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Gene: Ror2 (receptor tyrosine kinase-like orphan receptor 2) Rattus norvegicus

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Symbol:

Ror2

Name:

receptor tyrosine kinase-like orphan receptor 2

RGD ID:

1305275

Description:

Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and regulation of synaptic signaling by nitric oxide. Located in several cellular components, including cell surface; microtubule; and neuronal cell body. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC306782; tyrosine-protein kinase transmembrane receptor ROR2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	12,124,749 - 12,300,044 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	12,124,749 - 12,300,044 (+)	Ensembl				GRCr8
mRatBN7.2	17	11,972,830 - 12,148,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	11,972,830 - 12,148,152 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	11,902,485 - 12,082,513 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	13,505,264 - 13,680,160 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	11,822,226 - 11,997,115 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	11,953,552 - 12,134,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	11,953,552 - 12,134,386 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	14,049,344 - 14,228,982 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	17,735,999 - 17,917,032 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	11,736,765 - 11,913,446 (+)	NCBI		Celera
RGSC_v3.1	17	17,736,906 - 17,919,811 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant Robinow syndrome 1 (ISO)

autosomal recessive Robinow syndrome (ISO,ISS)

brachydactyly (ISO)

brachydactyly type B1 (ISO)

cleft lip (ISO)

cleft palate (ISO)

Desbuquois dysplasia (ISO)

Dwarfism (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

genetic disease (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

dexamethasone (EXP)

dimethylarsinic acid (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

furan (EXP)

indole-3-methanol (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium chromate (ISO)

pyrvinium (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trametinib (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

astrocyte development (IDA)

BMP signaling pathway (ISO)

bone mineralization (IEP)

cartilage condensation (ISO)

cell differentiation (ISO)

cell fate commitment (ISO)

cell surface receptor protein tyrosine kinase signaling pathway (IBA,IEA)

embryonic digit morphogenesis (ISO)

embryonic genitalia morphogenesis (ISO)

inner ear development (IEA)

inner ear morphogenesis (ISO)

JNK cascade (ISO)

macrophage migration (IMP)

male genitalia development (IEP)

modulation of chemical synaptic transmission (IDA,IMP)

negative regulation of canonical Wnt signaling pathway (ISO)

positive regulation of canonical Wnt signaling pathway (ISO)

positive regulation of cell migration (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of JUN kinase activity (IMP)

positive regulation of macrophage differentiation (IMP)

positive regulation of protein kinase C activity (IMP)

positive regulation of synaptic transmission, glutamatergic (IMP)

regulation of canonical Wnt signaling pathway (ISO)

regulation of postsynapse organization (IDA,IMP)

regulation of synaptic signaling by nitric oxide (IDA,IMP)

signal transduction (ISO)

skeletal system development (ISO)

SMAD protein signal transduction (ISO)

smoothened signaling pathway (ISO)

somitogenesis (ISO)

Wnt signaling pathway (IEA)

Wnt signaling pathway, calcium modulating pathway (ISO)

Wnt signaling pathway, planar cell polarity pathway (ISO)

Cellular Component

axon (IBA)

cell surface (IDA)

dendrite (IDA)

glutamatergic synapse (IDA,IMP)

membrane (IEA)

microtubule (IDA)

neuronal cell body (IDA)

plasma membrane (IBA)

postsynapse (IDA)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

frizzled binding (ISO)

mitogen-activated protein kinase kinase kinase binding (ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

signaling receptor activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA)

Wnt-protein binding (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons.	Alfaro IE, etal., Mol Cell Neurosci. 2015 Jul;67:22-30. doi: 10.1016/j.mcn.2015.05.002. Epub 2015 May 21.
2.	RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission.	Cerpa W, etal., Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4797-802. doi: 10.1073/pnas.1417053112. Epub 2015 Mar 30.
3.	Mutation screening in candidate genes in four Chinese brachydactyly families.	Dong S, etal., Ann Clin Lab Sci. 2015 Winter;45(1):94-9.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	A nonsense mutation in the gene ROR2 underlying autosomal dominant brachydactyly type B.	Habib R, etal., Clin Dysmorphol. 2013 Apr;22(2):47-50. doi: 10.1097/MCD.0b013e32835c6c8c.
7.	Wnt signalling in testicular descent: a candidate mechanism for cryptorchidism in Robinow syndrome.	Harisis GN, etal., J Pediatr Surg. 2013 Jul;48(7):1573-7. doi: 10.1016/j.jpedsurg.2012.08.038.
8.	A new mutation in the gene ROR2 causes brachydactyly type B1.	Huang D, etal., Gene. 2014 Aug 15;547(1):106-10. doi: 10.1016/j.gene.2014.06.035. Epub 2014 Jun 19.
9.	[Mutation analysis of the pathogenic gene in a Chinese family with Brachydactyly type B1].	Li CM, etal., Yi Chuan. 2011 Feb;33(2):147-52.
10.	A novel single-base deletion in ROR2 causes atypical brachydactyly type B1 with cutaneous syndactyly in a large Chinese family.	Lv D, etal., J Hum Genet. 2009 Jul;54(7):422-5. doi: 10.1038/jhg.2009.48. Epub 2009 May 22.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
13.	Differential subcellular localization of Ror tyrosine kinase receptors in cultured astrocytes.	Paganoni S, etal., Glia. 2004 May;46(4):456-66.
14.	Wnt5a inhibits K(+) currents in hippocampal synapses through nitric oxide production.	Parodi J, etal., Mol Cell Neurosci. 2015 Sep;68:314-22. doi: 10.1016/j.mcn.2015.08.011. Epub 2015 Aug 24.
15.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16.	The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.	Raz R, etal., Development. 2008 May;135(9):1713-23. doi: 10.1242/dev.015149. Epub 2008 Mar 19.
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.	Schwabe GC, etal., Dev Dyn. 2004 Feb;229(2):400-10.
22.	Identification of novel ROR2 gene mutations in Indian children with Robinow syndrome.	Tamhankar PM, etal., J Clin Res Pediatr Endocrinol. 2014;6(2):79-83. doi: 10.4274/Jcrpe.1233.
23.	ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population.	Wang H, etal., Chin Med J (Engl). 2012 Feb;125(3):476-80.
24.	The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification.	Xin H, etal., Int J Mol Med. 2013 Mar;31(3):583-8. doi: 10.3892/ijmm.2013.1242. Epub 2013 Jan 15.
25.	Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling.	Yang T, etal., J Dent Res. 2015 Jun;94(6):803-12. doi: 10.1177/0022034515576051. Epub 2015 Mar 6.

Additional References at PubMed

PMID:10700181	PMID:12839624	PMID:15702250	PMID:16602827	PMID:18215320	PMID:18606138	PMID:18762249	PMID:19486338	PMID:20660756	PMID:22609204	PMID:34728368	PMID:37832874

Genomics

Comparative Map Data

Ror2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	12,124,749 - 12,300,044 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	12,124,749 - 12,300,044 (+)	Ensembl				GRCr8
mRatBN7.2	17	11,972,830 - 12,148,152 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	11,972,830 - 12,148,152 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	11,902,485 - 12,082,513 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	13,505,264 - 13,680,160 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	11,822,226 - 11,997,115 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	11,953,552 - 12,134,386 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	11,953,552 - 12,134,386 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	14,049,344 - 14,228,982 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	17,735,999 - 17,917,032 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	11,736,765 - 11,913,446 (+)	NCBI		Celera
RGSC_v3.1	17	17,736,906 - 17,919,811 (-)	NCBI
Cytogenetic Map	17	p14	NCBI

ROR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	91,722,601 - 91,950,228 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	91,563,091 - 91,950,240 (-)	Ensembl			hg38	GRCh38
GRCh37	9	94,484,883 - 94,712,510 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	93,524,705 - 93,752,265 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	91,564,438 - 91,791,999	NCBI
Celera	9	64,921,783 - 65,148,752 (-)	NCBI		Celera
Cytogenetic Map	9	q22.31	NCBI
HuRef	9	64,163,034 - 64,390,111 (-)	NCBI		HuRef
CHM1_1	9	94,631,872 - 94,858,883 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	103,889,331 - 104,116,677 (-)	NCBI		T2T-CHM13v2.0

Ror2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	53,263,353 - 53,440,160 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	53,263,348 - 53,440,160 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	53,109,317 - 53,286,124 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	53,109,312 - 53,286,124 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	53,204,686 - 53,381,478 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	53,121,749 - 53,293,643 (-)	NCBI		MGSCv36	mm8
Celera	13	54,186,098 - 54,362,690 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	27.68	NCBI

Ror2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955515	313,604 - 553,774 (+)	Ensembl
ChiLan1.0	NW_004955515	313,612 - 554,751 (+)	NCBI	ChiLan1.0	ChiLan1.0

ROR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	47,544,807 - 47,768,359 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	47,547,221 - 47,770,508 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	62,782,183 - 63,005,626 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	90,879,826 - 90,939,834 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	90,851,983 - 90,965,084 (-)	Ensembl			panPan2	panpan1.1

ROR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	95,209,122 - 95,280,956 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	95,088,745 - 95,280,151 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	95,543,539 - 95,729,150 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	95,696,378 - 95,881,728 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	95,696,095 - 95,881,726 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	95,323,082 - 95,508,191 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	95,049,721 - 95,234,616 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	95,808,860 - 95,994,257 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ror2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	13,309,541 - 13,354,707 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936796	630,756 - 674,279 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936796	630,307 - 675,157 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ROR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	2,804,061 - 3,035,296 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	2,803,840 - 3,035,384 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	3,602,862 - 3,834,887 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ROR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	102,172,288 - 102,397,297 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	90,423,503 - 90,650,327 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ror2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624868	479,290 - 731,650 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624868	479,303 - 732,723 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ror2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	71,417,974 - 71,589,915 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ror2
1210 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	578
Count of miRNA genes:	290
Interacting mature miRNAs:	357
Transcripts:	ENSRNOT00000015504
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9206505	23859062	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9206505	23859062	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7985243	16523460	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9206505	23859062	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

D17Got13

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	12,095,135 - 12,095,268 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	12,081,372 - 12,081,504	NCBI	Rnor6.0
Rnor_5.0	17	14,175,968 - 14,176,100	UniSTS	Rnor5.0
RGSC_v3.4	17	17,788,880 - 17,789,012	UniSTS	RGSC3.4
RGSC_v3.4	17	17,788,879 - 17,789,012	RGD	RGSC3.4
Celera	17	11,860,445 - 11,860,585	UniSTS
RGSC_v3.1	17	17,788,880 - 17,789,012	RGD
RH 3.4 Map	17	114.1	UniSTS
RH 3.4 Map	17	114.1	RGD
RH 2.0 Map	17	84.7	RGD
Cytogenetic Map	17	p14	UniSTS

BF389188

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	12,093,810 - 12,093,981 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	12,080,047 - 12,080,217	NCBI	Rnor6.0
Rnor_5.0	17	14,174,643 - 14,174,813	UniSTS	Rnor5.0
RGSC_v3.4	17	17,790,167 - 17,790,337	UniSTS	RGSC3.4
Celera	17	11,859,120 - 11,859,290	UniSTS
RH 3.4 Map	17	112.7	UniSTS
Cytogenetic Map	17	p14	UniSTS

BF416265

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	12,147,762 - 12,147,958 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	12,133,997 - 12,134,192	NCBI	Rnor6.0
Rnor_5.0	17	14,228,593 - 14,228,788	UniSTS	Rnor5.0
RGSC_v3.4	17	17,736,193 - 17,736,388	UniSTS	RGSC3.4
Celera	17	11,913,057 - 11,913,252	UniSTS
RH 3.4 Map	17	113.8	UniSTS
Cytogenetic Map	17	p14	UniSTS

AU048412

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	12,074,972 - 12,075,187 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	12,061,034 - 12,061,248	NCBI	Rnor6.0
Rnor_5.0	17	14,155,630 - 14,155,844	UniSTS	Rnor5.0
RGSC_v3.4	17	17,808,957 - 17,809,171	UniSTS	RGSC3.4
Cytogenetic Map	17	p14	UniSTS

Ror2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	12,146,911 - 12,147,861 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	12,133,146 - 12,134,095	NCBI	Rnor6.0
Rnor_5.0	17	14,227,742 - 14,228,691	UniSTS	Rnor5.0
Celera	17	11,912,206 - 11,913,155	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	148	90	89	58	75	58	6	337	174	11	122	81	92	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000090782 ⟹ ENSRNOP00000069636

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	12,124,749 - 12,300,044 (+)	Ensembl
mRatBN7.2 Ensembl	17	11,972,830 - 12,148,152 (+)	Ensembl
Rnor_6.0 Ensembl	17	11,953,552 - 12,134,386 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112214 ⟹ ENSRNOP00000081027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	12,125,301 - 12,300,044 (+)	Ensembl
mRatBN7.2 Ensembl	17	11,973,382 - 12,148,152 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133382 ⟹ ENSRNOP00000103725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	12,171,779 - 12,300,044 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161242 ⟹ ENSRNOP00000111463

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	12,189,366 - 12,300,044 (+)	Ensembl

RefSeq Acc Id:

NM_001107339 ⟹ NP_001100809

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	12,124,749 - 12,300,044 (+)	NCBI
mRatBN7.2	17	11,972,830 - 12,148,152 (+)	NCBI
Rnor_6.0	17	11,953,552 - 12,134,386 (+)	NCBI
Rnor_5.0	17	14,049,344 - 14,228,982 (+)	NCBI
RGSC_v3.4	17	17,735,999 - 17,917,032 (-)	RGD
Celera	17	11,736,765 - 11,913,446 (+)	RGD

Sequence:

show sequence

GTGCCGGAGCCCCGGAGCCTCTGCAGCCGATCTGTGCATCGGGGCAGGGAGAGAGGGACGTCAG
AGTGGCCCTCGAAGGGAACCAGCTTGCGAAGCGCGGGGAAGGAAAGCGCGGACGCGTGGCGGGG
AGGGGTTAAGGCGCCCCGGCCCGAAGCCCGAAGGCCGAGCGCGGCAGGCGACCCGGCACCCACG
GCCCGCAGCATGGCTCGGGGCTGGGTGCGGCCGAGCCGAGTGCCTCTGTGCGTCCGGGCTGTCT
GGACGGCTGCTGCGCTCCTGCTCTGGACACCCTGGACGGCAGGTGAAGTGGAGGACTCAGAGGC
CATTGACACCTTGGGACAACTTGATGGCCCGGACAGCCCACTTCCCACTCTGAAAGGCTACTTT
CTGAATTTTCTGGAGCCCGTCAACAATATCACCATCGTCCAGGGCCAGACGGCAATTCTGCACT
GCAAGGTGGCGGGAAACCCACCTCCCAACGTGCGGTGGCTGAAGAATGATGCCCCTGTCGTACA
GGAGCCACGGAGGGTCATCATCCGGAAGACAGAATATGGCTCCCGGCTGCGGATCCAGGATCTG
GACACGACAGACACGGGCTACTACCAGTGCGTGGCTACCAACGGGCTGAAGACCATTACCGCCA
CTGGTGTTCTGTATGTGCGGCTCGGTCCAACGCACAGCCCGAACCACAATTTTCAGGATGACGA
CCAGGAAGATGGCTTCTGCCAACCTTACCGAGGGATCGCCTGTGCACGCTTCATTGGGAACCGA
ACTATTTATGTGGACTCCCTCCAGATGCAGGGGGAGATTGAAAACCGAATCACAGCTGCCTTCA
CCATGATTGGCACCTCCACGCACCTGTCAGACCAGTGCTCGCAGTTTGCCATCCCATCCTTCTG
CCACTTCGTCTTTCCTCTATGCGACGCGCGCTCCCGGGCGCCCAAGCCGCGGGAGCTGTGCCGG
GATGAATGTGAGGTGTTGGAGAATGACCTGTGCCGCCAGGAGTACACCATCGCCCGCTCCAACC
CTCTCATCCTCATGCGGCTCCAGCTGCCCAAGTGCGAAGCGCTGCCCATGCCCGAGAGCCCTGA
TGCTGCGAACTGCATGCGCATCGGGATCCCCGCCGAGAGGCTGGGTCGCTATCACCAGTGTTAC
AACGGCTCAGGCACTGATTACAGGGGCATGGCCAGCACCACCAAGTCAGGCCACCAATGTCAGC
CTTGGGCTCTGCAACATCCCCACAGCCATCGCCTGTCCAGCACAGAATTTCCAGAGCTGGGAGG
AGGCCACGCCTACTGCCGGAACCCGGGAGGCCAGATGGAAGGCCCGTGGTGCTTTACGCAGAAT
AAAAACGTACGAGTGGAACTGTGTGACGTACCCCCATGTAGTCCCCGAGACGGCAGCAAGATGG
GGATCCTGTACATCCTGGTCCCCAGCATTGCCATCCCCCTGGTCATCGCCTGCCTTTTCTTCCT
TGTCTGCATGTGCCGGAACAAGCAGAAGGCCTCAGCCTCCACCCCGCAGCGCCGGCAGCTGATG
GCCTCGCCCAGCCAGGATATGGAGATGCCACTCATCAGCCAGCACAAACAGGCCAAACTTAAAG
AGATCAGCTTGTCCACGGTGAGGTTCATGGAGGAGCTTGGGGAGGACCGGTTTGGCAAGGTCTA
CAAAGGCCACCTGTTCGGGCCCGCCCCAGGAGAACCAACCCAGGTGGTGGCCATCAAGACGTTG
AAAGACAAGGCTGAGGGGCCCCTGCGGGAGGAGTTCCGGCAAGAGGCCATGCTCCGGGCACGGC
TACAGCACCCCAACATCGTCTGTCTACTAGGTGTGGTGACCAAAGACCAACCCCTGAGCATGGT
CTTCAGTTACTGCTGCCACGGCGACCTCCACGAGTTCCTGGTCATGCGCTCACCGCACTCGGAC
GTGGGCAGCACTGACGATGACCGCACGGTGAAGTCAGCCCTGGAGCCCCCGGACTTCGTTCACG
TGGTGGCGCAGATCGCCGCGGGGATGGAGTTCCTGTCCAGCCACCACGTGGTCCATAAGGACCT
GGCCACCCGTAATGTGCTGGTGTATGACAAGCTGAACGTGAGGATCTCAGACTTGGGCCTCTTC
CGAGAGGTGTACTCCGCCGATTACTACAAACTCATGGGCAACTCGCTGCTTCCCATCCGCTGGA
TGTCCCCCGAGGCCGTCATGTACGGAAAGTTCTCCATTGACTCCGACATCTGGTCCTATGGTGT
GGTCCTCTGGGAGGTCTTCAGCTACGGCCTGCAGCCCTACTGTGGCTACTCCAACCAGGACGTG
GTGGAGATGATCCGTAGCCGGCAGGTACTGCCCTGCCCGGATGACTGCCCCGCCTGGGTCTACG
CCCTCATGATCGAATGCTGGAACGAGTTTCCTAGCGGGAGGCCCCGCTTTAAGGACATCCACGG
CCGGCTCCGATCCTGGGGCAACCTGTCCAACTACAATAGCTCGGCCCAGACCTCAGGAGCCAGC
AACACCACACAGACCAGCTCCCTGAGCACCAGCCCTGTTAGCAATGTGAGCAATGCCCGCTATA
TGGCACCTAAGCAGAAGGCCCAGCCCTTCCCACAGCCTCAGTTCATCCCCATGAAGGGTCAGAT
CAGACCCTTGGTGCCCCCGGCACAGCTCTACATCCCAGTTAATGGCTACCAGCCAGTACCGGCA
TATGGGGCCTACCTGCCCAACTTCTACCCGGTCCAAATCCCCATGCAGATGGCCCCACAGCAGG
TGCCCCCTCAGATGGTCCCCAAGCCCAGCTCACACCACAGTGGCAGCGGCTCCACCAGCACTGG
CTATGTCACCACGGCACCCTCTAACACATCTGTGGCGGACAGGGCAGCCCTCCTCTCGGAGGGC
ACTGAGGATGTACAAAACATGCCAGAAGACGTGGCCCAGAGCCCTGTGCAGGAAGCGGAGGAGG
AGGAGGAAGGTTCTGTCCCAGAGACTGAGCTCCTGGGAGACAGTGACACGCTCCAGGTGAACGA
GGCCCATGTCCACCTTGAAGCCTGAGCAGTATTCGGGGCCTGGAGCACTGGGGCGGAAAGTTCC
TGATGTGGCCAGTGGGGACCTCAAAATGGCTCTGAGAAATCCCCAAGAGGGGTCCATCACCAGA
GCCCAGGGACTGGCAGGCTGGTTTGAGCCTACCCACTTGAGACTGTGAGAGATCTTACACTATC
TCCTGCACCCTGTGCCCATAGAGCTGTCTCTGCAGCCCCGGTTCGGCTGGAGGCCATCTCAGCT
AGGGACCCCGGGCAGGGTCCCTGCAGCATGACCACCTCAGAAACGGGACGGGGAGACCCCCACC
TCTGTCTGCTTCATCCTCATGGTAGATGGGTAGTGAGCTAAAGATGCTGTGCAAAGAGACAGGC
TACATCTTCGCTCCCTGTTTTCTGGGCGGAAGATTCAGAAACTGGGGTAGAAACAGGGCTGTGA
AGGGTAGCAGAGAGGCGCCTTGGGGTGTAGATGCTGAGCGAGCCTCCTGCTGGCTGAGGACGGA
GAGAGAGCTGTTCTCTCTGTGGCCGGCTGCAGAACTTGTTCGTTTGAACAGCCAAAGGCCAGCA
GAAGCAGGATGCTGCCACCTGCTGGGGTCCGAAGGACAGGGGAGCTTCTGAACAGTTGGGAGTG
CCTTGTATTAAAGGGGGGGAAAGTGCCTTTACGAAAACCAGCACGACCTTGTATTTTGTGAAGG
GTTTTAATGATTACTGCGTATGTAATTCAAGGGTGGGGGGGGAATGTTTCCTGGGTTTAGAATG
TCCAAAAGGAAGCAACGTTGTACAAAAAAAAAAAAAAATCAGTGTTGTTAATTTTTTTTTTTTA
AGAATCCTGTGCAGACCTTAAATGTAATTTATATGGTTTTCTGTGTGCCATTTTCGTGGAAGTA
TTTTGATCCTAAATAATGAGTTAGTAATTTAATCATGT

hide sequence

RefSeq Acc Id:

XM_017600508 ⟹ XP_017455997

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	12,189,294 - 12,300,043 (+)	NCBI
mRatBN7.2	17	12,037,411 - 12,148,151 (+)	NCBI
Rnor_6.0	17	12,022,295 - 12,134,385 (+)	NCBI

Sequence:

show sequence

GCGCGCATGTGCTTGGGATGTACGTGCTTGGGGATTGGAAGGCTGGCAGTGCTCTCAGCACGCA
TTGACGTAAATGAAGGGCGACGGGCACCCCCAGGGCGGGTTGCTGTGGAAAGTAGTCTGGTGGT
CCTTGCCCTCAGATGACTGGTAGCTAGACCTCGGGCAGTTTGTATACCAGATCCTTTCTGCTCT
GTTCTTAGCAGATTGCCTTCGTTTTAAAACAATGGCCTTGGAGCCTTCGGCAGTGTTGTTATTA
ATCAAACAAAACGACATTTTCTTCTTTAATGACTAAATTACCCAAGCACCAGCTTAGATTGGTG
GTTGGCAAACCTTTTCCAGGAAAGACCAGGTTGCACATTGTTACGGTTTTCTGGGAAGACTTTG
GATGTCAAAACCATTCAGGTGAAGTGGAGGACTCAGAGGCCATTGACACCTTGGGACAACTTGA
TGGCCCGGACAGCCCACTTCCCACTCTGAAAGGCTACTTTCTGAATTTTCTGGAGCCCGTCAAC
AATATCACCATCGTCCAGGGCCAGACGGCAATTCTGCACTGCAAGGTGGCGGGAAACCCACCTC
CCAACGTGCGGTGGCTGAAGAATGATGCCCCTGTCGTACAGGAGCCACGGAGGGTCATCATCCG
GAAGACAGAATATGGCTCCCGGCTGCGGATCCAGGATCTGGACACGACAGACACGGGCTACTAC
CAGTGCGTGGCTACCAACGGGCTGAAGACCATTACCGCCACTGGTGTTCTGTATGTGCGGCTCG
GTCCAACGCACAGCCCGAACCACAATTTTCAGGATGACGACCAGGAAGATGGCTTCTGCCAACC
TTACCGAGGGATCGCCTGTGCACGCTTCATTGGGAACCGAACTATTTATGTGGACTCCCTCCAG
ATGCAGGGGGAGATTGAAAACCGAATCACAGCTGCCTTCACCATGATTGGCACCTCCACGCACC
TGTCAGACCAGTGCTCGCAGTTTGCCATCCCATCCTTCTGCCACTTCGTCTTTCCTCTATGCGA
CGCGCGCTCCCGGGCGCCCAAGCCGCGGGAGCTGTGCCGGGATGAATGTGAGGTGTTGGAGAAT
GACCTGTGCCGCCAGGAGTACACCATCGCCCGCTCCAACCCTCTCATCCTCATGCGGCTCCAGC
TGCCCAAGTGCGAAGCGCTGCCCATGCCCGAGAGCCCTGATGCTGCGAACTGCATGCGCATCGG
GATCCCCGCCGAGAGGCTGGGTCGCTATCACCAGTGTTACAACGGCTCAGGCACTGATTACAGG
GGCATGGCCAGCACCACCAAGTCAGGCCACCAATGTCAGCCTTGGGCTCTGCAACATCCCCACA
GCCATCGCCTGTCCAGCACAGAATTTCCAGAGCTGGGAGGAGGCCACGCCTACTGCCGGAACCC
GGGAGGCCAGATGGAAGGCCCGTGGTGCTTTACGCAGAATAAAAACGTACGAGTGGAACTGTGT
GACGTACCCCCATGTAGTCCCCGAGACGGCAGCAAGATGGGGATCCTGTACATCCTGGTCCCCA
GCATTGCCATCCCCCTGGTCATCGCCTGCCTTTTCTTCCTTGTCTGCATGTGCCGGAACAAGCA
GAAGGCCTCAGCCTCCACCCCGCAGCGCCGGCAGCTGATGGCCTCGCCCAGCCAGGATATGGAG
ATGCCACTCATCAGCCAGCACAAACAGGCCAAACTTAAAGAGATCAGCTTGTCCACGGTGAGGT
TCATGGAGGAGCTTGGGGAGGACCGGTTTGGCAAGGTCTACAAAGGCCACCTGTTCGGGCCCGC
CCCAGGAGAACCAACCCAGGTGGTGGCCATCAAGACGTTGAAAGACAAGGCTGAGGGGCCCCTG
CGGGAGGAGTTCCGGCAAGAGGCCATGCTCCGGGCACGGCTACAGCACCCCAACATCGTCTGTC
TACTAGGTGTGGTGACCAAAGACCAACCCCTGAGCATGGTCTTCAGTTACTGCTGCCACGGCGA
CCTCCACGAGTTCCTGGTCATGCGCTCACCGCACTCGGACGTGGGCAGCACTGACGATGACCGC
ACGGTGAAGTCAGCCCTGGAGCCCCCGGACTTCGTTCACGTGGTGGCGCAGATCGCCGCGGGGA
TGGAGTTCCTGTCCAGCCACCACGTGGTCCATAAGGACCTGGCCACCCGTAATGTGCTGGTGTA
TGACAAGCTGAACGTGAGGATCTCAGACTTGGGCCTCTTCCGAGAGGTGTACTCCGCCGATTAC
TACAAACTCATGGGCAACTCGCTGCTTCCCATCCGCTGGATGTCCCCCGAGGCCGTCATGTACG
GAAAGTTCTCCATTGACTCCGACATCTGGTCCTATGGTGTGGTCCTCTGGGAGGTCTTCAGCTA
CGGCCTGCAGCCCTACTGTGGCTACTCCAACCAGGACGTGGTGGAGATGATCCGTAGCCGGCAG
GTACTGCCCTGCCCGGATGACTGCCCCGCCTGGGTCTACGCCCTCATGATCGAATGCTGGAACG
AGTTTCCTAGCGGGAGGCCCCGCTTTAAGGACATCCACGGCCGGCTCCGATCCTGGGGCAACCT
GTCCAACTACAATAGCTCGGCCCAGACCTCAGGAGCCAGCAACACCACACAGACCAGCTCCCTG
AGCACCAGCCCTGTTAGCAATGTGAGCAATGCCCGCTATATGGCACCTAAGCAGAAGGCCCAGC
CCTTCCCACAGCCTCAGTTCATCCCCATGAAGGGTCAGATCAGACCCTTGGTGCCCCCGGCACA
GCTCTACATCCCAGTTAATGGCTACCAGCCAGTACCGGCATATGGGGCCTACCTGCCCAACTTC
TACCCGGTCCAAATCCCCATGCAGATGGCCCCACAGCAGGTGCCCCCTCAGATGGTCCCCAAGC
CCAGCTCACACCACAGTGGCAGCGGCTCCACCAGCACTGGCTATGTCACCACGGCACCCTCTAA
CACATCTGTGGCGGACAGGGCAGCCCTCCTCTCGGAGGGCACTGAGGATGTACAAAACATGCCA
GAAGACGTGGCCCAGAGCCCTGTGCAGGAAGCGGAGGAGGAGGAGGAAGGTTCTGTCCCAGAGA
CTGAGCTCCTGGGAGACAGTGACACGCTCCAGGTGAACGAGGCCCATGTCCACCTTGAAGCCTG
AGCAGTATTCGGGGCCTGGAGCACTGGGGCGGAAAGTTCCTGATGTGGCCAGTGGGGACCTCAA
AATGGCTCTGAGAAATCCCCAAGAGGGGTCCATCACCAGAGCCCAGGGACTGGCAGGCTGGTTT
GAGCCTACCCACTTGAGACTGTGAGAGATCTTACACTATCTCCTGCACCCTGTGCCCATAGAGC
TGTCTCTGCAGCCCCGGTTCGGCTGGAGGCCATCTCAGCTAGGGACCCCGGGCAGGGTCCCTGC
AGCATGACCACCTCAGAAACGGGACGGGGAGACCCCCACCTCTGTCTGCTTCATCCTCATGGTA
GATGGGTAGTGAGCTAAAGATGCTGTGCAAAGAGACAGGCTACATCTTCGCTCCCTGTTTTCTG
GGCGGAAGATTCAGAAACTGGGGTAGAAACAGGGCTGTGAAGGGTAGCAGAGAGGCGCCTTGGG
GTGTAGATGCTGAGCGAGCCTCCTGCTGGCTGAGGACGGAGAGAGAGCTGTTCTCTCTGTGGCC
GGCTGCAGAACTTGTTCGTTTGAACAGCCAAAGGCCAGCAGAAGCAGGATGCTGCCACCTGCTG
GGGTCCGAAGGACAGGGGAGCTTCTGAACAGTTGGGAGTGCCTTGTATTAAAGGGGGGGAAAGT
GCCTTTACGAAAACCAGCACGACCTTGTATTTTGTGAAGGGTTTTAATGATTACTGCGTATGTA
ATTCAAGGGTGGGGGGGGAATGTTTCCTGGGTTTAGAATGTCCAAAAGGAAGCAACGTTGTACA
AAAAAAAAAAAAAATCAGTGTTGTTAATTTTTTTTTTTTAAGAATCCTGTGCAGACCTTAAATG
TAATTTATATGGTTTTCTGTGTGCCATTTTCGTGGAAGTATTTTGATCCTAAATAATGAGTTAG
TAATTTAATCATG

hide sequence

RefSeq Acc Id:

XM_063276345 ⟹ XP_063132415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	12,131,789 - 12,300,043 (+)	NCBI

RefSeq Acc Id:

XM_063276346 ⟹ XP_063132416

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	12,209,292 - 12,300,043 (+)	NCBI

RefSeq Acc Id:

XM_063276347 ⟹ XP_063132417

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	12,291,056 - 12,300,043 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100809	(Get FASTA)	NCBI Sequence Viewer
	XP_017455997	(Get FASTA)	NCBI Sequence Viewer
	XP_063132415	(Get FASTA)	NCBI Sequence Viewer
	XP_063132416	(Get FASTA)	NCBI Sequence Viewer
	XP_063132417	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98062	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069636
	ENSRNOP00000069636.1
	ENSRNOP00000081027.1
	ENSRNOP00000103725.1
	ENSRNOP00000111463
	ENSRNOP00000111463.1

RefSeq Acc Id:	NP_001100809 ⟸ NM_001107339
- Peptide Label:	precursor
- UniProtKB:	D3ZNY8 (UniProtKB/TrEMBL), A6J6R2 (UniProtKB/TrEMBL), A0A8I5ZRJ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARGWVRPSRVPLCVRAVWTAAALLLWTPWTAGEVEDSEAIDTLGQLDGPDSPLPTLKGYFLNF LEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTT DTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIY VDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDEC EVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGS GTDYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNV RVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASP SQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQVVAIKTLKDK AEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMVFSYCCHGDLHEFLVMRSPHSDVGS TDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREV YSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEM IRSRQVLPCPDDCPAWVYALMIECWNEFPSGRPRFKDIHGRLRSWGNLSNYNSSAQTSGASNTT QTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGA YLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTED VQNMPEDVAQSPVQEAEEEEEGSVPETELLGDSDTLQVNEAHVHLEA hide sequence

RefSeq Acc Id:	XP_017455997 ⟸ XM_017600508
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZRJ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTKLPKHQLRLVVGKPFPGKTRLHIVTVFWEDFGCQNHSGEVEDSEAIDTLGQLDGPDSPLPTL KGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLR IQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARF IGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPR ELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRY HQCYNGSGTDYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWC FTQNKNVRVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQR RQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQVVA IKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMVFSYCCHGDLHEFLVMRS PHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISD LGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYS NQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSGRPRFKDIHGRLRSWGNLSNYNSSAQT SGASNTTQTSSLSTSPVSNVSNARYMAPKQKAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQ PVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAAL LSEGTEDVQNMPEDVAQSPVQEAEEEEEGSVPETELLGDSDTLQVNEAHVHLEA hide sequence

Ensembl Acc Id:

ENSRNOP00000069636 ⟸ ENSRNOT00000090782

Ensembl Acc Id:

ENSRNOP00000081027 ⟸ ENSRNOT00000112214

RefSeq Acc Id:	XP_063132415 ⟸ XM_063276345
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZRJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132416 ⟸ XM_063276346
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZRJ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132417 ⟸ XM_063276347
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000111463 ⟸ ENSRNOT00000161242

Ensembl Acc Id:

ENSRNOP00000103725 ⟸ ENSRNOT00000133382

Protein Domains

FZ Ig-like Kringle Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZNY8-F1-model_v2	AlphaFold	D3ZNY8	1-943	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700332

Promoter ID:

EPDNEW_R10856

Type:

initiation region

Name:

Ror2_1

Description:

receptor tyrosine kinase-like orphan receptor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	11,953,527 - 11,953,587	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305275	AgrOrtholog
BioCyc Gene	G2FUF-10120	BioCyc
Ensembl Genes	ENSRNOG00000053232	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000090782	ENTREZGENE
	ENSRNOT00000090782.3	UniProtKB/TrEMBL
	ENSRNOT00000112214.2	UniProtKB/TrEMBL
	ENSRNOT00000133382.1	UniProtKB/TrEMBL
	ENSRNOT00000161242	ENTREZGENE
	ENSRNOT00000161242.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/TrEMBL
	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Frizzled-like_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Kringle	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	RTK	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	Tyr_kinase_rcpt_ROR_subgr	UniProtKB/TrEMBL
	Tyr_prot_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:306782	UniProtKB/TrEMBL
NCBI Gene	306782	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE RECEPTOR	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2	UniProtKB/TrEMBL
Pfam	I-set	UniProtKB/TrEMBL
	Kringle	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Ror2	PhenoGen
PIRSF	TyrPK_TMrec_ROR	UniProtKB/TrEMBL
PRINTS	KRINGLE	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
	KRINGLE_1	UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000053232	RatGTEx
SMART	IGc2	UniProtKB/TrEMBL
	SM00130	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8I5ZRJ7	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L3K4_RAT	UniProtKB/TrEMBL
	A0ABK0M2Z2_RAT	UniProtKB/TrEMBL
	A6J6R2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZNY8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ror2	receptor tyrosine kinase-like orphan receptor 2	Ror2_predicted	receptor tyrosine kinase-like orphan receptor 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ror2_predicted	receptor tyrosine kinase-like orphan receptor 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - OMIM

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