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116706   ⟹   ENSRNOP00000090752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,860,678 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116983   ⟹   ENSRNOP00000082808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5127,792,299 - 127,864,207 (+)Ensembl
mRatBN7.2 Ensembl5122,563,453 - 122,631,352 (+)Ensembl
RefSeq Acc Id: NM_001427454   ⟹   NP_001414383
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,299 - 127,864,207 (+)NCBI
RefSeq Acc Id: XM_003749992   ⟹   XP_003750040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
mRatBN7.25122,563,475 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003749993   ⟹   XP_003750041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,238 - 127,864,207 (+)NCBI
mRatBN7.25122,563,474 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238567   ⟹   XP_006238629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,237 - 127,864,207 (+)NCBI
mRatBN7.25122,563,473 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238570   ⟹   XP_006238632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,236 - 127,864,207 (+)NCBI
mRatBN7.25122,563,472 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238571   ⟹   XP_006238633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,237 - 127,864,207 (+)NCBI
mRatBN7.25122,563,473 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238574   ⟹   XP_006238636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,242 - 127,864,207 (+)NCBI
mRatBN7.25122,563,479 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111148   ⟹   XP_038967076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,236 - 127,864,207 (+)NCBI
mRatBN7.25122,563,472 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111149   ⟹   XP_038967077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,237 - 127,864,207 (+)NCBI
mRatBN7.25122,563,472 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111150   ⟹   XP_038967078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,238 - 127,864,207 (+)NCBI
mRatBN7.25122,563,474 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111152   ⟹   XP_038967080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,238 - 127,864,207 (+)NCBI
mRatBN7.25122,563,473 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111153   ⟹   XP_038967081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
mRatBN7.25122,563,475 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111154   ⟹   XP_038967082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
mRatBN7.25122,563,475 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111155   ⟹   XP_038967083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
mRatBN7.25122,563,475 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111156   ⟹   XP_038967084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,241 - 127,864,207 (+)NCBI
mRatBN7.25122,563,478 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111157   ⟹   XP_038967085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,240 - 127,864,207 (+)NCBI
mRatBN7.25122,563,477 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111158   ⟹   XP_038967086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,241 - 127,864,207 (+)NCBI
mRatBN7.25122,563,477 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_039111160   ⟹   XP_038967088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,837,869 - 127,864,207 (+)NCBI
mRatBN7.25122,609,078 - 122,635,434 (+)NCBI
RefSeq Acc Id: XM_063287975   ⟹   XP_063144045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
RefSeq Acc Id: XM_063287977   ⟹   XP_063144047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,240 - 127,864,207 (+)NCBI
RefSeq Acc Id: XM_342877   ⟹   XP_342878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85127,792,239 - 127,864,207 (+)NCBI
mRatBN7.25122,563,476 - 122,635,434 (+)NCBI
Rnor_6.05127,404,417 - 127,476,636 (+)NCBI
Rnor_5.05131,252,497 - 131,324,785 (+)NCBI
RGSC_v3.45128,905,612 - 128,975,702 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001414383 (Get FASTA)   NCBI Sequence Viewer  
  XP_003750040 (Get FASTA)   NCBI Sequence Viewer  
  XP_003750041 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238629 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238632 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238633 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238636 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967076 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967077 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967078 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967080 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967081 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967082 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967083 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967084 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967085 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967088 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144045 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144047 (Get FASTA)   NCBI Sequence Viewer  
  XP_342878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90425 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017575
  ENSRNOP00000017575.8
  ENSRNOP00000081536
  ENSRNOP00000081536.2
  ENSRNOP00000082808
  ENSRNOP00000082808.1
  ENSRNOP00000087919
  ENSRNOP00000087919.2
  ENSRNOP00000088471
  ENSRNOP00000088471.1
  ENSRNOP00000088514
  ENSRNOP00000088514.1
  ENSRNOP00000090752.1
  ENSRNOP00000094896
  ENSRNOP00000094896.1
RefSeq Acc Id: XP_342878   ⟸   XM_342877
- Peptide Label: isoform X14
- UniProtKB: A0A8I6GH61 (UniProtKB/TrEMBL),   A0A8I5ZVL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003750040   ⟸   XM_003749992
- Peptide Label: isoform X11
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003750041   ⟸   XM_003749993
- Peptide Label: isoform X7
- UniProtKB: A0A8I5ZTA7 (UniProtKB/TrEMBL),   A6JYS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238632   ⟸   XM_006238570
- Peptide Label: isoform X1
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238633   ⟸   XM_006238571
- Peptide Label: isoform X4
- UniProtKB: D3ZE75 (UniProtKB/TrEMBL),   A6JYS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238629   ⟸   XM_006238567
- Peptide Label: isoform X8
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238636   ⟸   XM_006238574
- Peptide Label: isoform X20
- UniProtKB: A0A8I6A6L0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017575   ⟸   ENSRNOT00000017575
RefSeq Acc Id: XP_038967077   ⟸   XM_039111149
- Peptide Label: isoform X3
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967076   ⟸   XM_039111148
- Peptide Label: isoform X2
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967080   ⟸   XM_039111152
- Peptide Label: isoform X6
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967078   ⟸   XM_039111150
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ALZ7 (UniProtKB/TrEMBL),   A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967081   ⟸   XM_039111153
- Peptide Label: isoform X9
- UniProtKB: A0A8I6GFL9 (UniProtKB/TrEMBL),   A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967082   ⟸   XM_039111154
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967083   ⟸   XM_039111155
- Peptide Label: isoform X13
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967085   ⟸   XM_039111157
- Peptide Label: isoform X17
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967086   ⟸   XM_039111158
- Peptide Label: isoform X18
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967084   ⟸   XM_039111156
- Peptide Label: isoform X16
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967088   ⟸   XM_039111160
- Peptide Label: isoform X19
Ensembl Acc Id: ENSRNOP00000081536   ⟸   ENSRNOT00000096386
Ensembl Acc Id: ENSRNOP00000088471   ⟸   ENSRNOT00000112075
Ensembl Acc Id: ENSRNOP00000094896   ⟸   ENSRNOT00000114227
Ensembl Acc Id: ENSRNOP00000082808   ⟸   ENSRNOT00000116983
Ensembl Acc Id: ENSRNOP00000090752   ⟸   ENSRNOT00000116706
Ensembl Acc Id: ENSRNOP00000088514   ⟸   ENSRNOT00000103471
Ensembl Acc Id: ENSRNOP00000087919   ⟸   ENSRNOT00000112745
RefSeq Acc Id: XP_063144045   ⟸   XM_063287975
- Peptide Label: isoform X10
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144047   ⟸   XM_063287977
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZVL7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414383   ⟸   NM_001427454
- Peptide Label: precursor
- UniProtKB: A6JYS8 (UniProtKB/TrEMBL)
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE75-F1-model_v2 AlphaFold D3ZE75 1-953 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305729 AgrOrtholog
BioCyc Gene G2FUF-40406 BioCyc
Ensembl Genes ENSRNOG00000013064 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017575 ENTREZGENE
  ENSRNOT00000017575.9 UniProtKB/TrEMBL
  ENSRNOT00000096386 ENTREZGENE
  ENSRNOT00000096386.2 UniProtKB/TrEMBL
  ENSRNOT00000103471 ENTREZGENE
  ENSRNOT00000103471.2 UniProtKB/TrEMBL
  ENSRNOT00000112075 ENTREZGENE
  ENSRNOT00000112075.2 UniProtKB/TrEMBL
  ENSRNOT00000112745 ENTREZGENE
  ENSRNOT00000112745.2 UniProtKB/TrEMBL
  ENSRNOT00000114227 ENTREZGENE
  ENSRNOT00000114227.2 UniProtKB/TrEMBL
  ENSRNOT00000116706.2 UniProtKB/TrEMBL
  ENSRNOT00000116983 ENTREZGENE
  ENSRNOT00000116983.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  LDL_rcpt_classB_YWTD_rpt UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR-related UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classA_rpt UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
NCBI Gene 362558 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PhenoGen Lrp8 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013064 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A8I5ZTA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6L0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AE51_RAT UniProtKB/TrEMBL
  A0A8I6ALZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GH61 ENTREZGENE, UniProtKB/TrEMBL
  A6JYS8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZE75 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp8  LDL receptor related protein 8  Lrp8  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lrp8  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor   Lrp8_predicted  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lrp8_predicted  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED