Mars1 (methionyl-tRNA synthetase 1)

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Gene: Mars1 (methionyl-tRNA synthetase 1) Rattus norvegicus

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Symbol:

Mars1

Name:

methionyl-tRNA synthetase 1

RGD ID:

1305321

Description:

Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to epidermal growth factor stimulus; and cellular response to platelet-derived growth factor stimulus. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC299851; Mars; methionine--tRNA ligase, cytoplasmic; methionine-tRNA synthetase; methionyl-tRNA synthetase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MARS1 (methionyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mars1 (methionine-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MARS1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mars1 (methionyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LIPA (lipase A, lysosomal acid type)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MARS1 (methionyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mars1 (methionine-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mars (methionyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MES1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	MetRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mars1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	65,006,456 - 65,023,880 (-)	NCBI		GRCr8
mRatBN7.2	7	63,121,142 - 63,138,550 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,121,142 - 63,138,495 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	65,010,415 - 65,027,712 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,212,835 - 67,230,132 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	67,014,183 - 67,031,462 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	67,273,245 - 67,290,584 (-)	NCBI
Celera	7	60,261,413 - 60,278,690 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cataract 15 multiple types (ISO)

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease axonal type 2U (ISO)

familial melanoma (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 70 (ISO)

INTERSTITIAL LUNG AND LIVER DISEASE (ISO)

Nonphotosensitive Trichothiodystrophy 9 (ISO)

paraplegia (ISO)

pulmonary alveolar proteinosis (ISO)

spinal muscular atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1-naphthyl isothiocyanate (EXP)

1-nitropyrene (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-chloropropane-1,2-diol (EXP)

5-fluorouracil (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

gemcitabine (ISO)

ivermectin (ISO)

L-methionine (ISO)

lamivudine (ISO)

lead diacetate (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

nickel dichloride (ISO)

ochratoxin A (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

piroxicam (ISO)

progesterone (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

Salinomycin (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epidermal growth factor stimulus (ISO)

cellular response to platelet-derived growth factor stimulus (ISO)

methionyl-tRNA aminoacylation (IBA,ISO)

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (ISO)

rRNA transcription (ISO)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IBA,IDA,ISO)

cytoplasm (ISO)

cytosol (IBA,ISO)

nucleolus (ISO)

Molecular Function

ATP binding (IEA)

methionine-tRNA ligase activity (IBA,ISO)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

glycine N-methyltransferase deficiency pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

selenoamino acid metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.	Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
9.	LysRS serves as a key signaling molecule in the immune response by regulating gene expression.	Yannay-Cohen N, etal., Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.

Additional References at PubMed

PMID:10791971	PMID:11714285	PMID:12060739	PMID:18614015	PMID:19131329	PMID:19289464	PMID:19946888	PMID:20458337	PMID:22424946

Genomics

Comparative Map Data

Mars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	65,006,456 - 65,023,880 (-)	NCBI		GRCr8
mRatBN7.2	7	63,121,142 - 63,138,550 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	63,121,142 - 63,138,495 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	65,010,415 - 65,027,712 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	67,212,835 - 67,230,132 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	67,014,183 - 67,031,462 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	67,273,245 - 67,290,584 (-)	NCBI
Celera	7	60,261,413 - 60,278,690 (-)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

MARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	57,488,068 - 57,516,652 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	57,475,445 - 57,517,569 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	57,881,851 - 57,910,435 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,168,118 - 56,196,700 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	56,168,117 - 56,196,700	NCBI
Celera	12	57,535,658 - 57,566,266 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,919,857 - 54,948,436 (+)	NCBI		HuRef
CHM1_1	12	57,849,852 - 57,878,293 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	57,456,360 - 57,484,880 (+)	NCBI		T2T-CHM13v2.0

Mars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,132,090 - 127,147,655 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,132,090 - 127,147,655 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	127,296,221 - 127,311,786 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,296,221 - 127,311,786 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,733,277 - 126,748,842 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	126,699,175 - 126,714,588 (-)	NCBI		MGSCv36	mm8
Celera	10	129,688,532 - 129,704,394 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	74.5	NCBI

Mars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,215,853 - 5,233,037 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,215,853 - 5,233,037 (+)	NCBI	ChiLan1.0	ChiLan1.0

MARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	36,824,464 - 36,863,833 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	36,821,235 - 36,848,909 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	31,410,231 - 31,438,015 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	31,668,634 - 31,693,988 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,668,708 - 31,693,839 (-)	Ensembl	panpan1.1		panPan2

MARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,588,503 - 1,606,752 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,588,875 - 1,606,750 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,651,747 - 1,669,984 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	1,597,550 - 1,615,816 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	1,597,894 - 1,615,814 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	1,575,609 - 1,593,831 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,817,102 - 1,835,520 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,942,478 - 1,960,709 (+)	NCBI		UU_Cfam_GSD_1.0

Mars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,205,154 - 57,225,738 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	1,644,457 - 1,665,086 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	1,644,457 - 1,665,081 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,752,374 - 22,785,501 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,752,405 - 22,785,509 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,397,380 - 53,410,596 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	192,539,409 - 192,566,135 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	10,443,223 - 10,460,971 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	10,443,216 - 10,460,971 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mars1
26 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	16
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000035486
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	47251783	65728867	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat

Markers in Region

RH128750

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,121,211 - 63,121,513 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	70,585,083 - 70,585,384	NCBI	Rnor6.0
Rnor_5.0	7	70,759,229 - 70,759,530	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,580 - 67,252,881	UniSTS	RGSC3.4
Celera	7	60,261,483 - 60,261,784	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH141558

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,120,873 - 63,121,092 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	70,584,745 - 70,584,963	NCBI	Rnor6.0
Rnor_5.0	7	70,758,891 - 70,759,109	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,242 - 67,252,460	UniSTS	RGSC3.4
Celera	7	60,261,145 - 60,261,363	UniSTS
Cytogenetic Map	7	q22	UniSTS

PMC150726P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	63,120,763 - 63,121,067 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	70,584,635 - 70,584,938	NCBI	Rnor6.0
Rnor_5.0	7	70,758,781 - 70,759,084	UniSTS	Rnor5.0
RGSC_v3.4	7	67,252,132 - 67,252,435	UniSTS	RGSC3.4
Celera	7	60,261,035 - 60,261,338	UniSTS
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000035486 ⟹ ENSRNOP00000034945

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,121,144 - 63,138,454 (-)	Ensembl
Rnor_6.0 Ensembl	7	70,585,013 - 70,602,310 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106342 ⟹ ENSRNOP00000078365

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,121,144 - 63,138,454 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107571 ⟹ ENSRNOP00000089312

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	63,121,142 - 63,138,495 (-)	Ensembl

RefSeq Acc Id:

NM_001127659 ⟹ NP_001121131

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	65,006,456 - 65,023,753 (-)	NCBI
mRatBN7.2	7	63,121,142 - 63,138,439 (-)	NCBI
Rnor_6.0	7	70,585,013 - 70,602,310 (-)	NCBI
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI
RGSC_v3.4	7	67,252,510 - 67,269,807 (-)	RGD
Celera	7	60,261,413 - 60,278,690 (-)	RGD

Sequence:

show sequence

CCGAGACACGATGAGGCTGTTCGTGAGCGAAGGCTCCCCGGGTAGCCTGCCGGTGCTGGCTGCG
GCCGCGAGGGCCCGGGGCCGGGCGGAGCTGCTCATCAGCACCGTAGGCCCCGAAGAGTGTGTGG
TACCATTTCTTACCCGGCCTAAGGTCCCTGTCTTGCAGCTGGATAGCGGCAACTACCTCTTCTC
TGCTAGTGCAATCTGCCGATATTTTTTTCTGTTATGCGGCTGGGAACAAGATGATCTTACCAAC
CAATGGCTGGAATGGGAAGCAACAGAACTGCAGCCGGTTCTGTCTGCTGCCCTATACTGTCTAG
TGGTTCAAGGCAAAAAAGGGGAAGATGTACTTGGCCCACTTCGGAGAGTCCTGACTCACATTGA
TCACAGCTTGAGTCGGCAAAACTGTCCTTTCTTGGCAGGGGACACAGAATCTCTAGCTGACATT
GTTTTGTGGGGAGCACTATATCCTTTACTGCAAGACCCAGCTTACCTCCCTGAGGAGTTGGGTG
CCCTACAAAGCTGGTTCCAGACACTAAGTACCCAGGAGCCATGTCAGCGAGCTGCAGAGACTGT
GCTGAAACAGCAGGGTGTCCTGGCACTGCGTCCCTACCTCCAAAAACAGCCCCAGCCCCAGCCC
CTACCTCCTGAGGGGAGAGCTGTCAGCAATGAACCTGAGGAGGAAGAGCTGGCTACCCTGTCTG
AGGAGGACATCATTGCTGCTGTTGCTGCTTGGGAGAAGGGTCTGGAAAACTTACCTCCACTACA
GCCCCAGCAGCATCCAGTGTTGCCTGTGCCTGGAGAAAGGAATGTGCTCATCACGAGTGCCCTC
CCTTATGTCAACAATGTCCCCCACCTTGGAAACATCATTGGCTGTGTGCTCAGTGCTGATGTCT
TTGCAAGGTACTCTCGCCTTCGCCAGTGGAACACCCTCTATCTGTGTGGCACAGATGAGTATGG
TACTGCGACAGAGACCAAGGCCATGGAAGAGGGTCTAACCCCACAAGAAATCTGTGACAAATAC
CACGCCATACATGTTGACATCTACCGCTGGTTCAATATATCGTTTGATACGTTCGGTCGCACAA
CCACTCCTCTGCAGACCAAAATCACACAGGACATCTTCCAGAGGTTGCTGACACGGGGTTTTGT
GCTGCAAGATACTGTAGAGCAGCTTCGCTGTGAGCAGTGTGCACGTTTCTTGGCTGACCGCTTT
GTGGAGGGAGTGTGTCCCTTTTGTGGCTATGAAGAGGCCCGGGGTGACCAGTGTGACAAGTGTG
GCAAGCTCATCAATGCCATTGAGCTCAAGAGACCTCAGTGCAAAGTCTGCCGCTCCCACCCTGT
GGTGAAGTCCTCAAAGCACCTGTTTCTAGACTTGCCTAAGTTAGAGAAGCGCCTGGAGGACTGG
CTGGGGAAGACGATGCCTGGCAGTGACTGGACACCCAATGCCAGGTTCATTATTCGATCCTGGC
TTCGAGATGGACTCAAGCCACGATGCATCACCAGAGACCTCAAATGGGGAACTCCTGTGCCCTT
GGAAGGTTTTGAGGACAAGGTATTTTATGTCTGGTTTGATGCTACTATTGGCTATCTGTCCATC
ACAGCCAACTACACAGACCAGTGGGAGAGATGGTGGAAGAATCCAGAACAAGTGGACCTTTACC
AGTTCATGGCCAAAGACAATGTTCCCTTCCATGGCTTGGTCTTTCCTTGTTCAGCCCTAGGAGC
TGAGGATAACTACACCTTAGTCAAGAACCTCATCGCTACAGAATACCTGAACTACGAGGACGGG
AAGTTCTCTAAGAGCCGGGGGATAGGAGTGTTTGGAGACATGGCCCAAGATACAGGGATCCCTG
CTGACATCTGGCGATTCTATCTGCTATACATTCGGCCTGAGGGCCAGGACAGTGCCTTCTCCTG
GACAGACTTGCTGATTAAAAACAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAATAGA
GCTGGCATGTTCGTGTCTAAGTTTTTTGGGGGTTGTGTGCCTGAGATGGTGCTGACCCACGATG
ACAGACGCCTGGTGGCACATGTCTCCTGGGAACTCCAGCGCTATCACCAGCTGTTGGAAAAGGT
TCGGATCCGGGATGCCTTGCGCAGTATCCTTACCATATCTCGGCATGGCAACCAATATATTCAA
GTGAATGAGCCCTGGAAACGGATTAAAGGCGATGAGATGGACAGGCAGCGGGCAGGCACGGTGA
CAGGAATGGCAGTGAACATAGCTGCCTTGCTGTCTGTCATGCTCCAGCCGTACATGCCCACAGT
CAGCTCCACCATTCAGACCCAGCTCCAGCTCCCAGAGGCAGCCTGCCGCATCCTTGCCACAAGC
TTCATTTGTACCTTACCAGCAGGCCACCGAATTGGCACAGTCAGTCCTTTGTTCCAGAAATTGG
AAAATGACCAGATTGAAAATTTGAGGCAGCGCTTTGGAGGGGGCCAGGCTAAAGGGTCCCCCAA
GCCAGCAGTTGTTGAGGCAGTTACTACAGCAGGGTCGCAGGACATACAAGTGCTGGTGGATGAG
GTAACCAAACAGGGAAACATAGTTCGGGAACTGAAAGCACAGAAGGCAGACAAGAACCAGGTTG
CTGCAGAAGTGGCTAAACTCTTGGATCTAAAGAAACAGTTGGCTTTGGCTGAGGGGAAGCCCAT
TGAAACTCCGAAAGGCAAGAAGAAAAAGTGAGAGAATGTTCACACAAAGTCACTTTACTGGGTA
TGGACAGTAATAAAGAATGTACAGTGTACAA

hide sequence

RefSeq Acc Id:

XM_006241451 ⟹ XP_006241513

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	65,006,456 - 65,023,880 (-)	NCBI
mRatBN7.2	7	63,121,142 - 63,138,550 (-)	NCBI
Rnor_6.0	7	70,585,011 - 70,602,425 (-)	NCBI
Rnor_5.0	7	70,759,159 - 70,776,559 (-)	NCBI

Sequence:

show sequence

CGGCTTTCTTGGAGCTGACTGCGAGCGTGCGGCCGCCCCAGAACTCCATTTCCCTATATACCTT
GCAGCTTAACCCAGAAGCTGGAGGCCCGTTCCGGTTGCATCAGCGTGGGCTCCGAGACACGATG
AGGCTGTTCGTGAGCGAAGGCTCCCCGGGTAGCCTGCCGGTGCTGGCTGCGGCCGCGAGGGCCC
GGGGCCGGGCGGAGCTGCTCATCAGCACCGTAGGCCCCGAAGAGTGTGTGGTACCATTTCTTAC
CCGGCCTAAGGTCCCTGTCTTGCAGCTGGATAGCGGCAACTACCTCTTCTCTGCTAGTGCAATC
TGCCGATATTTTTTTCTGTTATGCGGCTGGGAACAAGATGATCTTACCAACCAATGGCTGGAAT
GGGAAGCAACAGAACTGCAGCCGGTTCTGTCTGCTGCCCTATACTGTCTAGTGGTTCAAGGCAA
AAAAGGGGAAGATGTACTTGGCCCACTTCGGAGAGTCCTGACTCACATTGATCACAGCTTGAGT
CGGCAAAACTGTCCTTTCTTGGCAGGGGACACAGAATCTCTAGCTGACATTGTTTTGTGGGGAG
CACTATATCCTTTACTGCAAGACCCAGCTTACCTCCCTGAGGAGTTGGGTGCCCTACAAAGCTG
GTTCCAGACACTAAGTACCCAGGAGCCATGTCAGCGAGCTGCAGAGACTGTGCTGAAACAGCAG
GGTGTCCTGGCACTGCGTCCCTACCTCCAAAAACAGCCCCAGCCCCAGCCCCTACCTCCTGAGG
GGAGAGCTGTCAGCAATGAACCTGAGGAGGAAGAGCTGGCTACCCTGTCTGAGGAGGACATCAT
TGCTGCTGTTGCTGCTTGGGAGAAGGGTCTGGAAAACTTACCTCCACTACAGCCCCAGCAGCAT
CCAGTGTTGCCTGTGCCTGGAGAAAGGAATGTGCTCATCACGAGTGCCCTCCCTTATGTCAACA
ATGTCCCCCACCTTGGAAACATCATTGGCTGTGTGCTCAGTGCTGATGTCTTTGCAAGGTACTC
TCGCCTTCGCCAGTGGAACACCCTCTATCTGTGTGGCACAGATGAGTATGGTACTGCGACAGAG
ACCAAGGCCATGGAAGAGGGTCTAACCCCACAAGAAATCTGTGACAAATACCACGCCATACATG
TTGACATCTACCGCTGGTTCAATATATCGTTTGATACGTTCGGTCGCACAACCACTCCTCTGCA
GACCAAAATCACACAGGACATCTTCCAGAGGTTGCTGACACGGGGTTTTGTGCTGCAAGATACT
GTAGAGCAGCTTCGCTGTGAGCAGTGTGCACGTTTCTTGGCTGACCGCTTTGTGGAGGGAGTGT
GTCCCTTTTGTGGCTATGAAGAGGCCCGGGGTGACCAGTGTGACAAGTGTGGCAAGCTCATCAA
TGCCATTGAGCTCAAGAGACCTCAGTGCAAAGTCTGCCGCTCCCACCCTGTGGTGAAGTCCTCA
AAGCACCTGTTTCTAGACTTGCCTAAGTTAGAGAAGCGCCTGGAGGACTGGCTGGGGAAGACGA
TGCCTGGCAGTGACTGGACACCCAATGCCAGGTTCATTATTCGATCCTGGCTTCGAGATGGACT
CAAGCCACGATGCATCACCAGAGACCTCAAATGGGGAACTCCTGTGCCCTTGGAAGGTTTTGAG
GACAAGGTATTTTATGTCTGGTTTGATGCTACTATTGGCTATCTGTCCATCACAGCCAACTACA
CAGACCAGTGGGAGAGATGGTGGAAGAATCCAGAACAAGTGGACCTTTACCAGTTCATGGCCAA
AGACAATGTTCCCTTCCATGGCTTGGTCTTTCCTTGTTCAGCCCTAGGAGCTGAGGATAACTAC
ACCTTAGTCAAGAACCTCATCGCTACAGAATACCTGAACTACGAGGACGGGAAGTTCTCTAAGA
GCCGGGGGATAGGAGTGTTTGGAGACATGGCCCAAGATACAGGGATCCCTGCTGACATCTGGCG
ATTCTATCTGCTATACATTCGGCCTGAGGGCCAGGACAGTGCCTTCTCCTGGACAGACTTGCTG
ATTAAAAACAATTCTGAGCTGCTTAACAACCTGGGCAACTTCATCAATAGAGCTGGCATGTTCG
TGTCTAAGTTTTTTGGGGGTTGTGTGCCTGAGATGGTGCTGACCCACGATGACAGACGCCTGGT
GGCACATGTCTCCTGGGAACTCCAGCGCTATCACCAGCTGTTGGAAAAGGTTCGGATCCGGGAT
GCCTTGCGCAGTATCCTTACCATATCTCGGCATGGCAACCAATATATTCAAGTGAATGAGCCCT
GGAAACGGATTAAAGGCGATGAGATGGACAGGCAGCGGGCAGGCACGGTGACAGGAATGGCAGT
GAACATAGCTGCCTTGCTGTCTGTCATGCTCCAGCCGTACATGCCCACAGTCAGCTCCACCATT
CAGACCCAGCTCCAGCTCCCAGAGGCAGCCTGCCGCATCCTTGCCACAAGCTTCATTTGTACCT
TACCAGCAGGCCACCGAATTGGCACAGTCAGTCCTTTGTTCCAGAAATTGGAAAATGACCAGAT
TGAAAATTTGAGGCAGCGCTTTGGAGGGGGCCAGCTAGAAGAGTCTTTGGAGTTACAGGCTAAA
GGGTCCCCCAAGCCAGCAGTTGTTGAGGCAGTTACTACAGCAGGGTCGCAGGACATACAAGTGC
TGGTGGATGAGGTAACCAAACAGGGAAACATAGTTCGGGAACTGAAAGCACAGAAGGCAGACAA
GAACCAGGTTGCTGCAGAAGTGGCTAAACTCTTGGATCTAAAGAAACAGTTGGCTTTGGCTGAG
GGGAAGCCCATTGAAACTCCGAAAGGCAAGAAGAAAAAGTGAGAGAATGTTCACACAAAGTCAC
TTTACTGGGTATGGACAGTAATAAAGAATGTACAGTGTACAAGC

hide sequence

RefSeq Acc Id:

XM_039078755 ⟹ XP_038934683

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	65,006,456 - 65,019,470 (-)	NCBI
mRatBN7.2	7	63,121,142 - 63,135,052 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121131	(Get FASTA)	NCBI Sequence Viewer
	XP_006241513	(Get FASTA)	NCBI Sequence Viewer
	XP_038934683	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM16472	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034945.4
	ENSRNOP00000078365.1
	ENSRNOP00000089312.1

RefSeq Acc Id:

NP_001121131 ⟸ NM_001127659

- UniProtKB:

D3Z941 (UniProtKB/TrEMBL), A0A8I6A8E9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASA
ICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSL
SRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQ
QGVLALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQ
HPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTAT
ETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQD
TVEQLRCEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKS
SKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGF
EDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDN
YTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDL
LIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIR
DALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSST
IQTQLQLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQAKGSPKPAV
VEAVTTAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETP
KGKKKK

hide sequence

RefSeq Acc Id:	XP_006241513 ⟸ XM_006241451
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZKR4 (UniProtKB/TrEMBL), A6HQU9 (UniProtKB/TrEMBL), A0A8I6A8E9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLFSASA ICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYCLVVQGKKGEDVLGPLRRVLTHIDHSL SRQNCPFLAGDTESLADIVLWGALYPLLQDPAYLPEELGALQSWFQTLSTQEPCQRAAETVLKQ QGVLALRPYLQKQPQPQPLPPEGRAVSNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQ HPVLPVPGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTAT ETKAMEEGLTPQEICDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQD TVEQLRCEQCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKS SKHLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVPLEGF EDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVFPCSALGAEDN YTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDL LIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRRLVAHVSWELQRYHQLLEKVRIR DALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRAGTVTGMAVNIAALLSVMLQPYMPTVSST IQTQLQLPEAACRILATSFICTLPAGHRIGTVSPLFQKLENDQIENLRQRFGGGQLEESLELQA KGSPKPAVVEAVTTAGSQDIQVLVDEVTKQGNIVRELKAQKADKNQVAAEVAKLLDLKKQLALA EGKPIETPKGKKKK hide sequence

Ensembl Acc Id:

ENSRNOP00000034945 ⟸ ENSRNOT00000035486

RefSeq Acc Id:	XP_038934683 ⟸ XM_039078755
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000078365 ⟸ ENSRNOT00000106342

Ensembl Acc Id:

ENSRNOP00000089312 ⟸ ENSRNOT00000107571

Protein Domains

GST C-terminal WHEP-TRS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z941-F1-model_v2	AlphaFold	D3Z941	1-902	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695257

Promoter ID:

EPDNEW_R5782

Type:

initiation region

Name:

Mars_1

Description:

methionyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	70,602,320 - 70,602,380	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305321	AgrOrtholog
BioCyc Gene	G2FUF-33753	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
BioCyc Pathway Image	TRNA-CHARGING-PWY	BioCyc
Ensembl Genes	ENSRNOG00000025459	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000035486.5	UniProtKB/TrEMBL
	ENSRNOT00000106342.1	UniProtKB/TrEMBL
	ENSRNOT00000107571.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	2.20.28.20	UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
	S15/NS1, RNA-binding	UniProtKB/TrEMBL
InterPro	aa-tRNA-synt_I	UniProtKB/TrEMBL
	aa-tRNA-synth_I_CS	UniProtKB/TrEMBL
	Anticodon_Met	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	MARS_N	UniProtKB/TrEMBL
	Met-tRNA_synth_1	UniProtKB/TrEMBL
	MetRS_core	UniProtKB/TrEMBL
	MetRS_Zn	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	S15_NS1_RNA-bd	UniProtKB/TrEMBL
	tRNA-synt_met_N	UniProtKB/TrEMBL
	tRNAsynth_1a_anticodon-bd	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
KEGG Report	rno:299851	UniProtKB/TrEMBL
NCBI Gene	299851	ENTREZGENE
PANTHER	METHIONINE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/TrEMBL
	PTHR45765	UniProtKB/TrEMBL
Pfam	Anticodon_3	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	GST_N_5	UniProtKB/TrEMBL
	tRNA-synt_1g	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
PhenoGen	Mars1	PhenoGen
PRINTS	TRNASYNTHMET	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/TrEMBL
	GST_CTER	UniProtKB/TrEMBL
	WHEP_TRS_1	UniProtKB/TrEMBL
	WHEP_TRS_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025459	RatGTEx
SMART	WHEP-TRS	UniProtKB/TrEMBL
Superfamily-SCOP	GST_C_like	UniProtKB/TrEMBL
	Nucleotidylyl transferase	UniProtKB/TrEMBL
	S15/NS1_bind	UniProtKB/TrEMBL
	SSF57770	UniProtKB/TrEMBL
	tRNAsyn_1a_bind	UniProtKB/TrEMBL
UniProt	A0A8I5ZKR4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A8E9	ENTREZGENE, UniProtKB/TrEMBL
	A6HQU9	ENTREZGENE, UniProtKB/TrEMBL
	D3Z941	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-08	Mars1	methionyl-tRNA synthetase 1	Mars	methionyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-05	Mars	methionyl-tRNA synthetase	Mars	methionine-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mars	methionine-tRNA synthetase	Mars_predicted	methionine-tRNA synthetase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mars_predicted	methionine-tRNA synthetase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

BioCyc Pathways