RGD Reference Report - RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission. - Rat Genome Database

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RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission.

Authors: Cerpa, W  Latorre-Esteves, E  Barria, A 
Citation: Cerpa W, etal., Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4797-802. doi: 10.1073/pnas.1417053112. Epub 2015 Mar 30.
RGD ID: 11537351
Pubmed: PMID:25825749   (View Abstract at PubMed)
PMCID: PMC4403196   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.1417053112   (Journal Full-text)

Wnt signaling has a well-established role as a regulator of nervous system development, but its role in the maintenance and regulation of established synapses in the mature brain remains poorly understood. At excitatory glutamatergic synapses, NMDA receptors (NMDARs) have a fundamental role in synaptogenesis, synaptic plasticity, and learning and memory; however, it is not known what controls their number and subunit composition. Here we show that the receptor tyrosine kinase-like orphan receptor 2 (RoR2) functions as a Wnt receptor required to maintain basal NMDAR-mediated synaptic transmission. In addition, RoR2 activation by a noncanonical Wnt ligand activates PKC and JNK and acutely enhances NMDAR synaptic responses. Regulation of a key component of glutamatergic synapses through RoR2 provides a mechanism for Wnt signaling to modulate synaptic transmission, synaptic plasticity, and brain function acutely beyond embryonic development.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite  IDA 11537351 RGD 
neuronal cell body  IDA 11537351 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ror2  (receptor tyrosine kinase-like orphan receptor 2)


Additional Information